메뉴 건너뛰기




Volumn 43, Issue 4, 2008, Pages 122-134

DPP-IV inhibitors: A review of sitagliptin, vildagliptin, alogliptin, and saxagliptin

Author keywords

[No Author keywords available]

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ALOGLIPTIN; DIGOXIN; DIPEPTIDYL PEPTIDASE IV INHIBITOR; GLIMEPIRIDE; GLIPIZIDE; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; HEMOGLOBIN A1C; INSULIN; METFORMIN; PIOGLITAZONE; PLACEBO; ROSIGLITAZONE; SAXAGLIPTIN; SITAGLIPTIN; SULFONYLUREA; VILDAGLIPTIN;

EID: 42949178414     PISSN: 1082801X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (7)

References (34)
  • 1
    • 42949109318 scopus 로고    scopus 로고
    • Centers for Disease Control and Prevention website, Accessed March 21, 2008
    • Centers for Disease Control and Prevention website. Diabetes: Sounding the alert on a debilitating disease. http://www.cdc.gov/features/diabetesalert/. Accessed March 21, 2008.
    • Diabetes: Sounding the alert on a debilitating disease
  • 2
    • 0032983666 scopus 로고    scopus 로고
    • Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: Progressive requirement for multiple therapies (UKPDS 49). UK Prospective Diabetes Study (UKPDS) Group
    • Turner RC, Cull CA, Frighi V, Holman RR. Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: Progressive requirement for multiple therapies (UKPDS 49). UK Prospective Diabetes Study (UKPDS) Group. JAMA. 1999;281:2005-2012.
    • (1999) JAMA , vol.281 , pp. 2005-2012
    • Turner, R.C.1    Cull, C.A.2    Frighi, V.3    Holman, R.R.4
  • 3
    • 33746588255 scopus 로고    scopus 로고
    • Nathan DM, Busc JB, Davidson MB, et al. Management of hyperglycemia in type 2 diabetes: A consensus algorithm for the initiation and adjustment of therapy: A consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes [erratum in Diabetes Care. 2006;49:2816-2818]. Diabetes Care. 2006;29:1963-1972.
    • Nathan DM, Busc JB, Davidson MB, et al. Management of hyperglycemia in type 2 diabetes: A consensus algorithm for the initiation and adjustment of therapy: A consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes [erratum in Diabetes Care. 2006;49:2816-2818]. Diabetes Care. 2006;29:1963-1972.
  • 4
    • 34250212715 scopus 로고    scopus 로고
    • Nissen SE, Wolski K. Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes [erratum in N Engl J Med. 2007;357:100]. N Engl J Med. 2007;356:2457-2471.
    • Nissen SE, Wolski K. Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes [erratum in N Engl J Med. 2007;357:100]. N Engl J Med. 2007;356:2457-2471.
  • 5
    • 15044359454 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV inhibitors: How do they work as new antidiabetic agents?
    • McIntosh CH, Demuth HU, Pospisilik JA, Pederson R. Dipeptidyl peptidase IV inhibitors: How do they work as new antidiabetic agents? Regul Pept. 2005;128:159-165.
    • (2005) Regul Pept , vol.128 , pp. 159-165
    • McIntosh, C.H.1    Demuth, H.U.2    Pospisilik, J.A.3    Pederson, R.4
  • 6
    • 3843072211 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV inhibitors for the treatment of diabetes
    • Weber AE. Dipeptidyl peptidase IV inhibitors for the treatment of diabetes. J Med Chem. 2004;47:4135-4141.
    • (2004) J Med Chem , vol.47 , pp. 4135-4141
    • Weber, A.E.1
  • 7
    • 34547617872 scopus 로고    scopus 로고
    • Vildagliptin: A novel oral therapy for type 2 diabetes mellitus
    • Lauster CD, McKaveney TP, Muench SV. Vildagliptin: A novel oral therapy for type 2 diabetes mellitus. Am J Health Syst Pharm. 2007;64:1265-1273.
    • (2007) Am J Health Syst Pharm , vol.64 , pp. 1265-1273
    • Lauster, C.D.1    McKaveney, T.P.2    Muench, S.V.3
  • 8
    • 15044352155 scopus 로고    scopus 로고
    • The [pre-] history of the incretin concept
    • Creutzfeldt W. The [pre-] history of the incretin concept. Regul Pept. 2005;128:87-91.
    • (2005) Regul Pept , vol.128 , pp. 87-91
    • Creutzfeldt, W.1
  • 9
    • 19944427998 scopus 로고    scopus 로고
    • Kim D, Wang L, Beconi M, et al. (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6- dihydro[1,2, 4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan- 2-amine: A potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. J Med Chem. 2005;48:141-151.
