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Volumn 18, Issue 3, 2011, Pages 93-105

Direct renin inhibition: From pharmacological innovation to novel therapeutic opportunities

Author keywords

ACE inhibitors; aliskiren; angiotensin receptor blockers; direct renin inhibition; hypertension

Indexed keywords

ALISKIREN; AMLODIPINE; ANGIOTENSIN I; ANGIOTENSIN RECEPTOR ANTAGONIST; ANGIOTENSINOGEN; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; CANDESARTAN HEXETIL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENALAPRIL; HYDROCHLOROTHIAZIDE; IRBESARTAN; LOSARTAN; PLACEBO; RAMIPRIL; RENIN INHIBITOR; VALSARTAN;

EID: 80053405422     PISSN: 11209879     EISSN: 11791985     Source Type: Journal    
DOI: 10.2165/11593540-000000000-00000     Document Type: Review
Times cited : (17)

References (56)
  • 1
    • 0042738775 scopus 로고    scopus 로고
    • Angiotensin II AT2 receptor subtype: An uprising frontier in cardiovascular disease?
    • DOI 10.1097/00004872-200308000-00001
    • Volpe M, Musumeci B, De Paolis P, et al. Angiotensin II AT2 receptor subtype: an uprising frontier in cardiovascular disease? J Hypertens 2003 Aug; 21 (8): 1429-43 (Pubitemid 36994116)
    • (2003) Journal of Hypertension , vol.21 , Issue.8 , pp. 1429-1443
    • Volpe, M.1    Musumeci, B.2    De Paolis, P.3    Savoia, C.4    Morganti, A.5
  • 3
    • 44349101152 scopus 로고    scopus 로고
    • Effects of different regimens to lower blood pressure on major cardiovascular events in older and younger people: Meta-analysis of randomised trials
    • DOI 10.1136/bmj.39548.738368.BE
    • Turnbull F, Neal B, Ninomiya T, et al. Effects of different regimens to lower blood pressure on major cardiovascular events in older and younger adults: meta-analysis of randomised trials. BMJ 2008 May 17; 336 (7653): 1121-3 (Pubitemid 351731743)
    • (2008) BMJ , vol.336 , Issue.7653 , pp. 1121-1123
    • Turnbull, F.1
  • 4
    • 55749095046 scopus 로고    scopus 로고
    • Do men and women respond differently to blood pressure-lowering treatment? Results of prospectively designed overviews of randomized trials
    • Nov
    • Turnbull F, Woodward M, Neal B, et al. Do men and women respond differently to blood pressure-lowering treatment? Results of prospectively designed overviews of randomized trials. EurHeart J 2008 Nov; 29 (21): 2669-80
    • (2008) EurHeart J , vol.29 , Issue.21 , pp. 2669-2680
    • Turnbull, F.1    Woodward, M.2    Neal, B.3
  • 5
    • 0242654867 scopus 로고    scopus 로고
    • Effects of different blood-pressure-lowering regimens on major cardiovascular events: Results of prospectively-designed overviews of randomised trials
    • DOI 10.1016/S0140-6736(03)14739-3
    • Turnbull F. Effects of different blood-pressure-lowering regimens on major cardiovascular events: results of prospectively-designed overviews of randomized trials. Lancet 2003 Nov 8; 362 (9395): 1527-35 (Pubitemid 37410190)
    • (2003) Lancet , vol.362 , Issue.9395 , pp. 1527-1535
    • Turnbull, F.1
  • 6
    • 22144477948 scopus 로고    scopus 로고
    • Effects of different blood pressure-lowering regimens on major cardiovascular events in individuals with and without diabetes mellitus: Results of prospectively designed overviews of randomized trials
