Neuroprotective effect of exogenous vascular endothelial growth factor on rat spinal cord neurons in vitro hypoxia

Chinese Medical Journal

Volumn 118, Issue 19, 2005, Pages 1644-1650

  Ding, Xin Min ^a   Mao, Bo Yong ^a   Jiang, Shu ^a   Li, Sheng Fu ^a   Deng, Yi Ling ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Hypoxia; Spinal cord; Vascular endothelial growth factor

Indexed keywords

PROTEIN TYROSINE KINASE INHIBITOR; VASCULOTROPIN; VASCULOTROPIN RECEPTOR; VASCULOTROPIN RECEPTOR 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BIOASSAY; BRAIN HYPOXIA; CELL COUNT; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; DRUG MECHANISM; FEMALE; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; NERVE CELL CULTURE; NEUROPROTECTION; NICK END LABELING; NONHUMAN; PROTEIN FUNCTION; RAT; SPINAL CORD NERVE CELL;

ANIMALS; CELL HYPOXIA; CELLS, CULTURED; CINNAMATES; FEMALE; NEUROPROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 27144541543     PISSN: 03666999     EISSN: 03666999     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Shweiki D, Itin A, Soffer D, et al. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 1992;359:843-845.
2. Breier G, Albrecht U, Sterrer S, et al. Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation. Development 1992;114:521-532.
3. Lee MY, Ju WK, Cha JH, et al. Expression of vascular endothelial growth factor mRNA following transient forebrain ischaemia in rats. Neurosci Lett 1999;16; 265:107-110.
4. Wang Y, Kilic E, Kilic U, et al. VEGF overexpression induces post-ischaemic neuroprotection, but facilitates haemodynamic steal phenomena. Brain 2005; 128:52-63.
5. Hayashi T, Abe K, Itoyama Y. Reduction of ischaemic damage by application of vascular endothelial growth factor in rat brain after transient ischaemia. J Cereb Blood Flow Metab 1998;18:887-895.
6. Jin KL, Mao XO, Greenberg DA. Vascular endothelial growth factor: direct neuroprotective effect in vitro ischaemia. Proc Natl Acad Sci U S A 2000;97:10242-10247.
7. Jin KL, Mao XO, Greenberg DA. Vascular endothelial growth factor rescues HN33 neural cells from death induced by serum withdrawal. J Mol Neurosci 2000;14: 197-203.
8. Han MK, Kim M, Bae SY. VEGF protects human cerebral hybrid neurons from in vitro ischaemia. Neuroreport 2004;15:847-850.
9. Oosthuyse B, Moons L, Storkebaum E, et al. Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration. Nat Genet 2001;28:131-138.
10. Skold M, Cullheim S, Hammarberg H, et al. Induction of VEGF and VEGF receptors in the spinal cord after mechanical spinal injury and prostaglandin administration. Eur J Neurosci 2000;12:3675-3686.
11. Widenfalk J, Lipson A, Jubran M, et al. Vascular endothelial growth factor improves functional outcome and decreases secondary degeneration in experimental spinal cord contusion injury. Neuroscience 2003; 120: 951-960.
12. Lennmyr F, Ata KA, Funa K, et al. Expression of vascular endothelial growth factor (VEGF) and its receptors (Flt-1 and Flk-1) following permanent and transient occlusion of the middle cerebral artery in the rat. J Neuropathol Exp Neurol 1998;57:874-882.
13. Storkebaum E, Lambrechts D, Dewerchin M. Treatment of motoneuron degeneration by intra-cerebroventricular delivery of VEGF in a rat model of ALS. Nat Neurosci 2005;8:85-92.
14. Shiote M, Nagano I, Ilieva H, et al. Reduction of a vascular endothelial growth factor receptor, fetal liver kinase-1, by antisense oligonucleotides induces motor neuron death in rat spinal cord exposed to hypoxia. Neuroscience 2005;132:175-182.
15. Gora-Kupilas K, Josko J, Folia Y. The neuroprotective function of vascular endothelial growth factor (VEGF). Neuropathol 2005;43:31-39.
16. Schanzer A, Wachs FP, Wilhelm D, et al. Direct stimulation of adult neural stem cells in vitro and neurogenesis in vivo by vascular endothelial growth factor. Brain Pathol 2004;14:237-248.
17. Weiss S, Dunne C, Hewson J, et al. Multipotent CNS stem cells are present in the adult mammalian spine cord and ventricular neuroaxis. J Neurosci 1996; 16: 7599-7609.
18. Khaibullina AA, Rosenstein JM, Krum JM. Vascular endothelial growth factor promotes neurite maturation in primary CNS neuronal cultures. Brain Res Dev Brain Res 2004;148:59-68.
19. Rosenstein JM, Mani N, Khaibullina A, et al. Neurotrophic effects of vascular endothelial growth factor on organotypic cortical explants and primary cortical neurons. J Neurosci 2003;23:11036-11044.
20. Peters KG, De Vries C, Williams LT. Vascular endothelial growth factor receptor expression during embryogenesis and tissue repair suggests a role in endothelial differentiation and blood vessel growth. Proc Natl Acad Sci U S A 1993;90:8915-8919.
21. Ogunshola OO, Antic A, Donoghue MJ, et al. Paracrine and autocrine functions of neuronal vascular endothelial growth factor (VEGF) in the central nervous system. J Biol Chem 2002;277:11410-11415.
22. Sondell M, Sundler F, Kanje M. Vascular endothelial growth factor is a neurotrophic factor which stimulates axonall outgrowth through the flk-1 receptor. Eur J Neurosci 2000;12:4243-4254.
23. Svensson B, Peters M, Konig HG. Vascular endothelial growth factor protects cultured rat hippocampal neurons against hypoxic injury via an antiexcitotoxic, caspase-independent mechanism. J Cereb Blood Flow Metab 2002;22:1170-1175.
24. Böcker-Meffert S, Rosenstiel P, Röhl C, et al. Erythropoietin and VEGF promote neural outgrowth from retinal explants in postnatal rats. Invest Ophthalmol Vis Sci 2002;43:2021-2026.
25. Facchiano F, Fernandez E, Mancarella S, et al. Promotion of regeneration of corticospinal tract axons in rats with recombinant vascular endothelial growth factor alone and combined with adenovirus coding for this factor. J Neurosurg 2002;97:161-168.
26. Isner JM, Ropper A, Hirst K. VEGF gene transfer for diabetic neuropathy. Hum Gene Ther 2001; 12: 1593-15934.
27. Yasuhara T, Shingo T, Muraoka K, et al. The differences between high and low-dose administration of VEGF to dopaminergic neurons of in vitro and in vivo Parkinson's disease model. Brain Res 2005; 1038: 1-10.