Neurobehavioral and genotoxic parameters of antipsychotic agent aripiprazole in mice

Acta Pharmacologica Sinica

Volumn 32, Issue 10, 2011, Pages 1225-1232

  Picada, Jaqueline Nascimento ^a   Dos Santos, Bruna De Jesus Neto ^a   Celso, Franciele ^a   Monteiro, Jéssica Dias ^a   Da Rosa, Kelly Morais ^a   Camacho, Leandro Rosa ^a   Vieira, Luciana Rodrigues ^a   Freitas, Taís Madelon ^a   Da Silva, Tatiana Grasiela ^a   Pontes, Viviane Minuzzo ^a   Pereira, Patrícia ^a  

^a UNIVERSIDADE LUTERANA DO BRASIL   (Brazil)

Author keywords

antipsychotic agent; aripiprazole; DNA damage; genotoxic mutagenic activities; lipoperoxidation; locomotion; memory

Indexed keywords

ARIPIPRAZOLE;

ANIMAL EXPERIMENT; ARTICLE; AVOIDANCE BEHAVIOR; BLOOD; BRAIN; COGNITION; COMET ASSAY; CONTROLLED STUDY; DNA STRAND BREAKAGE; DRUG SAFETY; DRUG STRUCTURE; GENOTOXICITY; LIPID PEROXIDATION; LONG TERM MEMORY; MALE; MICRONUCLEUS TEST; MOTOR DYSFUNCTION; MOUSE; MUTAGENIC ACTIVITY; NONHUMAN; OPEN FIELD TEST; TASK PERFORMANCE; TREATMENT DURATION;

ANIMALS; ANTIPSYCHOTIC AGENTS; AVOIDANCE LEARNING; BEHAVIOR, ANIMAL; BRAIN; COMET ASSAY; HUMANS; LIPID PEROXIDATION; MALE; MICE; MICRONUCLEUS TESTS; MUTAGENS; PIPERAZINES; QUINOLONES; SCHIZOPHRENIA;

EID: 80053924691     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2011.77     Document Type: Article

References (38)

