RB and p53 cooperate to prevent liver tumorigenesis in response to tissue damage

Gastroenterology

Volumn 141, Issue 4, 2011, Pages 1439-1450

  McClendon, A Kathleen ^a   Dean, Jeffry L ^a   Ertel, Adam ^a,b   Fu, Zhiyan ^c   Rivadeneira, Dayana B ^a   Reed, Christopher A ^a   Bourgo, Ryan J ^a   Witkiewicz, Agnieszka ^a   Addya, Sankar ^b   Mayhew, Christopher N ^d   Grimes, H Leighton ^d   Fortina, Paolo ^a,b   Knudsen, Erik S ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c WISTAR INSTITUTE   (United States)

^d CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

DEN; Genetics; Liver Cancer; Mouse Model; Tumor Environment

Indexed keywords

DIETHYLNITROSAMINE; PROTEIN P53; RETINOBLASTOMA PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CYCLE REGULATION; CELL PROLIFERATION; CHROMOSOME ABERRATION; COMPARATIVE GENOMIC HYBRIDIZATION; GENE CONTROL; GENE DELETION; GENETIC TRANSCRIPTION; GENOMIC INSTABILITY; GENOTOXICITY; GENOTYPE; HISTOPATHOLOGY; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; LIVER DEVELOPMENT; MICROARRAY ANALYSIS; MITOSIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN FUNCTION; TISSUE INJURY; TUMOR GROWTH;

EID: 80053588225     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2011.06.046     Document Type: Article

References (37)

