Physiological resilience

Resilience in Aging: Concepts, Research, and Outcomes

Volumn , Issue , 2011, Pages 89-103

  Hicks, Gregory ^b   Miller, Ram R ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF DELAWARE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 80053535867     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-4419-0232-0_6     Document Type: Chapter

References (102)

1. Abraham, E. (1999) Why immunomodulatory therapies have not worked in sepsis. Intensive Care Med, 25, 556-566.
2. Abramson, J. L., & Vaccarino, V. (2002) Relationship between physical activity and inflammation among apparently healthy middle-aged and older US adults. Arch Intern Med, 162, 1286-1292.
3. Almog, Y., Shefer, A., Novack, V., Maimon, N., Barski, L., Eizinger, M., et al. (2004) Prior statin therapy is associated with a decreased rate of severe sepsis. Circulation, 110(7), 880-885.
4. Ando, H., Takamura, T., Ota, T., HNagai, Y., & Kobayashi, K. (2000) Cerivastatin improves survival of mice with lipopolysaccharide-induced sepsis. J Pharmacol Exp Ther, 294, 1043-1046.
5. Arthur, H. M., Daniels, C., McKelvie, R., Hirsh, J., & Rush, B. (2000) Effect of a preoperative intervention on preoperative and postoperative outcomes in low-risk patients awaiting elective coronary artery bypass graft surgery. A randomized, controlled trial. Ann Intern Med, 133(4), 253-262.
6. Aust, S. D., Morehouse, L. A., & Thomas, C. E. (1985) Role of metals in oxygen radical reactions. Free Radic Biol Med, 1, 3.
7. Barbieri, M., Ferrucci, L., Ragno, E., Corsi, A. M., Bandinelli, S., Bonafe, M., et al. (2002) Chronic inflammation and the effect of IGF-1 on muscle strength and power in older persons. Am J Physiol Endocrinol Metab, 284, E481-E487.
8. Bartali, B., Frongillo, E. A., Guralnik, J. M., Stipanuk, M. H., Allore, H. G., Cherubini, A., et al. (2008) Serum micronutrient concentrations and decline in physical function among older persons. JAMA, 299(3), 308-315.
9. Bartali, B., Semba, R. D., Frongillo, E. A., Varadhan, R., Ricks, M. O., Blaum, C. S., et al. (2006) Low micronutrient levels as a predictor of incident disability in older women. Arch Intern Med, 166(21), 2335-2340.
10. Beale, R. J., Sherry, T., Lei, K., Campbell-Stephen, L., McCook, J., Smith, J., et al. (2008) Early enteral supplementation with key pharmaconutrients improves Sequential Organ Failure Assessment score in critically ill patients with sepsis: outcome of a randomized, controlled, double-blind trial. Crit Care Med, 36(1), 131-144.
11. Berger, M. M., & Chiolero, R. L. (2007) Antioxidant supplementation in sepsis and systemic inflammatory response syndrome. Crit Care Med, 35(Suppl. 9), S584-590.
12. Beutler, B., Mahoney, J., Le Trang, N., Pekala, P., & Cerami, A. (1985) Purification of cachectin, a lipoprotein lipase-suppressing hormone secreted by endotoxin induced raw 264.7 cells. J Exp Med, 161, 984-995.
13. Bischoff-Ferrari, H. A., Dawson-Hughes, B., Willett, W. C., Staehelin, H. B., Bazemore, M. G., Zee, R. Y., et al. (2004a) Effect of Vitamin D on falls: a meta-analysis. JAMA, 291 (16), 1999-2006.
14. Bischoff-Ferrari, H. A., Dietrich, T., Orav, E. J., Hu, F. B., Zhang, Y., Karlson, E. W., et al. (2004b) Higher 25-hydroxyvitamin D concentrations are associated with better lower-extremity function in both active and inactive persons aged 60 y. Am J Clin Nutr, 80, 752-758.
15. Boland, R., De Boland, A. R., Marinissen, M., Santillian, G., Vazquez, G., & Zanello, S. (1995) Avian muscle cells as targets for the secosteroid 1, 25-dihyroxyvitamin D3. Mol Cell Endocrinol, 114, 1-8.
