Opposite effects of amlodipine and enalapril on infarct collagen and remodelling during healing after reperfused myocardial infarction

Canadian Journal of Cardiology

Volumn 16, Issue 5, 2000, Pages 617-625

  Jugdutt, Bodh I ^a   Musat Marcu, Sorin ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

ACE inhibitors; Calcium channel blockers; Collagen; Myocardial infarction; Remodelling; Reperfusion

Indexed keywords

AMLODIPINE; ENALAPRIL; HYDROXYPROLINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOG; DRUG EFFECT; HEALING; HEART INFARCTION; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE REPERFUSION; HEART VENTRICLE REMODELING; NONHUMAN; PROTEIN CONTENT;

AMLODIPINE; ANALYSIS OF VARIANCE; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; CALCIUM CHANNEL BLOCKERS; COLLAGEN; DOGS; ENALAPRIL; FEMALE; MALE; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION; RANDOM ALLOCATION; VENTRICULAR REMODELING; WOUND HEALING;

EID: 0034040660     PISSN: 0828282X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. Weber KT. Cardiac interstitium in health and disease: the fibrillar collagen network. J Am Coll Cardiol 1989;13:1637-52.
2. Pfeffer MA, Braunwald E. Ventricular remodelling after myocardial infarction. Circulation 1990;81:1161-72.
3. Jugdutt BI. Prevention of ventricular remodelling post myocardial infarction: Timing and duration of therapy. Can J Cardiol 1993;9:103-14.
4. Jugdutt BI, Amy RW. Healing after myocardial infarction in the dog: Changes in infarct hydroxyproline and topography. J Am Coll Cardiol 1986;7:91-102.
5. Lerman RH, Apstein CS, Kagan MH, et al. Myocardial healing and repair after experimental infarction in the rabbit. Circ Res 1983;53:378-88.
6. Covell JW. Factors influencing diastolic function. Possible role of the extracellular matrix. Circulation 1990;81(Suppl III):115-58.
7. Jugdutt BI, Tang SB, Khan MI, Basualdo CA. Functional impact on remodeling during healing after non-Q-wave versus Q-wave anterior myocardial infarction in the dog. J Am Coll Cardiol 1992;20:722-31.
8. Jugdutt BI, Khan MI. Impact of infarct transmurality on remodeling and function during healing after anterior myocardial infarction in the dog. Can J Physiol Pharmacol 1992;70:949-58.
9. Olivetti C, Capasso JM, Sonnenblick EH, Anversa P. Side-to-side slippage of myocytes participates in ventricular wall remodeling acutely after myocardial infarction in rats. Circ Res 1990;67:23-34.
10. Jugdutt BI. Delayed effects of early infarct-limiting therapies on healing. Circulation 1985;72:907-14.
11. Jugdutt BI, Khan MI, Jugdutt SJ, Blinston GE. Effect of enalapril on ventricular remodeling and function during healing after anterior myocardial infarction in the dog. Circulation 1995;91:802-12.
12. Jugdutt BI. Effect of captopril and enalapril on left ventricular geometry, function and collagen during healing after anterior and inferior myocardial infarction in a dog model. J Am Coll Cardiol 1995;25:1718-25.
13. Jugdutt BI, Khan MI, Jugdutt SJ, Blinston GE. Combined captopril and isosorbide dinitrate during healing after myocardial infarction. Effect on ventricular remodeling, function, mass and collagen. J Am Coll Cardiol 1995;25:1089-96.
14. Jugdutt BI, Lucas A, Khan MI. Effect of angiotensin-converting enzyme inhibition on infarct collagen deposition and remodelling during healing after transmural canine myocardial infarction. Can J Cardiol 1997;13:657-68.
15. Whittaker P, Boughner DR, Kloner RA. Role of collagen in acute myocardial infarct expansion. Circulation 1991;84:2123-34.
16. Jugdutt BI. Effect of reperfusion on ventricular mass, topography and function during healing of anterior infarction. Am J Physiol 1997;272:H1205-11.
17. Zhao M, Zhang H, Robinson TF, Factor SM, Sonnenblick EH, Eng C. Profound structural alterations of the extracellular collagen matrix in postischemic dysfunctional ("stunned") but viable myocardium. J Am Coll Cardiol 1987;10:1322-34.
18. Latini R, Maggioni AP, Flather M, Sleight P, Tognoni G. ACE inhibitor use in patients with myocardial infarction. Summary of evidence from clinical trials. Circulation 1995;92:3132-7.
19. Pfeffer MA, Greaves SC, Arnold JM, et al. Early versus delayed angiotensin-converting enzyme inhibition therapy in acute myocardial infarction. The healing and early afterload reducing therapy trial. Circulation 1997;95:2643-51.
20. Nabel EG, Topol EJ, Galeana A, et al. A randomized placebo-controlled trial of combined early intravenous captopril and recombinant tissue-type plasminogen activator therapy in acute myocardial infarction. J Am Coll Cardiol 1991;17:467-73.
21. Packer M, O'Connor CM, Ghali JK, et al, for the PRAISE Study Group. Effect of amlodipine on morbidity and mortality in severe chronic heart failure. N Engl J Med 1996;335:1107-14.
