-
1
-
-
61849136670
-
Prognostic potential of the pre-therapeutic tumor oxygenation status
-
Vaupel P. Prognostic potential of the pre-therapeutic tumor oxygenation status. Adv Exp Med Biol 2009;645:241-6.
-
(2009)
Adv Exp Med Biol
, vol.645
, pp. 241-246
-
-
Vaupel, P.1
-
2
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
Semenza GL. Targeting HIF-1 for cancer therapy. Nat Rev 2003;3: 721-32.
-
(2003)
Nat Rev
, vol.3
, pp. 721-732
-
-
Semenza, G.L.1
-
4
-
-
12444279265
-
On the origin of cancer cells
-
Warburg O. On the origin of cancer cells. Science 1956;123:309-14.
-
(1956)
Science
, vol.123
, pp. 309-314
-
-
Warburg, O.1
-
5
-
-
0026568374
-
Variations in tumor cell growth rates and metabolism with oxygen concentration, glucose concentration, and extracellular pH
-
Casciari JJ, Sotirchos SV, Sutherland RM. Variations in tumor cell growth rates and metabolism with oxygen concentration, glucose concentration, and extracellular pH. J Cell Physiol 1992;151:386-94.
-
(1992)
J Cell Physiol
, vol.151
, pp. 386-394
-
-
Casciari, J.J.1
Sotirchos, S.V.2
Sutherland, R.M.3
-
7
-
-
0026667219
-
Role for c-myc in activation-induced apoptotic cell death in T cell hybridomas
-
Shi Y, Glynn JM, Guilbert LJ, Cotter TG, Bissonnette RP, Green DR. Role for c-myc in activation-induced apoptotic cell death in T cell hybridomas. Science 1992;257:212-4.
-
(1992)
Science
, vol.257
, pp. 212-214
-
-
Shi, Y.1
Glynn, J.M.2
Guilbert, L.J.3
Cotter, T.G.4
Bissonnette, R.P.5
Green, D.R.6
-
10
-
-
0031589555
-
Regulation of Cre recombinase activity by mutated estrogen receptor ligand-binding domains
-
Feil R, Wagner J, Metzger D, Chambon P. Regulation of Cre recombinase activity by mutated estrogen receptor ligand-binding domains. Biochem Biophys Res Commun 1997;237:752-7.
-
(1997)
Biochem Biophys Res Commun
, vol.237
, pp. 752-757
-
-
Feil, R.1
Wagner, J.2
Metzger, D.3
Chambon, P.4
-
11
-
-
0033571243
-
Temporally-controlled site-specific mutagenesis in the basal layer of the epidermis: Comparison of the recombinase activity of the tamoxifen- Inducible Cre-ER(T) and Cre-ER(T2) recombinases
-
Indra AK, Warot X, Brocard J, Bornert JM, Xiao JH, Chambon P, et al. Temporally-controlled site-specific mutagenesis in the basal layer of the epidermis: comparison of the recombinase activity of the tamoxifen- inducible Cre-ER(T) and Cre-ER(T2) recombinases. Nucleic Acids Res 1999;27:4324-7.
-
(1999)
Nucleic Acids Res
, vol.27
, pp. 4324-4327
-
-
Indra, A.K.1
Warot, X.2
Brocard, J.3
Bornert, J.M.4
Xiao, J.H.5
Chambon, P.6
-
12
-
-
0029164598
-
Conditional sitespecific recombination in mammalian cells using a ligand-dependent chimeric Cre recombinase
-
Metzger D, Clifford J, Chiba H, Chambon P. Conditional sitespecific recombination in mammalian cells using a ligand-dependent chimeric Cre recombinase. Proc Natl Acad Sci U S A 1995;92: 6991-5.
-
(1995)
Proc Natl Acad Sci U S A
, vol.92
, pp. 6991-6995
-
-
Metzger, D.1
Clifford, J.2
Chiba, H.3
Chambon, P.4
-
13
-
-
23844485492
-
Reduced expression of hypoxia-inducible factor-1alpha in perinecrotic regions of solid tumors
-
Sobhanifar S, Aquino-Parsons C, Stanbridge EJ, Olive P. Reduced expression of hypoxia-inducible factor-1alpha in perinecrotic regions of solid tumors. Cancer Res 2005;65:7259-66.
