Hoechst 33342 induces apoptosis in HL-60 cells and inhibits topoisomerase I in vivo

Archives of Pathology and Laboratory Medicine

Volumn 123, Issue 10, 1999, Pages 921-927

  Zhang, Xinbo ^a   Chen, Jenn ^a   Davis, Bruce ^a   Kiechle, Frederick ^a,b  

^a WILLIAM BEAUMONT HOSPITAL   (United States)

^b Department of Clinical Pathology ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 [5 (4 METHYL 1 PIPERAZINYL)[2,5' BI 1H BENZIMIDAZOL] 2' YL]PHENOL; DNA TOPOISOMERASE INHIBITOR; HOE 33342;

APOPTOSIS; ARTICLE; CELL STRAIN HL 60; CONTROLLED STUDY; DNA DEGRADATION; DOSE RESPONSE; ENZYME INHIBITION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; PROMYELOCYTIC LEUKEMIA;

EID: 0032860974     PISSN: 00039985     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (6)

1. Kiechle FL, Zhang X. Apoptosis: a brief review. J Clin Ligand Assay. 1998;21:58-61.
2. Allen RT, Hunter WJ III, Agrawal DK. Morphological and biochemical characterization and analysis of apoptosis. Pharmacol Toxicol Method. 1997;37:215-228.
3. Wertz IE, Hanley MR. Diverse molecular provocation of programmed cell death. Trend Biochem Sci. 1996;21:359-364.
4. Planchon SM, Wuerzberger S, Frydman B, et al. β-Lapachone-mediated apoptosis in human promyelocytic leukemia (HL-60) and human prostate cancer cells: a p53 independent response. Cancer Res. 1995;55:3706-3711.
5. Khaoustov VI, Ozer A, Smith JR, et al. Induction of senescent cell-derived inhibitor of DNA synthesis gene, SDI1, in hepatoblastoma (HepG2) cells arrested in the G2-phase of the cell cycle by 9-nitrocamptothecin. Lab Invest. 1995;73:118-127.
6. Zhang X, Kiechle FL. Hoechst 33342-induced apoptosis in BC3H-1 myocytes. Ann Clin Lab Sci. 1997;27:260-275.