A time course study on prothrombotic parameters and their modulation by anti-platelet drugs in hyperlipidemic hamsters

Journal of Physiology and Biochemistry

Volumn 67, Issue 2, 2011, Pages 205-216

  Singh, Vishal ^a   Jain, Manish ^a   Prakash, Prem ^a   Misra, Ankita ^a   Khanna, Vivek ^a   Tiwari, Rajiv Lochan ^a   Keshari, Ravi Shankar ^a   Singh, Shivendra ^a   Dikshit, Madhu ^a   Barthwal, Manoj Kumar ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

Aspirin; Clopidogrel; Hamsters; Hyperlipidemia; Inflammation; Platelet

Indexed keywords

ACETYLSALICYLIC ACID; ADENOSINE DIPHOSPHATE; CHOLESTEROL; CLOPIDOGREL; COLLAGEN; FERRIC CHLORIDE; FIBRINOGEN; GAMMA INTERFERON; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INDUCIBLE NITRIC OXIDE SYNTHASE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MESSENGER RNA; THROMBIN; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD CLOTTING; BLOOD CLOTTING PARAMETERS; BODY WEIGHT; CHOLESTEROL DIET; CONTROLLED STUDY; DRUG MECHANISM; ENDOTHELIAL DYSFUNCTION; FIBRINOGEN TIME; GLUCOSE BLOOD LEVEL; HAMSTER; HYPERLIPIDEMIA; INFLAMMATION; LIPID BLOOD LEVEL; MALE; NONHUMAN; PARTIAL THROMBOPLASTIN TIME; PROTEIN EXPRESSION; PROTHROMBIN TIME; SPLEEN CELL; THROMBIN TIME; THROMBOCYTE; THROMBOCYTE ACTIVATION; THROMBOCYTE ADHESION; THROMBOCYTE AGGREGATION; THROMBOSIS; ANIMAL; CHEMICALLY INDUCED DISORDER; DOSE RESPONSE; DRUG EFFECT; ENDOTHELIUM CELL; GENETICS; METABOLISM; THROMBOCYTE ADHESIVENESS; THROMBOCYTE COUNT; TIME;

CRICETINAE; MESOCRICETUS AURATUS;

ANIMALS; BLOOD COAGULATION; BLOOD PLATELETS; CRICETINAE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL CELLS; HYPERLIPIDEMIAS; MALE; PLATELET ACTIVATION; PLATELET ADHESIVENESS; PLATELET COUNT; THROMBOSIS; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 80053539550     PISSN: 11387548     EISSN: 18778755     Source Type: Journal    
DOI: 10.1007/s13105-010-0065-z     Document Type: Article

References (44)