-
(2005)
Cancer Res
, vol.65
, pp. 7259-7266
-
-
Sobhanifar, S.1
Aquino-Parsons, C.2
Stanbridge, E.J.3
Olive, P.4
-
14
-
-
33744959141
-
Expression of vascular endothelial growth factor receptor 1 in bone marrow-derived mesenchymal cells is dependent on hypoxia-inducible factor 1
-
Okuyama H, Krishnamachary B, Zhou YF, Nagasawa H, Bosch-Marce M, Semenza GL. Expression of vascular endothelial growth factor receptor 1 in bone marrow-derived mesenchymal cells is dependent on hypoxia-inducible factor 1. J Biol Chem 2006;281:15554-63.
-
(2006)
J Biol Chem
, vol.281
, pp. 15554-15563
-
-
Okuyama, H.1
Krishnamachary, B.2
Zhou, Y.F.3
Nagasawa, H.4
Bosch-Marce, M.5
Semenza, G.L.6
-
15
-
-
0031023381
-
Method for measuring a comprehensive energy budget in a proliferating cell system over multiple cell cycles
-
Guppy M, Kong SE, Niu X, Busfield S, Klinken SP. Method for measuring a comprehensive energy budget in a proliferating cell system over multiple cell cycles. J Cell Physiol 1997;170:1-7.
-
(1997)
J Cell Physiol
, vol.170
, pp. 1-7
-
-
Guppy, M.1
Kong, S.E.2
Niu, X.3
Busfield, S.4
Klinken, S.P.5
-
16
-
-
34247614521
-
HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity
-
Zhang H, Gao P, Fukuda R, Kumar G, Krishnamachary B, Zeller KI, et al. HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity. Cancer Cell 2007;11:407-20.
-
(2007)
Cancer Cell
, vol.11
, pp. 407-420
-
-
Zhang, H.1
Gao, P.2
Fukuda, R.3
Kumar, G.4
Krishnamachary, B.5
Zeller, K.I.6
-
17
-
-
31144478127
-
Mxi1 is induced by hypoxia in a HIF-1-dependent manner and protects cells from c-Myc-induced apoptosis
-
Corn PG, Ricci MS, Scata KA, Arsham AM, Simon MC, Dicker DT, et al. Mxi1 is induced by hypoxia in a HIF-1-dependent manner and protects cells from c-Myc-induced apoptosis. Cancer Biol Therapy 2005;4:1285-94.
-
(2005)
Cancer Biol Therapy
, vol.4
, pp. 1285-1294
-
-
Corn, P.G.1
Ricci, M.S.2
Scata, K.A.3
Arsham, A.M.4
Simon, M.C.5
Dicker, D.T.6
-
18
-
-
0026025416
-
Degradation of nuclear oncoproteins by the ubiquitin system in vitro
-
Ciechanover A, DiGiuseppe JA, Bercovich B, Orian A, Richter JD, Schwartz AL, et al. Degradation of nuclear oncoproteins by the ubiquitin system in vitro. Proc Natl Acad Sci U S A 1991;88:139-43.
-
(1991)
Proc Natl Acad Sci U S A
, vol.88
, pp. 139-143
-
-
Ciechanover, A.1
DiGiuseppe, J.A.2
Bercovich, B.3
Orian, A.4
Richter, J.D.5
Schwartz, A.L.6
-
19
-
-
0033081027
-
Destruction of Myc by ubiquitin-mediated proteolysis: Cancer-associated and transforming mutations stabilize Myc
-
Salghetti SE, Kim SY, Tansey WP. Destruction of Myc by ubiquitin-mediated proteolysis: cancer-associated and transforming mutations stabilize Myc. EMBO J 1999;18:717-26.
-
(1999)
EMBO J
, vol.18
, pp. 717-726
-
-
Salghetti, S.E.1
Kim, S.Y.2
Tansey, W.P.3
-
20
-
-
57449097020
-
Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice
-
Sonveaux P, Vegran F, Schroeder T,, Wergin MC, Verrax J, Rabbani ZN, et al. Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice. J Clin Invest 2008;118:3930-42.
-
(2008)
J Clin Invest
, vol.118
, pp. 3930-3942
-
-
Sonveaux, P.1
Vegran, F.2
Schroeder, T.3
Wergin, M.C.4
Verrax, J.5
Rabbani, Z.N.6
-
21
-
-
0024281372
-
Cell and environment interactions in tumor microregions: The multicell spheroid model
-
Sutherland RM. Cell and environment interactions in tumor microregions: the multicell spheroid model. Science 1988;240:177-84.
