The effect of topiramate monotherapy on bone mineral density and markers of bone and mineral metabolism in premenopausal women with epilepsy

Epilepsia

Volumn 52, Issue 10, 2011, Pages 1884-1889

  Heo, Kyoung ^a   Rhee, Yumie ^a   Lee, Hyang Woon ^b   Lee, Sang Ahm ^c   Shin, Dong Jin ^d   Kim, Won Joo ^a   Song, Hong Ki ^e   Song, Kijun ^a   Lee, Byung In ^a  

^a Yonsei University College of Medicine   (South Korea)

^b Ewha Womans University School of Medicine   (South Korea)

^c University of Ulsan College of Medicine   (South Korea)

^d Gachon University College of Medicine   (South Korea)

^e Hallym University   (South Korea)

Author keywords

Bone metabolism; Bone mineral density; Carbamazepine; Topiramate; Valproate; Vitamin D

Indexed keywords

25 HYDROXYVITAMIN D; ALKALINE PHOSPHATASE; BICARBONATE; CALCIFEDIOL; CARBAMAZEPINE; CARBOXY TERMINAL TELOPEPTIDE; COLLAGEN TYPE 1; OSTEOCALCIN; PARATHYROID HORMONE; TOPIRAMATE; VALPROIC ACID;

ADULT; ARTICLE; BICARBONATE BLOOD LEVEL; BLOOD ANALYSIS; BONE DENSITY; BONE MASS; BONE METABOLISM; BONE TURNOVER; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EFFECT; EPILEPSY; FEMALE; HUMAN; MINERAL METABOLISM; MONOTHERAPY; PREMENOPAUSE; PRIORITY JOURNAL;

ADULT; ALKALINE PHOSPHATASE; ANTICONVULSANTS; BICARBONATES; BONE AND BONES; BONE DENSITY; CALCIFICATION, PHYSIOLOGIC; CALCITRIOL; CALCIUM; CARBAMAZEPINE; EPILEPSY; FEMALE; FRUCTOSE; HUMANS; VALPROIC ACID; VITAMIN D;

EID: 80053566974     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/j.1528-1167.2011.03131.x     Document Type: Article

References (37)

