Comparison of a morphine and midazolam combination with morphine alone for paediatric displaced fractures: A randomized study

Acta Paediatrica, International Journal of Paediatrics

Volumn 100, Issue 11, 2011, Pages

  Wille Ledon, Chrystèle ^a   Chappuy, Hélène ^a,b,c   Giraud, Carole ^b   Tréluyer, Jean Marc ^b,c,d   Chéron, Gérard ^a  

^a HÔPITAL NECKER ENFANTS MALADES   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c HÔpital Européen Georges Pompidou   (France)

^d ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS   (France)

Author keywords

Analgesia; Fractures; Orthopaedic injury; Pain management; Sedation

Indexed keywords

MIDAZOLAM; MORPHINE;

ADOLESCENT; AGITATION; APNEA; ARTICLE; CHILD; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DROWSINESS; DRUG EFFICACY; DRUG SAFETY; EMERGENCY WARD; FEMALE; FIBULA FRACTURE; FRACTURE DISLOCATION; HUMAN; HUMERUS FRACTURE; LONG BONE; MAJOR CLINICAL STUDY; MALE; PAIN; PAIN ASSESSMENT; PRIORITY JOURNAL; RADIUS FRACTURE; RANDOMIZED CONTROLLED TRIAL; RASH; SEDATION; SIDE EFFECT; SOMNOLENCE; TIBIA FRACTURE; ULNA FRACTURE; VISUAL ANALOG SCALE; VOMITING;

ADMINISTRATION, ORAL; ADMINISTRATION, SUBLINGUAL; ADOLESCENT; ANALGESICS, OPIOID; CHILD; CHILD, PRESCHOOL; DRUG THERAPY, COMBINATION; FRACTURES, BONE; HUMANS; HYPNOTICS AND SEDATIVES; MIDAZOLAM; MORPHINE; PAIN; PAIN MEASUREMENT; PARIS; PROSPECTIVE STUDIES; SLEEP STAGES; TIME FACTORS;

EID: 80054019135     PISSN: 08035253     EISSN: 16512227     Source Type: Journal    
DOI: 10.1111/j.1651-2227.2011.02311.x     Document Type: Article

References (15)

1. The National Agency for Health Accreditation and Evaluation. Evaluation and management strategies for acute pain in ambulatory care of children aged 1 month to 15 years. Arch Pédiatr 2001; 8: 420-32.
2. Zempsky WT, Cravero JP,; and the Committee on Pediatric Emergency Medicine and Section on Anesthesiology and Pain Medicine. Relief of pain and anxiety in pediatric patients in emergency medical system. Pediatrics 2004; 114: 1348-56. (Pubitemid 41647700)
3. Suc A, Wood C,. Treatment of acute pain in children. In:, Ducassé JL, editor. Douleurs aiguës en situation d'urgence: des techniques à la démarche qualité. DeQuad Arnette 2004: 115-22.
4. Wille C, Bocquet N, Cojocaru B, Leis A, Chéron G,. Oral morphine administration for children's traumatic pain. Arch Pédiatr 2005; 12: 248-53. (Pubitemid 40340705)
5. Khalil S, Philbrook L, Rabb M, Wagner K, Jennings C, Chuang AZ, et al., Sublingual midazolam premedication in children: a dose responsive study. Paediatr Anaesth 1998; 8: 461-5. (Pubitemid 28523405)
6. Geldner G, Hubmann M, Knoll R, Jacobi K,. Comparison between three transmucosal routes of administration of midazolam in children. Paediatr Anaesth 1997; 7: 103-9. (Pubitemid 27241678)
7. Jasmin L, Wu MV, Ohara PT,. GABA puts a stop to pain. Curr Drug Targets CNS Neurol Disord 2004; 3: 487-505. (Pubitemid 40081277)
8. Zeilhofer HU, Möhler H, Di Lio A,. GABAergic analgesia: new insights from mutant mice and subtype-selective agonists. Trends Pharmacol Sci 2009; 30: 397-402.
9. Mirza NR, Munro G,. The role of GABA(A) receptor subtypes as analgesic targets. Drug News Perspect 2010; 23: 351-60.
10. Saari TI, Uusi-Oukari M, Ahonen J, Olkkola KT,. Enhancement of GABAergic activity: neuropharmacological effects of benzodiazepines and therapeutic use in anesthesiology. Pharmacol Rev 2011; 63: 243-67.
11. Friday JH, Kanegaye JT, McCaslin I, Zheng A, Harley JR,. Ibuprofen provides analgesia equivalent to acetaminophen-codeine in the treatment of acute pain in children with extremity injuries: a randomized clinical trial. Acad Emerg Med 2009; 16: 711-6.
12. Charney RL, Yan Y, Schootman M, Kennedy RM, Luhmann JD,. Oxycodone versus codeine for triage pain in children with suspected forearm fracture: a randomized controlled trial. Pediatr Emerg Care 2008; 24: 595-600.
13. Borland M, Jacobs I, King B, O'Brien D,. A randomized controlled trial comparing intranasal fentanyl to intravenous morphine for managing acute pain in children in the emergency department. Ann Emerg Med 2007; 49: 335-40.
14. Harrison D, Bueno M, Yamada J, Adams-Webber T, Stevens B,. Analgesic effects ofvsweet-tasting solutions for infants: current state of equipoise. Pediatrics 2010; 126: 894-902.
15. von Baeyer CL,. Children's self-report of pain intensity: what we know, where we are headed. Pain Res Manag 2009; 14: 39-45.