22. Jugdutt BI. Effects of amlodipine versus enalapril on left ventricular remodelling after reperfused anterior myocardial canine infarction. Can J Cardiol 1997;13:945-54.
23. Shimada S, Yoshiyama M, Takeuchi K, et al. Long acting calcium antagonist amlodipine prevents left ventricular remodeling after myocardial infarction. Cardiovasc Res 1998;37:618-26.
24. Watanabe M, Kawaguchi H, Onozuka H, et al. Chronic effects of enalapril and amlodipine on cardiac remodeling in cardiomyopathic hamster hearts. J Cardiovasc Pharmacol 1998;32:248-59.
25. Jugdutt BI, Khan MI, Jugdutt SJ, Blinston GE. Impact of left ventricular unloading after late reperfusion of canine anterior myocardial infarction on remodeling and function using isosorbide-5-mononitrate. Circulation 1995;92:926-34.
26. Lieberman AN, Weiss JL, Jugdutt BI, et al. Two-dimensional echocardiography and infarct size: relationship of regional wall motion and thickening to the extent of myocardial infarction in the dog. Circulation 1981;63:739-46.
27. Bergman I, Loxley R. Two improved and simplified methods for the spectrophoto-metric determination of hydroxyproline. Anal Chem 1963;35:1961-5.
28. Musat-Marcu S, Gunther HE, Jugdutt BI, Docherty JC. Ischemia-reperfusion induces apoptosis in rat myocardium through a cycloheximide-inhibitable pathway. J Mol Cell Cardiol 1999;31:1073-82.
29. Wallenstein S, Zucker CL, Fleiss JL. Some statistical methods useful in circulation research. Circ Res 1980;47:1-9.
30. Jugdutt BI. Intravenous nitroglycerin unloading in acute myocardial infarction. Am J Cardiol 1991;68:52D-63D.
31. Ertl G, Kloner RA, Alexander RW, Braunwald E. Limitation of experimental infarct size by an angiotensin-converting enzyme inhibitor. Circulation 1982;65:40-8.
32. Lucchesi BR, Tamura Y. Cardioprotective effects of amlodipine in the ischemic-reperfused heart. Am Heart J 1989;118:1121-2.
33. Kloner RA, Hale SL, Alker KJ. Absence of hemodynamic deterioration in the presence of amlodipine following experimental myocardial infarction. J Cardiovasc Pharmacol 1992;20:837-45.
34. Gross GJ, Farber NE, Pieper GM. Effects of amlodipine on myocardial ischemia-reperfusion injury in dogs. Am J Cardiol 1989;64:941-1001.
35. Deanfield JE, Detry JMRG, Lichtlen PR, Magnani B, Sellier P, Thaulow E. Amlodipine reduces transient myocardial ischemia in patients with coronary artery disease: double-blind circadian anti-ischemic program in Europe (CAPE trial). J Am Coll Cardiol 1994;24:1460-7.
36. Sharifi AM, Li JS, Endemann D, Schiffrin EL. Effects of enalapril and amlodipine on small-artery structure and composition, and on endothelial dysfunction in spontaneously hypertensive rats. J Hypertens 1998;16:457-66.
37. Kumamoto H, Okamoto H, Watanabe M, et al. Beneficial effect of myocardial angiogenesis on cardiac remodeling process by amlodipine and MCI-154. Am J Physiol 1999;45:H1117-23.
38. 1 receptor subtype. Circ Res 1993;73:413-23.
39. Linz W, Scholkens BA, Ganten D. Converting enzyme inhibition specifically prevents the development and induces regression of cardiac hypertrophy in rats. Clin Exp Hypertens 1989;A11:1325-50.
40. Zhang X, Hintze TH. Amlodipine releases nitric oxide from canine coronary microvessels. An unexpected mechanism of action of a calcium channel-blocking agent. Circulation 1998;97:576-80.
41. Hale SL, Kloner RA. Left ventricular topographic alterations in the completely healed rat infarct caused by early and late coronary artery reperfusion. Am Heart J 1988;116:1508-13.
42. Hager JM, Newman LG, Kloner RA. Effects of amlodipine on myocardial infarction, infarct expansion, and ventricular geometry in the rat. Am Heart J 1992;124:571-80.
43. Jugdutt BI, Humen DP. Limitation of left ventricular hypertrophy and dysfunction by ACE inhibition after anterior Q-wave myocardial infarction. Cardiology 1998;89:283-90.
44. Carroll JP, Janicki JS, Pick R, Weber KT. Myocardial stiffness and reparative fibrosis following coronary embolization in the rat. Cardiovasc Res 1989;23:655-61.
45. Pickering JG, Boughner DR. Fibrosis in the transplanted heart and its relation to donor ischemic time. Assessment with polarized light microscopy and digital image analysis. Circulation 1990;81:949-58.
46. Jugdutt BI, Joljart MJ, Khan MI. Rate of collagen deposition during healing after myocardial infarction in the rat and dog models: mechanistic insights into ventricular remodeling. Circulation 1996;94:94-101.
47. Michorowski BL, O'Kelly BF, Jugdutt BI. Chronic captopril therapy during healing of canine myocardial infarction improves LV topography and function. J Clin Invest Med 1987;10(Suppl):C64.
48. Jugdutt BI, Humen DP, Khan MI, Schwarz-Michorowski BL. Effect of left ventricular unloading with captopril on remodelling and function during healing of anterior transmural myocardial infarction in the dog. Can J Cardiol 1992;8:151-63.