1. Harvey PD, Green MF, Keefe RS, Velligan DI. Cognitive functioning in schezophrenia: a consenses on its role in the definition and evaluation of effective treatments for the illness. J Cli Psychiatry 2004; 65: 361-72.
2. Velligan DI, Kern RS, Gold JM. Cognitive rehabilitation for schizophrenia and the putative role of motivation and expectancies. Schizophr Bull 2006; 32: 474-85. (Pubitemid 43992321)
3. Kern RS, Hartzell AM, Izaguirre B, Hamilton AH. Declarative and nondeclarative memory in schizophrenia: what is impaired? What is spared? J Clin Exp Neuropsychol 2010; 32: 1017-27.
4. Ishiyama T, Tokuda K, Ishibashi T, Ito A, Ohno Y. Lurasidone (SM-13496), a novel atypical antipsychotic drug, reverses MK-801-induced impairment of learning and memory in the rat passive-avoidance test. Eur J Pharmacol 2007; 572: 160-70. (Pubitemid 47429645)
5. Enomoto T, Ishibashi T, Tokuda K, Ishiyama T, Toma S, Ito A. Lurasidone reverses MK-801-induced impairment of learning and memory in the Morris water maze and radial-arm maze tests in rats. Behav Brain Res 2008; 186: 197-207. (Pubitemid 350122756)
6. Kern KS, Green MF, Lornblatt BA, Owen JR, McQuade RD, Larson WH, et al. The neurocognitive effects of aripiprazole: an open-label comparison with olanzapine. Psychopharmacology 2006; 187: 312-20. (Pubitemid 44079923)
7. Kane JM, Larson WH, Saha AR, McQuade RD, Ingenito GG, Zimbroff DL. Efficacy and safety of aripiprazole and haloperidol versus placebo in patients with schizophrenia and schizoaffective disorder. J Clin Psychiatry 2002; 63: 763-11.
8. Miller DD, Eudicone JM, Pikalov A, Kim E. Comparative assessment of the incidence and severity of tardive dyskinesia in patients receiving aripiprazole or haloperidol for treatment of schizophrenia: a post hoc analysis. J Clin Psychiatry 2007; 68: 1901-6.
9. 1A receptors. Psychopharmacology 2009; 202: 315-28.
10. Pereira P, Tysca D, Oliveira P, da Silva Brum LF, Picada JN, Ardenghi P. Neurobehavioral and genotoxic aspects of rosmarinic acid. Pharmacol Res 2005; 52: 199-203. (Pubitemid 40981918)
11. Tice RR, Agurell E, Anderson D, Burlinson B, Hartmann A, Kobayashi Y, et al. Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing. Environ Mol Mutagen 2000; 35: 206-21. (Pubitemid 30196665)
12. Picada JN, Flores DG, Zettler CG, Marroni NP, Roesler R, Henriques JAP. DNA damage in brain cells of mice treated with an oxidized form of apomorphine. Mol Brain Res 2003; 114: 80-5. (Pubitemid 36627999)
13. Pereira P, Oliveira P, Ardenghi P, Rotta LN, Henriques JAP, Picada JN. Neuropharmacological analysis of caffeic acid in rats. Basic Clin Pharmacol Toxicol 2006; 99: 374-8. (Pubitemid 44673318)
14. Pereira P, Gianesini J, da Silva Barbosa C, Cassol GF, Von Borowski RG, Kahl VF, et al. Neurobehavioral and genotoxic parameters of duloxetine in mice using the inhibitory avoidance task and comet assay as experimental models. Pharmacol Res 2009; 59: 57-61.
15. Mavournin KH, Blakey DH, Cimino MC, Salamone MF, Heddle JA. The in vivo micronucleus assay in mammalian bone marrow and peripheral blood. A report of the US Environmental Protection Agency Gene-Tox Program. Mutat Res 1990; 239: 29-80.
16. Picada JN, da Silva KV, Erdtmann B, Henriques AT, Henriques JAP. Genotoxic effects of structurally related beta-carboline alkaloids. Mutat Res 1997; 379: 135-49. (Pubitemid 27450534)
17. Rodrigues CR, Dias JH, Semedo JG, da Silva J, Ferraz AB, Picada JN. Mutagenic and genotoxic effects of Baccharis dracunculifolia (DC). J Ethnopharmacol 2009; 124: 321-4.
18. Esterbauer H, Cheeseman KH. Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. Methods Enzymol 1990; 186: 407-21. (Pubitemid 20279982)
19. Lowry H, Rosebrough MJ, Farr AL. Protein measurement with the foline reagent. J Biol Chem 1951; 193: 265-75.
20. Bespalov A, Jongen-Rêlo AL, Van Gaalen M, Harich S, Schoemaker H, Gross G. Habituation deficits induced by metabotropic glutamate receptor 2/3 receptor blockade in mice: reversal by antipsychotic drugs. J Pharmacol Exp Ther 2007; 320: 944-50. (Pubitemid 46147979)
21. Jerlhag E. The antipsychotic aripiprazole antagonizes the ethanol-and amphetamine-induced locomotor stimulation in mice. Alcohol 2008; 42: 123-7. (Pubitemid 351389735)
22. Izquierdo I, Medina JH. Memory formation: the sequence of biochemical events in the hippocampus and its connections to activity in other brain structures. Neurobiol Learn Mem 1997; 68: 285-316. (Pubitemid 27506324)
23. Rossato JL, Bonini JS, Coitinho AS, Vianna MR, Medina JH, Cammarota M, et al. Retrograde amnésia induced by drugs acting on different molecular systems. Behav Neurosci 2004; 118: 563-8. (Pubitemid 38685323)
24. Rossato JI, Zinn CG, Furini C, Bevilaqua LR, Medina JH, Cammarota M, et al. A link between the hippocampal and the striatal memory systems of the brain. An Acad Bras Cienc 2006; 78: 515-23. (Pubitemid 44371942)
25. 2 receptor partial agonism? Am J Psychiatry 2007; 164: 1310-2. (Pubitemid 47461127)
26. Hartmann A, Agurell E, Beevers C, Brendler-Schwaab S, Burlinson B, Clay P, et al. Recommendations for conducting the in vivo alkaline Comet assay. Mutagenesis 2003; 18: 45-51. (Pubitemid 36118820)
27. Brambilla G, Mattioli F, Martelli A. Genotoxic and carcinogenic effects of antipsychotics and antidepressants. Toxicology 2009; 261: 77-88.
28. 1H NMR spectroscopy. J Proteome Res 2009; 8: 1943-52.
29. Yang TT, Wang SJ. Aripiprazole and its human metabolite OPC14857 reduce, through a presynaptic mechanism, glutamate release in rat prefrontal cortex: possible relevance to neuroprotective interventions in schizophrenia. Synapse 2008; 62: 804-18.
30. Park SW, Lee JG, Ha EK, Choi SM, Cho HY, Seo MK, et al. Differential effects of aripiprazole and haloperidol on BDNF-mediated signal changes in SH-SY5Y cells. Eur Neuropsychopharmacol 2009; 19: 356-62.
31. Urichuk L, Prior TI, Dursun S, Baker G. Metabolism of atypical antipsychotics: involvement of cytochrome P450 enzymes and relevance for drug-drug interactions. Curr Drug Metab 2008; 9: 410-8. (Pubitemid 352025195)
32. Waade RB, Christensen H, Rudberg I, Refsum H, Hermann M. Influence of comedication on serum concentrations of aripiprazole and dehydroaripiprazole. Ther Drug Monit 2009; 31: 233-8.
33. Halliwell B. Role of free radicals in the neurodegenerative diseases, thera peutic implications for antioxidant treatment. Drugs Aging 2001; 18: 685-716. (Pubitemid 32948277)
34. Arvindakshan M, Sitasawad S, Debsikdar V, Ghate M, Evans D, Horrobin DF, et al. Essential polyunsaturated fatty acid and lipid per oxide levels in never-medicated and medicated schizophrenia patients. Biol Psychiatry 2003; 53: 56-64. (Pubitemid 36050936)
35. Gama CS, Salvador M, Andreazza AC, Lobato MI, Berk M, Kapczinski F, et al. Elevated serum thiobarbituric acid reactive substances in clinically symptomatic schizophrenic males. Neurosci Lett 2008; 433: 270-3.
36. Martins MR, Petronilho FC, Gomes KM, Dal-Pizzol F, Streck EL, Quevedo J. Antipsychotic-induced oxidative stress in rat brain. Neurotox Res 2008; 13: 63-9.
37. Eren I, Nazioroglu M, Demirdas A. Protective effects of lamotrigine, aripiprazole and escitalopram on depression-induced oxidative stress in rat brain. Neurochem Res 2007; 32: 1188-95. (Pubitemid 46817468)
38. Streck EL, Rezin GT, Barbosa LM, Assis LC, Grandi E, Quevedo J. Effect of antipsychotics on succinate dehydrogenase and cytochrome oxidase activities in rat brain. Naunyn Schmiedeberg Arch Pharmacol 2007; 376: 127-33.