Endothelial progenitor cell - Dependent angiogenesis requires localization of the full-length form of uPAR in caveolae

Blood

Volumn 118, Issue 13, 2011, Pages 3743-3755

  Margheri, Francesca ^a   Chillà, Anastasia ^a   Laurenzana, Anna ^a   Serratì, Simona ^a   Mazzanti, Benedetta ^b   Saccardi, Riccardo ^b   Santosuosso, Michela ^b   Danza, Giovanna ^a   Sturli, Niccolò ^a   Rosati, Fabiana ^a   Magnelli, Lucia ^a   Papucci, Laura ^a   Calorini, Lido ^a   Bianchini, Francesca ^a   Del Rosso, Mario ^a   Fibbi, Gabriella ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b CAREGGI UNIVERSITY HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; CAVEOLIN 1; MACROPHAGE ELASTASE; MITOGEN ACTIVATED PROTEIN KINASE; UROKINASE RECEPTOR; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ARTICLE; CAVEOLA; COLONY FORMING CELL; CONTROLLED STUDY; ENDOTHELIAL COLONY FORMING CELL; ENDOTHELIAL PROGENITOR CELL; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MEMBRANE DAMAGE; MOLECULAR STABILITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS INHIBITION;

EID: 80053421131     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2011-02-338681     Document Type: Article

References (47)

