BDNF gene polymorphisms are associated with Alzheimer's disease-related depression and antidepressant response

Journal of Alzheimer's Disease

Volumn 26, Issue 3, 2011, Pages 523-530

  Zhang, Lu ^a   Fang, Yu ^b   Zeng, Zhaoshu ^a   Lian, Yajun ^a   Wei, Jianke ^a   Zhu, Hongcan ^a   Jia, Yanjie ^a   Zhao, Xinyu ^a   Xu, Yuming ^a  

^a ZHENGZHOU UNIVERSITY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIVERSITY   (China)

Author keywords

Alzheimer's disease related depression; brain derived neurotrophic factor; paroxetine; polymorphism

Indexed keywords

ANTIDEPRESSANT AGENT; BRAIN DERIVED NEUROTROPHIC FACTOR; PAROXETINE;

AGED; ALZHEIMER DISEASE; ALZHEIMER DISEASE RELATED DEPRESSION; ARTICLE; CORRELATION ANALYSIS; DEPRESSION; DISEASE PREDISPOSITION; DNA POLYMORPHISM; FEMALE; GENE FREQUENCY; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HAMILTON SCALE; HETEROZYGOTE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; TREATMENT RESPONSE;

EID: 80053503684     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-2011-110113     Document Type: Article

References (61)

