Zanthoxylum avicennae extracts induce cell apoptosis through protein phosphatase 2A activation in HA22T human hepatocellular carcinoma cells and block tumor growth in xenografted nude mice

International Journal of Molecular Medicine

Volumn 28, Issue 6, 2011, Pages 927-936

  Dung, Tran Duc ^a   Chang, Hsien Cheh ^a   Chen, Chung Yu ^b   Peng, Wen Huang ^a   Tsai, Chang Hai ^c   Tsai, Fuu Jen ^a   Kuo, Wei Wen ^a   Chen, Li Mien ^d,e   Huang, Chih Yang ^a,c  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^c ASIA UNIVERSITY   (Taiwan)

^d TAICHUNG ARMED FORCES GENERAL HOSPITAL   (Taiwan)

^e CENTRAL TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

Author keywords

Apoptosis; Hepatocellular carcinoma; Nude mice; Protein phosphatase 2A; Zanthoxylum avicennae (Ying Bu Bo)

Indexed keywords

PHOSPHOPROTEIN PHOSPHATASE 2A; PLANT EXTRACT; UNCLASSIFIED DRUG; ZANTHOXYLUM AVICENNAE EXTRACT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER GROWTH; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; LIVER CELL CARCINOMA; MALE; MEDICINAL PLANT; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR XENOGRAFT; ZANTHOXYLUM AVICENNAE;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CARCINOMA, HEPATOCELLULAR; CASPASE 3; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE SILENCING; HUMANS; IN SITU NICK-END LABELING; LIVER NEOPLASMS; MALE; MICE; MICE, NUDE; PLANT BARK; PLANT EXTRACTS; PROTEIN PHOSPHATASE 2; PROTO-ONCOGENE PROTEINS C-BCL-2; RNA, SMALL INTERFERING; TUMOR BURDEN; XENOGRAFT MODEL ANTITUMOR ASSAYS; ZANTHOXYLUM;

EID: 80053536992     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2011.780     Document Type: Article

References (40)