16. Brigelius-Flohe, R. T. M. (1999) Vitamin E: function and metabolism. FASEB J, 13(10), 1145-1155.
17. Bruunsgaard, H., Skinhoj, P., Qvist, J., & Pedersen, B. K. (1999) Elderly humans show prolonged in vivo inflammatory activity during pneumococcal infections. J Infect Dis, 180, 551-554.
18. Budgett, R. (1998) Fatigue and underperformance in athletes: the overtraining syndrome. Br J Sports Med, 32, 107-110.
19. Cai, D., Frantz, J. D., Tawa, N. E. J., Melendez, P. A., Oh, B. C., Lidov, H. G., et al. (2004) IKKbeta/NF-kappaB activation causes severe muscle wasting in mice. Cell, 119(2), 285-298.
20. Cappola, A., Xue, Q., Ferrucci, L., Guralnik, J., Volpato, S., & Fried, L. (2003a) Insulin-like growth factor I and interleukin-6 contribute synergistically to disability and mortality in older women. J Clin Endocrinol Metab, 88(5), 2019-2025.
21. Cappola, A. R., Xue, Q. L., Ferrucci, L., Guralnik, J. M., Volpato, S., & Fried, L. P. (2003b) Insulin-like growth factor I and interleukin-6 contribute synergistically to disability and mortality in older women. J Clin Endocrinol Metab, 88(5), 2019-2025.
22. Cesari, M., Pahor, M., Bartali, B., Cherubini, A., Penninx, B. W., Williams, G. R., et al. (2004a) Antioxidants and physical performance in elderly persons: the Invecchiare in Chianti (InCHIANTI) study. Am J Clin Nutr, 79, 289-294.
23. Cesari, M., Penninx, B. W. J. H., Pahor, M., Lauretani, F., Corsi, A. M., Williams, G. R., et al. (2004b) Inflammatory markers and physical performance in older persons: The InCHIANTI study. J Gerontol A Biol Sci Med Sci, 59A(3), 242-248.
24. Clarkson, P. M., & Thompson, S. (2000) Antioxidants: what role do they play in physical activity and health?, Am J Clin Nutr, 72, 637S-646S.
25. Clermont, G., Vergely, C., Jazayeri, S., Lahet, J. J., Goudeau, J. J., Lecour, S., et al. (2002) Systemic free radical activation is a major event involved in myocardial oxidative stress related to cardiopulmonary bypass. Anesthesiology, 96(1), 80-87.
26. Cohen, H. J., Pieper, C. F., Harris, T., Rao, K. M., & Currie, M. S. (1997) The association of plasma IL-6 levels with functional disability in community-dwelling elderly. J Gerontol A Biol Sci Med Sci, 52(4), M201-M208.
27. Colbert, L. H., Visser, M., Simonsick, E. M., Tracy, R. P., Newman, A. B., Kritchevsky, S. B., et al. (2004) Physical activity, exercise, and inflammatory markers in older adults: findings from The Health, Aging and Body Composition Study. J Am Geriatr Soc, 52, 1098-1104.
28. De Benedetti, F., Alonzi, T., Moretta, A., Lazzaro, D., Costa, P., Poli, V., et al. (1997) Interleukin 6 causes growth impairment in transgenic mice through a decrease in insulin-like growth factor-1. J Clin Invest, 99, 643-650.
29. De La Fuente, M. (2002) Effects of antioxidants on immune system ageing. Eur J Clin Nutr, 56, S5-S8.
30. Di Mascio, P., Kaiser, S., & Sies, H. (1989) Lycopene as the most efficient biological carotenoid singlet oxygen quencher. Arch Biochem Biophys, 274, 532-538.
31. Dröge, W. (2002) Free radicals in the physiological control of cell function. Physiol Rev, 82, 47-95.
32. El-Agamey, A., Lowe, G. M., McGarvey, D. J., Mortensen, A., Phillip, D. M., Truscott, T. G., et al. (2004) Carotenoid radical chemistry and antioxidant/pro-oxidant properties. Arch Biochem Biophys, 430(1), 37-48.
