Neuroprotective effects of granulocyte colony-stimulating factor and relationship to promotion of angiogenesis after spinal cord injury in rats: Laboratory investigation

Journal of Neurosurgery: Spine

Volumn 15, Issue 4, 2011, Pages 414-421

  Kawabe, Junko ^a   Koda, Masao ^b   Hashimoto, Masayuki ^a   Fujiyoshi, Takayuki ^a   Furuya, Takeo ^a   Endo, Tomonori ^a   Okawa, Akihiko ^a   Yamazaki, Masashi ^a  

^a CHIBA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b CHIBA AOBA MUNICIPAL HOSPITAL   (Japan)

Author keywords

Angiogenesis; Granulocyte colony stimulating factor; Hindlimb function; Spinal cord injury

Indexed keywords

ANGIOPOIETIN 1; CYTOKINE; FIBROBLAST GROWTH FACTOR 2; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; SCAVENGER RECEPTOR A; VASCULOTROPIN; VON WILLEBRAND FACTOR;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD SPINAL CORD BARRIER; BLOOD VESSEL DIAMETER; BONE MARROW CELL; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; CONVALESCENCE; DEMYELINATION; EXTRAVASATION; FEMALE; FUNCTION TEST; GENE EXPRESSION; GLIA; HINDLIMB; IMMUNOHISTOCHEMISTRY; MOTOR PERFORMANCE; NERVE CELL DIFFERENTIATION; NEUROPROTECTION; NONHUMAN; OLIGODENDROGLIA; PERMEABILITY BARRIER; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPINAL CORD INJURY;

ANIMALS; CYTOKINES; DISEASE MODELS, ANIMAL; FEMALE; GRANULOCYTE COLONY-STIMULATING FACTOR; MOTOR ACTIVITY; NEOVASCULARIZATION, PHYSIOLOGIC; NEURONS; NEUROPROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; RECOVERY OF FUNCTION; SPINAL CORD; SPINAL CORD INJURIES;

EID: 80053443043     PISSN: 15475654     EISSN: 15475646     Source Type: Journal    
DOI: 10.3171/2011.5.SPINE10421     Document Type: Article

References (31)

