Preadipocyte factor-1 levels are higher in women with hypothalamic amenorrhea and are associated with bone mineral content and bone mineral density through a mechanism independent of leptin

Journal of Clinical Endocrinology and Metabolism

Volumn 96, Issue 10, 2011, Pages

  Aronis, Konstantinos N ^a   Kilim, Holly ^a   Chamberland, John P ^a   Breggia, Anne ^c   Rosen, Clifford ^c   Mantzoros, Christos S ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c Maine Medical Center Research Institute   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL; LEPTIN; MEMBRANE PROTEIN; METRELEPTIN; OSTEOCALCIN; PLACEBO; PREADIPOCYTE FACTOR 1; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN C; UNCLASSIFIED DRUG;

ABNORMAL SUBSTRATE CONCENTRATION IN BLOOD; ADULT; AMENORRHEA; ARTICLE; BODY COMPOSITION; BODY MASS; BONE DENSITY; BONE MINERAL; CLINICAL ARTICLE; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DISEASE ASSOCIATION; FEMALE; GENE EXPRESSION REGULATION; HUMAN; HYPOLEPTINEMIA; HYPOTHALAMIC AMENORRHEA; MALE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; TREATMENT DURATION;

ADULT; AMENORRHEA; BODY COMPOSITION; BODY MASS INDEX; BODY WEIGHT; BONE DENSITY; CROSS-SECTIONAL STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; ENERGY METABOLISM; ESTRADIOL; EXERCISE; FEMALE; HUMANS; HYPOTHALAMIC DISEASES; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3; INSULIN-LIKE GROWTH FACTOR I; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LEPTIN; MEMBRANE PROTEINS; YOUNG ADULT;

EID: 80053538899     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2011-0600     Document Type: Article

References (20)

1. Beresford JN, Bennett JH, Devlin C, Leboy PS, Owen ME 1992 Evidence for an inverse relationship between the differentiation of adipocytic and osteogenic cells in rat marrow stromal cell cultures. J Cell Sci 102(Pt 2):341-351
2. Verma S, Rajaratnam JH, Denton J, Hoyland JA, Byers RJ 2002 Adipocytic proportion of bone marrow is inversely related to bone formation in osteoporosis. J Clin Pathol 55:693-698 (Pubitemid 34970093)
3. Sul HS 2009 Pref-1: role in adipogenesis and mesenchymal cell fate. Mol Endocrinol 23:1717-1725
4. Wang Y, Kim KA, Kim JH, Sul HS 2006 Pref-1, a preadipocyte secreted factor that inhibits adipogenesis. J Nutr 136:2953-2956 (Pubitemid 44878554)
5. Fazeli PK, Bredella MA, Misra M, Meenaghan E, Rosen CJ, Clemmons DR, Breggia A, Miller KK, Klibanski A 2010 Preadipocyte factor-1 is associated with marrow adiposity and bone mineral density in women with anorexia nervosa. J Clin Endocrinol Metab 95:407-413
6. Chan JL, Mantzoros CS 2005 Role of leptin in energy-deprivation states: normal human physiology and clinical implications for hypothalamic amenorrhoea and anorexia nervosa. Lancet 366:74-85 (Pubitemid 40956533)
7. Reindollar RH, Novak M, Tho SP, McDonough PG 1986 Adultonset amenorrhea: a study of 262 patients. Am J Obstet Gynecol 155:531-543 (Pubitemid 16031138)
8. Gordon CM 2010 Clinical practice. Functional hypothalamic amenorrhea. N Engl J Med 363:365-371
9. Grinspoon S, Miller K, Coyle C, Krempin J, Armstrong C, Pitts S, Herzog D, Klibanski A 1999 Severity of osteopenia in estrogendeficient women with anorexia nervosa and hypothalamic amenorrhea. J Clin Endocrinol Metab 84:2049-2055 (Pubitemid 30647032)
10. Warren MP, Voussoughian F, Geer EB, Hyle EP, Adberg CL, Ramos RH 1999 Functional hypothalamic amenorrhea: hypoleptinemia and disordered eating. J Clin Endocrinol Metab 84:873-877 (Pubitemid 29138211)
11. Miller KK, Klibanski A 1999 Amenorrheic bone loss. J Clin Endocrinol Metab 84:1775-1783
12. Welt CK, Chan JL, Bullen J, Murphy R, Smith P, DePaoli AM, Karalis A, Mantzoros CS 2004 Recombinant human leptin in women with hypothalamic amenorrhea. N Engl J Med 351:987-997 (Pubitemid 39166262)
13. Mantzoros CS 2000 Role of leptin in reproduction. Ann NY Acad Sci 900:174-183 (Pubitemid 30251467)
14. Chou SH, Chamberland JP, Liu X, Matarese G, Gao C, Stefanakis R, Brinkoetter MT, Gong H, Arampatzi K, Mantzoros CS 2011 Leptin is an effective treatment for hypothalamic amenorrhea. Proc Natl Acad Sci USA 108:6585-6590
15. Chan JL, Wong SL, Orlova C, Raciti P, Mantzoros CS 2007 Pharmacokinetics of recombinant methionyl human leptin after subcutaneous administration: variation of concentration-dependent parameters according to assay. J Clin Endocrinol Metab 92:2307-2311 (Pubitemid 46997138)
16. Chan JL, Wong SL, Mantzoros CS 2008 Pharmacokinetics of subcutaneous recombinant methionyl human leptin administration in healthy subjects in the fed and fasting states: regulation by gender and adiposity. Clin Pharmacokinet 47:753-764
17. Wong SL, DePaoli AM, Lee JH, Mantzoros CS 2004 Leptin hormonal kinetics in the fed state: effects of adiposity, age, and gender on endogenous leptin production and clearance rates. J Clin Endocrinol Metab 89:2672-2677 (Pubitemid 38766348)
18. Karsenty G, Oury F 2010 The central regulation of bone mass, the first link between bone remodeling and energy metabolism. J Clin Endocrinol Metab 95:4795-4801
19. Roemmich JN, Clark PA, Mantzoros CS, Gurgol CM, Weltman A, Rogol AD 2003 Relationship of leptin to bone mineralization in children and adolescents. J Clin Endocrinol Metab 88:599-604 (Pubitemid 36207797)
20. Farooqi IS, Matarese G, Lord GM, Keogh JM, Lawrence E, Agwu C, Sanna V, Jebb SA, Perna F, Fontana S, Lechler RI, DePaoli AM, O'Rahilly S 2002 Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. J Clin Invest 110:1093-1103 (Pubitemid 35215890)