Target-mediated metabolism and target-mediated drug disposition of the DPPIV inhibitor AMG 222

Xenobiotica

Volumn 41, Issue 11, 2011, Pages 945-957

  Greene, Robert J ^a   Tu, Hua ^b,c   Gibbs, John P ^a   Greg Slatter, J ^a  

^a AMGEN INC   (United States)

^b AMGEN INC   (United States)

^c LakePharma Inc   (United States)

Author keywords

Biotransformation; Diabetes; Dipeptidylpeptidase 4; Disposition; DPPIV; Enzyme kinetics; Kidney; Liver; Mass spectrometry; Metabolism; Microsomes; Pharmacokinetics protein binding

Indexed keywords

5 [2 [2 (2 CYANOPYRROLIDIN 1 YL) 2 OXOETHYLAMINO]PROPYL] 5 (1H TETRAZOL 5 YL) 10,11 DIHYDRO 5H DIBENZO[A,D]CYCLOHEPTENE 2,8 DICARBOXYLIC ACID BISDIMETHYLAMIDE; ALOGLIPTIN; AMG 222; AMIDE; CARBON 14; DIPEPTIDYL PEPTIDASE IV INHIBITOR; LINAGLIPTIN; S 44497; S 9; SAXAGLIPTIN; SITAGLIPTIN; UNCLASSIFIED DRUG; VILDAGLIPTIN;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DILUTION; DRUG DISPOSITION; DRUG HALF LIFE; DRUG HYDROLYSIS; DRUG METABOLISM; DRUG STRUCTURE; DRUG TRANSFORMATION; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME KINETICS; HUMAN; HUMAN TISSUE; IC 50; LIVER MICROSOME; MASS SPECTROMETRY; PLASMA PROTEIN BINDING;

ADAMANTANE; AMIDES; BLOOD PROTEINS; CARBON RADIOISOTOPES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIBENZOCYCLOHEPTENES; DIPEPTIDYL-PEPTIDASE IV INHIBITORS; DRUG DELIVERY SYSTEMS; HUMANS; INHIBITORY CONCENTRATION 50; KINETICS; NITRILES; PROTEIN BINDING; PYRAZINES; PYRROLIDINES; TETRAZOLES; TIME FACTORS; TRIAZOLES; ULTRACENTRIFUGATION;

EID: 80053950689     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.3109/00498254.2011.597455     Document Type: Article

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