    • DOI 10.1001/archinte.165.12.1410
    • Turnbull F, Neal B, Algert C, et al. Effects of different blood pressure-lowering regimens on major cardiovascular events in individuals with and without diabetes mellitus: results of prospectively designed overviews of randomized trials. Arch Intern Med 2005 Jun 27; 165 (12): 1410-9 (Pubitemid 40973424)
    • (2005) Archives of Internal Medicine , vol.165 , Issue.12 , pp. 1410-1419
    • Turnbull, F.1
  • 7
    • 6344221992 scopus 로고    scopus 로고
    • Effects of angiotensin converting enzyme inhibitors and angiotensin II receptor antagonists on mortality and renal outcomes in diabetic nephropathy: Systematic review
    • Oct 9
    • Strippoli GF, Craig M, Deeks JJ, et al. Effects of angiotensin converting enzyme inhibitors and angiotensin II receptor antagonists on mortality and renal outcomes in diabetic nephropathy: systematic review. BMJ 2004 Oct 9; 329 (7470): 828-39
    • (2004) BMJ , vol.329 , Issue.7470 , pp. 828-839
    • Strippoli, G.F.1    Craig, M.2    Deeks, J.J.3
  • 8
    • 38049139424 scopus 로고    scopus 로고
    • Meta-analysis: Effect of monotherapy and combination therapy with inhibitors of the renin-angiotensin system on proteinuria in renal disease
    • Kunz R, Friedrich C, Wolbers M, et al. Meta-analysis: effect of monotherapy and combination therapy with inhibitors of the renin angiotensin system on proteinuria in renal disease. Ann Intern Med 2008 Jan 1; 148 (1): 30-48 (Pubitemid 351688350)
    • (2008) Annals of Internal Medicine , vol.148 , Issue.1 , pp. 30-48
    • Kunz, R.1    Friedrich, C.2    Wolbers, M.3    Mann, J.F.E.4
  • 9
    • 67649655811 scopus 로고    scopus 로고
    • Angiotensin II receptor blockers and myocardial infarction: An updated analysis of randomized clinical trials
    • May
    • Volpe M, Tocci G, Sciarretta S, et al. Angiotensin II receptor blockers and myocardial infarction: an updated analysis of randomized clinical trials. J Hypertens 2009 May; 27 (5): 941-6
    • (2009) J Hypertens , vol.27 , Issue.5 , pp. 941-946
    • Volpe, M.1    Tocci, G.2    Sciarretta, S.3
  • 10
    • 79952598750 scopus 로고    scopus 로고
    • Antihypertensive treatment and development of heart failure in hypertension: A Bayesian network meta-analysis of studies in patients with hypertension and high cardiovascular risk
    • Sciarretta S, Palano F, Tocci G, et al. Antihypertensive treatment and development of heart failure in hypertension: a Bayesian network meta-analysis of studies in patients with hypertension and high cardiovascular risk. Arch Intern Med 2011; 171 (5): 384-94
    • (2011) Arch Intern Med , vol.171 , Issue.5 , pp. 384-394
    • Sciarretta, S.1    Palano, F.2    Tocci, G.3
  • 11
    • 34547925543 scopus 로고    scopus 로고
    • Aliskiren: A review of its use in the management of hypertension
    • DOI 10.2165/00003495-200767120-00008
    • Frampton JE, Curran MP. Aliskiren: a review of its use in the management of hypertension. Drugs 2007; 67 (12): 1767-92 (Pubitemid 47263181)
    • (2007) Drugs , vol.67 , Issue.12 , pp. 1767-1792
    • Frampton, J.E.1    Curran, M.P.2
  • 12
    • 34848880420 scopus 로고    scopus 로고
    • Aliskiren, the future of reninangiotensin systemblockade?
