Rare corneal clones in mice suggest an age-related decrease of stem cell activity and support the limbal epithelial stem cell hypothesis

Stem Cell Research

Volumn 8, Issue 1, 2012, Pages 109-119

  Douvaras, Panagiotis ^a,c   Webb, Sheila ^b   Whitaker, Duncan A ^b   Dorà, Natalie ^a   Hill, Robert E ^b   Dorin, Julia R ^b   West, John D ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c New York Stem Cell Foundation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; CYTOKERATIN 5; TRANSCRIPTION FACTOR PAX6;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL ACTIVITY; CELL AGING; CELL CLONE; CELL FUNCTION; CELL LINEAGE; CELL STRUCTURE; CONJUNCTIVA; CONTROLLED STUDY; CORNEA EPITHELIUM; CORNEA LIMBUS; DOWN REGULATION; GENOTYPE; HOMEOSTASIS; HYPOTHESIS; LIMBAL EPITHELIAL STEM CELL HYPOTHESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEM CELL; STEM CELL MOBILIZATION; TRANSGENIC MOUSE;

AGING; ANIMALS; BETA-GALACTOSIDASE; CLONE CELLS; EPITHELIAL CELLS; EPITHELIUM, CORNEAL; EYE PROTEINS; GENOTYPE; HOMEODOMAIN PROTEINS; HUMANS; KERATIN-5; LIMBUS CORNEAE; MICE; MICE, INBRED C57BL; MODELS, BIOLOGICAL; PAIRED BOX TRANSCRIPTION FACTORS; REPRESSOR PROTEINS; STAINING AND LABELING; STEM CELLS;

MUS; MUS MUSCULUS;

EID: 80053651004     PISSN: 18735061     EISSN: 18767753     Source Type: Journal    
DOI: 10.1016/j.scr.2011.08.007     Document Type: Article

References (35)