33. Fano, G., Mecocci, P., Vecchiet, J., Belia, S., Fulle, S., Polidori, M. C., et al. (2001) Age and sex influence on oxidative damage and functional status in human skeletal muscle. J Muscle Res Cell Motil, 22(4), 345-351.
34. Fernandez-Celemin, L., Pasko, N., Blomart, V., & Thissen, J. P. (2002) Inhibition of muscle insulin-like growth factor I expression by tumor necrosis factor-alpha. Am J Physiol Endocrinol Metab, 283, E1279-E1290.
35. Fernandez-Celemin, L., & Thissen, J. P. (2001) Interleukin-6 stimulates hepatic insulin-like growth factor binding protein-4 messenger ribonucleic acid and protein. Endocrinology, 142, 241-248.
36. Ferrucci, L., Harris, T. B., Guralnik, J. M., Tracy, R. P., Corti, M. C., Cohen, H. J., et al. (1999) Serum IL-6 level and the development of disability in older persons. J Am Geriatr Soc, 47(6), 639-646.
37. Fried, L. P., Tangen, C. M., Walston, J., Newman, A. B., Hirsch, C., Gottdiener, J., et al. (2001) Frailty in older adults: evidence for a phenotype.J Gerontol A Biol Sci Med Sci, 56A, M146-M156.
38. Gomez-Cabrera, M. C., Domenech, E., & Viña, J. (2008) Moderate exercise is an antioxidant: upregulation of antioxidant genes by training.Free Radic Biol Med, 44(2), 126-131.
39. Gosker, H. R., Kubat, B., Schaart, G., van der Vusse, G. J., Wouters, E. F., & Schols, A. M. (2003) Myopathological features in skeletal muscle of patients with chronic obstructive pulmonary disease.Eur Respir J, 22(2), 280-285.
40. Hall, G. M., Peerbhoy, D., Shenkin, A., Parker, C. J. R., & Salmon, P. (2001) Relationship of the functional recovery after hip arthroplasty to the neuroendocrine and inflammatory responses. Br J Anaesth, 87, 537-542.
41. Halliwell, B., & Gutteridge, J. M. C. (1999), Free Radicals in Biology and Medicine. (3rd ed.). Oxford, UK: Oxford University Press.
42. Holick, M. F. (2005) The vitamin D epidemic and its health consequences. J Nutr, 135, 2739S-2748S.
43. Huang, H. Y., & Appel, L. J. (2003) Supplementation of diets with alpha-tocopherol reduces serum concentrations of gamma-and delta-tocopherol in humans. J Nutr, 133(10), 3137-3140.
44. Ji, L. L. (2002) Exercise-induced modulation of antioxidant defense. Ann N Y Acad Sci, 959, 82-92.
45. Karolkiewicz, J., Szczesniak, L., Deskur-Smielecka, E., Nowak, A., Stemplewski, R., & Szeklicki, R. (2003) Oxidative stress and antioxidant defense system in healthy, elderly men: relationship to physical activity. Aging Male, 6(2), 100-105.
46. Kotler, D. P. (2000) Cachexia., Ann Intern Med, 133(8), 622-634.
47. Krabbe, K. S., Bruunsgaard, H., Hansen, C. M., Moller, K., Fonsmark, L., Qvist, J., et al. (2001) Ageing is associated with a prolonged fever response in human endotoxemia. Clin Diagn Lab Immunol, 8, 333-338.
48. Krabbe, K. S., Pedersen, M., & Bruunsgaard, H. (2004) Inflammatory mediators in the elderly. Exp Gerontol, 39, 687-699.
49. Kudoh, A., Katagai, H., Takazawa, T., & Matsuki, A. (2001) Plasma proinflammatory cytokine response to surgical stress in elderly patients. Cytokine, 15, 270-273.
50. Lauretani, F., Semba, R. D., Bandinelli, S., Ray, A. L., Guralnik, J. M., & Ferrucci, L. (2007) Association of low plasma selenium concentrations with poor muscle strength in older community-dwelling adults: the InCHIANTI Study. Am J Clin Nutr, 86(2), 347-352.
