Brain-derived neurotrophic factor (BDNF) gene: No major impact on antidepressant treatment response

International Journal of Neuropsychopharmacology

Volumn 13, Issue 1, 2010, Pages 93-101

  Domschke, Katharina ^a   Lawford, Bruce ^b,c   Laje, Gonzalo ^d   Berger, Klaus ^a   Young, Ross ^c   Morris, Phillip ^c   Deckert, Jürgen ^e   Arolt, Volker ^a   McMahon, Francis J ^d   Baune, Bernhard T ^f  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

^c QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

^d NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^e UNIVERSITY OF WÜRZBURG   (Germany)

^f JAMES COOK UNIVERSITY   (Australia)

Author keywords

Antidepressant; BDNF; D; Depression; Neurotrophins; Pharmacogenetics; STAR; Treatment response

Indexed keywords

ANTIDEPRESSANT AGENT; ATYPICAL ANTIPSYCHOTIC AGENT; BENZODIAZEPINE DERIVATIVE; BIOLOGICAL MARKER; BRAIN DERIVED NEUROTROPHIC FACTOR; CITALOPRAM; ESCITALOPRAM; LITHIUM; METHIONINE; MIRTAZAPINE; MONOAMINE OXIDASE INHIBITOR; OLANZAPINE; QUETIAPINE; RISPERIDONE; TRICYCLIC ANTIDEPRESSANT AGENT; VALINE; VALPROIC ACID; VENLAFAXINE;

ADULT; AMINO ACID SUBSTITUTION; ARTICLE; CLINICAL ASSESSMENT TOOL; CONTROLLED STUDY; DEPRESSION; ELECTROCONVULSIVE THERAPY; FEMALE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; GERMANY; HUMAN; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; MELANCHOLIA; PHARMACOGENETICS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; TREATMENT DURATION; TREATMENT OUTCOME; TREATMENT RESPONSE;

ANTIDEPRESSIVE AGENTS; ANXIETY; BRAIN-DERIVED NEUROTROPHIC FACTOR; DEPRESSIVE DISORDER, MAJOR; FEMALE; GENETIC ASSOCIATION STUDIES; GENOTYPE; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; TREATMENT OUTCOME;

EID: 77949580959     PISSN: 14611457     EISSN: 14695111     Source Type: Journal    
DOI: 10.1017/S1461145709000030     Document Type: Article

References (40)