1. Distler O, Neidhart M, Gay RE, Gay S. The molecular control of angiogenesis. Int Rev Immunol. 2002;21(1):33-49. (Pubitemid 34718259)
2. Carmeliet P. Mechanisms of angiogenesis and arteriogenesis. Nat Med. 2000;6(4):389-395. (Pubitemid 30208155)
3. Asahara T, Murohara T, Sullivan A, et al. Isolation of putative progenitor endothelial cells for angiogenesis. Science. 1997;275(5302):964-967. (Pubitemid 27087709)
4. Ingram DA, Mead LE, Tanaka H, et al. Identification of a novel hierarchy of endothelial progenitor cells using human peripheral and umbilical cord blood. Blood. 2004;104(9):2752-2760. (Pubitemid 39434958)
5. Timmermans F, Plum J, Yoder MC, Ingram DA, vandekerckhove B, Case J. Endothelial progenitor cells: identity defined? J Cell Mol Med. 2009;13(1):87-102.
6. Prater DN, Case J, Ingram DA, Yoder MC. Working hypothesis to redefine endothelial progenitor cells. Leukemia. 2007;21(6):1141-1149. (Pubitemid 46831802)
7. Yoder MC, Mead LE, Prater D, et al. Redefining endothelial progenitor cells via clonal analysis and hematopoietic stem/progenitor cell principals. Blood. 2007;109(5):1801-1809. (Pubitemid 46348173)
8. Pearson JD. Endothelial progenitor cells: an evolving story. Microvasc Res. 2010;79(3):162-168.
9. Del Rosso M, Fibbi G, Pucci M, et al. Multiple pathways of cell invasion are regulated by multiple families of serine proteases. Clin Exp Metastasis. 2002;19(3):193-207. (Pubitemid 34553521)
10. D'Alessio S, Fibbi G, Cinelli M, et al. Matrix metalloproteinase 12-dependent cleavage of urokinase receptor in systemic sclerosis microvascular endothelial cells results in impaired angiogenesis. Arthritis Rheum. 2004;50(10):3275-3285. (Pubitemid 39372005)
11. Margheri F, Serrati S, Lapucci A, et al. Modulation of the angiogenic phenotype of normal and systemic sclerosis endothelial cells by gain-loss of function of pentraxin 3 and matrix metalloproteinase 12. Arthritis Rheum. 2010;62(8):2488-2498.
12. Basire A, Sabatier F, Ravet S, et al. High urokinase expression contributes to the angiogenic properties of endothelial cells derived from circulating progenitors. Thromb Haemost. 2006;95(4):678-688.
13. Cunningham O, Andolfo A, Santovito ML, Iuzzolino L, Blasi F, Sidenius N. Dimerization controls the lipid raft partitioning of uPAR/CD87 and regulates its biological functions. EMBO J. 2003;22(22):5994-6003. (Pubitemid 37463243)
14. Kiyan J, Smith G, Haller H, Dumler I. Urokinase-receptor-mediated phenotypic changes in vascular smooth muscle cells require the involvement of membrane rafts. Biochem J. 2009;423(3):343-351.
15. Frank PG, Woodman SE, Park DS, Lisanti MP. Caveolin, caveolae, and endothelial cell function. Arterioscler Thromb Vasc Biol. 2003;23(7):1161-1168. (Pubitemid 36871269)
16. Tahir SA, Park S, Thompson TC. Caveolin-1 regulates VEGF-stimulated angiogenic activities in prostate cancer and endothelial cells. Cancer Biol Ther. 2009;8(23):2286-2296.
17. Liao WX, Feng L, Zhang H, Zheng J, Moore TR, Chen DB. Compartmentalizing VEGF-induced ERK2/1 signaling in placental artery endothelial cell caveolae: a paradoxical role of caveolin-1 in placental angiogenesis in vitro. Mol Endocrinol. 2009;23(9):1428-1444.
18. Burgermeister E, Liscovitch M, Rocken C, Schmid RM, Ebert MP. Caveats of caveolin-1 in cancer progression. Cancer Lett. 2008;268(2):187-201.
19. Corselli M, Parodi A, Mogni M, et al. Clinical scale ex vivo expansion of cord blood-derived outgrowth endothelial progenitor cells is associated with high incidence of karyotype aberrations. Exp Hematol. 2008;36(3):340-349.
20. Ostrom RS, Liu X. Detergent and detergent-free methods to define lipid rafts and caveolae. Methods Mol Biol. 2007;400:459-468. (Pubitemid 350183707)
21. Awasthi-Kalia M, Schnetkamp PP, Deans JP. Differential effects of filipin and methyl-betacyclodextrin on B cell receptor signaling. Biochem Biophys Res Commun. 2001;287(1):77-82. (Pubitemid 32912465)
22. Cecchi C, Rosati F, Pensalfini A, et al. Seladin-1/DHCR24 protects neuroblastoma cells against Abeta toxicity by increasing membrane cholesterol content. J Cell Mol Med. 2008;12(5B):1990-2002.
23. Quattrone A, Fibbi G, Anichini E, et al. Reversion of the invasive phenotype of transformed human fibroblasts by anti-messenger oligonucleotide inhibition of urokinase receptor gene expression. Cancer Res. 1995;55(1):90-95.
24. Margheri F, D'Alessio S, Serrati S, et al. Effects of blocking urokinase receptor signaling by antisense oligonucleotides in a mouse model of experimental prostate cancer bone metastases. Gene Ther. 2005;12(8):702-714. (Pubitemid 40575610)
