Thyroid-stimulating hormone induces a Wnt-dependent, feed-forward loop for osteoblastogenesis in embryonic stem cell cultures

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 39, 2011, Pages 16277-16282

  Baliram, Ramkumarie ^a   Latif, Rauf ^a   Berkowitz, Joshua ^a   Frid, Simon ^a   Colaianni, Graziana ^a   Sun, Li ^a   Zaidi, Mone ^a   Davies, Terry F ^a  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

OSTEOPROTEGERIN; PROTEIN KINASE C DELTA; THYROTROPIN; WNT PROTEIN; WNT5A PROTEIN;

ANIMAL CELL; ARTICLE; BONE DEVELOPMENT; BONE MARROW; BONE MASS; CELL DIFFERENTIATION; CONTROLLED STUDY; CYTOGENETICS; EMBRYONIC STEM CELL; HYPERTHYROIDISM; MOUSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOCLAST; OSTEOLYSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; THYROID GLAND; UPREGULATION;

ANIMALS; BONE DEVELOPMENT; EMBRYONIC STEM CELLS; MICE; OSTEOBLASTS; THYROTROPIN; WNT PROTEINS;

MURINAE;

EID: 80053652507     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1110286108     Document Type: Article

References (29)

1. Davies T, Marians R, Latif R (2002) The TSH receptor reveals itself. J Clin Invest 110:161-164. (Pubitemid 34787352)
2. Wang HC, Dragoo J, Zhou Q, Klein JR (2003) An intrinsic thyrotropin-mediated pathway of TNF-alpha production by bone marrow cells. Blood 101:119-123. (Pubitemid 36025897)
3. Inoue M, Tawata M, Yokomori N, Endo T, Onaya T (1998) Expression of thyrotropin receptor on clonal osteoblast-like rat osteosarcoma cells. Thyroid 8:1059-1064. (Pubitemid 28551089)
4. Abe E, et al. (2003) TSH is a negative regulator of skeletal remodeling. Cell 115:151-162. (Pubitemid 37329579)
5. Bauer DC, Ettinger B, Nevitt MC, Stone KL; Study of Osteoporotic Fractures Research Group (2001) Risk for fracture in women with low serum levels of thyroid-stimulating hormone. Ann Intern Med 134:561-568. (Pubitemid 32245317)
6. Martini G, et al. (2008) The effects of recombinant TSH on bone turnover markers and serum osteoprotegerin and RANKL levels. Thyroid 18:455-460. (Pubitemid 351519539)
7. Mazziotti G, et al. (2005) Recombinant human TSH modulates in vivo C-telopeptides of type-1 collagen and bone alkaline phosphatase, but not osteoprotegerin production in postmenopausal women monitored for differentiated thyroid carcinoma. J Bone Miner Res 20:480-486. (Pubitemid 40293497)
8. Zaidi M, et al. (2009) Thyroid-stimulating hormone, thyroid hormones, and bone loss. Curr Osteoporos Rep 7:47-52.
9. Zofkova I, Hill M (2008) Biochemical markers of bone remodeling correlate negatively with circulating TSH in postmenopausal women. Endocr Regul 42:121-127.
10. Iida K, Hino Y, Ohara T, Chihara K (2011) A case of myxedema coma caused by isolated thyrotropin stimulating hormone deficiency and Hashimoto's thyroiditis. Endocr J 58:143-148.
11. Peeters RP, van der Deure WM, Visser TJ (2006) Genetic variation in thyroid hormone pathway genes: Polymorphisms in the TSH receptor and the iodothyronine deiodinases. Eur J Endocrinol 155:655-662. (Pubitemid 44857488)
12. Ma R, Morshed S, Latif R, Zaidi M, Davies TF (2011) The influence of thyroid-stimulating hormone and thyroid-stimulating hormone receptor antibodies on. Thyroid 21:897-906.
13. Hase H, et al. (2006) TNFalpha mediates the skeletal effects of thyroid-stimulating hormone. Proc Natl Acad Sci USA 103:12849-12854. (Pubitemid 44298650)
14. Sun L, et al. (2008) Intermittent recombinant TSH injections prevent ovariectomy-induced bone loss. Proc Natl Acad Sci USA 105:4289-4294. (Pubitemid 351754373)
15. Sampath TK, et al. (2007) Thyroid-stimulating hormone restores bone volume, microarchitecture, and strength in aged ovariectomized rats. J Bone Miner Res 22:849-859. (Pubitemid 351339745)
16. Lin RY, Kubo A, Keller GM, Davies TF (2003) Committing embryonic stem cells to differentiate into thyrocyte-like cells in vitro. Endocrinology 144:2644-2649. (Pubitemid 36629917)
17. Tu X, et al. (2007) Noncanonical Wnt signaling through G protein-linked PKCdelta activation promotes bone formation. Dev Cell 12:113-127. (Pubitemid 46002598)
18. Thomas GP, Baker SU, Eisman JA, Gardiner EM (2001) Changing RANKL/OPG mRNA expression in differentiating murine primary osteoblasts. J Endocrinol 170:451-460. (Pubitemid 32771446)
19. Kubota T, Michigami T, Ozono K (2009) Wnt signaling in bone metabolism. J Bone Miner Metab 27:265-271.
20. Baron R, Rawadi G (2007) Targeting the Wnt/beta-catenin pathway to regulate bone formation in the adult skeleton. Endocrinology 148:2635-2643. (Pubitemid 46984775)
21. Yadav VK, et al. (2008) Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum. Cell 135:825-837.
22. Kato M, et al. (2002) Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor. J Cell Biol 157:303-314. (Pubitemid 34839826)
23. Person AD, et al. (2010) WNT5A mutations in patients with autosomal dominant Robinow syndrome. Dev Dyn 239:327-337.
24. Yu HC, et al. (2010) Mechanical stretching induces osteoprotegerin in differentiating C2C12 precursor cells through noncanonical Wnt pathways. J Bone Miner Res 25:1128-1137.
25. Yang D, Guo J, Divieti P, Bringhurst FR (2006) Parathyroid hormone activates PKC-delta and regulates osteoblastic differentiation via a PLC-independent pathway. Bone 38:485-496.
26. Lima F, Niger C, Hebert C, Stains JP (2009) Connexin43 potentiates osteoblast responsiveness to fibroblast growth factor 2 via a protein kinase C-delta/Runx2-dependent mechanism. Mol Biol Cell 20:2697-2708.
27. Vincent BH, et al. (2009) Bone marrow cells produce a novel TSHbeta splice variant that is upregulated in the thyroid following systemic virus infection. Genes Immun 10:18-26.
28. zur Nieden NI, Kempka G, Ahr HJ (2003) In vitro differentiation of embryonic stem cells into mineralized osteoblasts. Differentiation 71:18-27. (Pubitemid 38230416)
29. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265-275.