Granulocyte colony-stimulating factor attenuates neuronal death and promotes functional recovery after spinal cord injury in mice

Journal of Neuropathology and Experimental Neurology

Volumn 66, Issue 8, 2007, Pages 724-731

  Nishio, Yutaka ^a   Koda, Masao ^b   Kamada, Takahito ^a   Someya, Yukio ^a   Kadota, Ryo ^a   Mannoji, Chikato ^a   Miyashita, Tomohiro ^a   Okada, Seiji ^c   Okawa, Akihiko ^a   Moriya, Hideshige ^a   Yamazaki, Masashi ^a  

^a CHIBA UNIVERSITY   (Japan)

^b Chiba Prefectural Togane Hospital   (Japan)

^c KUMAMOTO UNIVERSITY   (Japan)

Author keywords

Apoptosis; Neuroprotection; Secondary injury

Indexed keywords

CRESYL VIOLET; DYE; GRANULOCYTE COLONY STIMULATING FACTOR RECEPTOR; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; EXPERIMENTAL MOUSE; FEMALE; HEMATOPOIESIS; HINDLIMB; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; SPINAL CORD INJURY;

ANIMALS; ANIMALS, NEWBORN; BEHAVIOR, ANIMAL; CASPASE 3; CELL DEATH; CELLS, CULTURED; CEREBELLUM; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FEMALE; GRANULOCYTE COLONY-STIMULATING FACTOR; MICE; MICE, INBRED BALB C; NEURONS; PHOSPHOPYRUVATE HYDRATASE; RECEPTORS, GRANULOCYTE COLONY-STIMULATING FACTOR; RECOVERY OF FUNCTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SPINAL CORD INJURIES; STATISTICS, NONPARAMETRIC; TIME FACTORS;

EID: 34548297819     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1097/nen.0b013e3181257176     Document Type: Article

References (26)

1. Profyris C, Cheema SS, Zang DW, et al. Degenerative and regenerative mechanisms governing spinal cord injury. Neurobiol Dis 2004;15:415-36
2. Nicola NA, Metcalf D, Matsumoto M, et al. Purification of a factor inducing differentiation in murine myelomonocytic leukemia cells. Identification as granulocyte colony-stimulating factor. J Biol Chem 1983;258:9017-23
3. Roberts AW. G-CSF: A key regulator of neutrophil production, but that's not all! Growth Factors 2005;23:33-41
4. Harada M, Qin Y, Takano H, et al. G-CSF prevents cardiac remodeling after myocardial infarction by activating the Jak-Stat pathway in cardiomyocytes. Nat Med 2005;11:305-11
5. Schäbitz WR, Kollmar R, Schwaninger M, et al. Neuroprotective effect of granulocyte colony-stimulating factor after focal cerebral ischemia. Stroke 2003;34:745-51
6. Schneider A, Kruger C, Steigleder T, et al. The hematopoietic factor G-CSF is a neuronal ligand that counteracts programmed cell death and drives neurogenesis. J Clin Invest 2005;115:2083-98
7. Komine-Kobayashi M, Zhang N, Liu M, et al. Neuroprotective effect of recombinant human granulocyte colony-stimulating factor in transient focal ischemia of mice. J Cereb Blood Flow Metab 2006;26:402-13
8. Kamada T, Koda M, Dezawa M, et al. Transplantation of bone marrow stromal cell-derived Schwann cells promotes axonal regeneration and functional recovery after complete transection of adult rat spinal cord. J Neuropathol Exp Neurol 2005;64:37-45
9. Koda M, Hashimoto M, Murakami M, et al. Adenovirus vector-mediated in vivo gene transfer of brain-derived neurotrophic factor (BDNF) promotes rubrospinal axonal regeneration and functional recovery after complete transection of the adult rat spinal cord. J Neurotrauma 2004;21:329-37
10. Farooque M, Isaksson J, Olsson Y. Improved recovery after spinal cord injury in neuronal nitric oxide synthase-deficient mice but not in TNF-α-deficient mice. J Neurotrauma 2001;18:105-14
11. Hu B, Yasui K. Effects of colony-stimulating factors (CSFs) on neutrophil apoptosis: Possible roles at inflammation site. Int J Hematol 1997;66:179-88
12. Chakraborty A, White SM, Schaefer TS, et al. Granulocyte colony-stimulating factor activation of Stat3α and Stat3β in immature normal and leukemic human myeloid cells. Blood 1996;88:2442-49
13. Dong F, Larner AC. Activation of Akt kinase by granulocyte colony-stimulating factor (G-CSF): Evidence for the role of a tyrosine kinase activity distinct from the Janus kinases. Blood 2000;95:1656-62
14. Fukada T, Hibi M, Yamanaka Y, et al. Two signals are necessary for cell proliferation induced by a cytokine receptor gp130: Involvement of STAT3 in anti-apoptosis. Immunity 1996;5:449-60
15. Datta SR, Brunet A, Greenberg ME. Cellular survival: A play in three Akts. Genes Dev 1999;13:2905-27
16. del Peso L, Gonzalez-Garcia M, Page C, et al. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. Science 1997;278:687-99
17. Ahmed NN, Grimes HL, Bellacosa A, et al. Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase. Proc Natl Acad Sci U S A 1997;94:3627-32
18. Schneider A, Kuhn HG, Schäbitz WR. A role for G-CSF (granulocytecolony stimulating factor) in the central nervous system. Cell Cycle 2005;4:1753-57
19. Zavala F, Abad S, Ezine S, et al. G-CSF therapy of ongoing experimental allergic encephalomyelitis via chemokine-and cytokine-based immune deviation. J Immunol 2002;168:2011-19
20. Nishiki S, Hato F, Kamata N, et al. Selective activation of STAT 3 in human monocytes stimulated by G-CSF: Implication in inhibition of LPS-induced TNF-α production. Am J Physiol Cell Physiol 2004;286:1302-11
21. Kawada H, Takizawa S, Takanashi T, et al. Administration of hematopoietic cytokines in the subacute phase after cerebral infarction is effective for functional recovery facilitating proliferation of intrinsic neural stem/progenitor cells and transition of bone marrow-derived neuronal cells. Circulation 2006;113:701-10
22. Urdzikova L, Jendelova P, Glogarova K, et al. Transplantation of bone marrow stem cells as well as mobilization by granulocyte-colony stimulating factor promotes recovery after spinal cord injury in rats. J Neurotrauma 2006;23:1379-91
23. Gibson C, Jones C, Prior MLW, et al. G-CSF suppresses edema formation and reduces interleukin-1A expression after cerebral ischemia in mice. J Neuropathol Exp Neurol 2005;64:763-69
24. Lee ST, Chua K, Jung KH, et al. Granulocyte colony-stimulating factor enhances angiogenesis after focal cerebral ischemia. Brain Res 2005;1058:120-28
25. Jung KH, Chu K, Lee ST, et al. Granulocyte colony-stimulating factor stimulates neurogenesis via vascular endothelial growth factor with STAT activation. Brain Res 2006;1073:190-201
26. Shyu WC, Lin SZ, Lee CC, et al. Granulocyte colony-stimulating factor for acute ischemic stroke: A randomized controlled trial. CMAJ 2006;174:927-33