51. LeBoff, M. S., Hawkes, W. G., Glowacki, J., Yu-Yahiro, J., Hurwitz, S., & Magaziner, J. (2008) Vitamin D-deficiency and post-fracture changes in lower extremity function and falls in women with hip fractures. Osteoporos Int, 19, 1283-1290.
52. Leng, S. X., Yang, H., & Walston, J. D. (2004) Decreased cell proliferation and altered cytokine production in frail older adults. Aging Clin Exp Res, 16, 249-252.
53. Li, X., Moody, M. R., Engel, D., Walker, S., Clubb, F. J. J., Sivasubramanian, N., et al. (2000) Cardiac-specific overexpression of tumor necrosis factor-alpha causes oxidative stress and contractile dysfunction in mouse diaphragm. Circulation, 102(14), 1690-1696.
54. Lichtenstein, A. H. (2009) Nutrient supplements and cardiovascular disease: a heartbreaking story.J Lipid Res, 50, S429-S433.
55. Luyten, C. R., van Overveld, F. J., De Backer, L. A., Sadowska, A. M., Rodrigus, I. E., De Hert, S. G., et al. (2005) Antioxidant defence during cardiopulmonary bypass surgery. Eur J Cardiothorac Surg, 27(4), 611-616.
56. Magaziner, J., Fredman, L., Hawkes, W., Hebel, J. R., Zimmerman, S., Orwig, D. L., et al. (2003) Changes in functional status attributable to hip fracture: a comparison of hip fracture patients to community-dwelling aged. Am J Epidemiol, 157(11), 1023-1031.
57. Magaziner, J., Hawkes, W., Hebel, J. R., Zimmerman, S. I., Fox, K. M., Dolan, M., et al. (2000) Recovery from hip fracture in eight areas of function. J Gerontol Med Sci, 55A(9), M498-M507.
58. Magaziner, J., Lydick, E., Hawkes, W., Zimmerman, S. I., Fox, K. M., Epstein, R. S., et al. (1997) Excess mortality attributable to hip fracture in white women aged 70 years and older. Am J Public Health, 87(10), 1630-1636.
59. Magaziner, J., Simonsick, E. M., Kashner, T. M., Hebel, J. R., & Kenzora, J. E. (1990) Predictors of functional recovery one year following hospital discharge for hip fracture: a prospective study. J Gerontol Med Sci, 45(3), M101-M107.
60. Maxwell, S. R. J. (1995) Prospects for the use of antioxidant therapies.Drugs, 349(3), 345-361.
61. Michelon, E., Blaum, C., Semba, R. D., Xue, Q. L., Ricks, M. O., & Fried, L. P. (2006) Vitamin and carotenoid status in older women: associations with the frailty syndrome. J Gerontol A Biol Sci Med Sci, 61(6), 600-607.
62. Miller, E. R. R., Pastor-Barriuso, R., Dalal, D., Riemersma, R. A., Appel, L. J., & Guallar, E. (2005) Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality. [see comment]. Ann Intern Med, 142(1), 37-46.
63. Miller, R. R., Cappola, A. R., Shardell, M. D., Hawkes, W., Hebel, J. R., Yu-Yahiro, J., et al. (2006) Persistent changes in interleukin-6 and lower extremity function following hip fracture. J Gerontol A Biol Sci Med Sci, 61, 1053-1058.
64. Nasraway, S. A. (2003) The problems and challenges of immunotherapy in sepsis. [Review] [65 refs].Chest, 123(Suppl. 5), 451S-459S.
65. Navas-Acien, A., Bleys, J., & Guallar, E. (2008) Selenium intake and cardiovascular risk: what is new? Curr Opin Lipidol, 19(1), 43-49.
66. Okita, K., Nishijima, H., Murakami, T., Nagai, T., Morita, N., Yonezawa, K., et al. (2004) Can exercise training with weight loss lower serum C-reactive protein levels? Arterioscler Thromb Vasc Biol, 24, 1868-1873.
67. Ostrowski, K., Rohde, T., Asp, S., Schjerling, P., & Pedersen, B. K. (1999) Pro-and anti-inflammatory cytokine balance in strenuous exercise in humans. J Physiol, 515, 287-291.
