Pro- and anti-inflammatory cytokine balance in strenuous exercise in humans

Journal of Physiology

Volumn 515, Issue 1, 1999, Pages 287-291

  Ostrowski, Kenneth ^a   Rohde, Thomas ^a   Asp, Sven ^a   Schjerling, Peter ^a   Pedersen, Bente Klarlund ^a  

^a University of Copenhagen   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR 1; TUMOR NECROSIS FACTOR RECEPTOR 2;

ADULT; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXERCISE; HUMAN; HUMAN EXPERIMENT; INFLAMMATION; MALE; MARATHON RUNNER; NORMAL HUMAN; PRIORITY JOURNAL; TIME; BLOOD SAMPLING; COMPETITION; CYTOKINE RELEASE; EXERCISE INTENSITY; EXERCISE PHYSIOLOGY; EXERCISE RECOVERY; OXYGEN CONSUMPTION; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN HOMEOSTASIS; RUNNING;

EID: 0033557703     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1469-7793.1999.287ad.x     Document Type: Article

References (26)

1. BAGBY, G. J., CROUCH, L. D. & SHEPHERD, R. E. (1996). Exercise and cytokines: Spontaneous and elicited response. In Exercise and Immune function, ed. HOFFMAN', G. L., pp. 55-78. CRC Press, New York.
2. BRUUNSGAARD, H., GALBO, H., HALKJAER, K. J., JOHANSEN, T. L., MACLEAN, D. A. & PEDERSEN, B. K. (1997). Exercise-induced increase in serum interleukin-6 in humans is related to muscle damage. Journal of Physiology 499, 833-841.
3. CANNON, J. G., EVANS, W. J., HUGHES, V. A., MEREDITH, C. N. & DINARELLO, C. A. (1986). Physiological mechanisms contributing to increased interleukin-1 secretion. Journal of Applied Physiology 61, 1869-1874.
4. CANNON, J. G. & KLUGER, M. J. (1983). Endogenous pyrogen activity in human plasma after exercise. Science 220, 617-619.
5. CASSATELLA, M. A., MEDA, L., GASPERINI, S., CALZETTI, F. & BONORA, S. (1994). Interleukin 10(IL-10) upregulates IL-1 receptor antagonist production from lipopolysaccharide-stimulated human polymorphonuclear leukocytes by delaying mRNA degradation. Journal of Experimental Medicine 179, 1695-1699.
6. CASTELL, L. M., POORTMANS, J. R., LECLERCQ, R., BRASSEUR, M., DUCHATEAU, J. & NEWSHOLME, E. A. (1997). Some aspects of the acute phase response after a marathon race, and the effects of glutamine supplementation. European Journal of Applied Physiology and Occupational Physiology 5, 47-53.
7. CHERNOFF, A. E., GRANOWITZ, E. V., SHAPIRO, L., VANNIER, E., LONNEMANN, G., ANGEL, J. B., KENNEDY, J. S., RABSON, A. R., WOLFF, S. M. & DINARELLO, C. A. (1995). A randomized, controlled trial of IL-10 in humans. Inhibition of inflammatory cytokine production and immune responses. Journal of Immunology 154, 5492-5499.
8. DILL, D. B. & COSTILL, D. L. (1974). Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. Journal of Applied Physiology 37, 247-248.
9. DINARELLO, C. A. (1992). Role of interleukin-1 in infectious diseases. Immunological Reviews 127, 119-146.
10. DRENTH, J. P., VAN UUM, S. H., VAN DEUREN, M., PESMAN, G. J., VAN DER VEN JONGEKRIJG, J. & VAN DER MEER, J. W. (1995). Endurance run increases circulating IL-6 and IL-1ra but downregulates ex vivo TNF-alpha and IL-1 beta production. Journal of Applied Physiology 79, 1497-1503.
11. DUFAUX, B. & ORDER, U. (1989). Plasma elastase-alpha 1-antitrypsin, neopterin, tumor necrosis factor, and soluble interleukin-2 receptor after prolonged exercise. International Journal of Sports Medicine 10, 434-438.
12. ESPERSEN, G. T., ELBAEK, A., ERNST, E., TOFT, E., KAALUND, S., JERSILD, C. & GRUNNET, N. (1990). Effect of physical exercise on cytokines and lymphocyte subpopulations in human peripheral blood. APMIS 98, 395-400.
