Crx broadly modulates the pineal transcriptome

Journal of Neurochemistry

Volumn 119, Issue 2, 2011, Pages 262-274

  Rovsing, Louise ^a,b   Clokie, Samuel ^b   Bustos, Diego M ^b,c   Rohde, Kristian ^a   Coon, Steven L ^b   Litman, Thomas ^a   Rath, Martin F ^a   Møller, Morten ^a   Klein, David C ^b  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^c INTECH ^*  (Argentina)

Author keywords

Crx; gene expression; Hoxc4; microarray; pineal gland; transcriptome profiling

Indexed keywords

MELATONIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR CRX; TRANSCRIPTOME; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL STRUCTURE; CONTROLLED STUDY; CRX GENE; DOWN REGULATION; FEMALE; GENE; GENE DELETION; GENE EXPRESSION; GENE FUNCTION; GENE SEQUENCE; HORMONE SYNTHESIS; HOXC4 GENE; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OTX2 GENE; PINEAL BODY; PRIORITY JOURNAL; TRANSCRIPTION REGULATION; UPREGULATION;

ANIMALS; CIRCADIAN RHYTHM; CLONING, MOLECULAR; COMPUTATIONAL BIOLOGY; DATA INTERPRETATION, STATISTICAL; DOWN-REGULATION; GENE DELETION; GENE EXPRESSION PROFILING; HOMEODOMAIN PROTEINS; MICE; MICE, KNOCKOUT; MICROARRAY ANALYSIS; MICROSCOPY, ELECTRON, TRANSMISSION; PINEAL GLAND; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC;

ANIMALIA; MAMMALIA;

EID: 80053575522     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2011.07405.x     Document Type: Article

References (45)

