Serotonin transporter genotype (5-HTTLPR) predicts utilitarian moral judgments

PLoS ONE

Volumn 6, Issue 10, 2011, Pages

  Marsh, Abigail A ^a,b   Crowe, Samantha L ^b   Yu, Henry H ^b   Gorodetsky, Elena K ^c   Goldman, David ^c   Blair, R J R ^b  

^a GEORGETOWN UNIVERSITY   (United States)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^c NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SEROTONIN TRANSPORTER; SLC6A4 PROTEIN, HUMAN;

ADULT; ARTICLE; BEHAVIOR; BEHAVIOR GENETICS; CONTROLLED STUDY; DECISION MAKING; EMOTION; FEMALE; GENE FREQUENCY; GENETIC POLYMORPHISM; GENOTYPE; HOMOZYGOTE; HUMAN; HUMAN EXPERIMENT; MALE; MORALITY; NEUROTRANSMISSION; NORMAL HUMAN; RESPONSE TIME; SEROTONINERGIC TRANSMISSION; VICTIM; ETHICAL THEORY; ETHICS; GENETICS; TIME;

ADULT; BEHAVIOR; ETHICAL THEORY; FEMALE; GENOTYPE; HOMOZYGOTE; HUMANS; MALE; MORALS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; TIME FACTORS;

EID: 80053605646     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0025148     Document Type: Article

References (18)

1. Emanuel EJ, Miller FG, (2001) The ethics of placebo-controlled trials-a middle ground. N Engl J Med 345: 915-919.
2. Harmon A, (2010) New drugs stir debate on rules of clinical trials. New York Times Sept 18. Available:http://www.nytimes.com/2010/09/19/health/research/19trial.html.
3. Kogut T, Ritov I, (2005) The singularity effect of identified victims in separate and joint evaluations. Org Behav Hum Decis Process 97: 106-116.
4. Greene JD, Sommerville RB, Nystrom LE, Darley JM, Cohen JD, (2001) An fMRI investigation of emotional engagement in moral judgment. Science 293: 2105-2108.
5. Borg JS, Hynes C, Van Horn J, Grafton S, Sinnott-Armstrong W, (2006) Consequences, action, and intention as factors in moral judgments: an FMRI investigation. J Cogn Neurosci 18: 803-817.
6. Koenigs M, Young L, Adolphs R, Tranel D, Cushman F, et al. (2007) Damage to the prefrontal cortex increases utilitarian moral judgments. Nature 446: 908-911.
7. Crockett MJ, Clark L, Hauser MD, Robbins TW, (2010) Serotonin selectively influences moral judgment and behavior through effects on harm aversion. Proc Natl Acad Sci USA 107: 17433-17438.
8. Blair RJ, (2007) The amygdala and ventromedial prefrontal cortex in morality and psychopathy. Trends Cogn Sci 11: 387-392.
9. Collier DA, Stober G, Li T, Heils A, Catalano M, et al. (1996) A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in susceptibility to affective disorders. Mol Psychiatry 1: 453-460.
10. Hariri AR, Holmes A, (2006) Genetics of emotional regulation: the role of the serotonin transporter in neural function. Trends Cogn Sci 10: 182-191.
11. Pezawas L, Meyer-Lindenberg A, Drabant EM, Verchinski BA, Munoz KE, et al. (2005) 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression. Nat Neurosci 8: 828-834.
12. Quill TE, Dresser R, Brock DW, (1997) The rule of double effect-a critique of its role in end-of-life decision making. N Engl J Med 337: 1768-1771.
13. Miczek KA, de Almeida RM, Kravitz EA, Rissman EF, de Boer SF, et al. (2007) Neurobiology of escalated aggression and violence. J Neurosci 27: 11803-11806.
14. Caspi A, Hariri AR, Holmes A, Uher R, Moffitt TE, (2010) Genetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traits. Am J Psychiatry 167: 509-527.
15. Jacobs N, Kenis G, Peeters F, Derom C, Vlietinck R, et al. (2006) Stress-related negative affectivity and genetically altered serotonin transporter function: evidence of synergism in shaping risk of depression. Arch Gen Psychiatry 63: 989-996.
16. Watson D, Clark LA, (1984) Negative affectivity: the disposition to experience aversive emotional states. Psychol Bull 96: 465-490.
17. Botvinick MM, Braver TS, Barch DM, Carter CS, Cohen JD, (2001) Conflict monitoring and cognitive control. Psychol Rev 108: 624-652.
18. Glenn AL, (2011) The other allele: Exploring the long allele of the serotonin transporter gene as a potential risk factor for psychopathy: A review of the parallels in findings. Neurosci Biobehav Rev 35: 612-620.