13. EVANS, W. J., MEREDITH, C. N., CANNON, J. G., DINARELLO, C. A., FRONTERA, W. R., HUGHES, V. A., JONES, B. H. & KNUTTGEN, H. G. (1986). Metabolic changes following eccentric exercise in trained and untrained men. Journal of Applied Physiology 61, 1864-1868.
14. HELLSTEN, Y., FRANDSEN, U., ORTHENBLAD, N., SJODIN, B. & RICHTER, E. A. (1997). Xanthine oxidase in human skeletal muscle following eccentric exercise: a role in inflammation. Journal of Physiology 498, 239-248.
15. JENKINS, J. K., MALYAK, M. & AREND, W. P. (1994). The effects of interleukin-10 on interleukin-1 receptor antagonist and interleukin-1 beta production in human monocytes and neutrophils. Lymphokine and Cytokine Research, 13, 47-54.
16. JORDAN, M., OTTERNESS, I. G., NG, R., GESSNER, A., ROLLINGHOFF, M. & BEUSCHER, H. U. (1995). Neutralization of endogenous IL-6 suppresses induction of IL-1 receptor antagonist. Journal of Immunology 154, 4081-4090.
17. NEHLSEN-CANNARELLA, S. L., FAGOAGA, O. R., NIEMAN, D. C., HENSON, D. A., BUTTERWORTH, D. K., SCHMITT, R. L., BAILEY, E. M., WARREN, B. J., UTTER, A. & DAVIS, J. M. (1997). Carbohydrate and the cytokine response to 2.5 h of running. Journal of Applied Physiology 82, 1662-1667.
18. NORTHOFF, H. & BERG, A. (1991). Immunologic mediators as parameters of the reaction to strenuous exercise. International Journal of Sports Medicine 12, suppl. 1, S9-15.
19. OSTROWSKI, K., ROHDE, T., ZACHO, M., ASP, S. & PEDERSEN, B. K. (1998). Evidence that interleukin-6 is produced in human skeletal muscle during prolonged running. Journal of Physiology 508, 949-953.
20. RICHARDS, C. D. & GAULDIE, J. (1998). Role of cytokines in acute-phase response. In Human cytokines: their Role in Disease and Therapy, ed. AGGARWAL, B. B. & PURI, P., pp. 253-269. Blackwell Science, Cambridge.
21. RIVIER, A., PENE, J., CHANEZ, P., ANSELME, F., CAILLAUD, C., PREFAUT, C., GODARD, P. & BOUSQUET, J. (1994). Release of cytokines by blood monocytes during strenuous exercise. International Journal of Sports Medicine 15, 192-198.
22. ROHDE, T., MACLEAN, D. A., RICHTER, K. A., KIENS, B. & PEDERSEN, B. K. (1997). Prolonged submaximal eccentric exercise is associated with increased levels of plasma IL-6. American Journal of Physiology 273, E85-91.
23. SPRENGER, H., JACOBS, C., NAIN, M., GRESSNER, A. M., PRINZ, H., WESEMANN, W. & GEMSA, D. (1992). Enhanced release of cytokines, interleukin-2 receptors, and neopterin after long-distance running. Clinical Immunology and Immunopathology 63, 188-195.
24. TILG, H., TREHU, E., ATKINS, M. B., DINARELLO, C. A. & MIER, J. W. (1994). Interleukin-6 (IL-6) as an anti-inflammatory cytokine: induction of circulating IL-1 receptor antagonist and soluble tumor necrosis factor receptor p55. Blood 83, 113-118.
25. ULLUM, H., HAAHR, P. M., DIAMANT, M., PALMO, J., HALKJAER, K. J. & PEDERSEN, B. K. (1994a). Bicycle exercise enhances plasma IL-6 but does not change IL-1 alpha, IL-1 beta, IL-6, or TNF-alpha premRNA in BMNC. Journal of Applied Physiology 77, 93-97.
26. ULLUM, H., PALMO, J., HALKJAER, K. J., DIAMANT, M., KLOKKER, M., KRUUSE, A., LAPERRIERE, A. & PEDERSEN, B. K. (1994b). The effect of acute exercise on lymphocyte subsets, natural killer cells, proliferative responses, and cytokines in HIV-seropositive persons. Journal of Acquired Immune Deficiency Syndromes 7, 1122-1133.