    • Sep
    • Uresin Y, Mehtar Bozkurt M, Sabirli S, et al. Aliskiren, the future of reninangiotensin systemblockade? ExpertRevCardiovasc Ther 2007 Sep; 5 (5): 835-49
    • (2007) Expert Rev Cardiovasc Ther , vol.5 , Issue.5 , pp. 835-849
    • Uresin, Y.1    Mehtar Bozkurt, M.2    Sabirli, S.3
  • 14
    • 0035922441 scopus 로고    scopus 로고
    • Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy
    • Sep 20
    • Brenner BM, Cooper ME, de Zeeuw D, et al. Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy. N Engl J Med 2001 Sep 20; 345 (12): 861-9
    • (2001) N Engl J Med , vol.345 , Issue.12 , pp. 861-869
    • Brenner, B.M.1    Cooper, M.E.2    De Zeeuw, D.3
  • 15
    • 0035922444 scopus 로고    scopus 로고
    • The effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes
    • Sep 20
    • Parving HH, Lehnert H, Brochner-Mortensen J, et al. The effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes. N Engl J Med 2001 Sep 20; 345 (12): 870-8
    • (2001) N Engl J Med , vol.345 , Issue.12 , pp. 870-878
    • Parving, H.H.1    Lehnert, H.2    Brochner-Mortensen, J.3
  • 16
    • 0037036971 scopus 로고    scopus 로고
    • Effects of losartan and captopril on mortality and morbidity in high-risk patients after acute myocardial infarction: The OPTIMAAL randomised trial
    • DOI 10.1016/S0140-6736(02)09895-1
    • Dickstein K, Kjekshus J. Effects of losartan and captopril on mortality and morbidity in high-risk patients after acute myocardial infarction: the OPTIMAAL randomised trial. Optimal Trial in Myocardial Infarction with Angiotensin II Antagonist Losartan. Lancet 2002 Sep 7; 360 (9335): 752-60 (Pubitemid 35247704)
    • (2002) Lancet , vol.360 , Issue.9335 , pp. 752-760
    • Dickstein, K.1    Kjekshus, J.2
  • 19
    • 0035818884 scopus 로고    scopus 로고
    • A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure
    • DOI 10.1056/NEJMoa010713
    • Cohn JN, Tognoni G. A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure. NEngl JMed 2001 Dec 6; 345 (23): 1667-75 (Pubitemid 33126822)
    • (2001) New England Journal of Medicine , vol.345 , Issue.23 , pp. 1667-1675
    • Cohn, J.N.1    Tognoni, G.2
  • 20
    • 71549127400 scopus 로고    scopus 로고
    • Effects of high-dose versus low-dose losartan on clinical outcomes in patients with heart failure (HEAAL study): A randomised, double-blind trial
    • Nov 28
    • KonstamMA, Neaton JD,Dickstein K, et al. Effects of high-dose versus low-dose losartan on clinical outcomes in patients with heart failure (HEAAL study): a randomised, double-blind trial. Lancet 2009 Nov 28; 374 (9704): 1840-8
    • (2009) Lancet , vol.374 , Issue.9704 , pp. 1840-1848
    • Konstam, M.A.1    Neaton, J.D.2    Dickstein, K.3
  • 21
    • 0037165243 scopus 로고    scopus 로고
    • From the HOPE to the ONTARGET and the TRANSCEND studies: Challenges in improving prognosis
    • Jan 24
    • Yusuf S. From the HOPE to the ONTARGET and the TRANSCEND studies: challenges in improving prognosis. Am J Cardiol 2002 Jan 24; 89 (2A): 18A-25A
    • (2002) Am J Cardiol , vol.89 , Issue.2 A
    • Yusuf, S.1
  • 22
    • 33748070612 scopus 로고    scopus 로고
    • Direct renin inhibition with aliskiren in hypertension and target organ damage
    • Mar
    • Muller DN, Luft FC. Direct renin inhibition with aliskiren in hypertension and target organ damage. Clin J Am Soc Nephrol 2006 Mar; 1 (2): 221-8
    • (2006) Clin J Am Soc Nephrol , vol.1 , Issue.2 , pp. 221-228
    • Muller, D.N.1    Luft, F.C.2
  • 23
    • 33644789557 scopus 로고    scopus 로고
    • Renin inhibition with aliskiren: Where are we now, and where are we going?