-
(1988)
Science
, vol.240
, pp. 177-184
-
-
Sutherland, R.M.1
-
22
-
-
34547121206
-
Hypoxia in cancer: Significance and impact on clinical outcome
-
Vaupel P, Mayer A. Hypoxia in cancer: significance and impact on clinical outcome. Cancer Metastasis Rev 2007;26:225-39.
-
(2007)
Cancer Metastasis Rev
, vol.26
, pp. 225-239
-
-
Vaupel, P.1
Mayer, A.2
-
23
-
-
0035925098
-
Tumor hypoxia: Definitions and current clinical, biologic, and molecular aspects
-
Hockel M, Vaupel P. Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects. J Natl Cancer Inst 2001;93:266-76.
-
(2001)
J Natl Cancer Inst
, vol.93
, pp. 266-276
-
-
Hockel, M.1
Vaupel, P.2
-
24
-
-
7744220635
-
MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer
-
Shachaf CM, Kopelman AM, Arvanitis C, Karlsson A, Beer S, Mandl S, et al. MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer. Nature 2004;431:1112-7.
-
(2004)
Nature
, vol.431
, pp. 1112-1117
-
-
Shachaf, C.M.1
Kopelman, A.M.2
Arvanitis, C.3
Karlsson, A.4
Beer, S.5
Mandl, S.6
-
25
-
-
0037025201
-
Sustained loss of a neoplastic phenotype by brief inactivation of MYC
-
Jain M, Arvanitis C, Chu K, Dewey W, Leonhardt E, Trinh M, , et al. Sustained loss of a neoplastic phenotype by brief inactivation of MYC. Science 2002;297:102-4.
-
(2002)
Science
, vol.297
, pp. 102-104
-
-
Jain, M.1
Arvanitis, C.2
Chu, K.3
Dewey, W.4
Leonhardt, E.5
Trinh, M.6
-
26
-
-
19644376774
-
Tumor dormancy and MYC inactivation: Pushing cancer to the brink of normalcy
-
Shachaf CM, Felsher DW. Tumor dormancy and MYC inactivation: pushing cancer to the brink of normalcy. Cancer Res 2005;65:4471-4.
-
(2005)
Cancer Res
, vol.65
, pp. 4471-4474
-
-
Shachaf, C.M.1
Felsher, D.W.2
-
27
-
-
34547580590
-
HIF and c-Myc: Sibling rivals for control of cancer cell metabolism and proliferation
-
Gordan JD, Thompson CB, Simon MC. HIF and c-Myc: sibling rivals for control of cancer cell metabolism and proliferation. Cancer Cell 2007;12:108-13.
-
(2007)
Cancer Cell
, vol.12
, pp. 108-113
-
-
Gordan, J.D.1
Thompson, C.B.2
Simon, M.C.3
-
29
-
-
3142631736
-
HIF-1alpha induces cell cycle arrest by functionally counteracting Myc
-
Koshiji M, Kageyama Y, Pete EA, Horikawa I, Barrett JC, Huang LE. HIF-1alpha induces cell cycle arrest by functionally counteracting Myc. EMBO J 2004;23:1949-56.
-
(2004)
EMBO J
, vol.23
, pp. 1949-1956
-
-
Koshiji, M.1
Kageyama, Y.2
Pete, E.A.3
Horikawa, I.4
Barrett, J.C.5
Huang, L.E.6
-
30
-
-
33947217823
-
Interaction between beta-catenin and HIF-1 promotes cellular adaptation to hypoxia
-
Kaidi A, Williams AC, Paraskeva C. Interaction between beta-catenin and HIF-1 promotes cellular adaptation to hypoxia. Nat Cell Biol 2007;9:210-7.
-
(2007)
Nat Cell Biol
, vol.9
, pp. 210-217
-
-
Kaidi, A.1
Williams, A.C.2
Paraskeva, C.3
-
31
-
-
0021688655
-
Proteins encoded by the human c-myc oncogene: Differential expression in neoplastic cells
-
Hann SR, Eisenman RN. Proteins encoded by the human c-myc oncogene: differential expression in neoplastic cells. Mol Cell Biol 1984;4:2486-97.
-
(1984)
Mol Cell Biol
, vol.4
, pp. 2486-2497
-
-
Hann, S.R.1
Eisenman, R.N.2
-
32
-
-
2942650133
-
The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation
-
Welcker M, Orian A, Jin J, Grim JE, Harper JW, Eisenman RN, et al. The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation- dependent c-Myc protein degradation. Proc Natl Acad Sci U S A 2004;101:9085-90.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 9085-9090
-
-
Welcker, M.1
Orian, A.2
Jin, J.3
Grim, J.E.4
Harper, J.W.5
Eisenman, R.N.6
-
33
-
-
2942614705
-
Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7
-
Yada M, Hatakeyama S, Kamura T, Nishiyama M, Tsunematsu R, Imaki H, et al. Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7. EMBO J 2004;23:2116-25.