1. Albertin G., Malendowicz L. K., Macchi C., Markowska A., and, Nussdorfer G. G., (2000) Cerebellin stimulates the secretory activity of the rat adrenal gland: in vitro and in vivo studies. Neuropeptides 34, 7-11. (Pubitemid 30164275)
2. Appelbaum L., and, Gothilf Y., (2006) Mechanism of pineal-specific gene expression: the role of E-box and photoreceptor conserved elements. Mol. Cell. Endocrinol. 252, 27-33.
3. Bailey M. J., Beremand P. D., Hammer R., Bell-Pedersen D., Thomas T. L., and, Cassone V. M., (2003) Transcriptional profiling of the chick pineal gland, a photoreceptive circadian oscillator and pacemaker. Mol. Endocrinol. 17, 2084-2095. (Pubitemid 37281799)
4. Bailey M. J., Coon S. L., Carter D. A., et al. (2009) Night/day changes in pineal expression of > 600 genes: central role of adrenergic/cAMP signaling. J. Biol. Chem. 284, 7606-7622.
5. Bernard M., Dinet V., and, Voisin P., (2001) Transcriptional regulation of the chicken hydroxyindole-O-methyltransferase gene by the cone-rod homeobox-containing protein. J. Neurochem. 79, 248-257. (Pubitemid 32988940)
6. Bobola N., Briata P., Ilengo C., Rosatto N., Craft C., Corte G., and, Ravazzolo R., (1999) OTX2 homeodomain protein binds a DNA element necessary for interphotoreceptor retinoid binding protein gene expression. Mech. Dev. 82, 165-169. (Pubitemid 29243062)
7. Burris T. P., (2008) Nuclear hormone receptors for heme: REV-ERBalpha and REV-ERBbeta are ligand-regulated components of the mammalian clock. Mol. Endocrinol. 22, 1509-1520. (Pubitemid 351920387)
8. Chen S., Wang Q. L., Nie Z., Sun H., Lennon G., Copeland N. G., Gilbert D. J., Jenkins N. A., and, Zack D. J., (1997) Crx, a novel Otx-like paired-homeodomain protein, binds to and transactivates photoreceptor cell-specific genes. Neuron 19, 1017-1030. (Pubitemid 27512363)
9. Coon S. L., Zarazaga L. A., Malpaux B., Ravault J. P., Bodin L., Voisin P., Weller J. L., Klein D. C., and, Chemineau P., (1999) Genetic variability in plasma melatonin in sheep is due to pineal weight, not to variations in enzyme activities. Am. J. Physiol. 277, E792-E797.
10. Coon S. L., Del Olmo E., Young W. S., III, and, Klein D. C., (2002) Melatonin synthesis enzymes in Macaca mulatta: focus on arylalkylamine N-acetyltransferase (EC 2.3.1.87). J. Clin. Endocrinol. Metab. 87, 4699-4706. (Pubitemid 35247064)
11. Dinet V., Girard-Naud N., Voisin P., and, Bernard M., (2006) Melatoninergic differentiation of retinal photoreceptors: activation of the chicken hydroxyindole-O-methyltransferase promoter requires a homeodomain-binding element that interacts with Otx2. Exp. Eye Res. 83, 276-290. (Pubitemid 43850943)
12. Edgar R., Domrachev M., and, Lash A. E., (2002) Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res. 30, 207-210. (Pubitemid 34679544)
13. Furukawa T., Morrow E. M., and, Cepko C. L., (1997) Crx, a novel otx-like homeobox gene, shows photoreceptor-specific expression and regulates photoreceptor differentiation. Cell 91, 531-541. (Pubitemid 27508242)
14. Furukawa T., Morrow E. M., Li T., Davis F. C., and, Cepko C. L., (1999) Retinopathy and attenuated circadian entrainment in Crx-deficient mice. Nat. Genet. 23, 466-470.
15. Geada A. M., Gaunt S. J., Azzawi M., Shimeld S. M., Pearce J., and, Sharpe P. T., (1992) Sequence and embryonic expression of the murine Hox-3.5 gene. Development 116, 497-506.
16. Goto M., Oshima I., Tomita T., and, Ebihara S., (1989) Melatonin content of the pineal gland in different mouse strains. J. Pineal Res. 7, 195-204. (Pubitemid 19192739)
17. Hsiau T. H., Diaconu C., Myers C. A., Lee J., Cepko C. L., and, Corbo J. C., (2007) The cis-regulatory logic of the mammalian photoreceptor transcriptional network. PLoS ONE 2, e643.
18. Johnston J. D., Bashforth R., Diack A., Andersson H., Lincoln G. A., and, Hazlerigg D. G., (2004) Rhythmic melatonin secretion does not correlate with the expression of arylalkylamine N-acetyltransferase, inducible cyclic amp early repressor, period1 or cryptochrome1 mRNA in the sheep pineal. Neuroscience 124, 789-795. (Pubitemid 38328768)
19. Kelai S., Maussion G., Noble F., Boni C., Ramoz N., Moalic J. M., Peuchmaur M., Gorwood P., and, Simonneau M., (2008) Nrxn3 upregulation in the globus pallidus of mice developing cocaine addiction. Neuroreport 19, 751-755. (Pubitemid 351555984)
20. Kikuchi T., Raju K., Breitman M. L., and, Shinohara T., (1993) The proximal promoter of the mouse arrestin gene directs gene expression in photoreceptor cells and contains an evolutionarily conserved retinal factor-binding site. Mol. Cell. Biol. 13, 4400-4408. (Pubitemid 23187669)