1. Okuda K: Hepatocellular carcinoma. J Hepatol 32: 225-237, 2000.
2. Parkin DM, Bray F, Ferlay J and Pisani P: Estimating the world cancer burden: Globocan 2000. Int J Cancer 94: 153-156, 2001. (Pubitemid 32911406)
3. Kerr JF, Wyllie AH and Currie AR: Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 26: 239-257, 1972.
4. Hill PA, Tumber A and Meikle MC: Multiple extracellular signals promote osteoblast survival and apoptosis. Endocrinology 138: 3849-3858, 1997. (Pubitemid 27351939)
5. Kawazoe N, Watabe M, Masuda Y, Nakajo S and Nakaya K: Tiam1 is involved in the regulation of bufalin-induced apoptosis in human leukemia cells. Oncogene 18: 2413-2421, 1999. (Pubitemid 29206154)
6. Mizukami S, Kikuchi K, Higuchi T, Urano Y, Mashima T, Tsuruo T and Nagano T: Imaging of caspase-3 activation in HeLa cells stimulated with etoposide using a novel fluorescent probe. FEBS Lett 453: 356-360, 1999. (Pubitemid 29326678)
7. Kim SO and Han J: Pan-caspase inhibitor zVAD enhances cell death in RAW246.7 macrophages. J Endotoxin Res 7: 292-296, 2001.
8. Iizuka N, Miyamoto K, Okita K, Tangoku A, Hayashi H, Yosino S, Abe T, Morioka T, Hazama S and Oka M: Inhibitory effect of Coptidis Rhizoma and berberine on the proliferation of human esophageal cancer cell lines. Cancer Lett 148: 19-25, 2000. (Pubitemid 30012124)
9. Kao ST, Yeh CC, Hsieh CC, Yang MD, Lee MR, Liu HS and Lin JG: The Chinese medicine Bu-Zhong-Yi-Qi-Tang inhibited proliferation of hepatoma cell lines by inducing apoptosis via G0/G1 arrest. Life Sci 69: 1485-1496, 2001.
10. Huerta S, Arteaga JR, Irwin RW, Ikezoe T, Heber D and Koeffler HP: PC-SPES inhibits colon cancer growth in vitro and in vivo. Cancer Res 62: 5204-5209, 2002. (Pubitemid 35024591)
11. Zu BX: Whole China herb conglomeration edition. J People's Public Health 1: 928-929, 1975.
12. Zhang LC: Dictionary of Chinese herbs. Chao Ren Press 5: 5513-5514, 1981.
13. Hsu H-Y, Chen Y-P, Shen S-J, Hsu C-S, Chen C-C and Chang H-C: Oriental Materia Medica. Oriental Healing Arts Institute, Long Beach, CA, pp365-366, 1986.
14. Xiang-Ping G-PZ and Shen T: Dictionary of Chinese Herbs. Shanghai Science and Technology Press 2: 3825-3826, 2006.
15. Neviani P, Santhanam R, Trotta R, Notari M, Blaser BW, Liu S, Mao H, Chang JS, Galietta A, Uttam A, Roy DC, Valtieri M, Bruner-Klisovic R, Caligiuri MA, Bloomfield CD, Marcucci G and Perrotti D: The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein. Cancer Cell 8: 355-368, 2005. (Pubitemid 41579831)
16. Alessandri G, Filippeschi S, Sinibaldi P, Mornet F, Passera P, Spreafico F, Cappa PM and Gullino PM: Influence of gangliosides on primary and metastatic neoplastic growth in human and murine cells. Cancer Res 47: 4243-4247, 1987. (Pubitemid 17124310)
17. Kang YH, Yi MJ, Kim MJ, Park MT, Bae S, Kang CM, Cho CK, Park IC, Park MJ, Rhee CH, Hong SI, Chung HY, Lee YS and Lee SJ: Caspase-independent cell death by arsenic trioxide in human cervical cancer cells: reactive oxygen species-mediated poly(ADP-ribose) polymerase-1 activation signals apoptosisinducing factor release from mitochondria. Cancer Res 64: 8960-8967, 2004. (Pubitemid 39665504)
18. Espinosa M, Cantu D, Herrera N, Lopez CM, De la Garza JG, Maldonado V and Melendez-Zajgla J: Inhibitors of apoptosis proteins in human cervical cancer. BMC Cancer 6: 45, 2006.
19. Hengartner MO: The biochemistry of apoptosis. Nature 407: 770-776, 2000.
20. Tokunaga E, Oki E, Egashira A, Sadanaga N, Morita M, Kakeji Y and Maehara Y: Deregulation of the Akt pathway in human cancer. Curr Cancer Drug Targets 8: 27-36, 2008. (Pubitemid 351237907)
21. Kornblau SM: The role of apoptosis in the pathogenesis, prognosis, and therapy of hematologic malignancies. Leukemia 12 (Suppl 1): S41-S46, 1998.
22. Jin Z and El-Deiry WS: Overview of cell death signaling pathways. Cancer Biol Ther 4: 139-163, 2005. (Pubitemid 41351311)
23. Thorburn A: Death receptor-induced cell killing. Cell Signal 16: 139-144, 2004.
24. Reed JC: Cytochrome c: can't live with it - can't live without it. Cell 91: 559-562, 1997.
25. Green DR and Reed JC: Mitochondria and apoptosis. Science 281: 1309-1312, 1998. (Pubitemid 28406816)
26. Kroemer G, Dallaporta B and Resche-Rigon M: The mitochondrial death/life regulator in apoptosis and necrosis. Annu Rev Physiol 60: 619-642, 1998. (Pubitemid 28157889)
27. Chinta SJ, Rane A, Yadava N, Andersen JK, Nicholls DG and Polster BM: Reactive oxygen species regulation by AIF- and complex I-depleted brain mitochondria. Free Radic Biol Med 46: 939-947, 2009.
28. Hisatomi T, Ishibashi T, Miller JW and Kroemer G: Pharmacological inhibition of mitochondrial membrane permeabilization for neuroprotection. Exp Neurol 218: 347-352, 2009.
29. Kagan VE, Bayir HA, Belikova NA, Kapralov O, Tyurina YY, Tyurin VA, Jiang J, Stoyanovsky DA, Wipf P, Kochanek PM, Greenberger JS, Pitt B, Shvedova AA and Borisenko G: Cytochrome c/cardiolipin relations in mitochondria: a kiss of death. Free Radic Biol Med 46: 1439-1453, 2009.
30. Antonsson B and Martinou JC: The Bcl-2 protein family. Exp Cell Res 256: 50-57, 2000. (Pubitemid 30211166)
31. Kluck RM, Bossy-Wetzel E, Green DR and Newmeyer DD: The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science 275: 1132-1136, 1997. (Pubitemid 27097313)
32. Zhao L, Guo QL, You QD, Wu ZQ and Gu HY: Gambogic acid induces apoptosis and regulates expressions of Bax and Bcl-2 protein in human gastric carcinoma MGC-803 cells. Biol Pharm Bull 27: 998-1003, 2004. (Pubitemid 41701748)
33. Fan J, Li R, Zhang R, Liu HL, Zhang N, Zhang FQ and Dou KF: Effect of Bcl-2 and Bax on survival of side population cells from hepatocellular carcinoma cells. World J Gastroenterol 13: 6053-6059, 2007. (Pubitemid 350238275)
34. Salakou S, Kardamakis D, Tsamandas AC, Zolota V, Apostolakis E, Tzelepi V, Papathanasopoulos P, Bonikos DS, Papapetropoulos T, Petsas T and Dougenis D: Increased Bax/Bcl-2 ratio up-regulates caspase-3 and increases apoptosis in the thymus of patients with myasthenia gravis. In Vivo 21: 123-132, 2007. (Pubitemid 46359209)
35. Ellouk-Achard S, Djenabi S, De Oliveira GA, Desauty G, Duc HT, Zohair M, Trojan J, Claude JR, Sarasin A and Lafarge-Frayssinet C: Induction of apoptosis in rat hepatocarcinoma cells by expression of IGF-I antisense c-DNA. J Hepatol 29: 807-818, 1998. (Pubitemid 28505939)
36. Vintermyr OK, Mellgren G, Boe R and Doskeland SO: Cyclic adenosine monophosphate acts synergistically with dexamethasone to inhibit the entrance of cultured adult rat hepatocytes into S-phase: with a note on the use of nucleolar and extranucleolar [3H]-thymidine labelling patterns to determine rapid changes in the rate of onset of DNA replication. J Cell Physiol 141: 371-382, 1989. (Pubitemid 19272280)
37. Kinoshita N, Ohkura H and Yanagida M: Distinct, essential roles of type 1 and 2A protein phosphatases in the control of the fission yeast cell division cycle. Cell 63: 405-415, 1990.
38. Lewin B: Driving the cell cycle: M phase kinase, its partners, and substrates. Cell 61: 743-752, 1990.
39. Cohen P, Holmes CF and Tsukitani Y: Okadaic acid: a new probe for the study of cellular regulation. Trends Biochem Sci 15: 98-102, 1990.
40. Cohen P: Classification of protein-serine/threonine phosphatases: identification and quantitation in cell extracts. Methods Enzymol 201: 389-398, 1991.