1. Wilson RS, Barnes LL, Mendes de Leon CF, Aggarwal NT, Schneider JS, Bach J, Pilat J, Beckett LA, Arnold SE, Evans DA, Bennett DA (2002) Depressive symptoms, cognitive decline, and risk of AD in older persons. Neurology 59, 364-370.
2. Modrego PJ (2010) Depression in Alzheimer's Disease. Pathophysiology, Diagnosis, and Treatment. J Alzheimers Dis 21, 1077-1087.
3. Lee HB, Lyketsos CG (2003) Depression in Alzheimer's disease: heterogeneity and related issues. Biol Psychiatry 54,353-362.
4. Wilson RS, Mendes De Leon CF, Bennett DA, Bienias JL, EvansDA(2004) Depressive symptoms and cognitive decline in a community population of older persons. J Neurol Neurosurg Psychiatry 75, 126-129.
5. Siebner HR, Callicott JH, Sommer T, Mattay VS (2009) From the genome to the phenome and back: linking genes with human brain function and structure using genetically informed neuroimaging. Neuroscience 164, 1-6.
6. Mattson MP, Maudsley S, Martin B (2004) BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders. Trends Neurosci 27, 589-594.
7. Tapia-Arancibia L, Aliaga E, Silhol M, Arancibia S (2008) New insights into brain BDNF function in normal aging and Alzheimer disease. Brain Res Rev 59, 201-220.
8. Hu Y, Russek SJ (2008) BDNF and the diseased nervous system: a delicate balance between adaptive and pathological processes of gene regulation. J Neurochem 105, 1-17.
9. Phillips HS, Hains JM, Armanini M, Laramee GR, Johnson SA, Winslow JW (1991) BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease. Neuron 7, 695-702.
10. Narisawa-Saito M, Wakabayashi K, Tsuji S, Takahashi H, Nawa H (1996) Regional specificity of alterations in NGF, BDNF and NT-3 levels in Alzheimer's disease. Neurorepor 7, 2925-2928.
11. Holsinger RM, Schnarr J, Henry P, Castelo VT, Fahnestock M (2000) Quantitation of BDNF mRNA in human parietal cortex by competitive reverse transcription-polymerase chain reaction: decreased levels in Alzheimer's disease. Brain Res Mol Brain Res 76, 347-354.
12. Peng S, Wuu J, Mufson EJ, Fahnestock M (2005) Precursor form of brain-derived neurotrophic factor and mature brainderived neurotrophic factor are decreased in the pre-clinical stages of Alzheimer's disease. J Neurochem 93, 1412-1421.
13. Chen B, Dowlatshahi D, MacQueen GM, Wang JF, Young LT (2001) Increased hippocampal BDNF immunoreactivity in subjects treated with antidepressant medication. Biol Psychiatry 50, 260-265.
14. Castren E (2004) Neurotrophic effects of antidepressant drugs. Curr Opin Pharmacol 4, 58-64.
15. Nibuya M, Morinobu S, Duman RS (1995) Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments. J Neurosci 15, 7539-7547.
16. Angelucci F, Brene S, MatheAA(2005)BDNFin schizophrenia, depression and corresponding animal models. Mol Psychiatry 10, 345-352.
17. Dias BG, Banerjee SB, Duman RS, Vaidya VA (2003) Differential regulation of brain derived neurotrophic factor transcripts by antidepressant treatments in the adult rat brain. Neuropharmacology 45, 553-563.
18. Tsankova NM, Berton O, Renthal W, Kumar A, Neve RL, Nestler EJ (2006) Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action. Nat Neurosci 9, 519-525.
19. Altar CA, Whitehead RE, Chen R,Wortwein G, Madsen TM (2003) Effects of electroconvulsive seizures and antidepressant drugs on brain-derived neurotrophic factor protein in rat brain. Biol Psychiatry 54, 703-709.
20. Dwivedi Y, Rizavi HS, Conley RR, Roberts RC, Tamminga CA, Pandey GN (2003) Altered gene expression of brainderived neurotrophic factor and receptor tyrosine kinase B in postmortem brain of suicide subjects. Arch Gen Psychiatry 60, 804-815.
21. Karege F, Perret G, Bondolfi G, Schwald M, Bertschy G, Aubry JM (2002) Decreased serum brain-derived neurotrophic factor levels in major depressed patients. Psychiatry Res 109, 143-148.
22. Shimizu E, Hashimoto K, Okamura N, Koike K, Komatsu N, Kumakiri C, Nakazato M,Watanabe H, Shinoda N, Okada S, IyoM(2003) Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants. Biol Psychiatry 54, 70-75.
