Comparative metabolism of sildenafil in liver microsomes of different species by using LC/MS-based multivariate analysis

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 879, Issue 28, 2011, Pages 3005-3011

  Lee, Sang Kyu ^a   Kim, Dong Hyun ^b   Yoo, Hye Hyun ^c  

^a Kyungpook National University   (South Korea)

^b Inje University College of Medicine   (South Korea)

^c Hanyang University   (South Korea)

Author keywords

Comparative metabolism; LC MS; Multivariate analysis; Sildenafil

Indexed keywords

ANALYTICAL APPROACH; HUMAN LIVER MICROSOMES; IN-VITRO; LC/MS; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; LIVER MICROSOMES; METABOLIC PROFILES; MULTIVARIATE ANALYSIS; MULTIVARIATE STATISTICAL ANALYSIS; PEAK AREA RATIOS; PRINCIPAL COMPONENTS; PRINCIPAL COMPONENTS ANALYSIS; REACTION MIXTURE; SILDENAFIL; SIMILARITY INDICES;

BIOCHEMISTRY; FAULT TOLERANT COMPUTER SYSTEMS; LIQUID CHROMATOGRAPHY; MAMMALS; MASS SPECTROMETRY; METABOLISM; MULTIVARIANT ANALYSIS; NATURAL LANGUAGE PROCESSING SYSTEMS; PHYSIOLOGY;

PRINCIPAL COMPONENT ANALYSIS;

DRUG METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SILDENAFIL; XENOBIOTIC AGENT;

ANIMAL TISSUE; ARTICLE; DOG; DRUG METABOLISM; DRUG TRANSFORMATION; HAPLORHINI; HUMAN; HUMAN TISSUE; IN VITRO STUDY; LIQUID CHROMATOGRAPHY; LIVER; LIVER MICROSOME; MASS SPECTROMETRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; SCORING SYSTEM; XENOBIOTIC METABOLISM;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOGS; HAPLORHINI; HUMANS; MASS SPECTROMETRY; MICE; MICROSOMES, LIVER; MULTIVARIATE ANALYSIS; PIPERAZINES; PURINES; RATS; SPECIES SPECIFICITY; SULFONES;

ANIMALIA; CANIS FAMILIARIS; MUS; RATTUS;

EID: 80053570253     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2011.08.037     Document Type: Article

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