    • DOI 10.1097/01.hjh.0000202812.72341.99, PII 0000487220060200000004
    • Azizi M, Webb R, Nussberger J, et al. Renin inhibitionwith aliskiren: where are we now, and where are we going? J Hypertens 2006 Feb; 24 (2): 243-56 (Pubitemid 43348229)
    • (2006) Journal of Hypertension , vol.24 , Issue.2 , pp. 243-256
    • Azizi, M.1    Webb, R.2    Nussberger, J.3    Hollenberg, N.K.4
  • 24
    • 33845366982 scopus 로고    scopus 로고
    • Renin inhibition with aliskiren provides additive antihypertensive efficacy when used in combination with hydrochlorothiazide
    • DOI 10.1097/HJH.0b013e3280103a6b, PII 0000487220070100000030
    • Villamil A, Chrysant SG, Calhoun D, et al. Renin inhibition with aliskiren provides additive antihypertensive efficacy when used in combination with hydrochlorothiazide. J Hypertens 2007 Jan; 25 (1): 217-26 (Pubitemid 44885684)
    • (2007) Journal of Hypertension , vol.25 , Issue.1 , pp. 217-226
    • Villamil, A.1    Chrysant, S.G.2    Calhoun, D.3    Schober, B.4    Hsu, H.5    Matrisciano-Dimichino, L.6    Zhang, J.7
  • 25
    • 36248931230 scopus 로고    scopus 로고
    • Antihypertensive efficacy of the oral direct renin inhibitor aliskiren as add-on therapy in patients not responding to amlodipine monotherapy
    • Oct
    • Drummond W, Munger MA, Rafique Essop M, et al. Antihypertensive efficacy of the oral direct renin inhibitor aliskiren as add-on therapy in patients not responding to amlodipine monotherapy. J Clin Hypertens (Greenwich) 2007 Oct; 9 (10): 742-50
    • (2007) J Clin Hypertens (Greenwich) , vol.9 , Issue.10 , pp. 742-750
    • Drummond, W.1    Munger, M.A.2    Rafique Essop, M.3
  • 26
    • 70449851433 scopus 로고    scopus 로고
    • Reappraisal of European guidelines on hypertensionmanagement: A European Society of Hypertension Task Force document
    • Nov
    • Mancia G, Laurent S, Agabiti-Rosei E, et al. Reappraisal of European guidelines on hypertensionmanagement: a European Society of Hypertension Task Force document. J Hypertens 2009 Nov; 27 (11): 2121-58
    • (2009) J Hypertens , vol.27 , Issue.11 , pp. 2121-2158
    • Mancia, G.1    Laurent, S.2    Agabiti-Rosei, E.3
  • 27
    • 75149195876 scopus 로고    scopus 로고
    • Maintenance of blood-pressure-lowering effect following amissed dose of aliskiren irbesartan or ramipril: Results of a randomized double-blind study
    • Feb
    • Palatini P, Jung W, Shlyakhto E, et al. Maintenance of blood-pressure-lowering effect following amissed dose of aliskiren, irbesartan or ramipril: results of a randomized, double-blind study. JHumHypertens 2010Feb; 24 (2): 93-103
    • (2010) J Hum Hypertens , vol.24 , Issue.2 , pp. 93-103
    • Palatini, P.1    Jung, W.2    Shlyakhto, E.3
  • 28
    • 0034688194 scopus 로고    scopus 로고
    • Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients
    • DOI 10.1056/NEJM200001203420301
    • Yusuf S, Sleight P, Pogue J, et al. Effects of an angiotensin-converting- enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators.NEngl JMed 2000 Jan 20; 342 (3): 145-53 (Pubitemid 30051645)
    • (2000) New England Journal of Medicine , vol.342 , Issue.3 , pp. 145-153
    • Yusuf, S.1
  • 29
    • 53049109468 scopus 로고    scopus 로고
    • Effects of the angiotensin-receptor blocker telmisartan on cardiovascular events in high-risk patients intolerant to angiotensin-converting enzyme inhibitors: A randomised controlled trial
    • Sep 27
    • Yusuf S, Teo K, Anderson C, et al. Effects of the angiotensin-receptor blocker telmisartan on cardiovascular events in high-risk patients intolerant to angiotensin-converting enzyme inhibitors: a randomised controlled trial. Lancet 2008 Sep 27; 372 (9644): 1174-83
