Immunologically restricted patients exhibit a pronounced inflammation and inadequate response to hypoxia in fracture hematomas

Immunologic Research

Volumn 51, Issue 1, 2011, Pages 116-122

  Hoff, Paula ^a,b   Gaber, T ^a,b,c   Schmidt Bleek, K ^a   Senturk U ^a   Tran, C L ^a,b   Blankenstein, K ^a,b   Lutkecosmann S ^a,b   Bredahl, J ^d   Schuler H J ^d   Simon, P ^a   Wassilew, G ^a   Unterhauser, F ^a   Burmester, G R ^a,b   Schmidmaier, G ^a   Perka, C ^a,c   Duda, G N ^a,c   Buttgereit, F ^a,b,c  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b DEUTSCHES RHEUMA FORSCHUNGSZENTRUM   (Germany)

^c Berlin Brandenburg Center for Regenerative Therapies   (Germany)

^d Department of Traumatology   (Germany)

Author keywords

Bone healing; Fracture hematoma; Hypoxia; Immune function; Inflammation

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INTERLEUKIN 8; LACTATE DEHYDROGENASE; OSTEOPONTIN; PHOSPHOGLYCERATE KINASE; PHOSPHOGLYCERATE KINASE 1; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG; VASCULOTROPIN;

ADULT; AGED; ARTICLE; BONE CELL; BONE DEVELOPMENT; CELL DIFFERENTIATION; CELL HYPOXIA; CELLULAR STRESS RESPONSE; CYTOKINE RESPONSE; FRACTURE HEALING; FRACTURE HEMATOMA; GENE EXPRESSION REGULATION; GENE TARGETING; HEMATOMA; HUMAN; HUMAN CELL; IMMUNOCOMPROMISED PATIENT; INFLAMMATION; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADULT; AGED; AGED, 80 AND OVER; BONE REGENERATION; CELL HYPOXIA; CORE BINDING FACTOR ALPHA 1 SUBUNIT; FEMALE; FRACTURES, BONE; HEMATOMA; HUMANS; IMMUNOCOMPROMISED HOST; INFLAMMATION; INTERLEUKIN-8; MALE; MIDDLE AGED; OSTEOGENESIS; OSTEOPONTIN; PHOSPHOGLYCERATE KINASE; RECEPTORS, CXCR4;

EID: 80053571487     PISSN: 0257277X     EISSN: 15590755     Source Type: Journal    
DOI: 10.1007/s12026-011-8235-9     Document Type: Article

References (25)