23. Borroni B, Archetti S, Costanzi C, Grassi M, Ferrari M, Radeghieri A, Caimi L, Caltagirone C, Di Luca M, Padovani A (2009) Role of BDNF Val66Met functional polymorphism in Alzheimer's disease-related depression. Neurobiol Aging 30, 1406-1412.
24. Egan MF, Kojima M, Callicott JH, Goldberg TE, Kolachana BS, Bertolino A, Zaitsev E, Gold B, Goldman D, Dean M, Lu B, Weinberger DR (2003) The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 112, 257-269.
25. Hwang JP, Tsai SJ, Hong CJ, Yang CH, Lirng JF, Yang YM (2006) The Val66Met polymorphism of the brain-derived neurotrophic-factor gene is associated with geriatric depression. Neurobiol Aging 27, 1834-1837.
26. Ribeiro L, Busnello JV, Cantor RM, Whelan F, Whittaker P, Deloukas P, Wong ML, Licinio J (2007) The brain-derived neurotrophic factor rs6265 (Val66Met) polymorphism and depression in Mexican-Americans. Neuroreport 18, 1291-1293
27. Hong CJ, Huo SJ, Yen FC, Tung CL, Pan GM, Tsai SJ (2003) Association study of a brain-derived neurotrophic factor genetic polymorphism and mood disorders, age of onset and suicidal behavior. Neuropsychobiology 48, 186-189.
28. Tsai SJ, Cheng CY, Yu YW, Chen TJ, Hong CJ (2003) Association study of a brain-derived neurotrophic-factor genetic polymorphism and major depressive disorders, symptomatology, and antidepressant response. Am J Med Genet B Neuropsychiatr Genet 123B, 19-22.
29. Kunugi H, Ueki A, Otsuka M, Isse K, Hirasawa H, Kato N, Nabika T, Kobayashi S, Nanko S (2001) A novel polymorphism of the brain-derived neurotrophic factor (BDNF) gene associated with late-onset Alzheimer's disease. Mol Psychiatry 6, 83-86.
30. Olin D, MacMurray J, Comings DE (2005) Risk of late-onset Alzheimer's disease associated with BDNF C270T polymorphism. Neurosci Lett 381, 275-278.
31. Grunblatt E, Hupp E, Bambula M, Zehetmayer S, Jungwirth S, Tragl KH, Fischer P, Riederer P (2006) Association study of BDNF and CNTF polymorphism to depression in nondemented subjects of the "VITA" study. J Affect Disord 96, 111-116
32. Zhang H, Ozbay F, Lappalainen J, Kranzler HR, van Dyck CH, Charney DS, Price LH, Southwick S,Yang BZ, Rasmussen A, Gelernter J (2006) Brain derived neurotrophic factor (BDNF) gene variants and Alzheimer's disease, affective disorders, posttraumatic stress disorder, schizophrenia, and substance dependence. Am J Med Genet B Neuropsychiatr Genet 141B, 387-393.
33. Oswald P, Del-Favero J, Massat I, Souery D, Claes S, Van Broeckhoven C, Mendlewicz J (2005) No implication of brain-derived neurotrophic factor (BDNF) gene in unipolar affective disorder: evidence from Belgian first and replication patient-control studies. Eur Neuropsychopharmacol 15, 491-495.
34. Borroni B, Grassi M, Archetti S, Costanzi C, Bianchi M, Caimi L, Caltagirone C, Di Luca M, PadovaniA(2009)BDNF genetic variations increase the risk of Alzheimer's diseaserelated depression. J Alzheimers Dis 18, 867-875.
35. Cummings JL, Mega M, Gray K, Rosenberg-Thompson S, Carusi DA, Gornbein J (1994) The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia. Neurology 44, 2308-2314.
36. Yesavage JA, Brink TL, Rose TL, Lum O, Huang V, AdeyM, Leirer VO (1982) Development and validation of a geriatric depression screening scale: a preliminary report. J Psychiatr Res 17, 37-49.
37. Hamilton MA. (1960) A rating scale for depression. J Neurol Neurosurg Psychiatry 23, 56-62.
38. Hughes CP, Berg L, Danziger WL, Coben LA, Martin RL (1982) A new clinical scale for the staging of dementia. Br J Psychiatry 140, 566-572.
39. Folstein MF, Folstein SE, McHugh PR (1975) "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12, 189-198.
40. Lawton MP, Brody EM (1969) Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist 9, 179-186.
41. Barrett JC, Fry B, Maller J, Daly MJ (2005) Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21, 263-265.
42. Gabriel SB, Schaffner SF, Nguyen H, Moore JM, Roy J, Blumenstiel B, Higgins J, DeFelice M, Lochner A, Faggart M, Liu-Cordero SN, Rotimi C, Adeyemo A, Cooper R, Ward R, Lander ES, Daly MJ, Altshuler D (2002) The structure of haplotype blocks in the human genome. Science 296, 2225-2229.