1. Alexaki A, Wilson TA, Atallah MT, Handelman G, Nicolosi RJ (2004) Hamsters fed diets high in saturated fat have increased cholesterol accumulation and cytokine production in the aortic arch compared with cholesterol-fed hamsters with moderately elevated plasma non-HDL cholesterol concentrations. J Nutr 134:410-415 (Pubitemid 38141825)
2. Angel K, Provan SA, Gulseth HL, Mowinckel P, Kvien TK, Atar D (2010) Tumor necrosis factor-alpha antagonists improve aortic stiffness in patients with inflammatory arthropathies: a controlled study. Hypertension 55:333-338
3. Aoki R, Ikarugi H, Naemura A, Ijiri Y, Yamashita T, Yamamoto J (2006) Endothelial dysfunction precedes atherosclerotic lesions and platelet activation in high fat diet-induced prothrombotic state. Thromb Res 117:529-535 (Pubitemid 43326138)
4. Arakawa M, Mita T, Azuma K, Ebato C, Goto H, Nomiyama T, Fujitani Y, Hirose T, Kawamori R, Watada H (2010) Inhibition of monocyte adhesion to endothelial cells and attenuation of atherosclerotic lesion by a glucagon-like peptide-1 receptor agonist, exendin-4. Diabetes 59:1030-1037
5. Bartus M, Lomnicka M, Lorkowska B, Franczyk M, Kostogrys RB, Pisulewski PM, Chlopicki S (2005) Hyper-triglyceridemia but not hypercholesterolemia induces en-dothelial dysfunction in the rat. Pharmacol Rep 57 Suppl:127-137
6. Basu R, Bhaumik S, Basu JM, Naskar K, De T, Roy S (2005) Kinetoplastid membrane protein-11 DNA vaccina tion induces complete protection against both pentavalent antimonial-sensitive and-resistant strains of Leishmania donovani that correlates with inducible nitric oxide synthase activity and IL-4 generation: evidence for mixed Th1-and Th2-like responses in visceral leishmaniasis. J Immunol 174:7160-7171 (Pubitemid 40705683)
7. Bekker LG, Freeman S, Murray PJ, Ryffel B, Kaplan G (2001) TNF-alpha controls intracellular mycobacterial growth by both inducible nitric oxide synthase-dependent and inducible nitric oxide synthase-independent pathways. J Immunol 166:6728-6734 (Pubitemid 32467216)
8. Cappelli-Bigazzi M, Rubattu S, Battaglia C, Russo R, Enea I, Ambrosio G, Chiariello M, Volpe M (1997) Effects of high-cholesterol and atherogenic diets on vascular relaxation in spontaneously hypertensive rats. Am J Physiol 273:H647-H654
9. Davignon J, Ganz P (2004) Role of endothelial dysfunction in atherosclerosis. Circulation 109:III27-III32 (Pubitemid 38786440)
10. Felmeden D, Nadar SK, Lip GY (2005) Aspirin and endothelial function in hypertension. J Hum Hypertens 19:663-665 (Pubitemid 43118087)
11. Ferroni P, Basili S, Davi G (2003) Platelet activation, inflammatory mediators and hypercholesterolemia. Curr Vasc Pharmacol 1:157-169
12. Glass CK, Witztum JL (2001) Atherosclerosis. The road ahead. Cell 104:503-516
13. Gurbel PA, Bliden KP, Tantry US (2006) Effect of clopidogrel with and without eptifibatide on tumor necrosis factor-alpha and C-reactive protein release after elective stenting: results from the CLEAR PLATELETS 1b study. J Am Coll Cardiol 48:2186-2191 (Pubitemid 44855418)
14. Heitzer T, Rudolph V, Schwedhelm E, Karstens M, Sydow K, Ortak M, Tschentscher P, Meinertz T, Boger R, Baldus S (2006) Clopidogrel improves systemic endothelial nitric oxide bioavailability in patients with coronary artery disease: evidence for antioxidant and antiinflammatory effects. Arterioscler Thromb Vasc Biol 26:1648-1652 (Pubitemid 44288996)
15. Hundal RS, Petersen KF, Mayerson AB, Randhawa PS, Inzucchi S, Shoelson SE, Shulman GI (2002) Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes. J Clin Invest 109:1321-1326 (Pubitemid 34546896)
16. Ikenoya M, Yoshinaka Y, Kobayashi H, Kawamine K, Shibuya K, Sato F, Sawanobori K, Watanabe T, Miyazaki A (2007) A selective ACAT-1 inhibitor, K-604, suppresses fatty streak lesions in fat-fed hamsters without affecting plasma cholesterol levels. Atherosclerosis 191:290-297 (Pubitemid 46400712)
17. Ivandic BT, Schlick P, Staritz P, Kurz K, Katus HA, Giannitsis E (2006) Determination of clopidogrel resistance by whole blood platelet aggregometry and inhibitors of the P2Y12 receptor. Clin Chem 52:383-388
18. Joussen AM, Poulaki V, Mitsiades N, Kirchhof B, Koizumi K, Dohmen S, Adamis AP (2002) Nonsteroidal anti-inflammatory drugs prevent early diabetic retinopathy via TNF-alpha suppression. FASEB J 16:438-440
19. Kouraklis G, Patapis P, Misiakos E, Glinavou A, Sioka C, Karayiannakos PE (2004) Effects of acetylsalicylic acid on experimental atherogenesis induced in rabbits. Int Angiol 23:139-143 (Pubitemid 39419775)
20. Lazar HL, Joseph L, San Mateo C, Frame J, Cabral HJ, McDonnell M, Chipkin S (2010) Expression of inducible nitric oxide synthase in conduits used in patients with diabetes mellitus undergoing coronary revascularization. J Card Surg 25:120-126
21. Mangiapane EH, McAteer MA, Benson GM, White DA, Salter AM (1999) Modulation of the regression of atherosclerosis in the hamster by dietary lipids: comparison of coconut oil and olive oil. Br J Nutr 82:401-409 (Pubitemid 29531270)