1. Buck R.C. Measurement of centripetal migration of normal corneal epithelial cells in the mouse. Invest. Ophthalmol. Vis. Sci. 1985, 26:1296-1299.
2. Byrne C., Fuchs E. Probing keratinocyte and differentiation specificity of the human K5 promoter in vitro and in transgenic mice. Mol. Cell. Biol. 1993, 13:3176-3190.
3. Chaloin-Dufau C., Pavitt I., Delorme P., Dhouailly D. Identification of keratin-3 and keratin-12 in corneal epithelium of vertebrates. Epithelial Cell Biol. 1993, 2:120-125.
4. +/- mouse. Invest. Ophthalmol. Vis. Sci. 2004, 45:1101-1108.
5. Collinson J.M., Morris L., Reid A.I., Ramaesh T., Keighren M.A., Flockhart J.H., Hill R.E., Tan S.S., Ramaesh K., Dhillon B., West J.D. Clonal analysis of patterns of growth, stem cell activity, and cell movement during the development and maintenance of the murine corneal epithelium. Dev. Dyn. 2002, 224:432-440.
6. Cotsarelis G., Cheng S.Z., Dong G., Sun T.T., Lavker R.M. Existence of slow-cycling limbal epithelial basal cells that can be preferentially stimulated to proliferate: implications on epithelial stem cells. Cell 1989, 57:201-209.
7. Davanger M., Evensen A. Role of the pericorneal papillary structure in renewal of corneal epithelium. Nature 1971, 229:560-561.
8. Davis J., Duncan M.K., Robison W.G., Piatigorsky J. Requirement for Pax6 in corneal morphogenesis: a role in adhesion. J. Cell Sci. 2003, 116:2157-2167.
9. Dobie K., Mehtali M., McClenaghan M., Lathe R. Variegated gene expression in mice. Trends Genet. 1997, 13:127-130.
10. Ebato B., Friend J., Thoft R.A. Comparison of limbal and peripheral human corneal epithelium in tissue culture. Invest. Ophthalmol. Vis. Sci. 1988, 29:1533-1537.
11. Endo M., Zoltick P.W., Chung D.C., Bennett J., Radu A., Muvarak N., Flake A.W. Gene transfer to ocular stem cells by early gestational intraamniotic injection of lentiviral vector. Mol. Ther. 2007, 15:579-587.
12. Hesse M., Zimek A., Weber K., Magin T.M. Comprehensive analysis of keratin gene clusters in humans and rodents. Eur. J. Cell Biol. 2004, 83:19-26.
13. Hogan B., Beddington R., Costantini F., Lacy E. Manipulating the Mouse Embryo. A Laboratory Manual 1994, Cold Spring Harbor Laboratory Press. Second ed.
14. Holland E.J., Djalilian A.R., Schwartz G.S. Management of aniridic keratopathy with keratolimbal allograft: a limbal stem cell transplantation technique. Ophthalmology 2003, 110:125-130.
15. Kanakubo S., Nomura T., Yamamura K.I., Miyazaki J.I., Tamai M., Osumi N. Abnormal migration and distribution of neural crest cells in Pax6 heterozygous mutant eye, a model for human eye diseases. Genes Cells 2006, 11:919-933.
16. Kenyon K.R., Tseng S.C.G. Limbal autograft transplantation for ocular surface disorders. Ophthalmology 1989, 96:709-723.
17. Kinoshita S., Friend J., Thoft R.A. Sex chromatin of donor corneal epithelium in rabbits. Invest. Ophthalmol. Vis. Sci. 1981, 21:434-441.
18. Lehrer M.S., Sun T.T., Lavker R.M. Strategies of epithelial repair: modulation of stem cell and transit amplifying cell proliferation. J. Cell Sci. 1998, 111:2867-2875.
19. Lu H., Zimek A., Chen J., Hesse M., Bussow H., Weber K., Magin T.M. Keratin 5 knockout mice reveal plasticity of keratin expression in the corneal epithelium. Eur. J. Cell Biol. 2006, 85:803-811.
20. Majo F., Rochat A., Nicolas M., Jaoude G.A., Barrandon Y. Oligopotent stem cells are distributed throughout the mammalian ocular surface. Nature 2008, 456:250-255.
21. Mort R.L., Ramaesh T., Kleinjan D.A., Morley S.D., West J.D. Mosaic analysis of stem cell function and wound healing in the mouse corneal epithelium. BMC Dev. Biol. 2009, 9:4.
22. Nagasaki T., Zhao J. Centripetal movement of corneal epithelial cells in the normal adult mouse. Invest. Ophthalmol. Vis. Sci. 2003, 44:558-566.
23. Nagasaki T., Zhao J. Uniform distribution of epithelial stem cells in the bulbar conjunctiva. Invest. Ophthalmol. Vis. Sci. 2005, 46:126-132.
24. Nishida K., Kinoshita S., Ohashi Y., Kuwayama Y., Yamamoto S. Ocular surface abnormalities in aniridia. Am. J. Ophthalmol. 1995, 120:368-375.
25. +/- aniridia-related keratopathy. J. Pathol. 2008, 215:421-430.
26. Pellegrini G., Golisano O., Paterna P., Lambiase A., Bonini S., Rama P., De Luca M. Location and clonal analysis of stem cells and their differentiated progeny in the human ocular surface. J. Cell Biol. 1999, 145:769-782.
27. Pajoohesh-Ganji A., Stepp M.A. In search of markers for the stem cells of the corneal epithelium. Biol. Cell 2005, 97:265-276.
28. Quinn J.C., West J.D., Hill R.E. Multiple functions for Pax6 in mouse eye and nasal development. Genes Dev. 1996, 10:435-446.
29. +/- small eye mice mimic human aniridia-related keratopathy. Invest. Ophthalmol. Vis. Sci. 2003, 44:1871-1878.
30. +/- mouse model of aniridia. Exp. Eye Res. 2005, 81:224-235.
31. Schermer A., Galvin S., Sun T.T. Differentiation-related expression of a major 64k corneal keratin in vivo and in culture suggests limbal location of corneal epithelial stem cells. J. Cell Biol. 1986, 103:49-62.
32. Schlotzer-Schrehardt U., Kruse F.E. Identification and characterization of limbal stem cells. Exp. Eye Res. 2005, 81:247-264.
33. Smith R.S., Sundberg J.P., John S.W.M. The anterior segment and ocular adnexae. Systematic Evaluation of the Mouse Eye. Anatomy, Pathology and Biomethods 2002, 1-23. CRC Press, Boca Raton, Florida. R.S. Smith (Ed.).
34. Whitaker D.A. Transgenic approaches for the investigation of putative airway stem cells as potential targets for gene correction therapy. PhD thesis 2004, 295. University of Edinburgh, Edinburgh.
35. Wolosin J.M., Budak M.T., Akinci M.A.M. Ocular surface epithelial and stem cell development. Int. J. Dev. Biol. 2004, 48:981-991.