-
(2004)
EMBO J
, vol.23
, pp. 2116-2125
-
-
Yada, M.1
Hatakeyama, S.2
Kamura, T.3
Nishiyama, M.4
Tsunematsu, R.5
Imaki, H.6
-
34
-
-
0037648338
-
Skp2 regulates Myc protein stability and activity
-
Kim SY, Herbst A, Tworkowski KA, Salghetti SE, Tansey WP. Skp2 regulates Myc protein stability and activity. Mol Cell 2003;11:1177-88.
-
(2003)
Mol Cell
, vol.11
, pp. 1177-1188
-
-
Kim, S.Y.1
Herbst, A.2
Tworkowski, K.A.3
Salghetti, S.E.4
Tansey, W.P.5
-
35
-
-
12444264823
-
The F-box protein Skp2 participates in c-Myc proteosomal degradation and acts as a cofactor for c-Myc-regulated transcription
-
von der Lehr N, Johansson S, Wu S, Bahram F, Castell A, Cetinkaya C, et al. The F-box protein Skp2 participates in c-Myc proteosomal degradation and acts as a cofactor for c-Myc-regulated transcription. Mol Cell 2003;11:1189-200.
-
(2003)
Mol Cell
, vol.11
, pp. 1189-1200
-
-
Von Der Lehr, N.1
Johansson, S.2
Wu, S.3
Bahram, F.4
Castell, A.5
Cetinkaya, C.6
-
36
-
-
34347401998
-
The ubiquitin-specific protease USP28 is required for MYC stability
-
Popov N, Wanzel M, Madiredjo M, Zhang D, Beijersbergen R, Bernards R, et al. The ubiquitin-specific protease USP28 is required for MYC stability. Nat Cell Biol 2007;9:765-74.
-
(2007)
Nat Cell Biol
, vol.9
, pp. 765-774
-
-
Popov, N.1
Wanzel, M.2
Madiredjo, M.3
Zhang, D.4
Beijersbergen, R.5
Bernards, R.6
-
37
-
-
56849096837
-
HIF-alpha effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma
-
Gordan JD, Lal P, Dondeti VR, Letrero R, Parekh KN, Oquendo CE, et al. HIF-alpha effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma. Cancer Cell 2008;14:435-46.
-
(2008)
Cancer Cell
, vol.14
, pp. 435-446
-
-
Gordan, J.D.1
Lal, P.2
Dondeti, V.R.3
Letrero, R.4
Parekh, K.N.5
Oquendo, C.E.6
-
38
-
-
77949514451
-
Mechanisms of c-myc degradation by nickel compounds and hypoxia
-
Li Q, Kluz T, Sun H, Costa M. Mechanisms of c-myc degradation by nickel compounds and hypoxia. PLoS One 2009;4:e8531.
-
(2009)
PLoS One
, vol.4
-
-
Li, Q.1
Kluz, T.2
Sun, H.3
Costa, M.4
-
39
-
-
0032905924
-
c-Myc target genes involved in cell growth, apoptosis, and metabolism
-
Dang CV. c-Myc target genes involved in cell growth, apoptosis, and metabolism. Mol Cell Biol 1999;19:1-11.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 1-11
-
-
Dang, C.V.1
-
40
-
-
0025937489
-
Constitutive cmyc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis
-
Askew DS, Ashmun RA, Simmons BC, Cleveland JL. Constitutive cmyc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis. Oncogene 1991;6:1915-22.
-
(1991)
Oncogene
, vol.6
, pp. 1915-1922
-
-
Askew, D.S.1
Ashmun, R.A.2
Simmons, B.C.3
Cleveland, J.L.4
-
41
-
-
0026642195
-
Induction of apoptosis in fibroblasts by c-myc protein
-
Evan GI, Wyllie AH, Gilbert CS, Littlewood TD, Land H, Brooks M, et al. Induction of apoptosis in fibroblasts by c-myc protein. Cell 1992;69: 119-28.
-
(1992)
Cell
, vol.69
, pp. 119-128
-
-
Evan, G.I.1
Wyllie, A.H.2
Gilbert, C.S.3
Littlewood, T.D.4
Land, H.5
Brooks, M.6
-
42
-
-
0037663490
-
Werner syndrome protein limits MYC-induced cellular senescence
-
Grandori C, Wu KJ, Fernandez P, Ngouenet C, Grim J, Clurman BE, et al. Werner syndrome protein limits MYC-induced cellular senescence. Genes Dev 2003;17:1569-74.
