Involvement of the bulge region with decreased expression of hair follicle stem cell markers in senile female cases of alopecia areata

Journal of the European Academy of Dermatology and Venereology

Volumn 25, Issue 11, 2011, Pages 1346-1350

  Yoshida, R ^a   Tanaka, K ^a   Amagai, M ^a   Ohyama, M ^a  

^a KEIO UNIVERSITY   (Japan)

Author keywords

alopecia areata; bulge; CD200; keratin15

Indexed keywords

CD200 ANTIGEN; CELL ANTIBODY; CYTOKERATIN 15; PROTEIN ANTIBODY; TRIAMCINOLONE ACETONIDE;

AGED; ALOPECIA AREATA; ARTICLE; CASE REPORT; CORTICOSTEROID THERAPY; DISEASE MARKER; FEMALE; HAIR FOLLICLE; HAIR FOLLICLE STEM CELL; HAIR GROWTH; HAIR LOSS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LYMPHOCYTIC INFILTRATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PUNCH BIOPSY; SENILITY; STEM CELL;

AGED; ALOPECIA AREATA; BIOLOGICAL MARKERS; FEMALE; HAIR; HUMANS; IMMUNOHISTOCHEMISTRY; STEM CELLS;

EID: 80054015517     PISSN: 09269959     EISSN: 14683083     Source Type: Journal    
DOI: 10.1111/j.1468-3083.2010.03956.x     Document Type: Article

References (13)

1. Gilhar A, Paus R, Kalish RS,. Lymphocytes, neuropeptides, and genes involved in alopecia areata. J Clin Invest 2007; 117: 2019-2027. (Pubitemid 47219540)
2. Alkhalifah A, Alsantali A, Wang E, et al. Alopecia areata update: part I. Clinical picture, histopathology, and pathogenesis. J Am Acad Dermatol 2010; 62: 177-188.
3. Whiting DA,. Histopathology of alopecia areata in horizontal sections of scalp biopsies. J Invest Dermatol 1995; 104: 26S-27S.
4. Cotsarelis G, Sun TT, Lavker RM,. Label-retaining cells reside in the bulge area of pilosebaceous unit: implications for follicular stem cells, hair cycle, and skin carcinogenesis. Cell 1990; 61: 1329-1337.
5. Ohyama M, Terunuma A, Tock CL, et al. Characterization and isolation of stem cell-enriched human hair follicle bulge cells. J Clin Invest 2006; 116: 249-260. (Pubitemid 43121810)
6. Cotsarelis G, Millar SE,. Towards a molecular understanding of hair loss and its treatment. Trends Mol Med 2001; 7: 293-301. (Pubitemid 32606568)
7. Mobini N, Tam S, Kamino H,. Possible role of the bulge region in the pathogenesis of inflammatory scarring alopecia: lichen planopilaris as the prototype. J Cutan Pathol 2005; 32: 675-679. (Pubitemid 41719747)
8. Lyle S, Christofidou-Solomidou M, Liu Y, et al. The C8/144B monoclonal antibody recognizes cytokeratin 15 and defines the location of human hair follicle stem cells. J Cell Sci 1998; 111: 3179-3188. (Pubitemid 28532428)
9. Hoang MP, Keady M, Mahalingam M,. Stem cell markers (cytokeratin 15, CD34 and nestin) in primary scarring and nonscarring alopecia. Br J Dermatol 2009; 160: 609-615.
10. Harries MJ, Meyer KC, Chaudhry IH, et al. Does collapse of immune privilege in the hair-follicle bulge play a role in the pathogenesis of primary cicatricial alopecia? Clin Exp Dermatol 2010; 35: 637-644.
11. Rosenblum MD, Olasz EB, Yancey KB, et al. Expression of CD200 on epithelial cells of the murine hair follicle: a role in tissue-specific immune tolerance? J Invest Dermatol 2004; 123: 880-887. (Pubitemid 39391933)
12. Meyer KC, Klatte JE, Dinh HV, et al. Evidence that the bulge region is a site of relative immune privilege in human hair follicles. Br J Dermatol 2008; 159: 1077-1085.
13. Ohyama M,. Hair follicle bulge: a fascinating reservoir of epithelial stem cells. J Dermatol Sci 2007; 46: 81-89. (Pubitemid 46467282)