    • Kim D, Wang L, Beconi M, et al. (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6- dihydro[1,2, 4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan- 2-amine: A potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. J Med Chem. 2005;48:141-151.
  • 10
    • 0001095690 scopus 로고    scopus 로고
    • Reduced postprandial concentrations of intact biologically active glucagon-like peptide 1 in type 2 diabetic patients
    • Vilsbøll T, Krarup T, Deacon CF, Madsbad S, Holst JJ. Reduced postprandial concentrations of intact biologically active glucagon-like peptide 1 in type 2 diabetic patients. Diabetes. 2001;50:609-613.
    • (2001) Diabetes , vol.50 , pp. 609-613
    • Vilsbøll, T.1    Krarup, T.2    Deacon, C.F.3    Madsbad, S.4    Holst, J.J.5
  • 11
    • 33847024333 scopus 로고    scopus 로고
    • Efficacy and tolerability of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy over 12 weeks in patients with type 2 diabetes
    • Scott R, Wu M, Sanchez M, Stein P. Efficacy and tolerability of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy over 12 weeks in patients with type 2 diabetes. Int J Clin Pract. 2007;61:171-180.
    • (2007) Int J Clin Pract , vol.61 , pp. 171-180
    • Scott, R.1    Wu, M.2    Sanchez, M.3    Stein, P.4
  • 12
    • 33845489598 scopus 로고    scopus 로고
    • Raz I, Hanefeld M, Xu L, Caria C, Williams-Herman D, Khatami H; Sitagliptin Study 023 Group. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy in patients with type 2 diabetes mellitus. Diabetologia. 2006;49:2564-2571.
    • Raz I, Hanefeld M, Xu L, Caria C, Williams-Herman D, Khatami H; Sitagliptin Study 023 Group. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy in patients with type 2 diabetes mellitus. Diabetologia. 2006;49:2564-2571.
  • 13
    • 33845472504 scopus 로고    scopus 로고
    • Aschner P, Kipnes MS, Lunceford JK, Sanchez M, Mickel C, Williams-Herman DE; Sitagliptin Study 021 Group. Effect of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy on glycemic control in patients with type 2 diabetes. Diabetes Care. 2006;29:2632-2637.
    • Aschner P, Kipnes MS, Lunceford JK, Sanchez M, Mickel C, Williams-Herman DE; Sitagliptin Study 021 Group. Effect of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy on glycemic control in patients with type 2 diabetes. Diabetes Care. 2006;29:2632-2637.
  • 14
    • 33846796143 scopus 로고    scopus 로고
    • Effect of adding sitagliptin, a dipeptidyl peptidase-4 inhibitor, to metformin on 24-h glycaemic control and beta-cell function in patients with type 2 diabetes
    • Brazg R, Xu L, Dalla Man C, Cobelli C, Thomas K, Stein PP. Effect of adding sitagliptin, a dipeptidyl peptidase-4 inhibitor, to metformin on 24-h glycaemic control and beta-cell function in patients with type 2 diabetes. Diabetes Obes Metab. 2007;9:186-193.
    • (2007) Diabetes Obes Metab , vol.9 , pp. 186-193
    • Brazg, R.1    Xu, L.2    Dalla Man, C.3    Cobelli, C.4    Thomas, K.5    Stein, P.P.6
  • 15
    • 34547660561 scopus 로고    scopus 로고
    • Goldstein BJ, Feinglos MN, Lunceford JK, Johnson J, Williams-Herman DE; Sitagliptin 036 Study Group. Effect of initial combination therapy with sitagliptin, a dipeptidyl peptidase-4 inhibitor, and metformin on glycemic control in patients with type 2 diabetes. Diabetes Care. 2007;30:1979-1987.
    • Goldstein BJ, Feinglos MN, Lunceford JK, Johnson J, Williams-Herman DE; Sitagliptin 036 Study Group. Effect of initial combination therapy with sitagliptin, a dipeptidyl peptidase-4 inhibitor, and metformin on glycemic control in patients with type 2 diabetes. Diabetes Care. 2007;30:1979-1987.
  • 16
    • 33845476757 scopus 로고    scopus 로고
    • Charbonnel B, Karasik A, Liu J, Wu M, Meininger G; Sitagliptin Study 020 Group. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes inadequately controlled with metformin alone. Diabetes Care. 2006;29:2638-2643.
    • Charbonnel B, Karasik A, Liu J, Wu M, Meininger G; Sitagliptin Study 020 Group. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes inadequately controlled with metformin alone. Diabetes Care. 2006;29:2638-2643.
