SH3KBP1-binding protein 1 prevents epidermal growth factor receptor degradation by the interruption of c-Cbl-CIN85 complex

Cell Biochemistry and Function

Volumn 29, Issue 7, 2011, Pages 589-596

  Feng, Lifeng ^a   Wang, Jin Tao ^b   Jin, Hongchuan ^a   Qian, Kaixian ^a   Geng, Jian Guo ^b  

^a ZHEJIANG UNIVERSITY   (China)

^b UNIVERSITY OF MICHIGAN SCHOOL OF DENTISTRY   (United States)

Author keywords

C Cbl; Cbl interacting protein of 85 kDa (CIN85); Down regulation; Epidermal growth factor receptor; SH3KBP1 binding protein 1

Indexed keywords

CARRIER PROTEINS AND BINDING PROTEINS; EPIDERMAL GROWTH FACTOR RECEPTOR; HYBRID PROTEIN; PROTEIN C CBL CIN85; SH3KBP1 BINDING PROTEIN 1; UNCLASSIFIED DRUG;

ARTICLE; COMPLEX FORMATION; DOWN REGULATION; HELA CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; SERUM RESPONSIVE ELEMENT; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; CARRIER PROTEINS; EPIDERMAL GROWTH FACTOR; GENES, REPORTER; HEK293 CELLS; HELA CELLS; HUMANS; MULTIPROTEIN COMPLEXES; PLASMIDS; PROTEIN INTERACTION MAPPING; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-CBL; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; TRANSCRIPTIONAL ACTIVATION; TRANSFECTION; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 80053624907     PISSN: 02636484     EISSN: 10990844     Source Type: Journal    
DOI: 10.1002/cbf.1792     Document Type: Article

References (23)

1. Dikic I, Giordano S. Negative receptor signalling. Curr Opin Cell Biol 2003; 15: 128-135. doi:10.1016/S0955-0674(03)00004-8.
2. Haglund K, Shimokawa N, Szymkiewicz I, Dikic I. Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors. Proc Natl Acad Sci USA 2002; 99: 12191-12196. doi:10.1073/pnas.192462299.
3. Schneider MR, Sibilia M, Erben RG. The EGFR network in bone biology and pathology. Trends Endocrinol Metab 2009; 20: 517-524. doi:10.1016/j.tem.2009.06.008.
4. Soubeyran P, Kowanetz K, Szymkiewicz I, Langdon WY, Dikic I. Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors. Nature 2002; 416: 183-187. doi:10.1038/416183a.
5. Waterman H, Yarden Y. Molecular mechanisms underlying endocytosis and sorting of ErbB receptor tyrosine kinases. FEBS Lett 2001; 490: 142-152. doi:10.1016/S0014-5793(01)02117-2.
6. Saif MW. Colorectal cancer in review: the role of the EGFR pathway. Expert Opin Investig Drugs 2010; 19: 357-369. doi:10.1517/13543781003593962.
7. Thien CB, Langdon WY. Cbl: many adaptations to regulate protein tyrosine kinases. Nat Rev Mol Cell Biol 2001; 2: 294-307. doi:10.1038/35067100.
8. Szymkiewicz I, Kowanetz K, Soubeyran P, Dinarina A, Lipkowitz S, Dikic I. CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases. J Biol Chem 2002; 277: 39666-39672. doi:10.1074/jbc.M205535200.
9. Pennock S, Wang Z. A tale of two Cbls: interplay of c-Cbl and Cbl-b in epidermal growth factor receptor downregulation. Mol Cell Biol 2008; 28: 3020-3037. doi:10.1128/MCB.01809-07.
10. Tan YH, Krishnaswamy S, Nandi S, et al. CBL is frequently altered in lung cancers: its relationship to mutations in MET and EGFR tyrosine kinases. PLoS One 2010; 5: e8972. doi:10.1371/journal.pone.0008972.
11. Jozic D, Cardenes N, Deribe YL, Moncalian G, Hoeller D, Groemping Y, Dikic I, Rittinger K, Bravo J. Cbl promotes clustering of endocytic adaptor proteins. Nat Struct Mol Biol 2005; 12: 972-979. doi:10.1038/nsmb1000.
12. Take H, Watanabe S, Takeda K, Yu ZX, Iwata N, Kajigaya S. Cloning and characterization of a novel adaptor protein, CIN85, that interacts with c-Cbl. Biochem Biophys Res Commun 2000; 268: 321-328. doi:10.1006/bbrc.2000.2147.
13. Watanabe S, Take H, Takeda K, Yu ZX, Iwata N, Kajigaya S. Characterization of the CIN85 adaptor protein and identification of components involved in CIN85 complexes. Biochem Biophys Res Commun 2000; 278: 167-174. doi:10.1006/bbrc.2000.3760S0006-291X(00)93760-4.
14. Dikic I. CIN85/CMS family of adaptor molecules. FEBS Lett 2002; 529: 110-115. doi:10.1016/S0014-5793(02)03188-5.
15. Kowanetz K, Husnjak K, Holler D, et al. CIN85 associates with multiple effectors controlling intracellular trafficking of epidermal growth factor receptors. Mol Biol Cell 2004; 15: 3155-3166. doi:10.1091/mbc.E03-09-0683.
16. Hall AB, Jura N, DaSilva J, Jang YJ, Gong D, Bar-Sagi D. hSpry2 is targeted to the ubiquitin-dependent proteasome pathway by c-Cbl. Curr Biol 2003; 13: 308-314. doi:10.1016/S0960-9822(03)00086-1.
17. Haglund K, Schmidt MH, Wong ES, Guy GR, Dikic I. Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation. EMBO Rep 2005; 6: 635-641. doi:10.1038/sj.embor.7400453.
18. Feng Q, Baird D, Peng X, Wang J, Ly T, Guan JL, Cerione RA. Cool-1 functions as an essential regulatory node for EGF receptor- and Src-mediated cell growth. Nat Cell Biol 2006; 8: 945-956. doi:10.1038/ncb1453.
19. Liang Y, Kurakin A, Roizman B. Herpes simplex virus 1 infected cell protein 0 forms a complex with CIN85 and Cbl and mediates the degradation of EGF receptor from cell surfaces. Proc Natl Acad Sci USA 2005; 102: 5838-5843. doi:10.1073/pnas.0501253102.
20. Wang HB, Wang JT, Zhang L, et al. P-selectin primes leukocyte integrin activation during inflammation. Nat Immunol 2007; 8: 882-892. doi:10.1038/ni1491.
21. Wang B, Xiao Y, Ding BB, et al. Induction of tumor angiogenesis by Slit-Robo signaling and inhibition of cancer growth by blocking Robo activity. Cancer Cell 2003; 4: 19-29. doi:10.1016/S1535-6108(03)00164-8.
22. Criqui-Filipe P, Ducret C, Maira SM, Wasylyk B. Net, a negative Ras-switchable TCF, contains a second inhibition domain, the CID, that mediates repression through interactions with CtBP and de-acetylation. EMBO J 1999; 18: 3392-3403. doi:10.1093/emboj/18.12.3392.
23. Zhang J, Zheng X, Yang X, Liao K. CIN85 associates with endosomal membrane and binds phosphatidic acid. Cell Res 2009; 19: 733-746. doi:10.1038/cr.2009.51.