New insight into the molecular mechanisms of the biological effects of DNA minor groove binders

PLoS ONE

Volumn 6, Issue 10, 2011, Pages

  Zhang, Xinbo ^a,b   Zhang, Siyu Crystal ^c   Sun, Dejun ^d   Hu, Jiang ^e   Wali, Anil ^f   Pass, Harvey ^g   Fernandez Madrid, Felix ^a,b   Harbut, Michael R ^b,h   Tang, Naimei ^a,b  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b KARMANOS CANCER INSTITUTE   (United States)

^c WAYNE STATE UNIVERSITY   (United States)

^d Research Institute of Respiratory and Critical Care Medicine   (China)

^e Surgical Department of Central Hospital   (China)

^f NATIONAL CANCER INSTITUTE   (United States)

^g NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^h PROVIDENCE HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 [5 (4 METHYL 1 PIPERAZINYL)[2,5' BI 1H BENZIMIDAZOL] 2' YL]PHENOL; BISBENZIMIDE; CASPASE 3; CELL PROTEIN; CYTOCHROME C; DNA; HOE 33342; BENZIMIDAZOLE DERIVATIVE; COLORING AGENT; PIBENZIMOL; TRANSCRIPTOME;

APOPTOSIS; ARTICLE; BIOINFORMATICS; BIOLOGICAL ACTIVITY; CANCER CELL; CELL STRUCTURE; CELL SURVIVAL; CELL VIABILITY; CELLULAR DISTRIBUTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA BINDING; DRUG MECHANISM; ENZYME ACTIVATION; GENE EXPRESSION PROFILING; GENE OVEREXPRESSION; GENE STRUCTURE; GENETIC ANALYSIS; HUMAN; HUMAN CELL; MESOTHELIOMA; MICROARRAY ANALYSIS; MOLECULAR DYNAMICS; MORPHOLOGICAL TRAIT; NUCLEOTIDE SEQUENCE; PROTEIN CLEAVAGE; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; STAINING; STRUCTURE ANALYSIS; TRANSCRIPTION REGULATION; UPREGULATION; CHEMISTRY; CONFORMATION; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; TUMOR CELL LINE;

APOPTOSIS; BENZIMIDAZOLES; BISBENZIMIDAZOLE; CELL LINE, TUMOR; COLORING AGENTS; DNA; DRUG ANTAGONISM; HUMANS; NUCLEIC ACID CONFORMATION; SIGNAL TRANSDUCTION; TRANSCRIPTOME;

EID: 80053589725     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0025822     Document Type: Article

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