1. H.B. El-Serag, and K.L. Rudolph Hepatocellular carcinoma: epidemiology and molecular carcinogenesis Gastroenterology 132 2007 2557 2576 (Pubitemid 46890874)
2. A. Teufel, F. Staib, and S. Kanzler Genetics of hepatocellular carcinoma World J Gastroenterol 13 2007 2271 2282 (Pubitemid 46860727)
3. C.M. Wong, and I.O. Ng Molecular pathogenesis of hepatocellular carcinoma Liver Int 28 2008 160 174 (Pubitemid 351201031)
4. M.C. Yu, and J.M. Yuan Environmental factors and risk for hepatocellular carcinoma Gastroenterology 127 2004 S72 S78
5. D.R. McGivern, and S.M. Lemon Tumor suppressors, chromosomal instability, and hepatitis C virus-associated liver cancer Annu Rev Pathol 4 2009 399 415
6. F. Azam, and A. Koulaouzidis Hepatitis B virus and hepatocarcinogenesis Ann Hepatol 7 2008 125 129 (Pubitemid 351845522)
7. P. Iakova, L. Timchenko, and N.A. Timchenko Intracellular signaling and hepatocellular carcinoma Semin Cancer Biol 21 2010 28 34
8. S.H. Lau, and X.Y. Guan Cytogenetic and molecular genetic alterations in hepatocellular carcinoma Acta Pharmacol Sin 26 2005 659 665
9. J.R. Nevins The Rb/E2F pathway and cancer Hum Mol Genet 10 2001 699 703 (Pubitemid 32331578)
10. M.P. Markey, S.P. Angus, and M.W. Strobeck Unbiased analysis of RB-mediated transcriptional repression identifies novel targets and distinctions from E2F action Cancer Res 62 2002 6587 6597 (Pubitemid 35364125)
11. R. Vernell, K. Helin, and H. Muller Identification of target genes of the p16INK4A-pRB-E2F pathway J Biol Chem 278 2003 46124 46137 (Pubitemid 37432763)
12. E.S. Knudsen, and K.E. Knudsen Tailoring to RB: tumour suppressor status and therapeutic response Nat Rev Cancer 8 2008 714 724
13. C.N. Mayhew, S.L. Carter, and S.R. Fox RB loss abrogates cell cycle control and genome integrity to promote liver tumorigenesis Gastroenterology 133 2007 976 984 (Pubitemid 47374137)
14. C.J. Sherr, and F. McCormick The RB and p53 pathways in cancer Cancer Cell 2 2002 103 112 (Pubitemid 41039110)
15. T.M. Wise-Draper, and S.I. Wells Papillomavirus E6 and E7 proteins and their cellular targets Front Biosci 13 2008 1003 1017 (Pubitemid 351594744)
16. D. Menendez, A. Inga, and M.A. Resnick The expanding universe of p53 targets Nat Rev Cancer 9 2009 724 737
17. K.A. Boehme, and C. Blattner Regulation of p53insights into a complex process Crit Rev Biochem Mol Biol 44 2009 367 392
18. D.W. Meek Tumour suppression by p53: a role for the DNA damage response? Nat Rev Cancer 9 2009 714 723
19. O. Shakhova, C. Leung, and E. van Montfort Lack of Rb and p53 delays cerebellar development and predisposes to large cell anaplastic medulloblastoma through amplification of N-Myc and Ptch2 Cancer Res 66 2006 5190 5200 (Pubitemid 43844942)
20. Z. Jiang, T. Deng, and R. Jones Rb deletion in mouse mammary progenitors induces luminal-B or basal-like/EMT tumor subtypes depending on p53 status J Clin Invest 120 2010 3296 3309
21. J. Jonkers, R. Meuwissen, and H. van der Gulden Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer Nat Genet 29 2001 418 425 (Pubitemid 34326692)
22. L. Litovchick, S. Sadasivam, and L. Florens Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence Mol Cell 26 2007 539 551 (Pubitemid 46779093)
23. G.L. Wang, E. Salisbury, and X. Shi HDAC1 cooperates with C/EBPalpha in the inhibition of liver proliferation in old mice J Biol Chem 283 2008 26169 26178
24. T. Watanabe, G. Tanaka, and S. Hamada Dose-dependent alterations in gene expression in mouse liver induced by diethylnitrosamine and ethylnitrosourea and determined by quantitative real-time PCR Mutat Res 673 2009 9 20
25. W.R. Taylor, and G.R. Stark Regulation of the G2/M transition by p53 Oncogene 20 2001 1803 1815 (Pubitemid 32458690)
26. S.H. Kimura, M. Ikawa, and A. Ito Cyclin G1 is involved in G2/M arrest in response to DNA damage and in growth control after damage recovery Oncogene 20 2001 3290 3300 (Pubitemid 32553681)
27. T.F. Burns, P. Fei, and K.A. Scata Silencing of the novel p53 target gene Snk/Plk2 leads to mitotic catastrophe in paclitaxel (taxol)-exposed cells Mol Cell Biol 23 2003 5556 5571 (Pubitemid 36951322)
28. J. Lee, J.A. Kim, and V. Barbier DNA damage triggers p21WAF1-dependent Emi1 down-regulation that maintains G2 arrest Mol Biol Cell 20 2009 1891 1902
29. N.I. Herath, B.A. Leggett, and G.A. MacDonald Review of genetic and epigenetic alterations in hepatocarcinogenesis J Gastroenterol Hepatol 21 2006 15 21
30. Y. Matsuda Molecular mechanism underlying the functional loss of cyclindependent kinase inhibitors p16 and p27 in hepatocellular carcinoma World J Gastroenterol 14 2008 1734 1740 (Pubitemid 351493379)
31. Y.J. Zhang, W. Jiang, and C.J. Chen Amplification and overexpression of cyclin D1 in human hepatocellular carcinoma Biochem Biophys Res Commun 196 1993 1010 1016 (Pubitemid 23337708)
32. K. Endo, T. Ueda, and T. Ohta Protein expression of MDM2 and its clinicopathological relationships in human hepatocellular carcinoma Liver 20 2000 209 215 (Pubitemid 30342718)
33. A.B. Martinez-Cruz, M. Santos, and M.F. Lara Spontaneous squamous cell carcinoma induced by the somatic inactivation of retinoblastoma and Trp53 tumor suppressors Cancer Res 68 2008 683 692 (Pubitemid 351206743)
34. Z. Zhou, A. Flesken-Nikitin, and D.C. Corney Synergy of p53 and Rb deficiency in a conditional mouse model for metastatic prostate cancer Cancer Res 66 2006 7889 7898 (Pubitemid 44299151)
35. S.D. Berman, E. Calo, and A.S. Landman Metastatic osteosarcoma induced by inactivation of Rb and p53 in the osteoblast lineage Proc Natl Acad Sci U S A 105 2008 11851 11856
36. G.L. Wang, X. Shi, and S. Haefliger Elimination of C/EBPalpha through the ubiquitin-proteasome system promotes the development of liver cancer in mice J Clin Invest 120 2010 2549 2562
37. N. Nishida, T. Nishimura, and T. Ito Chromosomal instability and human hepatocarcinogenesis Histol Histopathol 18 2003 897 909 (Pubitemid 36773234)