Dicer1 depletion in male germ cells leads to infertility due to cumulative meiotic and spermiogenic defects

PLoS ONE

Volumn 6, Issue 10, 2011, Pages

  Romero, Yannick ^a   Meikar, Oliver ^b   Papaioannou, Marilena D ^a   Conne, Béatrice ^a   Grey, Corinne ^c   Weier, Manuela ^d   Pralong, François ^e   de Massy, Bernard ^c   Kaessmann, Henrik ^d   Vassalli, Jean Dominique ^a   Kotaja, Noora ^b   Nef, Serge ^a  

^a UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

^b UNIVERSITY OF TURKU   (Finland)

^c INSTITUTE OF HUMAN GENETICS   (France)

^d UNIVERSITY OF LAUSANNE   (Switzerland)

^e LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

DICER; DICER 1; UNCLASSIFIED DRUG; DDX4 PROTEIN, MOUSE; DEAD BOX PROTEIN; DICER1 PROTEIN, MOUSE; MICRORNA; RIBONUCLEASE III;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL MOTILITY; CELL RENEWAL; CELL SHAPE; CONTROLLED STUDY; CYTOPATHOLOGY; FLAGELLUM; GERM CELL; MALE; MALE INFERTILITY; MEIOSIS; MEIOTIC PROPHASE I; MOUSE; NONHUMAN; PROTEIN DEPLETION; SHORT INTERSPERSED REPEAT; SPERMATID; SPERMATOCYTE; SPERMATOGENESIS; SPERMATOZOON; SPERMATOZOON ABNORMALITY; SPERMATOZOON MATURATION; TRANSPOSON; UPREGULATION; ANIMAL; GENE DELETION; GENE SILENCING; GENETICS; METABOLISM; ORGAN SIZE; PATHOLOGY; SEMINIFEROUS TUBULE; SPERMATOZOON COUNT; TRANSGENIC MOUSE;

ANIMALIA; MUS;

ANIMALS; APOPTOSIS; DEAD-BOX RNA HELICASES; DNA TRANSPOSABLE ELEMENTS; GENE DELETION; GENE SILENCING; INFERTILITY, MALE; MALE; MEIOSIS; MICE; MICE, TRANSGENIC; MICRORNAS; ORGAN SIZE; RIBONUCLEASE III; SEMINIFEROUS TUBULES; SPERM COUNT; SPERMATOCYTES; SPERMATOGENESIS; SPERMATOZOA;

EID: 80053614178     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0025241     Document Type: Article

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