Does collapse of immune privilege in the hair-follicle bulge play a role in the pathogenesis of primary cicatricial alopecia?

Clinical and Experimental Dermatology

Volumn 35, Issue 6, 2010, Pages 637-644

  Harries, M J ^a   Meyer, K C ^b   Chaudhry, I H ^c   Griffiths, C E M ^a   Paus, R ^a,b  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF LÜBECK   (Germany)

^c MANCHESTER ROYAL INFIRMARY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

11 HYDROXYCORTICOSTEROID; ANTIINFECTIVE AGENT; ANTINUCLEAR ANTIBODY; BETA 2 MICROGLOBULIN; CELL NUCLEUS ANTIGEN; CLINDAMYCIN; CLOBETASOL PROPIONATE; CYTOKERATIN 15; DOUBLE STRANDED DNA ANTIBODY; HYDROXYCHLOROQUINE; ISOTRETINOIN; OXYTETRACYCLINE; RIFAMPICIN;

ADULT; ALOPECIA; ARTICLE; CASE REPORT; CHINESE HERB; DISCOID LUPUS ERYTHEMATOSUS; FEMALE; FOLLICULITIS; FOLLICULITIS DECALVANS; HAIR FOLLICLE; HAIR LOSS; HUMAN; IMMUNITY; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LICHEN PLANOPILARIS; LICHEN PLANUS; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; PRIMARY CICATRICIAL ALOPECIA; PRIORITY JOURNAL; SCALP; SKIN BIOPSY;

ADULT; ALOPECIA; FEMALE; HAIR FOLLICLE; HUMANS; IMMUNOHISTOCHEMISTRY; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; MIDDLE AGED; STEM CELLS;

EID: 77954338176     PISSN: 03076938     EISSN: 13652230     Source Type: Journal    
DOI: 10.1111/j.1365-2230.2009.03692.x     Document Type: Article

References (25)

1. Harries MJ, Trueb RM, Tosti A et al. How not to get scar(r)ed: pointers to the correct diagnosis in patients with suspected primary cicatricial alopecia. Br J Dermatol 2009 160: 482 501.
2. Harries MJ, Meyer KC, Paus R. Hair loss as a result of cutaneous autoimmunity: frontiers in the immunopathogenesis of primary cicatricial alopecia. Autoimmun Rev 2009 8: 478 483.
3. Harries MJ, Paus R. Scarring alopecia and the PPAR-gamma connection. J Invest Dermatol 2009 129: 1066 1070.
4. Hoang MP, Keady M, Mahalingam M. Stem cell markers (cytokeratin 15, CD34 and nestin) in primary scarring and nonscarring alopecia. Br J Dermatol 2009 160: 609 615.
5. Pozdnyakova O, Mahalingam M. Involvement of the bulge region in primary scarring alopecia. J Cutan Pathol 2008 35: 922 925.
6. Al-Refu K, Goodfield M. Hair follicle stem cells in the pathogenesis of the scarring process in cutaneous lupus erythematosus. Autoimmun Rev 2009 8: 474 477.
7. Ito M, Liu Y, Yang Z et al. Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis. Nat Med 2005 11: 1351 1354.
8. Paus R, Cotsarelis G. The biology of hair follicles. N Engl J Med 1999 341: 491 497.
9. Paus R, Nickoloff BJ, Ito T. A 'hairy' privilege. Trends Immunol 2005 26: 32 40.
10. Harries MJ, Sinclair R, MacDonald-Hull S et al. Primary cicatricial alopecias: options for treatment. Br J Dermatol 2008 159: 1 22.
11. Niederkorn JY. See no evil, hear no evil, do no evil: the lessons of immune privilege. Nat Immunol 2006 7: 354 359.
12. Christoph T, Muller-Rover S, Audring H et al. The human hair follicle immune system: cellular composition and immune privilege. Br J Dermatol 2000 142: 862 873.
13. Ito T, Ito N, Bettermann A et al. Collapse and restoration of MHC class-I-dependent immune privilege: exploiting the human hair follicle as a model. Am J Pathol 2004 164: 623 634.
14. Meyer KC, Klatte JE, Dinh HV et al. Evidence that the bulge region is a site of relative immune privilege in human hair follicles. Br J Dermatol 2008 159: 1077 1085.
15. Lyle S, Christofidou-Solomidou M, Liu Y et al. The C8/144B monoclonal antibody recognizes cytokeratin 15 and defines the location of human hair follicle stem cells. J Cell Sci 1998 111: 3179 3188.
16. Cotsarelis G, Sun TT, Lavker RM. Label-retaining cells reside in the bulge area of pilosebaceous unit: implications for follicular stem cells, hair cycle, and skin carcinogenesis. Cell 1990 61: 1329 1337.
17. Amoh Y, Li L, Katsuoka K et al. Multipotent nestin-positive, keratin-negative hair-follicle bulge stem cells can form neurons. Proc Natl Acad Sci USA 2005 102: 5530 5534.
18. Claudinot S, Nicolas M, Oshima H et al. Long-term renewal of hair follicles from clonogenic multipotent stem cells. Proc Natl Acad Sci USA 2005 102: 14677 14682.
19. Blanpain C, Lowry WE, Geoghegan A et al. Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche. Cell 2004 118: 635 648.
20. Ohyama M, Terunuma A, Tock CL et al. Characterization and isolation of stem cell-enriched human hair follicle bulge cells. J Clin Invest 2006 116: 249 260.
21. Rosenblum MD, Yancey KB, Olasz EB et al. CD200, a 'no danger' signal for hair follicles. J Dermatol Sci 2006 41: 165 174.
22. Gilhar A, Paus R, Kalish RS. Lymphocytes, neuropeptides, and genes involved in alopecia areata. J Clin Invest 2007 117: 2019 2027.
23. Tiede S, Kloepper JE, Bodo E et al. Hair follicle stem cells: walking the maze. Eur J Cell Biol 2007 86: 355 376.
24. Kloepper JE, Tiede S, Brinckmann J et al. Immunophenotyping of the human bulge region: the quest to define useful in situ markers for human epithelial hair follicle stem cells and their niche. Exp Dermatol 2008 17: 592 609.
25. Lu Z, Hasse S, Bodo E et al. Towards the development of a simplified long-term organ culture method for human scalp skin and its appendages under serum-free conditions. Exp Dermatol 2007 16: 37 44.