  • 17
    • 33846817233 scopus 로고    scopus 로고
    • Nauck M, Meininger G, Sheng D, Terranella L, Stein PP; Sitagliptin Study 024 Group. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor, sitagliptin, compared with the sulfonylurea, glipizide, in patients with type 2 diabetes inadequately controlled on metformin alone: A randomized, double-blind, non-inferiority trial. Diabetes Obes Metab. 2007;9:194-205.
    • Nauck M, Meininger G, Sheng D, Terranella L, Stein PP; Sitagliptin Study 024 Group. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor, sitagliptin, compared with the sulfonylurea, glipizide, in patients with type 2 diabetes inadequately controlled on metformin alone: A randomized, double-blind, non-inferiority trial. Diabetes Obes Metab. 2007;9:194-205.
  • 18
    • 34547863123 scopus 로고    scopus 로고
    • Hermansen K, Kipnes M, Luo E, Fanurik D, Khatami H, Stein P; Sitagliptin Study 035 Group. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor, sitagliptin, in patients with type 2 diabetes mellitus inadequately controlled on glimepiride alone or on glimepiride and metformin. Diabetes Obes Metab. 2007;9:733-745.
    • Hermansen K, Kipnes M, Luo E, Fanurik D, Khatami H, Stein P; Sitagliptin Study 035 Group. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor, sitagliptin, in patients with type 2 diabetes mellitus inadequately controlled on glimepiride alone or on glimepiride and metformin. Diabetes Obes Metab. 2007;9:733-745.
  • 19
    • 33751557143 scopus 로고    scopus 로고
    • Rosenstock J, Brazg R, Andryuk PJ, Lu K, Stein P; Sitagliptin Study 019 Group. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing pioglitazone therapy in patients with type 2 diabetes: A 24-week, multicenter, randomized, double-blind, placebo-controlled, parallel-group study. Clin Ther. 2006;28:1556-1568.
    • Rosenstock J, Brazg R, Andryuk PJ, Lu K, Stein P; Sitagliptin Study 019 Group. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing pioglitazone therapy in patients with type 2 diabetes: A 24-week, multicenter, randomized, double-blind, placebo-controlled, parallel-group study. Clin Ther. 2006;28:1556-1568.
  • 20
    • 2442482515 scopus 로고    scopus 로고
    • Inhibition of dipeptidyl peptidase-4 reduces glycemia, sustains insulin levels, and reduces glucagon levels in type 2 diabetes
    • Ahren B, Landin-Olsson M, Jansson PA, Svensson M, Holmes D, Schweizer A. Inhibition of dipeptidyl peptidase-4 reduces glycemia, sustains insulin levels, and reduces glucagon levels in type 2 diabetes. J Clin Endocrinol Metab. 2004;89:2078-2084.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 2078-2084
    • Ahren, B.1    Landin-Olsson, M.2    Jansson, P.A.3    Svensson, M.4    Holmes, D.5    Schweizer, A.6
  • 21
    • 27744540889 scopus 로고    scopus 로고
    • Ristic S, Byiers S, Foley J, Holmes D. Improved glycaemic control with dipeptidyl peptidase-4 inhibition in patients with type 2 diabetes: Vildagliptin (LAF237) dose response. Diabetes Obes Metab. 20057:692-698.
    • Ristic S, Byiers S, Foley J, Holmes D. Improved glycaemic control with dipeptidyl peptidase-4 inhibition in patients with type 2 diabetes: Vildagliptin (LAF237) dose response. Diabetes Obes Metab. 20057:692-698.
  • 22
    • 33745903093 scopus 로고    scopus 로고
    • Twelve-week monotherapy with the DPP-4 inhibitor vildagliptin improves glycemic control in subjects with type 2 diabetes
    • Pratley RE, Jauffret-Kamel S, Galbreath E, Holmes D. Twelve-week monotherapy with the DPP-4 inhibitor vildagliptin improves glycemic control in subjects with type 2 diabetes. Horm Metab Res. 2006;38:423-428.
    • (2006) Horm Metab Res , vol.38 , pp. 423-428
    • Pratley, R.E.1    Jauffret-Kamel, S.2    Galbreath, E.3    Holmes, D.4
  • 23
    • 33847687205 scopus 로고    scopus 로고
    • Dejager S, Razac S, Foley JE, Schweizer A. Vildagliptin in drug-naïve patients with type 2 diabetes: A 24-week, double-blind, randomized, placebo-controlled, multiple-dose study. Horm Metab Res. 2007;39:218-223.
    • Dejager S, Razac S, Foley JE, Schweizer A. Vildagliptin in drug-naïve patients with type 2 diabetes: A 24-week, double-blind, randomized, placebo-controlled, multiple-dose study. Horm Metab Res. 2007;39:218-223.