    • (2008) Lancet , vol.372 , Issue.9644 , pp. 1174-1183
    • Yusuf, S.1    Teo, K.2    Anderson, C.3
  • 31
    • 24644510705 scopus 로고    scopus 로고
    • Long-term effects of ramipril on cardiovascular events and on diabetes: Results of the HOPE study extension
    • DOI 10.1161/CIRCULATIONAHA.105.548461
    • Bosch J, Lonn E, Pogue J, et al. Long-term effects of ramipril on cardiovascular events and on diabetes: results of the HOPE study extension. Circulation 2005 Aug 30; 112 (9): 1339-46 (Pubitemid 41266730)
    • (2005) Circulation , vol.112 , Issue.9 , pp. 1339-1346
    • Bosch, J.1    Lonn, E.2    Pogue, J.3    Arnold, J.M.O.4    Dagenais, G.R.5    Yusuf, S.6
  • 32
    • 0037716744 scopus 로고    scopus 로고
    • Effect of enalapril on 12-year survival and life expectancy in patients with left ventricular systolic dysfunction: A follow-up study
    • DOI 10.1016/S0140-6736(03)13501-5
    • Jong P, Yusuf S, Rousseau MF, et al. Effect of enalapril on 12-year survival and life expectancy in patients with left ventricular systolic dysfunction: a followup study. Lancet 2003 May 31; 361 (9372): 1843-8 (Pubitemid 36645177)
    • (2003) Lancet , vol.361 , Issue.9372 , pp. 1843-1848
    • Jong, P.1    Yusuf, S.2    Rousseau, M.F.3    Ahn, S.A.4    Bangdiwala, S.I.5
  • 33
    • 61349170589 scopus 로고    scopus 로고
    • Effect of the direct rennin inhibitor aliskiren, the angiotensin receptor blocker losartan, or both on left ventricular mass in patients with hypertension and left ventricular hypertrophy
    • Feb 3
    • Solomon SD, Appelbaum E, Manning WJ, et al. Effect of the direct rennin inhibitor aliskiren, the angiotensin receptor blocker losartan, or both on left ventricular mass in patients with hypertension and left ventricular hypertrophy. Circulation 2009 Feb 3; 119 (4): 530-7
    • (2009) Circulation , vol.119 , Issue.4 , pp. 530-537
    • Solomon, S.D.1    Appelbaum, E.2    Manning, W.J.3
  • 35
    • 79958249630 scopus 로고    scopus 로고
    • Effects of the oral direct renin inhibitor aliskiren in patients with symptomatic heart failure
    • May
    • McMurray JJ, Pitt B, Latini R, et al. Effects of the oral direct renin inhibitor aliskiren in patients with symptomatic heart failure. Circ Heart Fail 2008 May; 1 (1): 17-24
    • (2008) Circ Heart Fail , vol.1 , Issue.1 , pp. 17-24
    • McMurray, J.J.1    Pitt, B.2    Latini, R.3
  • 36
    • 58849142527 scopus 로고    scopus 로고
    • Cardiovascular risk in hypertension-can we ask for more? Focus on aliskiren
    • Volpe M. Cardiovascular risk in hypertension-can we ask for more? Focus on aliskiren. High Blood Press Cardiovasc Prev 2008; 15 (4): 255-68
    • (2008) High Blood Press Cardiovasc Prev , vol.15 , Issue.4 , pp. 255-268
    • Volpe, M.1
  • 37
    • 0015491624 scopus 로고
    • Essential hypertension: Renin and aldosterone, heart attack and stroke
    • Brunner HR, Laragh JH, Baer L, et al. Essential hypertension: renin and aldosterone, heart attack and stroke. N Engl J Med 1972; 286: 441-9
    • (1972) N Engl J Med , vol.286 , pp. 441-449
    • Brunner, H.R.1    Laragh, J.H.2    Baer, L.3
  • 38
    • 0025794059 scopus 로고
    • Association of the renin-sodium profile with the risk of myocardial infarction in patients with hypertension
    • Alderman MH, Madhavan S, Ooi WL, et al. Association of the renin-sodium profile with the risk of myocardial infarction in patients with hypertension. N Engl J Med 1991; 324: 1098-104
    • (1991) N Engl J Med , vol.324 , pp. 1098-1104
    • Alderman, M.H.1    Madhavan, S.2    Ooi, W.L.3
  • 40
    • 0027167633 scopus 로고
    • Plasma norepinephrine, plasma renin activity, and congestive heart failure: Relations to survival and the effects of therapy in V-HeFT II
