Evaluation of testicular toxicology of doxorubicin based on microarray analysis of testicular specific gene expression

Journal of Toxicological Sciences

Volumn 36, Issue 5, 2011, Pages 559-567

  Takahashi, Hikari ^a   Tainaka, Hitoshi ^a   Umezawa, Masakazu ^a   Takeda, Ken ^a   Tanaka, Hiromitsu ^b   Nishimune, Yoshitake ^c   Oshio, Shigeru ^d  

^a TOKYO UNIVERSITY OF SCIENCE   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c OSAKA UNIVERSITY   (Japan)

^d OHU UNIVERSITY   (Japan)

Author keywords

Medical subject headings; Microarray; Sertoli cell; Spermatogenesis; Testis; Toxicity

Indexed keywords

COMPLEMENTARY DNA; DOXORUBICIN; TESTOSTERONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DNA MICROARRAY; GENE EXPRESSION; GERM CELL; MALE; MALE INFERTILITY; MESH HEADING; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; ORGAN WEIGHT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEMINIFEROUS TUBULE; SERTOLI CELL; SPERMATOGENESIS; SPERMATOZOON COUNT; SPERMATOZOON MOTILITY; TESTIS FUNCTION; TESTOSTERONE BLOOD LEVEL;

MUS;

EID: 80053540685     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.36.559     Document Type: Article

References (37)