25. Margheri F, Manetti M, Serrati S, et al. Domain 1 of the urokinase-type plasminogen activator receptor is required for its morphologic and functional, beta2 integrin-mediated connection with actin cytoskeleton in human microvascular endothelial cells: failure of association in systemic sclerosis endothelial cells. Arthritis Rheum. 2006;54(12):3926-3938. (Pubitemid 44955896)
26. Li Q, Lau A, Morris TJ, Guo L, Fordyce CB, Stanley EF. A syntaxin 1, Galpha(o), and N-type calcium channel complex at a presynaptic nerve terminal: analysis by quantitative immunocolocalization. J Neurosci. 2004;24(16):4070- 4081. (Pubitemid 38544233)
27. Bolte S, Cordelieres FP. A guided tour into subcellular colocalization analysis in light microscopy. J Microsc. 2006;224(3):213-232. (Pubitemid 46010930)
28. Tamarat R, Silvestre JS, Durie M, Levy BI. Angiotensin II angiogenic effect in vivo involves vascular endothelial growth factor- and inflammation-related pathways. Lab Invest. 2002;82(6):747-756. (Pubitemid 34633824)
29. Griffoni C, Spisni E, Santi S, Riccio M, Guarnieri T, Tomasi V. Knockdown of caveolin-1 by antisense oligonucleotides impairs angiogenesis in vitro and in vivo. Biochem Biophys Res Commun. 2000;276(2):756-761.
30. Liu J, Wang XB, Park DS, Lisanti MP. Caveolin-1 expression enhances endothelial capillary tubule formation. J Biol Chem. 2002;277(12):10661-10668. (Pubitemid 34968193)
31. Fibbi G, Ziche M, Morbidelli L, Magnelli L, Del Rosso M. Interaction of urokinase with specific receptors stimulates mobilization of bovine adrenal capillary endothelial cells. Exp Cell Res. 1988;179(2):385-395. (Pubitemid 19002930)
32. Fibbi G, Caldini R, Chevanne M, et al. Urokinase-dependent angiogenesis in vitro and diacylglycerol production are blocked by antisense oligonucleotides against the urokinase receptor. Lab Invest. 1998;78(9):1109-1119. (Pubitemid 28440827)
33. Kirton JP, Xu Q. Endothelial precursors in vascular repair. Microvasc Res. 2010;79(3):193-199.
34. Patenaude A, Parker J, Karsan A. Involvement of endothelial progenitor cells in tumor vascularization. Microvasc Res. 2010;79(3):217-223.
35. Binder BR, Mihaly J, PragerGW. uPAR-uPA-PAI-1 interactions and signaling: a vascular biologist's view. Thromb Haemost. 2007;97(3):336-342. (Pubitemid 46437793)
36. Bompais H, Chagraoui J, Canron X, et al. Human endothelial cells derived from circulating progenitors display specific functional properties compared with mature vessel wall endothelial cells. Blood. 2004;103(7):2577-2584. (Pubitemid 38393010)
37. Labrecque L, Royal I, Surprenant DS, Patterson C, Gingras D, Beliveau R. Regulation of vascular endothelial growth factor receptor-2 activity by caveolin-1 and plasma membrane cholesterol. Mol Biol Cell. 2003;14(1):334-347. (Pubitemid 36106041)
38. Nykjaer A, Conese M, Christensen EI, et al. Recycling of the urokinase receptor upon internalization of the uPA:serpin complexes. EMBO J. 1997;16(10):2610-2620. (Pubitemid 27226200)
39. Kumar AH, Caplice NM. Clinical potential of adult vascular progenitor cells. Arterioscler Thromb Vasc Biol. 2010;30(6):1080-1087.
40. Distler JH, Beyer C, Schett G, Luscher TF, Gay S, Distler O. Endothelial progenitor cells: novel players in the pathogenesis of rheumatic diseases. Arthritis Rheum. 2009;60(11):3168-3179.
41. Avouac J, Uzan G, Kahan A, Boileau C, Allanore Y. Endothelial progenitor cells and rheumatic disorders. Joint Bone Spine. 2008;75(2):131-137.
42. Ahn GO, Brown JM. Role of endothelial progenitors and other bone marrow-derived cells in the development of the tumor vasculature. Angiogenesis. 2009;12(2):159-164.
43. Yoder MC, Ingram DA. Endothelial progenitor cell: ongoing controversy for defining these cells and their role in neoangiogenesis in the murine system. Curr Opin Hematol. 2009;16(4):269-273.
44. Ferrari N, Glod J, Lee J, Kobiler D, Fine HA. Bone marrow-derived, endothelial progenitor-like cells as angiogenesis-selective gene-targeting vectors. Gene Ther. 2003;10(8):647-656. (Pubitemid 36553610)
45. Gonyeau MJ, YuenDW.Aclinical review of statins and cancer: helpful or harmful? Pharmacotherapy. 2010;30(2):177-194.
46. Bardou M, Barkun A, Martel M. Effect of statin therapy on colorectal cancer. Gut. 2010;59(11):1572-1585.
47. Elewa HF, El-Remessy AB, Somanath PR, Fagan SC. Diverse effects of statins on angiogenesis: new therapeutic avenues. Pharmacotherapy. 2010;30(2):169-176.