-
(2003)
Genes Dev
, vol.17
, pp. 1569-1574
-
-
Grandori, C.1
Wu, K.J.2
Fernandez, P.3
Ngouenet, C.4
Grim, J.5
Clurman, B.E.6
-
43
-
-
0021178906
-
Biological activities of v-myc and rearranged c-myc oncogenes in rat fibroblast cells in culture
-
Mougneau E, Lemieux L, Rassoulzadegan M, Cuzin F. Biological activities of v-myc and rearranged c-myc oncogenes in rat fibroblast cells in culture. Proc Natl Acad Sci U S A 1984;81:5758-62.
-
(1984)
Proc Natl Acad Sci U S A
, vol.81
, pp. 5758-5762
-
-
Mougneau, E.1
Lemieux, L.2
Rassoulzadegan, M.3
Cuzin, F.4
-
44
-
-
0033001621
-
Reversible activation of c-Myc in skin: Induction of a complex neoplastic phenotype by a single oncogenic lesion
-
Pelengaris S, Littlewood T, Khan M, Elia G, Evan G. Reversible activation of c-Myc in skin: induction of a complex neoplastic phenotype by a single oncogenic lesion. Mol Cell 1999;3:565-77.
-
(1999)
Mol Cell
, vol.3
, pp. 565-577
-
-
Pelengaris, S.1
Littlewood, T.2
Khan, M.3
Elia, G.4
Evan, G.5
-
45
-
-
0028891783
-
Apoptosis, oncosis, and necrosis. An overview of cell death
-
Majno G, Joris I. Apoptosis, oncosis, and necrosis. An overview of cell death. Am J Pathol 1995;146:3-15.
-
(1995)
Am J Pathol
, vol.146
, pp. 3-15
-
-
Majno, G.1
Joris, I.2
-
46
-
-
73549104022
-
Molecular mechanisms of necrosis in glioblastoma: The role of glutamate excitotoxicity
-
Noch E, Khalili K. Molecular mechanisms of necrosis in glioblastoma: the role of glutamate excitotoxicity. Cancer Biol Ther 2009;8:1791-7.
-
(2009)
Cancer Biol Ther
, vol.8
, pp. 1791-1797
-
-
Noch, E.1
Khalili, K.2
-
47
-
-
27344438327
-
Cells die with increased cytosolic ATP during apoptosis: A bioluminescence study with intracellular luciferase
-
Zamaraeva MV, Sabirov RZ, Maeno E, Ando-Akatsuka Y, Bessonova SV, Okada Y. Cells die with increased cytosolic ATP during apoptosis: a bioluminescence study with intracellular luciferase. Cell Death Differ 2005;12:1390-7.
-
(2005)
Cell Death Differ
, vol.12
, pp. 1390-1397
-
-
Zamaraeva, M.V.1
Sabirov, R.Z.2
Maeno, E.3
Ando-Akatsuka, Y.4
Bessonova, S.V.5
Okada, Y.6
-
48
-
-
0024545981
-
Energy dependence of different steps in the autophagic-lysosomal pathway
-
Plomp PJ, Gordon PB, Meijer AJ, Hoyvik H, Seglen PO. Energy dependence of different steps in the autophagic-lysosomal pathway. J Biol Chem 1989;264:6699-704.
-
(1989)
J Biol Chem
, vol.264
, pp. 6699-6704
-
-
Plomp, P.J.1
Gordon, P.B.2
Meijer, A.J.3
Hoyvik, H.4
Seglen, P.O.5
-
49
-
-
0034856827
-
Glutamine and cancer
-
discussion 50S-1S
-
Medina MA. Glutamine and cancer. J Nutr 2001;131(9Suppl):2539S- 42S; discussion 50S-1S.
-
(2001)
J Nutr
, vol.131
, Issue.9 SUPPL.
-
-
Medina, M.A.1
-
50
-
-
34347402459
-
Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells
-
Yuneva M, Zamboni N, Oefner P, Sachidanandam R, Lazebnik Y. Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells. J Cell Biol 2007;178:93-105.
-
(2007)
J Cell Biol
, vol.178
, pp. 93-105
-
-
Yuneva, M.1
Zamboni, N.2
Oefner, P.3
Sachidanandam, R.4
Lazebnik, Y.5
|