21. Klein D. C., (2004) The 2004 Aschoff/Pittendrigh lecture: theory of the origin of the pineal gland - a tale of conflict and resolution. J. Biol. Rhythms 19, 264-279. (Pubitemid 38943762)
22. Klein D. C., (2007) Arylalkylamine N-acetyltransferase: "the Timezyme". J. Biol. Chem. 282, 4233-4237.
23. Klein D. C., Reiter R. J., and, Weller J. L., (1971) Pineal N-acetyltransferase activity in blinded and anosmic male rats. Endocrinology 89, 1020-1023.
24. Klein D. C., Namboodiri M. A., and, Auerbach D. A., (1981) The melatonin rhythm generating system: developmental aspects. Life Sci. 28, 1975-1986. (Pubitemid 11081289)
25. Koike C., Nishida A., Ueno S., et al. (2007) Functional roles of Otx2 transcription factor in postnatal mouse retinal development. Mol. Cell. Biol. 27, 8318-8329. (Pubitemid 350234243)
26. Li X., Chen S., Wang Q., Zack D. J., Snyder S. H., and, Borjigin J., (1998) A pineal regulatory element (PIRE) mediates transactivation by the pineal/retina-specific transcription factor CRX. Proc. Natl. Acad. Sci. USA 95, 1876-1881. (Pubitemid 28103487)
27. Linder J. U., (2006) Class III adenylyl cyclases: molecular mechanisms of catalysis and regulation. Cell. Mol. Life Sci. 63, 1736-1751. (Pubitemid 44223083)
28. Mano H., and, Fukada Y., (2007) A median third eye: pineal gland retraces evolution of vertebrate photoreceptive organs. Photochem. Photobiol. 83, 11-18. (Pubitemid 46697218)
29. Meng Q. J., McMaster A., Beesley S., et al. (2008) Ligand modulation of REV-ERBalpha function resets the peripheral circadian clock in a phasic manner. J. Cell Sci. 121, 3629-3635.
30. Møller M., van Deurs B., and, Westergaard E., (1978) Vascular permeability to proteins and peptides in the mouse pineal gland. Cell Tiss. Res. 195, 1-15. (Pubitemid 9074938)
31. Møller M., Phansuwan-Pujito P., Morgan K. C., and, Badiu C., (1997) Localization and diurnal expression of mRNA encoding the beta1-adrenoceptor in the rat pineal gland: an in situ hybridization study. Cell Tissue Res. 288, 279-284. (Pubitemid 27187066)
32. Muñoz E. M., Bailey M. J., Rath M. F., Shi Q., Morin F., Coon S. L., Møller M., and, Klein D. C., (2007) NeuroD1: developmental expression and regulated genes in the rodent pineal gland. J. Neurochem. 102, 887-899. (Pubitemid 47057304)
33. Nishida A., Furukawa A., Koike C., Tano Y., Aizawa S., Matsuo I., and, Furukawa T., (2003) Otx2 homeobox gene controls retinal photoreceptor cell fate and pineal gland development. Nat. Neurosci. 6, 1255-1263. (Pubitemid 37485118)
34. Panda S., Provencio I., Tu D. C., et al. (2003) Melanopsin is required for non-image-forming photic responses in blind mice. Science 301, 525-527. (Pubitemid 36900311)
35. Prinster S. C., Hague C., and, Hall R. A., (2005) Heterodimerization of g protein-coupled receptors: specificity and functional significance. Pharmacol. Rev. 57, 289-298. (Pubitemid 41196951)
36. Quay W. B,. (1974) Pineal Chemistry, pp. 5-13. Charles C. Thomas, Springfield, IL, USA.
37. Quay W. B., and, Levine B. E., (1957) Pineal growth and mitotic activity in the rat and the effects of colchicine and sex hormones. Anat. Rec. 129, 65-77.
38. Rath M. F., Muñoz E., Ganguly S., Morin F., Shi Q., Klein D. C., and, Møller M., (2006) Expression of the Otx2 homeobox gene in the developing mammalian brain: embryonic and adult expression in the pineal gland. J. Neurochem. 97, 556-566.
39. Rath M. F., Morin F., Shi Q., Klein D. C., and, Møller M., (2007) Ontogenetic expression of the Otx2 and Crx homeobox genes in the retina of the rat. Exp. Eye Res. 85, 65-73. (Pubitemid 47017268)
40. Rovsing L., Rath M. F., Lund-Andersen C., Klein D. C., and, Møller M., (2010) A neuroanatomical and physiological study of the non-image forming visual system of the cone-rod homeobox gene (Crx) knock out mouse. Brain Res. 1343, 54-65.
41. Sun X., Deng J., Liu T., and, Borjigin J., (2002) Circadian 5-HT production regulated by adrenergic signaling. Proc. Natl. Acad. Sci. USA 99, 4686-4691. (Pubitemid 34286045)
42. Tosini G., Pozdeyev N., Sakamoto K., and, Iuvone P. M., (2008) The circadian clock system in the mammalian retina. Bioessays 30, 624-633. (Pubitemid 351898012)
43. Toyama R., Chen X., Jhawar N., Aamar E., Epstein J., Reany N., Alon S., Gothilf Y., Klein D. C., and, Dawid I. B., (2009) Transcriptome analysis of the zebrafish pineal gland. Dev. Dyn. 238, 1813-1826.
44. Upson R. H., Benson B., and, Satterfield V., (1976) Quantitation of ultrastructural changes in the mouse pineal in response to continuous illumination. Anat. Rec. 184, 311-323.
45. Vandesompele J., De Preter K., Pattyn F., Poppe B., Van Roy N., De Paepe A., and, Speleman F., (2002) Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol. 3, RESEARCH0034.