Rho kinase-related proteins in human vaginal arteries: An immunohistochemical and functional study

Journal of Sexual Medicine

Volumn 8, Issue 10, 2011, Pages 2739-2745

  Ückert, Stefan ^a   Waldkirch, Eginhard S ^a   Kauffels, Wolfgang ^b   Kuczyk, Markus A ^a   Hedlund, Petter ^c,d  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b Klinikum Hildesheim GmbH   (Germany)

^c LUND UNIVERSITY HOSPITAL   (Sweden)

^d SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

Human vaginal arteries; Immunohistochemistry; Rho kinases; Rho related proteins; Tissue bath studies; Vaginal blood flow

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; ALPHA ACTIN; ALPHA ADRENERGIC RECEPTOR; PHENYLEPHRINE; PROTEIN RHOGDI; RHO KINASE; RHO KINASE 1; RHO KINASE 2; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG;

ADULT; ARTERIOLE; ARTERY; ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; ISOLATED ARTERY; POSTMENOPAUSE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SMOOTH MUSCLE; VAGINA; VAGINAL ARTERY; VASCULAR TISSUE;

EID: 80053564380     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/j.1743-6109.2011.02390.x     Document Type: Article

References (22)

1. Traish AM, Kim NN, Munarriz R, Moreland R, Goldstein I. Biochemical and physiological mechanisms of female genital sexual arousal. Arch Sex Behav 2002;31:393-400.
2. Traish AM, Botchevar E, Kim NN. Biochemical factors modulating female genital sexual arousal physiology. J Sex Med 2010;7:2925-46.
3. Kim SW, Jeong SJ, Munarriz R, Kim NN, Goldstein I, Traish AM. Role of the nitric oxide-cyclic GMP pathway in regulation of vaginal blood flow. Int J Impot Res 2003;15:355-61.
4. Andersson KE, Wagner G. Pharmacology of penile erection. Pharmacol Rev 2001;53:17-50.
5. Pfaus JG. Pathways of sexual desire. J Sex Med 2009;6:1506-33.
6. Kureishi Y, Kobayashi S, Amano M, Kimura K, Kanaide H, Nakano T, Kaibuchi K, Ito M. Rho-associated kinase directly induces smooth muscle contraction through myosin light chain phosphorylation. J Biol Chem 1997;272:12257-60.
7. Wettschurek N, Offermanns S. Rho/Rho-kinase mediated signaling in physiology and pathophysiology. J Mol Med 2002;80:629-38.
8. Chitaley K, Webb R, Mills TM. Rho A/Rho-kinase: A novel player in the regulation of penile erection. Int J Impot Res 2001;13:67-72.
9. Rees RW, Foxwell NA, Ralph DJ, Kell PD, Moncada S, Cellek S. Y-27632, a Rho-kinase inhibitor, inhibits proliferation and adrenergic contraction of prostatic smooth muscle cells. J Urol 2003;170:2517-22.
10. 2+ sensitization in the contraction of human prostate. Neurourol Urodyn 2007;26:547-51.
11. 2+ sensitization in contraction of human bladder smooth muscle. J Urol 2004;172:748-52.
12. Park JK, Lee SO, Kim YG, Kim SH, Koh GY, Cho KW. Role of Rho-kinase activity in angiotensin II-induced contraction of rabbit clitoral cavernosum smooth muscle. Int J Impot Res 2002;14:472-7.
13. Cellek S. The Rho-kinase inhibitor Y-27632 and the soluble guanylyl cyclase activator BAY41-2272 relax rabbit vaginal wall and clitoral corpus cavernosum. Br J Pharmacol 2003;138:287-90.
14. Allahdadi KJ, Hannan JL, Tostes RC, Webb RC. Endothelin-1 induces contraction of female rat internal pudendal and clitoral arteries through ET(A) receptor and Rho-kinase activation. J Sex Med 2010;7:2096-103.
15. Data on file. Available at: (accessed April 2011).
16. Christ GJ, Andersson KE. Rho-kinase and effects of Rho-kinase inhibition on the lower urinary tract. Neurourol Urodyn 2007;26(6 suppl):948-54.
17. Park K, Kim SW, Rhu KS, Paick JS. Chronic administration of an oral Rho kinase inhibitor prevents the development of vasculogenic erectile dysfunction in a rat model. J Sex Med 2006;3:996-1003.
18. Lau DH, Kommu S, Mumtaz FH, Morgan RJ, Thompson CS, Mikhailidis DP. The management of phosphodiesterase 5 (PDE5) inhibitor failure. Curr Vasc Pharmacol 2006;4:89-93.
19. Rees RW, Ziessen T, Ralph DJ, Kell P, Moncada S, Cellek S. Human and rabbit cavernosal smooth muscle cells express Rho-kinase. Int J Impot Res 2002;14:1-7.
20. Lartey J, Gampel A, Pawade J, Mellor H, Bernal AL. Expression of RND proteins in human myometrium. Biol Reprod 2006;75:452-61.
21. Ark M, Yilmaz N, Yazici G, Kubat H, Aktaş S. Rho-associated protein kinase II (Rock II) expression in normal and preeclamptic human placentas. Placenta 2005;26:81-4.
22. Cheng C, Webber CA, Wang J, Xu Y, Martinez JA, Liu WQ, McDonald D, Guo GF, Nguyen MD, Zochodne DW. Activated RhoA and peripheral axon regeneration. Exp Neurol 2008;212:358-69.