1. G Schmidmaier P Schwabe B Wildemann NP Haas 2007 Use of bone morphogenetic proteins for treatment of non-unions and future perspectives Injury 38 Suppl 4 S35 S41 18224735 10.1016/S0020-1383(08)70007-X (Pubitemid 351162870)
2. K Taguchi R Ogawa M Migita H Hanawa H Ito H Orimo 2005 The role of bone marrow-derived cells in bone fracture repair in a green fluorescent protein chimeric mouse model Biochem Biophys Res Commun 331 31 36 15845353 10.1016/j.bbrc.2005.03.119 1:CAS:528:DC%2BD2MXjsFChs70%3D (Pubitemid 40545137)
3. AM Phillips 2005 Overview of the fracture healing cascade Injury 36 Suppl 3 S5 S7 16188551 10.1016/j.injury.2005.07.027
4. A Schindeler MM McDonald P Bokko DG Little 2008 Bone remodeling during fracture repair: the cellular picture Semin Cell Dev Biol 19 459 466 18692584 10.1016/j.semcdb.2008.07.004 1:CAS:528:DC%2BD1cXht1Knt73L
5. P Kolar K Schmidt-Bleek H Schell T Gaber D Toben G Schmidmaier C Perka F Buttgereit GN Duda 2010 The early fracture hematoma and its potential role in fracture healing Tissue Eng Part B Rev 16 427 434 20196645 10.1089/ten.teb.2009. 0687
6. T Gaber R Dziurla R Tripmacher GR Burmester F Buttgereit 2005 Hypoxia inducible factor (HIF) in rheumatology: low O2! See what HIF can do! Ann Rheum Dis 64 971 980 15800008 10.1136/ard.2004.031641 1:CAS:528:DC%2BD2MXntFGlt7g%3D (Pubitemid 40909509)
7. T Cramer Y Yamanishi BE Clausen I Forster R Pawlinski N Mackman VH Haase R Jaenisch M Corr V Nizet GS Firestein HP Gerber N Ferrara RS Johnson 2003 HIF-1alpha is essential for myeloid cell-mediated inflammation Cell 112 645 657 12628185 10.1016/S0092-8674(03)00154-5 1:CAS:528:DC%2BD3sXitFykurY%3D (Pubitemid 36331777)
8. T Gaber T Haupl G Sandig K Tykwinska M Fangradt M Tschirschmann M Hahne R Dziurla K Erekul M Lautenbach P Kolar GR Burmester F Buttgereit 2009 Adaptation of human CD4+ T cells to pathophysiological hypoxia: a transcriptome analysis J Rheumatol 36 2655 2669 19884271 10.3899/jrheum.090255 1:CAS:528: DC%2BC3cXhtVWnu7k%3D
9. DR Epari JP Kassi H Schell GN Duda 2007 Timely fracture-healing requires optimization of axial fixation stability J Bone Joint Surg Am 89 1575 1585 17606797 10.2106/JBJS.F.00247 (Pubitemid 47041535)
10. J Lienau H Schell DR Epari N Schutze F Jakob GN Duda HJ Bail 2006 CYR61 (CCN1) protein expression during fracture healing in an ovine tibial model and its relation to the mechanical fixation stability J Orthop Res 24 254 262 16435358 10.1002/jor.20035 1:CAS:528:DC%2BD2sXlsFWms78%3D (Pubitemid 43773036)
11. ER Bogoch EL Moran 1999 Bone abnormalities in the surgical treatment of patients with rheumatoid arthritis Clin Orthop Relat Res 366 8 21 10627713 10.1097/00003086-199909000-00003 (Pubitemid 29439333)
12. B Dominiak W Oxberry P Chen 2005 Study on a nonhealing fracture from a patient with systemic lupus erythematosus and its pathogenetic mechanisms Ultrastruct Pathol 29 107 120 16028667 10.1080/01913120590912214 (Pubitemid 40605094)
13. N Follak I Kloting H Merk 2005 Influence of diabetic metabolic state on fracture healing in spontaneously diabetic rats Diabetes Metab Res Rev 21 288 296 15693070 10.1002/dmrr.537 (Pubitemid 40716162)
14. LS Kidder X Chen AH Schmidt WD Lew 2009 Osteogenic protein-1 overcomes inhibition of fracture healing in the diabetic rat: a pilot study Clin Orthop Relat Res 467 3249 3256 18663547 10.1007/s11999-008-0405-2
15. B Stromqvist 1984 Hip fracture in rheumatoid arthritis Acta Orthop Scand 55 624 628 6524328 10.3109/17453678408992409 1:STN:280:DyaL2M7hvVahsA%3D%3D (Pubitemid 15160156)
16. WA Tyndall HA Beam C Zarro JP O'Connor SS Lin 2003 Decreased platelet derived growth factor expression during fracture healing in diabetic animals Clin Orthop Relat Res 408 319 330 12616077 10.1097/00003086-200303000-00043 (Pubitemid 36307525)
17. Kolar P, Gaber T, Perka C, Duda GN, Buttgereit F. Human early fracture hematoma is characterized by inflammation and hypoxia. Clin Orthop Relat Res. 2011. Epub ahead of print.
18. AJ Busti JS Hooper CJ Amaya S Kazi 2005 Effects of perioperative antiinflammatory and immunomodulating therapy on surgical wound healing Pharmacotherapy 25 1566 1591 16232020 10.1592/phco.2005.25.11.1566 1:CAS:528:DC%2BD2MXht1Cgs7jI (Pubitemid 41566917)
19. SM Chidrawar N Khan YL Chan L Nayak PA Moss 2006 Ageing is associated with a decline in peripheral blood CD56bright NK cells Immun Ageing 3 10 17134511 10.1186/1742-4933-3-10 (Pubitemid 44942881)
20. M Ishikawa M Nishioka N Hanaki T Miyauchi Y Kashiwagi Y Kawasaki H Miki H Kagawa H Ioki Y Nakamura 2006 Postoperative host responses in elderly patients after gastrointestinal surgery Hepatogastroenterology 53 730 735 17086878 1:STN:280:DC%2BD28nltlegtQ%3D%3D (Pubitemid 44682992)
21. RM Smith 2007 Immunity, trauma and the elderly Injury 38 1401 1404 18045600 10.1016/j.injury.2007.09.013 1:STN:280:DC%2BD2sjit1Wntg%3D%3D (Pubitemid 350192399)
22. DL Woodland MA Blackman 2006 Immunity and age: living in the past? Trends Immunol 27 303 307 16731040 10.1016/j.it.2006.05.002 1:CAS:528: DC%2BD28XmsFSrtrs%3D (Pubitemid 43963474)
23. SC Kang T Matsutani MA Choudhry MG Schwacha LW Rue KI Bland IH Chaudry 2004 Are the immune responses different in middle-aged and young mice following bone fracture, tissue trauma and hemorrhage? Cytokine 26 223 230 15157900 10.1016/j.cyto.2004.03.005 1:CAS:528:DC%2BD2cXkt1Wqtbc%3D (Pubitemid 38639751)
24. GJ Arason GH Jorgensen BR Ludviksson 2010 Primary immunodeficiency and autoimmunity: lessons from human diseases Scand J Immunol 71 317 328 20500682 10.1111/j.1365-3083.2010.02386.x 1:CAS:528:DC%2BC3cXmslCht7s%3D
25. D Yu CG Vinuesa 2010 Multiple checkpoints keep follicular helper T cells under control to prevent autoimmunity Cell Mol Immunol 7 198 203 20364160 10.1038/cmi.2010.18