68. Ostrowski, K., Schjerling, P., & Pedersen, B. K. (2000) Physical activity and plasma interleukin-6 in humans-effect of intensity of exercise. Eur J Appl Physiol, 83, 512-515.
69. Payette, H., Roubenoff, R., Jacques, P. F., Dinarello, C. A., Wilson, P. W. F., Abad, L. W., et al. (2003) Insulin-like growth factor-1 and interleukin-6 predict sarcopenia in very old community-living men and women: the Framingham Study. J Am Geriatr Soc, 51, 1237-1243.
70. Peterlik, M., & Cross, H. S. (2005) Vitamin D and calcium deficits predispose for multiple chronic diseases. Eur J Clin Invest, 35(5), 290-304.
71. Puts, M. T. E., Visser, M., Twisk, J. W. R., Deeg, D. J. H., & Lips, P. (2005) Endocrine and inflammatory markers as predictive of frailty. Clin Endocrinol, 63, 403-411.
72. Rayman, M. P. (2000) The importance of selenium to human health., Lancet, 356(9225), 233-241.
73. Reid, M. B., Lannergren, J., & Westerblad, H. (2002) Respiratory and limb muscle weakness induced by tumor necrosis factor-alpha. Am J Respir Crit Care Med, 166, 479-484.
74. Reid, M. B., & Li, Y. P. (2001) Cytokines and oxidative signalling in skeletal muscle. Acta Physiol Scand, 171, 225-232.
75. Reuben, D. B., Cheh, A. I., Harris, T. B., Ferrucci, L., Rowe, J. W., Tracy, R. P., et al. (2002) Peripheral blood markers of inflammation predict mortality and functional decline in high-functioning community-dwelling older persons. J Am Geriatr Soc, 50(4), 638-644.
76. Rimm, E. R., Stampfer, M. J., Ascherio, A., Giovannucci, E., Colditz, G. A., & Willett, W. C. (1993) Vitamin E consumption and the risk of coronary heart disease in men. N Eng J Med, 328, 1450-1456.
77. Rodman, J. S., & Baker, T. (1978) Changes in the kinetics of muscle contration in vitamin D-depleted rats.Kidney Int, 13, 189-193.
78. Rousseau, A. S., Margaritis, I., Arnaud, J., Faure, H., & Roussel, A. M. (2006) Physical activity alters antioxidant status in exercising elderly subjects. J Nutr Biochem, 17(7), 463-470.
79. Sakr, Y., Reinhart, K., Bloos, F., Marx, G., Russwurm, S., Bauer, M., et al. (2007) Time course and relationship between plasma selenium concentrations, systemic inflammatory response, sepsis, and multiorgan failure. Br J Anaesth, 98(6), 775-784.
80. Semba, R. D., Bartali, B., Zhou, J., Blaum, C., Ko, C. W., & Fried, L. P. (2006) Low serum micro-nutrient concentrations predict frailty among older women living in the community. J Gerontol A Biol Sci Med Sci, 61(6), 594-599.
81. Semba, R. D., Ferrucci, L., Sun, K., Walston, J., Varadhan, R., Guralnik, J. M., et al. (2007a) Oxidative stress and severe walking disability among older women. Am J Med, 120(12), 1084-1089.
82. Semba, R. D., Lauretani, F., & Ferrucci, L. (2007b) Carotenoids as protection against sarcopenia in older adults. Arch Biochem Biophys, 458(2), 141-145.
83. Semba, R. D., Varadhan, R., Bartali, B., Ferrucci, L., Ricks, M. O., Blaum, C., et al. (2007c) Low serum carotenoids and development of severe walking disability among older women living in the community: the women's health and aging study I. Age Ageing, 36(1), 62-67.
84. Sevenian, A., & Hochstein, P. (1985) Mechanisms and consequences of lipid peroxidation in biological systems. Annu Rev Nutr, 5, 365-375.
85. Simpson, R. U., Thomas, G. A., & Arnold, A. J. (1985) Identification of 1, 25-dihydroxyvitamin D3 receptors and activities in muscle. J Biol Chem, 260, 8882-8891.
