Bone mineral density of epileptic patients on long-term antiepileptic drug therapy: A quantitative digital radiography study

Epilepsy Research

Volumn 33, Issue 2-3, 1999, Pages 93-97

  Kubota, Fumio ^a   Kifune, Akira ^a   Shibata, Nobuyoshi ^a   Akata, Takusirou ^a   Takeuchi, Kazuo ^b   Takahashi, Shigeru ^c   Ohsawa, Minoru ^a   Takama, Fumiko ^a  

^a GUNMA UNIVERSITY   (Japan)

^b GUNMA PREFECTURAL COLLEGE OF HEALTH SCIENCES   (Japan)

^c Gunma Pref Mental Health Center   (Japan)

Author keywords

Antiepileptic drug; Bone mineral density; Epileptic patients; Quantitative digital radiography (QDR)

Indexed keywords

ACETAZOLAMIDE; ANTICONVULSIVE AGENT; BARBITURIC ACID DERIVATIVE; CARBAMAZEPINE; CLONAZEPAM; PHENOBARBITAL; PHENYTOIN; VALPROIC ACID;

ADULT; ARTICLE; BONE ATROPHY; BONE DENSITY; BONE MINERAL; CLINICAL ARTICLE; CONTROLLED STUDY; DIGITAL RADIOGRAPHY; DRUG INDUCED DISEASE; EPILEPSY; FEMALE; FEMUR NECK; HUMAN; LONG TERM CARE; LUMBAR SPINE; MALE; PRIORITY JOURNAL;

ACETAZOLAMIDE; ADULT; ANTICONVULSANTS; BARBITURATES; BONE DENSITY; DENSITOMETRY, X-RAY; EPILEPSY; FEMALE; HUMANS; MALE; MIDDLE AGED; PHENYTOIN; RADIOGRAPHIC IMAGE ENHANCEMENT; REFERENCE VALUES; TIME FACTORS;

EID: 0033002623     PISSN: 09201211     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0920-1211(98)00077-1     Document Type: Article

References (18)

1. Christiansen C., Rodbro P., Lund M. Incidence of anticonvulsant osteomalacia and effect of vitamin D: Controlled therapeutic trial. Br. Med. J. 22:1973;695-701.
2. Gotfredsen A., Borg J., Nilas L., Tjellesen L., Christiansen C. Representativity of regional to total bone mineral in hearty subjects and anticonvulsive treated epileptic patients. Measurements by single and dual photon absorptiometry. Eur. J. Clin. Invest. 16:1986;198-203.
3. Hahn T.J., Hendin B.A., Scharp C.R., Scharp C.R., Haddad J.G. Effect of chronic anticonvulsant therapy on serum 25-hydroxycholecalciferol levels in adults. New Engl. J. Med. 289:1972;900-904.
4. Hepner G.W., Hofmann A.F. Inhibition of intesinal ATPase by diphenylhydantoin and acetazolamide. Clin. Res. 18:1970;382-389.
5. Huntera J., Maxell J.D., Stewart D.A., Parrsons V., Williams R. Aitered calcium metabolism in epileptic children on anticonvulsants. Br. Med. J. 4:1971;202-204.
6. Iwata Y., Amano K., Kawamura H., Tanikawa T., Kawabata H., Notani M., Iseki H., Shiwaku T., Nagano T., Taira T., Kubo O., Kitamura K. Evalualion of anticonvulsant-induced bone chage by microdensitometric method. Noushinkei Geka. 13:1985;293-299.
7. Jubiz W., Haussler M.R., McCain T.A., Tolman K.G. Plasma 1,25-hydroxyvitamin D levels in patients receiving anticonvulsant drugs. J. Clin. Endocrinol. Metab. 44:1977;617-621.
8. Kelly T.L., Slovik D.M., Schenfeld D.A., Neer R.M. Quantitative digital radiography versus dual photon absorptiometry of the lumbar spine. J. Clin. Endocrinol. Metab. 67:1988;839-844.
9. Kugyou T., Yamamoto M., Hosokawa K. Osteopathy associated with antiepilptic drug therapy - A study by microdensitometric method. Rinshou Seishin Igaku. 12:1983;333-339.
10. Kushida K., Inoue T., Sumi Y., Denda M., Yamazaki K., Ohya K., Okamoto S., Hujiwara T., Kinn K., Taniguti K., Ohishi T. Osteoporosis - bone mineral measurement using DEXA. Nippon Rinshou. 12:1990;2845-2850.
11. Livingstone A. Antiepileptic drug and development of rickets. J. Pediatr. 82:1973;347-352.
12. Nakamura T., Kamogawa M., Yoshikawa S., Okano I. Anticonvulsant osteomalacia. Kotutaisya. 12:1980;228-237.
13. Renri F., Ueda S., Anraku T., Ishida S., Satoh H., Tsujimaru S., Ueda J. Antiepileptics and bone atrophy - a 3-year follow-up study. Jpn. J. Psychiat. Neurol. 44:1990;385-386.
14. Schmid F. Osteopathien bei antiepileptischer Dauerbehandlung. Fortschr. Med. 85:1967;381-382.
15. Takeno Y. Evaluation of bone atrophy by microdensitometory and effects of active vitamin D3 (1 α-OH-D3). Nou to Shinkei. 41:1989;887-893.
16. Suzuki T., Tanaka K., Miyauchi T., Miyauchi T., Hagimoto H., Saito T., Yamaguchi T., Yamamoto Y. Osteo-metabolic abnormality in epileptic patients taking antiepileptic drugs. Seishin Igaku. 33:1991;601-608.
17. Tjellesen L., Gotfredsen A., Borg J., Christiansen C. Relationship between local and total body bone mineral in epileptic patients and normal subjects. Clin. Physiol. 3:1983;359-364.
18. Uechi H., Ogura C., Katsuyama N., Norimatsu T. Bone mineral density in epileptic patients receiving antiepileptic drugs - measurement by dual photon absorptiometry. Seishin Shinkeigaku Zashi. 94:1992;487-501.