22. Mito N, Yoshino H, Hosoda T, Sato K (2004) Analysis of the effect of leptin on immune function in vivo using diet-induced obese mice. J Endocrinol 180:167-173 (Pubitemid 38180768)
23. Monroe DM, Hoffman M, Roberts HR (2002) Platelets and thrombin generation. Arterioscler Thromb Vasc Biol 22:1381-1389
24. Nakamura T, Jamieson GA, Okuma M, Kambayashi J, Tandon NN (1998) Platelet adhesion to native type I collagen fibrils. Role of GPVI in divalent cation-dependent and-independent adhesion and thromboxane A2 generation. J Biol Chem 273:4338-4344 (Pubitemid 28103168)
25. Onley DJ, Knight CG, Tuckwell DS, Barnes MJ, Farndale RW (2000) Micromolar Ca2+ concentrations are essential for Mg2+-dependent binding of collagen by the integrin alpha 2beta 1 in human platelets. J Biol Chem 275:24560-24564 (Pubitemid 30626552)
26. Picchi A, Gao X, Belmadani S, Potter BJ, Focardi M, Chilian WM, Zhang C (2006) Tumor necrosis factor-alpha induces endothelial dysfunction in the prediabetic metabolic syndrome. Circ Res 99:69-77 (Pubitemid 44297057)
27. Prociuk MA, Edel AL, Richard MN, Gavel NT, Ander BP, Dupasquier CM, Pierce GN (2008) Cholesterol-induced stimulation of platelet aggregation is prevented by a hempseed-enriched diet. Can J Physiol Pharmacol 86:153-159 (Pubitemid 351536445)
28. Raymond C, Menon V (2009) Dual antiplatelet therapy in coronary artery disease: a case-based approach. Cleve Clin J Med 76:663-670
29. Remijn JA, Wu YP, Jeninga EH, IJ MJ, van Willigen G, de Groot PG, Sixma JJ, Nurden AT, Nurden P (2002) Role of ADP receptor P2Y(12) in platelet adhesion and thrombus formation in flowing blood. Arterioscler Thromb Vasc Biol 22:686-691 (Pubitemid 34408754)
30. Santhanam AV, Viswanathan S, Dikshit M (2007) Activation of protein kinase B/Akt and endothelial nitric oxide synthase mediates agmatine-induced endothelium-dependent relaxation. Eur J Pharmacol 572:189-196 (Pubitemid 47429648)
31. Schafer A, Bauersachs J (2008) Endothelial dysfunction, impaired endogenous platelet inhibition and platelet activation in diabetes and atherosclerosis. Curr Vasc Pharmacol 6:52-60
32. Shenkman B, Matetzky S, Fefer P, Hod H, Einav Y, Lubetsky A, Varon D, Savion N (2008) Variable responsiveness to clopidogrel and aspirin among patients with acute coronary syndrome as assessed by platelet function tests. Thromb Res 122:336-345
33. Siegel-Axel D, Daub K, Seizer P, Lindemann S, Gawaz M (2008) Platelet lipoprotein interplay: trigger of foam cell formation and driver of atherosclerosis. Cardiovasc Res 78:8-17 (Pubitemid 351430965)
34. Singh V, Tiwari RL, Dikshit M, Barthwal MK (2009) Models to study atherosclerosis: a mechanistic insight. Curr Vasc Pharmacol 7:75-109
35. Surin WR, Prakash P, Barthwal MK, Dikshit M (2010) Optimization of ferric chloride induced thrombosis model in rats: effect of anti-platelet and anti-coagulant drugs. J Pharmacol Toxicol Methods 61:287-291
36. Tancevski I, Wehinger A, Schgoer W, Eller P, Cuzzocrea S, Foeger B, Patsch JR, Ritsch A (2006) Aspirin regulates expression and function of scavenger receptor-BI in macro-phages: studies in primary human macrophages and in mice. FASEB J 20:1328-1335 (Pubitemid 44943840)
37. Tandon NN, Kralisz U, Jamieson GA (1989) Identification of glycoprotein IV (CD36) as a primary receptor for platelet-collagen adhesion. J Biol Chem 264:7576-7583 (Pubitemid 19119175)
38. Tauseef M, Shahid M, Sharma KK, Fahim M (2008) Antioxidative action of aspirin on endothelial function in hypercholesterolaemic rats. Basic Clin Pharmacol Toxicol 103:314-321
39. Tedgui A, Mallat Z (2006) Cytokines in atherosclerosis: pathogenic and regulatory pathways. Physiol Rev 86:515-581
40. Tiwari RL, Singh V, Barthwal MK (2008) Macrophages: an elusive yet emerging therapeutic target of atherosclerosis. Med Res Rev 28:483-544 (Pubitemid 351842141)
41. Venter JC, Adams MD, Myers EW, Li PW, Mural RJ, Sutton GG, Smith HO, Yandell M, Evans CA, Holt RA et al (2001) The sequence of the human genome. Science 291:1304-1351 (Pubitemid 32173090)
42. Waksman R, Ajani AE, White RL, Pinnow E, Dieble R, Bui AB, Taaffe M, Gruberg L, Mintz GS, Satler LF et al (2001) Prolonged antiplatelet therapy to prevent late thrombosis after intracoronary gamma-radiation in patients with in-stent restenosis: Washington radiation for in-stent restenosis trial plus 6 months of clopidogrel (WRIST PLUS). Circulation 103:2332-2335 (Pubitemid 32448795)
43. Waksman R, Pakala R, Roy P, Baffour R, Hellinga D, Seabron R, Chan R, Scheinowitz M, Kolodgie F, Virmani R (2008) Effect of clopidogrel on neointimal formation and inflammation in balloon-denuded and radiated hypercho-lesterolemic rabbit iliac arteries. J Interv Cardiol 21:122-128 (Pubitemid 351490138)
44. Zhou X, Paulsson G, Stemme S, Hansson GK (1998) Hypercholesterolemia is associated with a T helper (Th) 1/Th2 switch of the autoimmune response in atherosclerotic apo E-knockout mice. J Clin Invest 101:1717-1725 (Pubitemid 28198502)