1. Ateşşahin, A., Turk, G., Karahan, I., Yilmaz, S., Ceribaşi, A.O. and Bulmuş, O. (2006): Lycopene prevents adriamycin-induced testicular toxicity in rats. Fertil. Steril., 85, Suppl. 1, 1216-1222.
2. Bao, S., Miller, D.J., Ma, Z., Wohltmann, M., Eng, G., Ramanadham, S., Moley, K. and Turk, J. (2004): Male mice that do not express group VIA phospholipase A2 produce spermatozoa with impaired motility and have greatly reduced fertility. J. Biol. Chem., 279, 38194-38200.
3. Casanova, M.B., Lustig, L., Diaz, E.S., Pellizzari, E.H., Cigorraga, B. and Denduchis, B. (2006): Expression of caveolin-1 in rat Leydig cells. Biocell, 30, 431-438.
4. Gye, M.C., Choi, J.K., Ahn, H.S. and Kim, Y.S. (2004): Expression of p50 C-terminal Src kinase (Csk) in mouse testis. Arch. Androl., 50, 287-293.
5. Hou, M., Chrysis, D., Nurmio, M., Parvinen, M., Eksborg, S., Soder, O. and Jahnukainen, K. (2005): Doxorubicin induces apoptosis in germ line stem cells in the immature rat testis and amifostine cannot protect against this cytotoxicity. Cancer Res., 65, 9999-10005.
6. Imahie, H., Adachi, T., Nakagawa, Y., Nagasaki, T., Yamamura, T. and Hori, M. (1995): Effects of adriamycin, an anticancer drug showing testicular toxicity, on fertility in male rats. J. Toxicol. Sci., 20, 183-193.
7. Kato, M., Makino, S., Kimura, H., Ota, T., Furuhashi, T. and Nagamura, Y. (2001): Sperm motion analysis in rats treated with adriamycin and its applicability to male reproductive toxicity studies. J. Toxicol. Sci., 26, 51-59.
8. Lee, N.P. and Cheng, C.Y. (2005): Protein kinases and adherens junction dynamics in the seminiferous epithelium of the rat testis. J. Cell. Physiol., 202, 344-360.
9. Lizama, C., Alfaro, I., Reyes, J.G. and Moreno, R.D. (2007): Upregulation of CD95 (Apo-1/Fas) is associated with spermatocyte apoptosis during the first round of spermatogenesis in the rat. Apoptosis, 12, 499-512.
10. Lu, Q., Gore, M., Zhang, Q., Camenisch, T., Boast, S., Casagranda, F., Lai, C., Skinner, M.K., Klein, R., Matsushima, G.K., Earp, H.S., Goff, S.P. and Lemke, G. (1999): Tyro-3 family receptors are essential regulators of mammalian spermatogenesis. Nature, 398, 723-728.
11. Meistrich, M.L. (1982) Quantitative correlation between testicular stem cell survival, sperm production, and fertility in the mouse after treatment with different cytotoxic agents. J. Androl., 3, 58-68.
12. Meroni, S.B., Riera, M.F., Pellizzari, E.H., Schteingart, H.F. and Cigorraga, S.B. (2003): Possible role of arachidonic acid in the regulation of lactate production in rat Sertoli cells. Int. J. Androl., 26, 310-317.
13. Masys, D.R., Welsh, J.B., Lynn Fink, J., Gribskov, M., Klacansky, I. and Corbeil, J. (2001): Use of keyword hierarchies to interpret gene expression patterns. Bioinformatics, 17, 319-326.
14. Matsui, H. and Takahashi, M. (1999): A novel quantitative morphometry of germ cells for the histopathological evaluation of rat testicular toxicity. J. Toxicol. Sci., 24, 17-25.
15. Musa, F.R., Tokuda, M., Kuwata, Y., Ogawa, T., Tomizawa, K., Konishi, R., Takenaka, I. and Hatase, O. (1998): Expression of cyclin-dependent kinase 5 and associated cyclins in Leydig and Sertoli cells of the testis. J. Androl., 19, 657-666.
16. Nakazato, T., Takinaka, T., Mizuguchi, H., Matsuda, H., Bono, H. and Asogawa, M. (2007): BioCompass: a novel functional inference tool that utilizes MeSH hierarchy to analyze group of genes. In Silico Biol, 8, 53-61.
17. Nambu, A. and Kumamoto, Y. (1995): Effect of follicle-stimulating hormone (FSH) on protection or acceleration to recovery from spermatogenic damage induced by anti-cancer agents. Nippon Hinyokika Gakkai Zasshi, 86,1231-1239.
18. Nambu, A., Kumamoto, Y. and Mikuma, N. (1995): Effects of anticancer agents on cultured rat Sertoli cells. Nippon Hinyokika Gakkai Zasshi, 86, 1132-1136.
19. Nishikawa, S., Yamashita, T., Imai, T., Yoshida, M., Sakuratani, Y., Yamada, J., Maekawa, A., Hayashi, M. (2010): Thesaurus for histopathological findings in publically available reports of repeated-dose oral toxicity studies in rats for 156 chemicals. J. Toxicol. Sci., 35, E1-E8.
20. Ono, N., Oshio, S., Niwata, Y., Yoshida, S., Tsukue, N., Sugawara, I., Takano, H. and Takeda, K. (2008): Detrimental effects of prenatal exposure to filtered diesel exhaust on mouse spermatogenesis. Arch. Toxicol., 82, 851-859.
21. Ono, N., Oshio, S., Niwata, Y., Yoshida, S., Tsukue, N., Sugawara, I., Takano, H. and Takeda, K. (2007): Prenatal exposure to diesel exhaust impairs mouse spermatogenesis. Inhal. Toxicol., 19, 275-281.
22. Oshio, S., Ozaki, I., Tajima, T., Kaneko, S. and Mohri, H. (1987): Damaging effects of adriamycin on mouse spermatozoa. Adv. Contra. Delv. Sys., 3, 215-224.
23. Oshio, S., Ozaki, S., Ohkawa, I., Tajima, T., Kaneko, S. and Mohri, H. (1989): Mecobalamin promotes mouse sperm maturation. Andrologia, 21, 167-173.
24. Oshio, S., Tomomasa, H., Amemiya, H., Yazaki, T., Mohri, H., Umeda, T. and Waku, M. (1990): Damaging effects of cisplatin on mouse spermatozoa. Arch. Androl., 24, 113-120.
25. Peters, A.H., O'Carroll, D., Scherthan, H., Mechtler, K., Sauer, S., Schofer, C., Weipoltshammer, K., Pagani, M., Lachner, M., Kohlmaier, A., Opravil, S., Doyle, M., Sibilia, M. and Jenuwein, T. (2001): Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability. Cell, 107, 323-337.
26. Prahalathan, C., Selvakumar, E. and Varalakshmi, P. (2005): Protective effect of lipoic acid on adriamycin-induced testicular toxicity. Clin. Chim. Acta, 360, 160-166.
27. Session, D.R., Fautsch, M.P., Avula, R., Jones, W.R., Nehra, A. and Wieben, E.D. (2001): Cyclin-dependent kinase 5 is expressed in both Sertoli cells and metaphase spermatocytes. Fertil. Steril., 75, 669-673.
28. Sharpe, R.M., McKinnell, C., Kivlin, C. and Fisher, J.S. (2003): Proliferation and functional maturation of Sertoli cells, and their relevance to disorders of testis function in adulthood. Reproduction, 125, 769-784.
29. Shimizu, M., Tainaka, H., Oba, T., Mizuo, K., Umezawa, M. and Takeda, K. (2009): Maternal exposure to nanoparticulate titanium dioxide during the prenatal period alters gene expression related to brain development in the mouse. Part. Fibre Toxicol., 6, 20.
30. Shinoda, K., Mitsumori, K., Yasuhara, K., Uneyama, C., Onodera, H., Hirose, M. and Uehara, M. (1999): Doxorubicin induces male germ cell apoptosis in rats. Arch. Toxicol., 73, 274-281.
31. Travis, A.J., Merdiushev, T., Vargas, L.A., Jones, B.H., Purdon, M.A., Nipper, R.W., Galatioto, J., Moss, S.B., Hunnicutt, G.R. and Kopf, G.S. (2001): Expression and localization of caveolin- 1, and the presence of membrane rafts, in mouse and Guinea pig spermatozoa. Dev. Biol., 240, 599-610.
32. Ulisse, S., Cinque, B., Silvano, G., Rucci, N., Biordi, L., Cifone, M.G., D'Armiento, M. (2000): Erk-dependent cytosolic phospholipase A2 activity is induced by CD95 ligand cross-linking in the mouse derived Sertoli cell line TM4 and is required to trigger apoptosis in CD95 bearing cells. Cell Death Differ., 7, 916-924.
33. Umezawa, M., Tanaka, N., Tainaka, H., Takeda, K., Ihara, T. and Sugamata, M. (2009): Microarray analysis provides insight into the early steps of pathophysiology of mouse endometriosis model induced by autotransplantation of endometrium. Life Sci., 84, 832-837.
34. Valdivia, A., Irazusta, J., Fernandez, D., Mugica, J., Ochoa, C. and Casis, L. (2004): Pyroglutamyl peptidase I and prolyl endopeptidase in human semen: increased activity in necrozoospermia. Regul. Pept., 122, 79-84.
35. Wang, H., Chen, Y., Ge, Y., Ma, P., Ma, Q., Ma, J., Wang, H., Xue, S. and Han, D. (2005): Immunoexpression of Tyro 3 family receptors--Tyro 3, Axl, and Mer--and their ligand Gas6 in postnatal developing mouse testis. J. Histochem. Cytochem., 53, 1355-1364.
36. Whorton, D., Krauss, R.M., Marshall, S. and Milby, T.H. (1977): Infertility in male pesticide workers. Lancet, 2, 1259-1261.
37. Wine, R.N. and Chapin, R.E. (1999): Adhesion and signaling proteins spatiotemporally associated with spermiation in the rat. J. Androl., 20, 198-213.