    • Francis GS, Cohn JN, Johnson G, et al. Plasma norepinephrine, plasma rennin activity, and congestive heart failure: relations to survival and the effects of therapy in V-HeFT II. The V-HeFT VA Cooperative Studies Group. Circulation. 1993; 87: VI40-48 (Pubitemid 23164221)
    • (1993) Circulation , vol.87 , Issue.6 SUPPL. VI
    • Francis, G.S.1    Cohn, J.N.2    Johnson, G.3    Rector, T.S.4    Goldman, S.5    Simon, A.6
  • 43
    • 77956343748 scopus 로고    scopus 로고
    • Relation of elevated plasma rennin activity at baseline to cardiac events in patients with angiographically proven coronary artery disease
    • Sep 15
    • Muhlestein JB, May HT, Bair TL, et al. Relation of elevated plasma rennin activity at baseline to cardiac events in patients with angiographically proven coronary artery disease. Am J Cardiol 2010 Sep 15; 106 (6): 764-9
    • (2010) Am J Cardiol , vol.106 , Issue.6 , pp. 764-769
    • Muhlestein, J.B.1    May, H.T.2    Bair, T.L.3
  • 44
    • 80053405623 scopus 로고    scopus 로고
    • Measurement of bioactive rennin concentration and renin activity in the presence of exogenous renin substrate: Effect of the oral direct renin inhibitor aliskiren
    • Frandsen E, Boomsma F, Persson F, et al. Measurement of bioactive rennin concentration and renin activity in the presence of exogenous renin substrate: effect of the oral direct renin inhibitor aliskiren. J Renin Angiotensin Aldosterone Syst 2008; 9 Suppl.: S12
    • (2008) J Renin Angiotensin Aldosterone Syst , vol.9 SUPPL.
    • Frandsen, E.1    Boomsma, F.2    Persson, F.3
  • 45
    • 60549087324 scopus 로고    scopus 로고
    • Long-term antihypertensive efficacy and safety of the oral direct renin inhibitor aliskiren: A 12-month randomized, double-blind comparator trial with hydrochlorothiazide
    • Jan 27
    • Schmieder RE, Philipp T, Guerediaga J, et al. Long-term antihypertensive efficacy and safety of the oral direct renin inhibitor aliskiren: a 12-month randomized, double-blind comparator trial with hydrochlorothiazide. Circulation 2009 Jan 27; 119 (3): 417-25
    • (2009) Circulation , vol.119 , Issue.3 , pp. 417-425
    • Schmieder, R.E.1    Philipp, T.2    Guerediaga, J.3
  • 47
    • 70349690296 scopus 로고    scopus 로고
    • Renal effects of aliskiren compared with and in combination with irbesartan in patients with type 2 diabetes, hypertension, and albuminuria
    • Oct
    • Persson F, Rossing P, Reinhard H, et al. Renal effects of aliskiren compared with and in combination with irbesartan in patients with type 2 diabetes, hypertension, and albuminuria. Diabetes Care 2009 Oct; 32 (10): 1873-9
    • (2009) Diabetes Care , vol.32 , Issue.10 , pp. 1873-9
    • Persson, F.1    Rossing, P.2    Reinhard, H.3
  • 48
    • 78649929199 scopus 로고    scopus 로고
    • Impact of baseline renal function on the efficacy and safety of aliskiren added to losartan in patients with type 2 diabetes and nephropathy
    • Nov
    • Persson F, Lewis JB, Lewis EJ, et al. Impact of baseline renal function on the efficacy and safety of aliskiren added to losartan in patients with type 2 diabetes and nephropathy. Diabetes Care 2010 Nov; 33 (11): 2304-9
    • (2010) Diabetes Care , vol.33 , Issue.11 , pp. 2304-2309
    • Persson, F.1    Lewis, J.B.2    Lewis, E.J.3
  • 49
    • 65249182083 scopus 로고    scopus 로고
    • Aliskiren trial in type 2 diabetes using cardio-renal endpoints (ALTITUDE): Rationale and study design
    • May
    • Parving HH, Brenner BM, McMurray JJ, et al. Aliskiren Trial in Type 2 Diabetes Using Cardio-Renal Endpoints (ALTITUDE): rationale and study design. Nephrol Dial Transplant 2009 May; 24 (5): 1663-71