1. Altar CA, Whitehead RE, Chen G, Wörtwein G, Madsen TM (2003). Effects of electroconvulsive seizures and antidepressant drugs on brain-derived neurotrophic factor protein in rat brain. Biological Psychiatry 54, 703-709.
2. Anttila S, Huuhka K, Huuhka M, Rontu R, Hurme M, Leinonen E, Lehtimäki T (2007). Interaction between 5-HT1A and BDNF genotypes increases the risk of treatment-resistant depression. Journal of Neural Transmission 114, 1065-1068.
3. Baune BT, Hohoff C, Berger K, Neumann A, Mortensen S, Roehrs T, Deckert J, Arolt V, Domschke K (2008a). Association of the COMT val158met variant with antidepressant treatment response in major depression. Neuropsychopharmacology 33, 924-932.
4. Baune BT, Hohoff C, Roehrs T, Deckert J, Arolt V, Domschke K (2008b). Serotonin receptor 1A-1019C/G variant: impact on antidepressant pharmacoresponse in melancholic depression? Neuroscience Letters 436, 111-115.
5. Benjamini Y, Hochberg Y (1995). Controlling the false discovery rate-a practical and powerful approach to multiple testing. Journal of the Royal Statistical Society B 57, 289-300.
6. Chen B, Dowlatshahi D, MacQueen GM, Wang JF, Young LT (2001). Increased hippocampal BDNF immunoreactivity in subjects treated with antidepressant medication. Biological Psychiatry 50, 260-265.
7. Chen L, Lawlor D, Lewis S, Yuan W, Abdollahi M, Timpson N, Day I, Ebrahim S, Smith G, Shugart Y (2008). Genetic association study of BDNF in depression: finding from two cohort studies and a meta-analysis. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics 147B, 814-821.
8. Choi M, Kang R, Lim S, Oh K, Lee M (2006). Brain-derived neurotrophic factor gene polymorphism (Val66Met) and citalopram response in major depressive disorder. Brain Research 1118, 176-182.
9. Domschke K, Dannlowski U, Ohrmann P, Lawford B, Bauer J, Kugel H, Heindel W, Young R, Morris P, Arolt V, et al. (2008a). Cannabinoid receptor 1 (CNR1) gene: impact on antidepressant treatment response and emotion processing in major depression. European Journal of Neuropsychopharmacology 18, 751-759.
10. Domschke K, Hohoff C, Mortensen L, Roehrs T, Deckert J, Arolt V, Baune B (2008b). Monoamine oxidase A variant influences antidepressant treatment response in female patients with major depression. Progress in Neuropsychopharmacology & Biological Psychiatry 32, 224-228.
11. Duman R (1999). The neurochemistry of mood disorders: preclinical studies. In: Charney D, Nestler E, Bunney B (Eds), The Neurobiology of Mental Illness (pp. 333-347). New York: Oxford University Press.
12. Egan M, Kojima M, Callicott J, Goldberg T, Kolachana B, Bertolino A, Zaitsev E, Gold B, Goldman D, Dean M, Lu B, Weinberger D (2003). The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 112, 257-269.
13. Fava M, Rush A, Alpert J, Balasubramani G, Wisniewski S, Carmin C, Biggs M, Zisook S, Leuchter A, Howland R, Warden D, Trivedi M (2008). Difference in treatment outcome in outpatients with anxious versus nonanxious depression: a STAR*D report. American Journal of Psychiatry 165, 342-351.
14. Green E Craddock N (2003). Brain-derived neurotrophic factor as a potential risk locus for bipolar disorder: evidence, limitations, and implications. Current Psychiatry Reports 5, 469-476.
15. Hong C, Huo S, Yen F, Tung C, Pan G, Tsai S (2003). Association study of a brain-derived neurotrophic-factor genetic polymorphism and mood disorders, age of onset and suicidal behavior. Neuropsychobiology 48, 186-189.
16. Huang R, Huang J, Cathcart H, Smith S, Poduslo S (2007). Genetic variants in brain-derived neurotrophic factor associated with Alzheimer's disease. Journal of Medical Genetics 44, 66-71.
17. Hwang J, Tsai S, Hong C, Yang C, Lirng J, Yang Y (2006). The Val66Met polymorphism of the brain-derived neurotrophic-factor gene is associated with geriatric depression. Neurobiology of Aging 27, 1834-1837.
18. Iga J, Ueno S, Yamauchi K, Numata S, Tayoshi-Shibuya S, Kinouchi S, Nakataki M, Song H, Hokoishi K, Tanabe H, Sano A, Ohmori T (2007). The Val66Met polymorphism of the brain-derived neurotrophic factor gene is associated with psychotic feature and suicidal behavior in Japanese major depressive patients. American Journal of Medical Genetics, Part B Neuropsychiatric Genetics 144, 1003-1006.
19. Jansson M, Gatz M, Berg S, Johansson B, Malmberg B, McClearn G, Schalling M, Pedersen N (2004). Gender differences in heritability of depressive symptoms in the elderly. Psychological Medicine 34, 471-479.