86. Spatz, E. S., Canavan, M. E., & Desai, M. M. (2009) From here to JUPITER identifying new patients for statin therapy using data from the 1999-2004 National Health and Nutrition Examination Survey. Circ Cardiovasc Qual Outcomes, 2, 41-48.
87. Stampfer, M., Hennekens, C., Manson, J., Colditz, G., Rosner, B., & Willett, W. C. (1993) Vitamin E consumption and the risk of coronary disease in women. N Eng J Med, 328, 1444-1449.
88. Starkie, R., Ostrowski, S. R., Jauffred, S., Febbraio, M., & Pedersen, B. K. (2003) Exercise and IL-6 infusion inhibit endotoxin-induced TNF-alpha production in humans. FASEB J, 17, 884-886.
89. Terblanche, M., Almog, Y., Rosenson, R. S., Smith, T. S., & Hackam, D. G. (2006) Statins: panacea for sepsis? Lancet Infect Dis, 6(4), 242-248.
90. Terblanche, M., Almog, Y., Rosenson, R. S., Smith, T. S., & Hackam, D. G. (2007) Statins and sepsis: multiple modifications at multiple levels. Lancet Infect Dis, 7(5), 358-368.
91. Toft, A. D., Jensen, L. B., Bruunsgaard, H., Ibfelt, T., Halkjaer-Kristensen, J., Febbraio, M., et al. (2002) Cytokine response to eccentric exercise in young and elderly humans. Am J Physiol Cell Physiol, 283, C289-C295.
92. van Etten, E., & Mathieu, C. (2005) Immunoregulation by 1, 25-dihydroxyvitamin D3: basic concepts. J Steroid Biochem Mol Biol, 97, 93-101.
93. Vescovo, G., Volterrani, M., Zennaro, R., Sandri, M., Ceconi, C., Lorusso, R., et al. (2000) Apoptosis in the skeletal muscle of patients with heart failure: investigation of clinical and biochemical changes. Heart, 84(4), 431-437.
94. Visser, M., Deeg, D. J. H., & Lips, P. (2003) Low vitamin D and high parathyroid hormone levels as determinants of loss of muscle strength and muscle mass (sarcopenia): the Longitudinal Aging Study Amsterdam. J Clin Endocrinol Metab, 88, 5766-5772.
95. Vivekananthan, D. P., Penn, M. S., Sapp, S. K., Hsu, A., & Topol, E. J. (2003) Use of antioxidant vitamins for the prevention of cardiovascular disease: meta-analysis of randomised trials. Lancet, 361, 2017-2023.
96. Voutilainen, S., Nurmi, T., Mursu, J., & Rissanen, T. H. (2006) Carotenoids and cardiovascular health. Am J Clin Nutr, 83(6), 1265-1271.
97. Walston, J., McBurnie, M. A., Newman, A., Tracy, R. P., Kop, W. J., Hirsch, C. H., et al. (2002) Frailty and activation of inflammation and coagulation systems with and without clinical comorbidities. Arch Intern Med, 162, 2333-2341.
98. Wannamethee, S. G., Lowe, G. D. O., Whincup, P. H., Rumley, A., Walker, M., & Lennon, L. (2002) Physical activity and hemostatic and inflammatory variables in elderly men. Circulation, 105, 1785-1790.
99. Wassner, S. J., Li, J. B., Sperduto, A., & Norman, M. E. (1983) Vitamin D deficiency, hypocalcemia, and increased skeletal muscle degradation in rats. J Clin Invest, 72, 102-112.
100. Wei, J., Xu, H., Davies, J. L., & Hemmings, G. P. (1992) Increase of plasma IL-6 concentrations with age in healthy subjects. Life Sci, 51, 1953-1956.
101. Yau, T. M., Weisel, R. D., Mickle, D. A., Burton, G. W., Ingold, K. U., Ivanov, J., et al. (1994) Vitamin E for coronary bypass operations. A prospective, double-blind, randomized trial.J Thorac Cardiovasc Surg, 108(2), 302-310.
102. Yetley, E. A. (2008) Assessing the vitamin D status of the US population. Am J Clin Nutr, 88(2), 558S-564S.