    • (2009) Nephrol Dial Transplant , vol.24 , Issue.5 , pp. 1663-1671
    • Parving, H.H.1    Brenner, B.M.2    McMurray, J.J.3
  • 50
    • 77955921291 scopus 로고    scopus 로고
    • Aliskiren for geriatric lowering of systolic hypertension: A randomized controlled trial
    • Sep
    • Duprez DA, Munger MA, Botha J, et al. Aliskiren for geriatric lowering of systolic hypertension: a randomized controlled trial. J Hum Hypertens 2010 Sep; 24 (9): 600-8
    • (2010) J Hum Hypertens , vol.24 , Issue.9 , pp. 600-608
    • Duprez, D.A.1    Munger, M.A.2    Botha, J.3
  • 51
    • 66149177166 scopus 로고    scopus 로고
    • Cardio-renal protection with aliskiren, a direct renin inhibitor, in the ASPIRE HIGHER program
    • Mar
    • Lee HY, Oh BH. Cardio-renal protection with aliskiren, a direct renin inhibitor, in the ASPIRE HIGHER program. Expert Rev Cardiovasc Ther 2009 Mar; 7 (3): 251-7
    • (2009) Expert Rev Cardiovasc Ther , vol.7 , Issue.3 , pp. 251-257
    • Lee, H.Y.1    Oh, B.H.2
  • 52
    • 78650344825 scopus 로고    scopus 로고
    • Rationale and design of the multicentre, randomized, double-blind, placebo-controlled Aliskiren Trial on Acute Heart Failure Outcomes (ASTRONAUT)
    • Jan
    • Gheorghiade M, Albaghdadi M, Zannad F, et al. Rationale and design of the multicentre, randomized, double-blind, placebo-controlled Aliskiren Trial on Acute Heart Failure Outcomes (ASTRONAUT). Eur J Heart Fail 2011 Jan; 13 (1): 100-6
    • (2011) Eur J Heart Fail , vol.13 , Issue.1 , pp. 100-106
    • Gheorghiade, M.1    Albaghdadi, M.2    Zannad, F.3
  • 53
    • 78650380191 scopus 로고    scopus 로고
    • Direct renin inhibition in addition to or as an alternative to angiotensin converting enzyme inhibition in patientswith chronic systolic heart failure: Rationale and design of the Aliskiren Trial to Minimize OutcomeS in Patients with HEart failuRE (ATMOSPHERE) study
    • Jan
    • Krum H, Massie B, Abraham WT, et al. Direct renin inhibition in addition to or as an alternative to angiotensin converting enzyme inhibition in patientswith chronic systolic heart failure: rationale and design of the Aliskiren Trial to Minimize OutcomeS in Patients with HEart failuRE (ATMOSPHERE) study. Eur J Heart Fail 2011 Jan; 13 (1): 107-14
    • (2011) Eur J Heart Fail , vol.13 , Issue.1 , pp. 107-114
    • Krum, H.1    Massie, B.2    Abraham, W.T.3
  • 55
    • 53249090182 scopus 로고    scopus 로고
    • ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2008
    • The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM), Oct
    • Dickstein K, Cohen-Solal A, Filippatos G, et al. ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2008. The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM). Eur Heart J 2008 Oct; 29 (19): 2388-442
    • (2008) Eur Heart J , vol.29 , Issue.19 , pp. 2388-2442
    • Dickstein, K.1    Cohen-Solal, A.2    Filippatos, G.3
  • 56
    • 65549154913 scopus 로고    scopus 로고
    • Focused update: ACCF/AHA guidelines for the diagnosis and management of heart failure in adults: A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines
    • Developed in collaboration with the International Society for Heart and Lung Transplantation, Apr 14
    • Jessup M, Abraham WT, Casey DE, et al. 2009 focused update: ACCF/AHA guidelines for the diagnosis and management of heart failure in adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Developed in collaboration with the International Society for Heart and Lung Transplantation. Circulation 2009 Apr 14; 119 (14): 1977-2016
    • (2009) Circulation 2009 , vol.119 , Issue.14 , pp. 1977-2016
    • Jessup, M.1    Abraham, W.T.2    Casey, D.E.3


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