  • 24
    • 33846905487 scopus 로고    scopus 로고
    • Efficacy and tolerability of vildagliptin monotherapy in drug-naïve patients with type 2 diabetes
    • Pi-Sunyer FX, Schweizer A, Mills D, Dejager S. Efficacy and tolerability of vildagliptin monotherapy in drug-naïve patients with type 2 diabetes. Diabetes Res Clin Pract. 2007;76:132-138.
    • (2007) Diabetes Res Clin Pract , vol.76 , pp. 132-138
    • Pi-Sunyer, F.X.1    Schweizer, A.2    Mills, D.3    Dejager, S.4
  • 25
    • 33846694046 scopus 로고    scopus 로고
    • Rosenstock J, Baron MA, Dejager S, Mills D, Schweizer A. Comparison of vildagliptin and rosiglitazone monotherapy in patients with type 2 diabetes : A 24-week, double-blind, randomized, trial [erratum in Diabetes Care. 2007;30:1330]. Diabetes Care, 2007;30:217-223.
    • Rosenstock J, Baron MA, Dejager S, Mills D, Schweizer A. Comparison of vildagliptin and rosiglitazone monotherapy in patients with type 2 diabetes : A 24-week, double-blind, randomized, trial [erratum in Diabetes Care. 2007;30:1330]. Diabetes Care, 2007;30:217-223.
  • 26
    • 9444285818 scopus 로고    scopus 로고
    • Twelve- and 52-week efficacy of the dipeptidyl peptidase IV inhibitor LAF237 in metformin-treated patients with type 2 diabetes
    • Ahren B, Gomis R, Standi E, Mills D, Schweizer A. Twelve- and 52-week efficacy of the dipeptidyl peptidase IV inhibitor LAF237 in metformin-treated patients with type 2 diabetes. Diabetes Care. 2004;27:2874-2880.
    • (2004) Diabetes Care , vol.27 , pp. 2874-2880
    • Ahren, B.1    Gomis, R.2    Standi, E.3    Mills, D.4    Schweizer, A.5
  • 27
    • 34147093268 scopus 로고    scopus 로고
    • Effects of vildagliptin on glucose control over 24 weeks in patients with type 2 diabetes inadequately controlled with metformin
    • Bosi E, Camisasca RP, Collober C, Rochotte E, Garber AJ. Effects of vildagliptin on glucose control over 24 weeks in patients with type 2 diabetes inadequately controlled with metformin. Diabetes Care. 2007;30:890-895.
    • (2007) Diabetes Care , vol.30 , pp. 890-895
    • Bosi, E.1    Camisasca, R.P.2    Collober, C.3    Rochotte, E.4    Garber, A.J.5
  • 28
    • 85069419146 scopus 로고    scopus 로고
    • The use of vildagliptin for treatment of patients with type 2 diabetes [abstract]
    • Presented at: June 9-13, Washington, DC. Abstract 6-LBCS
    • Rosenstock J, Baron MA, Lebeaut A. The use of vildagliptin for treatment of patients with type 2 diabetes [abstract]. Presented at: American Diabetes Association 66th Annual Scientific Sessions; June 9-13,2006; Washington, DC. Abstract 6-LBCS.
    • (2006) American Diabetes Association 66th Annual Scientific Sessions
    • Rosenstock, J.1    Baron, M.A.2    Lebeaut, A.3
  • 31
    • 50149118157 scopus 로고    scopus 로고
    • Saxagliptin added to metformin improves glycemia control in patients with type 2 diabetes [abstract]
    • Presented at: June 22-26, Chicago, IL. Abstract 02850OR
    • Defronzo RA, Hissa M, Blauwet MB, Chen RS. Saxagliptin added to metformin improves glycemia control in patients with type 2 diabetes [abstract]. Presented at: American Diabetes Association 67th Annual Scientific Sessions; June 22-26, 2007; Chicago, IL. Abstract 02850OR.
    • (2007) American Diabetes Association 67th Annual Scientific Sessions
    • Defronzo, R.A.1    Hissa, M.2    Blauwet, M.B.3    Chen, R.S.4
  • 32
    • 85069424539 scopus 로고    scopus 로고
    • Januvia [package insert, Whitehouse Station, NJ: Merck & Co; 2007
    • Januvia [package insert]. Whitehouse Station, NJ: Merck & Co; 2007.
  • 33
    • 85069422090 scopus 로고    scopus 로고
    • Red Book. 2007 edition. Montvale, NJ: Thompson PDR; 2007.
    • Red Book. 2007 edition. Montvale, NJ: Thompson PDR; 2007.
  • 34
    • 0033619675 scopus 로고    scopus 로고
    • Dipeptidyl-peptidase IV (CD26) - role in the inactivation of regulatory peptides
    • Mentlein R. Dipeptidyl-peptidase IV (CD26) - role in the inactivation of regulatory peptides. Regul Pept. 1999;85:9-24.
    • (1999) Regul Pept , vol.85 , pp. 9-24
    • Mentlein, R.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.