43. Weiner MF, Doody RS, Sairam R, Foster B, Liao TY (2002) Prevalence and incidence of major depressive disorder in Alzheimer's disease: findings from two databases. Dement Geriatr Cogn Disord 13, 8-12.
44. Zubenko GS, Zubenko WN, McPherson S, Spoor E, Marin DB, FarlowMR, Smith GE, Geda YE, Cummings JL, Petersen RC, Sunderland T (2003) A collaborative study of the emergence and clinical features of the major depressive syndrome of Alzheimer's disease. Am J Psychiatry 160, 857-866.
45. Schumacher J, Jamra RA, Becker T, Ohlraun S, Klopp N, Binder EB, Schulze TG, Deschner M, Schmal C, Hofels S, Zobel A, Illig T, Propping P, Holsboer F, Rietschel M, Nothen MM, Cichon S (2005) Evidence for a relationship between genetic variants at the brain-derived neurotrophic factor (BDNF) locus and major depression. Biol Psychiatry 58, 307-314.
46. Choi MJ, Kang RH, Lim SW, Oh KS, Lee MS (2006) Brainderived neurotrophic factor gene polymorphism (Val66Met) and citalopram response in major depressive disorder. Brain Res 1118, 176-182.
47. KimJM, Stewart R,KimSW,Yang SJ, Shin IS,KimYH,Yoon JS (2008) BDNF genotype potentially modifying the association between incident stroke and depression. Neurobiol Aging 29, 789-792.
48. Riemenschneider M, Schwarz S, Wagenpfeil S, Diehl J, Muller U, Forstl H, Kurz A (2002) A polymorphism of the brain-derived neurotrophic factor (BDNF) is associated with Alzheimer's disease in patients lacking the Apolipoprotein E epsilon4 allele. Mol Psychiatry 7, 782-785.
49. Ventriglia M, Bocchio Chiavetto L, Benussi L, Binetti G, Zanetti O, Riva MA, Gennarelli M (2002) Association between the BDNF 196 A/G polymorphism and sporadic Alzheimer's disease. Mol Psychiatry 7, 136-137.
50. Tsai SJ, Hong CJ, Liu HC, Liu TY, Hsu LE, Lin CH (2004) Association analysis of brain-derived neurotrophic factor Val66Met polymorphisms with Alzheimer's disease and age of onset. Neuropsychobiology 49, 10-12.
51. Desai P, Nebes R, DeKosky ST, Kamboh MI (2005) Investigation of the effect of brain-derived neurotrophic factor (BDNF) polymorphisms on the risk of late-onset Alzheimer's disease (AD) and quantitative measures of AD progression. Neurosci Lett 379, 229-234.
52. Proschel M, Saunders A, Roses AD, Muller CR (1992) Dinucleotide repeat polymorphism at the human gene for the brain-derived neurotrophic factor (BDNF). Hum Mol Gene 1, 353.
53. Lu B, Pang PT, Woo NH (2005) The yin and yang of neurotrophin action. Nat Rev Neurosci 6, 603-614.
54. Chen ZY, Patel PD, Sant G, Meng CX, Teng KK, Hempstead BL, Lee FS (2004) Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons. J Neurosci 24, 4401-4411.
55. Chen ZY, Jing D, Bath KG, Ieraci A, Khan T, Siao CJ, Herrera DG, Toth M, Yang C, McEwen BS, Hempstead BL, Lee FS (2006) Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior. Science 314, 140-143.
56. McCauley JL, Olson LM, Dowd M, Amin T, Steele A, Blakely RD, Folstein SE, Haines JL, Sutcliffe JS (2004) Linkage and association analysis at the serotonin transporter (SLC6A4) locus in a rigid-compulsive subset of autism. Am J Med Genet B Neuropsychiatr Genet 127B, 104-112.
57. Rajewska-Rager A, Skibinska M, Szczepankiewicz A, Kapelski P, Dmitrzak-Weglarz M, Leszczynska-Rodziewicz A, Hauser J (2008) Association between polymorphisms of Val66Met in the BDNF gene and the response to escitalopram and nortriptyline treatment in the light of the neurodevelopmental hypothesis of depression. Psychiatr Pol 42, 915-923.
58. Domschke K, Lawford B, Laje G, Berger K, Young R, Morris P, Deckert J, Arolt V, McMahon FJ, Baune BT (2010) Brainderived neurotrophic factor (BDNF) gene: no major impact on antidepressant treatment response. Int J Neuropsychopharmacol 13, 93-101.
59. Swartz M, Barak Y, Mirecki I, Naor S, Weizman A (2000) Treating depression in Alzheimer's disease: integration of differing guidelines. Int Psychogeriatr 12, 353-358.
60. Lyketsos CG, Lee HB (2004) Diagnosis and treatment of depression in Alzheimer's disease. A practical update for the clinician. Dement Geriatr Cogn Disord 17, 55-64.
61. Mignone F, Gissi C, Liuni S, Pesole G (2002) Untranslated regions of mRNAs. Genome Biol 3, REVIEWS0004.