20. Jiang X, Xu K, Hoberman J, Tian F, Marko AJ, Waheed JF, Harris CR, Marini AM, Enoch MA, Lipsky RH (2005). BDNF variation and mood disorders: a novel functional promoter polymorphism and Val66Met are associated with anxiety but have opposing effects. Neuropsychopharmacology 30, 1353-1361.
21. Kendler K, Gatz M, Gardner C, Pedersen N (2006). A Swedish national twin study of lifetime major depression. American Journal of Psychiatry 163, 109-114.
22. Lang U, Hellweg R, Kalus P, Bajbouj M, Lenzen K, Sander T, Kunz D, Gallinat J (2005). Association of a functional BDNF polymorphism and anxiety-related personality traits. Psychopharmacology 180, 95-99.
23. Martinowich K, Lu B (2008). Interaction between BDNF and serotonin: role in mood disorders. Neuropsychopharmacology 33, 73-83.
24. McMahon FJ, Buervenich S, Charney D, Lipsky R, Rush AJ, Wilson AF, Sorant AJ, Papanicolaou GJ, Laje G, Fava M, et al. (2006). Variation in the gene encoding the serotonin 2A receptor is associated with outcome of antidepressant treatment. American Journal of Human Genetics 78, 804-814.
25. Mercader J, Ribasés M, Gratacòs M, González J, Bayés M, de Cid R, Badía A, Fernández-Aranda F, Estivill X (2007). Altered brain-derived neurotrophic factor blood levels and gene variability are associated with anorexia and bulimia. Genes Brain Behavior 6, 706-716.
26. Neeper S, Gomez-Pinilla F, Choi J, Cotman C (1996). Physical activity increases mRA for brain-derived neurotrophic factor and nerve growth factor in rat brain. Brain Research 726, 49-56.
27. Nibuya M, Morinobu S, Duman R (1995). Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments. Journal of Neuroscience 15, 7539-7547.
28. TM assay: increased plexing efficiency and flexibility for MassARRAY system through single base primer extension with mass-modified terminators (http://www.agrf.org.au/docstore/snp/iPlex.pdf). Accessed 21 June 2008.
29. Radloff L (1977). The CES-D Scale: a self-report depression scale for research in the general population. Applied Psychological Measurement 1, 385-401.
30. Ribeiro L, Busnello J, Cantor R, Whelan F, Whittaker P, Deloukas P, Wong M, Licinio J (2007). The brain-derived neurotrophic factor rs6265 (Val66Met) polymorphism and depression in Mexican-Americans. Neuroreport 18, 1291-1293.
31. Saarelainen T, Hendolin P, Lucas G, Koponen E, Sairanen M, MacDonald E, Agerman K, Haapasalo A, Nawa H, Aloyz R, Ernfors P, Castrén E (2003). Activation of the TrkB neurotrophin receptor is induced by antidepressant drugs and is required for antidepressant-induced behavioral effects. Journal of Neuroscience 23, 349-357.
32. Schumacher J, Jamra R, Becker T, Ohlraun S, Klopp N, Binder E, Schulze T, Deschner M, Schmäl C, Höfels S, et al. (2005). Evidence for a relationship between genetic variants at the brain-derived neurotrophic factor (BDNF) locus and major depression. Biological Psychiatry 58, 307-314.
33. Seidah N, Benjannet S, Pareek S, Chrétien M, Murphy R (1996). Cellular processing of the neurotrophin precursors of NT3 and BDNF by the mammalian proprotein convertases. FEBS Letters 379, 247-250.
34. Sen S, Nesse R, Stoltenberg S, Li S, Gleiberman L, Chakravarti A, Weder A, Burmeister M (2003). A BDNF coding variant is associated with the NEO personality inventory domain neuroticism, a risk factor for depression. Neuropsychopharmacology 28, 397-401.
35. Shirayama Y, Chen A, Nakagawa S, Russell D, Duman R (2002). Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression. Journal of Neuroscience 22, 3251-3261.
36. Siuciak J, Lewis D, Wiegand S, Lindsay R (1997). Antidepressant-like effect of brain-derived neurotrophic factor (BDNF). Pharmacology Biochemistry Behavior 56, 131-137.
37. Smith M, Makino S, Kvetnansky R, Post R (1995). Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus. Journal of Neuroscience 15, 1768-1777.
38. Tsai S, Cheng C, Yu Y, Chen T, Hong C (2003). Association study of a brain-derived neurotrophic-factor genetic polymorphism and major depressive disorders, symptomatology, and antidepressant response. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics 123, 19-22.
39. Ventriglia M, Bocchio Chiavetto L, Benussi L, Binetti G, Zanetti O, Riva MA, Gennarelli M (2002). Association between the BDNF 196 A/G polymorphism and sporadic Alzheimer's disease. Molecular Psychiatry 7, 136-137.
40. Weissman M, Bland R, Joyce P, Newman S, Wells J, Wittchen H (1993). Sex differences in rates of depression: cross-national perspectives. Journal of Affective Disorder 29, 77-84.