In vitro metabolism of nobiletin, a polymethoxy-flavonoid, by human liver microsomes and cytochrome P450

Xenobiotica

Volumn 41, Issue 11, 2011, Pages 927-933

  Koga, Nobuyuki ^a   Ohta, Chiho ^a   Kato, Yoshihisa ^b   Haraguchi, Koichi ^c   Endo, Tetsuya ^d   Ogawa, Kazunori ^e   Ohta, Hideaki ^a   Yano, Masamichi ^f  

^a NAKAMURA GAKUEN UNIVERSITY   (Japan)

^b TOKUSHIMA BUNRI UNIVERSITY   (Japan)

^c DAIICHI UNIVERSITY OF PHARMACY   (Japan)

^d HEALTH SCIENCES UNIVERSITY OF HOKKAIDO   (Japan)

^e NATIONAL INSTITUTE OF FRUIT TREE SCIENCE   (Japan)

^f NARO Bio oriented Technology Research Advancement Institution   (Japan)

Author keywords

Cytochrome P450 (CYP); Flavonoids; Human liver microsomes; Metabolism; Nobiletin

Indexed keywords

4' HYDROXYNOBILETIN; 6 HYDROXYNOBILETIN; ALPHA NAPHTHOFLAVONE; COMPLEMENTARY DNA; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 1B1; CYTOCHROME P450 2A6; CYTOCHROME P450 2B6; CYTOCHROME P450 2C19; CYTOCHROME P450 2C8; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; CYTOCHROME P450 3A4; CYTOCHROME P450 3A5; DRUG METABOLITE; FLAVONOID; FURAFYLLINE; KETOCONAZOLE; NOBILETIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TROLEANDOMYCIN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEMETHYLATION; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN TISSUE; IN VITRO STUDY; LIVER MICROSOME; MALE; NONHUMAN; RAT;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRICETINAE; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INHIBITORS; FEMALE; FLAVONES; GUINEA PIGS; HUMANS; MALE; MICROSOMES, LIVER; RATS; RATS, WISTAR; RECOMBINANT PROTEINS;

EID: 80053985116     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.3109/00498254.2011.593208     Document Type: Article

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