Heterozygosity in the glutathione synthesis gene Gclm increases sensitivity to diesel exhaust particulate induced lung inflammation in mice

Inhalation Toxicology

Volumn 23, Issue 12, 2011, Pages 724-735

  Weldy, Chad S ^a   White, Collin C ^a   Wilkerson, Hui Wen ^a   Larson, Timothy V ^b   Stewart, James A ^a   Gill, Sean E ^a   Parks, William C ^a   Kavanagh, Terrance J ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b University of Washington   (United States)

Author keywords

Diesel exhaust particulate; Glutamate cysteine ligase; Glutathione; Lung inflammation; Oxidative stress

Indexed keywords

DIESEL FUEL; GLUTAMATE CYSTEINE LIGASE; GLUTAMATE CYSTEINE LIGASE CATALYTIC SUBUNIT; GLUTAMATE CYSTEINE LIGASE MODIFIER SUBUNIT; GLUTATHIONE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 1BETA; INTERLEUKIN 6; MATRIX METALLOPROTEINASE; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; MYELOPEROXIDASE; PROTEIN SUBUNIT; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE PREDISPOSITION; ENZYME ACTIVITY; EXHAUST GAS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC SUSCEPTIBILITY; GLUTATHIONE METABOLISM; HETEROZYGOSITY; LUNG LAVAGE; LUNG PARENCHYMA; MALE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; OXIDATIVE STRESS; PARTICULATE MATTER; PNEUMONIA; PRIORITY JOURNAL; PROTEIN CONTENT; TISSUE LEVEL; WILD TYPE;

AIR POLLUTANTS; ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; GENE EXPRESSION REGULATION; GLUTAMATE-CYSTEINE LIGASE; GLUTATHIONE; HETEROZYGOTE; INFLAMMATION; LUNG DISEASES; MALE; MICE; PARTICULATE MATTER; PROTEIN SUBUNITS; VEHICLE EMISSIONS;

MUS;

EID: 80053485020     PISSN: 08958378     EISSN: 10917691     Source Type: Journal    
DOI: 10.3109/08958378.2011.608095     Document Type: Article

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