1. Augustin HG: Antiangiogenic tumour therapy: will it work? Trends Pharmacol Sci 19:216-222, 1998
2. Basso DM, Beattie MS, Bresnahan JC: A sensitive and reliable locomotor rating scale for open field testing in rats. J Neurotrauma 12:1-21, 1995
3. Benton RL, Whittemore SR: VEGF165 therapy exacerbates secondary damage following spinal cord injury. Neurochem Res 28:1693-1703, 2003 (Pubitemid 37296211)
4. Casella GT, Marcillo A, Bunge MB, Wood PM: New vascular tissue rapidly replaces neural parenchyma and vessels destroyed by a contusion injury to the rat spinal cord. Exp Neurol 173:63-76, 2002 (Pubitemid 34081726)
5. Date I, Takagi N, Takagi K, Kago T, Matsumoto K, Nakamura T, et al: Hepatocyte growth factor attenuates cerebral ischemia-induced learning dysfunction. Biochem Biophys Res Commun 319:1152-1158, 2004 (Pubitemid 38759532)
6. Ding XM, Mao BY, Jiang S, Li SF, Deng YL: Neuroprotective effect of exogenous vascular endothelial growth factor on rat spinal cord neurons in vitro hypoxia. Chin Med J (Engl) 118:1644-1650, 2005 (Pubitemid 41489041)
7. el Hafny B, Bourre JM, Roux F: Synergistic stimulation of gamma-glutamyl transpeptidase and alkaline phosphatase activities by retinoic acid and astroglial factors in immortalized rat brain microvessel endothelial cells. J Cell Physiol 167:451-460, 1996
8. Gibson CL, Jones NC, Prior MJ, Bath PM, Murphy SP: GCSF suppresses edema formation and reduces interleukin-1β expression after cerebral ischemia in mice. J Neuropathol Exp Neurol 64:763-769, 2005 (Pubitemid 41285808)
9. Hayashi T, Abe K, Itoyama Y: Reduction of ischemic damage by application of vascular endothelial growth factor in rat brain after transient ischemia. J Cereb Blood Flow Metab 18:887-895, 1998 (Pubitemid 28359907)
10. Jansen J, Hanks S, Thompson JM, Dugan MJ, Akard LP: Transplantation of hematopoietic stem cells from the peripheral blood. J Cell Mol Med 9:37-50, 2005
11. Kitamura K, Iwanami A, Nakamura M, Yamane J, Watanabe K, Suzuki Y, et al: Hepatocyte growth factor promotes endogenous repair and functional recovery after spinal cord injury. J Neurosci Res 85:2332-2342, 2007 (Pubitemid 47204748)
12. Koda M, Nishio Y, Kamada T, Someya Y, Okawa A, Mori C, et al: Granulocyte colony-stimulating factor (G-CSF) mobilizes bone marrow-derived cells into injured spinal cord and promotes functional recovery after compression-induced spinal cord injury in mice. Brain Res 1149:223-231, 2007 (Pubitemid 46659901)
13. Langford D, Hurford R, Hashimoto M, Digicaylioglu M, Masliah E: Signalling crosstalk in FGF2-mediated protection of endothelial cells from HIV-gp120. BMC Neurosci 6:8, 2005
14. Lee ST, Chu K, Jung KH, Ko SY, Kim EH, Sinn DI, et al: Granulocyte colony-stimulating factor enhances angiogenesis after focal cerebral ischemia. Brain Res 1058:120-128, 2005 (Pubitemid 41416806)
15. Loy DN, Crawford CH, Darnall JB, Burke DA, Onifer SM, Whittemore SR: Temporal progression of angiogenesis and basal lamina deposition after contusive spinal cord injury in the adult rat. J Comp Neurol 445:308-324, 2002 (Pubitemid 34252854)
16. Lu CZ, Xiao BG: G-CSF and neuroprotection: a therapeutic perspective in cerebral ischaemia. Biochem Soc Trans 34:1327-1333, 2006
17. Minatoguchi S, Takemura G, Chen XH, Wang N, Uno Y, Koda M, et al: Acceleration of the healing process and myocardial regeneration may be important as a mechanism of improvement of cardiac function and remodeling by postinfarction granulocyte colony-stimulating factor treatment. Circulation 109:2572-2580, 2004
18. Nishio Y, Koda M, Kamada T, Someya Y, Kadota R, Mannoji C, et al: Granulocyte colony-stimulating factor attenuates neuronal death and promotes functional recovery after spinal cord injury in mice. J Neuropathol Exp Neurol 66:724-731, 2007 (Pubitemid 47344251)
19. Ohki Y, Heissig B, Sato Y, Akiyama H, Zhu Z, Hicklin DJ, et al: Granulocyte colony-stimulating factor promotes neovascularization by releasing vascular endothelial growth factor from neutrophils. FASEB J 19:2005-2007, 2005 (Pubitemid 41759746)
20. Rivlin AS, Tator CH: Objective clinical assessment of motor function after experimental spinal cord injury in the rat. J Neurosurg 47:577-581, 1977 (Pubitemid 8193904)
21. Roberts AW: G-CSF: a key regulator of neutrophil production, but that's not all! Growth Factors 23:33-41, 2005
22. Schäbitz WR, Kollmar R, Schwaninger M, Juettler E, Bardutzky J, Schölzke MN, et al: Neuroprotective effect of granulocyte colony-stimulating factor after focal cerebral ischemia. Stroke 34:745-751, 2003 (Pubitemid 36307405)
23. Schneider A, Kuhn HG, Schäbitz WR: A role for G-CSF (granulocyte-colony stimulating factor) in the central nervous system. Cell Cycle 4:1753-1757, 2005 (Pubitemid 41827320)
24. Schoch HJ, Fischer S, Marti HH: Hypoxia-induced vascular endothelial growth factor expression causes vascular leakage in the brain. Brain 125:2549-2557, 2002 (Pubitemid 35303512)
25. Tator CH, Fehlings MG: Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms. J Neurosurg 75:15-26, 1991
26. Wamil AW, Wamil BD, Hellerqvist CG: CM101-mediated recovery of walking ability in adult mice paralyzed by spinal cord injury. Proc Natl Acad Sci U S A 95:13188-13193, 1998 (Pubitemid 28509546)
27. Welte K, Platzer E, Lu L, Gabrilove JL, Levi E, Mertelsmann R, et al: Purification and biochemical characterization of human pluripotent hematopoietic colony-stimulating factor. Proc Natl Acad Sci U S A 82:1526-1530, 1985 (Pubitemid 15120576)
28. Whalen MJ, Carlos TM, Wisniewski SR, Clark RS, Mellick JA, Marion DW, et al: Effect of neutropenia and granulocyte colony stimulating factor-induced neutrophilia on blood-brain barrier permeability and brain edema after traumatic brain injury in rats. Crit Care Med 28:3710-3717, 2000
29. Widenfalk J, Lipson A, Jubran M, Hofstetter C, Ebendal T, Cao Y, et al: Vascular endothelial growth factor improves functional outcome and decreases secondary degeneration in experimental spinal cord contusion injury. Neuroscience 120:951-960, 2003 (Pubitemid 36966647)
30. Yata K, Matchett GA, Tsubokawa T, Tang J, Kanamaru K, Zhang JH: Granulocyte-colony stimulating factor inhibits apoptotic neuron loss after neonatal hypoxia-ischemia in rats. Brain Res 1145:227-238, 2007 (Pubitemid 46497988)
31. Zhang ZG, Zhang L, Jiang Q, Zhang R, Davies K, Powers C, et al: VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain. J Clin Invest 106:829-838, 2000