Clinical scale ex vivo expansion of cord blood-derived outgrowth endothelial progenitor cells is associated with high incidence of karyotype aberrations

Experimental Hematology

Volumn 36, Issue 3, 2008, Pages 340-349

  Corselli, Mirko ^a   Parodi, Alessia ^a   Mogni, Massimo ^b   Sessarego, Nadia ^a   Kunkl, Annalisa ^a   Dagna Bricarelli, Franca ^b   Ibatici, Adalberto ^a   Pozzi, Sarah ^a   Bacigalupo, Andrea ^a   Frassoni, Francesco ^a   Piaggio, Giovanna ^a  

^a UNIVERSITY OF GENOA   (Italy)

^b GALLIERA HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AGAR;

ARTICLE; CARCINOGENIC ACTIVITY; CARCINOGENICITY; CELL CULTURE; CELL FUNCTION; CELL MATURATION; CELL POPULATION; CELL PROLIFERATION; CHROMOSOMAL INSTABILITY; CHROMOSOME ABERRATION; CHROMOSOME ANALYSIS; CONTROLLED STUDY; DIABETES MELLITUS; ENDOTHELIUM CELL; FLOW CYTOMETRY; HUMAN; HUMAN CELL; INCIDENCE; KARYOTYPE; KARYOTYPING; PHENOTYPE; PRIORITY JOURNAL; RISK ASSESSMENT; SCALE UP; SCID MOUSE; STEM CELL; UMBILICAL CORD BLOOD;

CELL CULTURE TECHNIQUES; CELL PROLIFERATION; CELLS, CULTURED; CHROMOSOME ABERRATIONS; COLONY-FORMING UNITS ASSAY; ENDOTHELIAL CELLS; FETAL BLOOD; FLOW CYTOMETRY; HUMANS; IMMUNOPHENOTYPING; KARYOTYPING; RISK FACTORS; STEM CELLS;

MUS;

EID: 39149092060     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exphem.2007.10.008     Document Type: Article

References (30)

1. Simons M. Angiogenesis: where do we stand now?. Circulation 111 (2005) 1556-1566
2. Rafii S., and Lyden D. Therapeutic stem and progenitor cells transplantation for organ vascularization and regeneration. Nat Med 9 (2003) 702-712
3. Asahara T., Masuda H., Takahashi T., et al. Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization. Circ Res 85 (1999) 221-228
4. Asahara T., Murohara T., Sullivan A., et al. Isolation of putative progenitor endothelial cells for angiogenesis. Science 275 5302 (1997) 964-967
5. Hur J., Yoon C.H., Kim H.S., et al. Characterization of two types of endothelial progenitor cells and their different contributions to neovasculogenesis. Arterioscler Thromb Vasc Biol (2004) 288-293
6. Kawamoto A., Tkebuchava T., Yamaguchi J., et al. Intramyocardial transplantation of autologous endothelial progenitor cells for therapeutic neovascularization of myocardial ischemia. Circulation 107 (2003) 461-468
7. Kawamoto A., Gwon H.C., Iwaguro H., et al. Therapeutic potential of ex vivo expanded endothelial progenitor cells for myocardial ischemia. Circulation 103 (2001) 634-637
8. Kalka C., Masuda H., Takahashi T., et al. Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization. Proc Natl Acad Sci U S A 97 (2000) 3422-3427
9. Assmus B., Honold J., Schächinger V., et al. Transcoronary transplantation of progenitor cells after myocardial infarction. N Engl J Med 355 (2006) 1222-1232
10. Schächinger V., Erbs S., Elsässer A., et al. Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction. N Engl J Med 355 (2006) 1210-1221
11. Lunde K., Solheim S., Aakhus S., et al. Intracoronary injection of mononuclear bone marrow cells in acute myocardial infarction. N Engl J Med 355 (2006) 1199-1209
12. Werner N., Kosiol S., Schiegl T., et al. Circulating endothelial progenitor cells and cardiovascular outcomes. N Engl J Med 353 (2005) 999-1007
13. Schmidt-Lucke C., Rossig L., Fichtlscherer S., et al. Reduced number of circulating endothelial progenitor cells predicts future cardiovascular events: proof of concept for the clinical importance of endogenous vascular repair. Circulation 111 (2005) 2981-2987
14. Tepper O.M., Galiano R.D., Capla J.M., et al. Human endothelial progenitor cells from type II diabetics exhibit impaired proliferation, adhesion, and incorporation into vascular structures. Circulation 106 (2002) 2781-2786
15. Loomans C.J., de Koning E.J., Staal F.J., et al. Endothelial progenitor cell dysfunction: a novel concept in the pathogenesis of vascular complications of type 1 diabetes. Diabetes 53 (2004) 195-199
16. Nieda M., Nicol A., Denning-Kendall P., et al. Endothelial cell precursors are normal components of human umbilical cord blood. Br J Haematol 98 (1997) 775-777
17. Murohara T., Ikeda H., Duan J., et al. Transplanted cord blood-derived endothelial precursor cells augment postnatal neovascularization. J Clin Invest 105 (2000) 1527-1536
18. Ingram D.A., Mead L.E., Tanaka H., et al. Identification of a novel hierarchy of endothelial progenitor cells using human peripheral and umbilical cord blood. Blood 104 (2004) 2752-2760
19. Zhang L., Yang R., and Han Z.C. Transplantation of umbilical cord blood derived endothelial progenitor cells: a promising method of therapeutic revascularisation. Eur J Haematol 76 (2006) 1-8
20. Ott I., Keller U., Knoedler M., et al. Endothelial-like cells expanded from CD34+ blood cells improve left ventricular function after experimental myocardial infarction. FASEB J 19 (2005) 992-994
21. Yoder M.C., Mead L.E., Prater D., et al. Re-defining endothelial progenitor cells via clonal analysis and hematopoietic stem/progenitor cell principals. Blood 109 (2007) 1801-1809
22. Untergasser G., Koeck R., Wolf D., et al. CD34+/CD133- circulating endothelial precursor cells (CEP): characterization, senescence and in vivo application. Exp Gerontol 41 (2006) 600-608
23. Rubio D., Garcia-Castro J., Martìn M.C., et al. Spontaneous human adult stem cell transformation. Cancer Res 65 (2005) 3035-3039
24. Casalone R., Granata C.P., Minelli E., et al. Significance of the clonal and sporadic chromosome abnormalities in non-neoplastic renal tissue. Hum Genet 90 (1992) 71-78
25. Heim S., Mandahl N., Jin Y., et al. Trisomy 7 and sex chromosome loss in human brain tissue. Cytogenet Cell Genet 52 (1989) 136-138
26. Yang J., Chang E., Cherry A.M., et al. Human endothelial cell life extension by telomerase expression. J Biol Chem 274 (1999) 26141-26148
27. Nichols W.W., Buynak E.B., Bradt C., et al. Cytogenetic evaluation of human endothelial cell cultures. J Cell Physiol 132 (1987) 453-462
28. Johnson T.E., Umbenhauer D.R., Hill R., et al. Karyotypic and phenotypic changes during in vitro aging of human endothelial cells. J Cell Physiol 150 (1992) 17-27
29. Zhang L., Aviv H., Gardner P., et al. Loss of chromosome 13 in cultured human vascular endothelial cells. Exp Cell Res 260 (2000) 357-364
30. Ingram D.A., Mead L.E., Moore D.B., et al. Vessel wall-derived endothelial cells rapidly proliferate because they contain a complete hierarchy of endothelial progenitor cells. Blood 105 (2005) 2783-2786