Germline genetic variants disturbing the let-7/LIN28 double-negative feedback loop alter breast cancer susceptibility

PLoS Genetics

Volumn 7, Issue 9, 2011, Pages

  Chen, Ao Xiang ^a   Yu, Ke Da ^a   Fan, Lei ^a   Li, Ji Yu ^a   Yang, Chen ^a   Huang, A Ji ^a   Shao, Zhi Ming ^a  

^a FUDAN UNIVERSITY SHANGHAI CANCER CENTER   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOSINE; MESSENGER RNA; PROTEIN LIN28; REGULATOR PROTEIN; THYMINE; UNCLASSIFIED DRUG; LIN 28 PROTEIN, HUMAN; LIN-28 PROTEIN, HUMAN; MICRORNA; MIRNLET7 MICRORNA, HUMAN; RNA BINDING PROTEIN;

ALLELE; ARTICLE; BINDING SITE; BREAST CANCER; CANCER RISK; CANCER SUSCEPTIBILITY; CELL TRANSFORMATION; CONTROLLED STUDY; DOWN REGULATION; EX VIVO STUDY; GENE DISRUPTION; GENE EXPRESSION; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; GERM LINE; HIGH RISK POPULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; LET 7 GENE; NEGATIVE FEEDBACK; PROTEIN SYNTHESIS; REPRESSOR GENE; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM; BREAST TUMOR; CASE CONTROL STUDY; CELL LINE; CHINA; FEEDBACK SYSTEM; FEMALE; GENETIC PREDISPOSITION; GENETICS; GERM CELL; METABOLISM; RISK FACTOR;

BINDING SITES; BREAST NEOPLASMS; CASE-CONTROL STUDIES; CELL LINE; CELL TRANSFORMATION, NEOPLASTIC; CHINA; FEEDBACK, PHYSIOLOGICAL; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GERM CELLS; HUMANS; MICRORNAS; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; RNA-BINDING PROTEINS;

EID: 80053436022     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1002259     Document Type: Article

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