1. Îngehagen M, Ben-Menachem E, Shank R, Rönnbäck L, Hansson E,. (2004) Topiramate modulation of kainate-induced calcium currents is inversely related to channel phosphorylation level. J Neurochem 88: 320-325. (Pubitemid 38084548)
2. Îngehagen M, Rönnbäck L, Hansson E, Ben-Menachem E,. (2005) Topiramate reduces AMPA-induced Ca(2+) transients and inhibits GluR1 subunit phosphorylation in astrocytes from primary cultures. J Neurochem 94: 1124-1130. (Pubitemid 41170598)
3. Australian Institute of Health and Welfare (AIHW). (2003) The Active Australia Survey: A Guide and Manual for Implementation, Analysis and Reporting. AIHW, Canberra, Australia.
4. Bösel J, John M, Freichel M, Blind E,. (2003) Signaling of the human calcium-sensing receptor expressed in HEK293-cells is modulated by protein kinases A and C. Exp Clin Endocrinol Diabetes 111: 21-26. (Pubitemid 36336812)
5. Coppola G, Fortunato D, Auricchio G, Mainolfi C, Operto FF, Signoriello G, Pascotto A, Salvatore M,. (2009) Bone mineral density in children, adolescents, and young adults with epilepsy. Epilepsia 50: 2140-2146.
6. Curia G, Aracri P, Sancini G, Mantegazza M, Avanzini G, Franceschetti S,. (2004) Protein-kinase C-dependent phosphorylation inhibits the effect of the antiepileptic drug topiramate on the persistent fraction of sodium currents. Neuroscience 127: 63-68. (Pubitemid 38829152)
7. Curia G, Aracri P, Colombo E, Scalmani P, Mantegazza M, Avanzini G, Franceschetti S,. (2007) Phosphorylation of sodium channels mediated by protein kinase-C modulates inhibition by topiramate of tetrodotoxin-sensitive transient sodium current. Br J Pharmacol 150: 792-797. (Pubitemid 46440214)
8. Fraser WD,. (2009) Hyperparathyroidism. Lancet 374: 145-158.
9. Gorman MP, Soul JS,. (2007) Neonatal hypocalcemic seizures in siblings exposed to topiramate in utero. Pediatr Neurol 36: 274-276. (Pubitemid 46601351)
10. Gough H, Goggin T, Bissessar A, Baker M, Crowley M, Callaghan N,. (1986) A comparative study of the relative influence of different anticonvulsant drugs, UV exposure and diet on vitamin D and calcium metabolism in out-patients with epilepsy. Q J Med 59: 569-577. (Pubitemid 16071008)
11. Hall GE, Kenny AD,. (1987) Role of carbonic anhydrase in bone resorption: effect of acetazolamide on basal and parathyroid hormone-induced bone metabolism. Calcif Tissue Int 40: 212-218. (Pubitemid 18005033)
12. Hoikka V, Alhava EM, Karjalainen P, Keranen T, Savolainen KE, Riekkinen P, Korhonen R,. (1984) Carbamazepine and bone mineral metabolism. Acta Neurol Scand 70: 77-80. (Pubitemid 14065226)
13. Kim SH, Lee JW, Choi KG, Chung HW, Lee HW,. (2007) A 6-month longitudinal study of bone mineral density with antiepileptic drug monotherapy. Epilepsy Behav 10: 291-295. (Pubitemid 46432218)
14. Kubota F, Kifune A, Shibata N, Akata T, Takeuchi K, Takahashi S, Ohsawa M, Takama F,. (1999) Bone mineral density of epileptic patients on long-term antiepileptic drug therapy: a quantitative digital radiography study. Epilepsy Res 33: 93-97. (Pubitemid 29143347)
15. Lamberg-Allardt C, Wilska M, Saraste KL, Gronlund T,. (1990) Vitamin D status of ambulatory and nonambulatory mentally retarded children with and without carbamazepine treatment. Ann Nutr Metab 34: 216-220. (Pubitemid 20242391)
16. Lehenkari P, Hentunen TA, Laitala-Leinonen T, Tuukkanen J, Väänänen HK,. (1998) Carbonic anhydrase II plays a major role in osteoclast differentiation and bone resorption by effecting the steady state intracellular pH and Ca2+. Exp Cell Res 242: 128-137. (Pubitemid 28366528)
17. Lineberry MD, Waite LC,. (1979) Acidosis inhibits the hypocalcemic effect of acetazolamide. J Pharmacol Exp Ther 211: 452-455. (Pubitemid 10128312)
18. Minkin C, Jennings JM,. (1972) Carbonic anhydrase and bone remodeling: sulfonamide inhibition of bone resorption in organ culture. Science 176: 1031-1033.
19. Mintzer S, Boppana P, Toguri J, DeSantis A,. (2006) Vitamin D levels and bone turnover in epilepsy patients taking carbamazepine or oxcarbazepine. Epilepsia 47: 510-515. (Pubitemid 43351553)
20. Mirza N, Marson AG, Pirmohamed M,. (2009) Effect of topiramate on acid-base balance: extent, mechanism and effects. Br J Clin Pharmacol 68: 655-661.
21. Pack AM, Morrell MJ,. (2004) Epilepsy and bone health in adults. Epilepsy Behav 5 (Suppl. 2): S24-S29. (Pubitemid 38404510)
22. Pack AM, Morrell MJ, Marcus R, Holloway L, Flaster E, Doňe S, Randall A, Seale C, Shane E,. (2005) Bone mass and turnover in women with epilepsy on antiepileptic drug monotherapy. Ann Neurol 57: 252-257. (Pubitemid 40179863)
23. Pack AM, Morrell MJ, Randall A, McMahon DJ, Shane E,. (2008) Bone health in young women with epilepsy after one year of antiepileptic drug monotherapy. Neurology 70: 1586-1593. (Pubitemid 351620313)
24. Pierce WM Jr, Nardin GF, Fuqua MF, Sabah-Maren E, Stern SH,. (1991) Effect of chronic carbonic anhydrase inhibitor therapy on bone and mineral density in white women. J Bone Miner Res 6: 347-354.
25. Ramsay ER, Leung AT,. (2006) Effect of topiramate on bone resorption in adults. Epilepsia 47 (Suppl. 4): S171. Abstract.
26. Sato Y, Kondo I, Ishida S, Motooka H, Takayama K, Tomita Y, Maeda H, Satoh K,. (2001) Decreased bone mass and increased bone turnover with valproate therapy in adults with epilepsy. Neurology 57: 445-449. (Pubitemid 32757591)
27. Shank RP, Gardocki JF, Streeter AJ, Maryanoff BE,. (2000) An overview of the preclinical aspects of topiramate: pharmacology, pharmacokinetics, and mechanism of action. Epilepsia 41 (Suppl. 1): S3-S9.
28. Sheth RD, Hermann BP,. (2007) Bone mineral density with lamotrigine monotherapy for epilepsy. Pediatr Neurol 37: 250-254. (Pubitemid 47446154)
29. Sheth RD, Wesolowski CA, Jacob JC, Penney S, Hobbs GR, Riggs JE, Bodensteiner JB,. (1995) Effect of carbamazepine and valproate on bone mineral density. J Pediatr 127: 256-262.
30. Shim JS, Oh KW, Suh I, Kim MY, Shon CY, Lee EJ, Nam CM,. (2002) A study on validity of a semi-quantitative food frequency questionnaire for Korean adults. Korean J Community Nutr 7: 484-494, Article in Korean.
31. Tjellesen L, Christiansen C,. (1982) Serum vitamin D metabolites in epileptic patients treated with 2 different anti-convulsants. Acta Neurol Scand 66: 335-341. (Pubitemid 12061608)
32. Verrotti A, Greco R, Morgese G, Chiarelli F,. (2000) Increased bone turnover in epileptic patients treated with carbamazepine. Ann Neurol 47: 385-388. (Pubitemid 30141852)
33. Verrotti A, Greco R, Latini G, Morgese G, Chiarelli Fl,. (2002) Increased bone turnover in prepubertal, pubertal, and postpubertal patients receiving carbamazepine. Epilepsia 43: 1488-1492. (Pubitemid 35429765)
34. Verrotti A, Coppola G, Parisi P, Mohn A, Chiarelli F,. (2010) Bone and calcium metabolism and antiepileptic drugs. Clin Neurol Neurosurg 112: 1-10.
35. Vestergaard P, Rejnmark L, Mosekilde L,. (2004) Fracture risk associated with use of antiepileptic drugs. Epilepsia 45: 1330-1337. (Pubitemid 39470036)
36. Waite LC, Volkert WA, Kenny AD,. (1970) Inhibition of bone resorption by acetazolamide in the rat. Endocrinology 87: 1129-1139.
37. Weinstein RS, Bryce GF, Sappington LJ, King DW, Gallagher BB,. (1984) Decreased serum ionized calcium and normal vitamin D metabolite levels with anticonvulsant drug treatment. J Clin Endocrinol Metab 58: 1003-1009. (Pubitemid 14084009)