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Volumn 15, Issue 4, 2008, Pages 255-268

Cardiovascular risk in hypertension - Can we ask for more? Focus on aliskiren

Author keywords

Cardiovascular disease; Cardiovascular prevention; Direct renin inhibitors; Hypertension; Organ damage; Renal disease

Indexed keywords

ALISKIREN; AMLODIPINE; ANGIOTENSIN 1 RECEPTOR; ENALAPRIL; HYDROCHLOROTHIAZIDE; IRBESARTAN; LOSARTAN; RAMIPRIL; VALSARTAN;

EID: 58849142527     PISSN: 11209879     EISSN: None     Source Type: Journal    
DOI: 10.2165/0151642-200815040-00005     Document Type: Review
Times cited : (3)

References (83)
  • 1
    • 39549093148 scopus 로고    scopus 로고
    • General cardiovascular risk profile for use in primary care: The Framingham Heart Study
    • Feb 12;
    • D'Agostino Sr RB, Vasan RS, Pencina MJ, et al. General cardiovascular risk profile for use in primary care: the Framingham Heart Study. Circulation 2008 Feb 12; 117 (6): 743-53
    • (2008) Circulation , vol.117 , Issue.6 , pp. 743-753
    • D'Agostino Sr, R.B.1    Vasan, R.S.2    Pencina, M.J.3
  • 2
    • 0033953535 scopus 로고    scopus 로고
    • Risk stratification in hypertension: New insights from the Framingham Study
    • Jan;
    • Kannel WB. Risk stratification in hypertension: new insights from the Framingham Study. Am J Hypertens 2000 Jan; 13 (1 Pt 2): 3S-10S
    • (2000) Am J Hypertens , vol.13 , Issue.1 PART 2
    • Kannel, W.B.1
  • 3
    • 0038047699 scopus 로고    scopus 로고
    • Hypertension prevalence and blood pressure levels in 6 European countries, Canada, and the United States
    • May 14;
    • Wolf-Maier K, Cooper RS, Banegas JR, et al. Hypertension prevalence and blood pressure levels in 6 European countries, Canada, and the United States. JAMA 2003 May 14; 289 (18): 2363-9
    • (2003) JAMA , vol.289 , Issue.18 , pp. 2363-2369
    • Wolf-Maier, K.1    Cooper, R.S.2    Banegas, J.R.3
  • 4
    • 34547841317 scopus 로고    scopus 로고
    • Essential hypertension
    • Aug 18;
    • Messerli FH, Williams B, Ritz E. Essential hypertension. Lancet 2007 Aug 18; 370 (9587): 591-603
    • (2007) Lancet , vol.370 , Issue.9587 , pp. 591-603
    • Messerli, F.H.1    Williams, B.2    Ritz, E.3
  • 5
    • 34547841331 scopus 로고    scopus 로고
    • Hypertension: Uncontrolled and conquering the world
    • Aug 18;
    • Hypertension: uncontrolled and conquering the world. Lancet 2007 Aug 18; 370 (9587): 539
    • (2007) Lancet , vol.370 , Issue.9587 , pp. 539
  • 6
    • 33847096347 scopus 로고    scopus 로고
    • Blood pressure parameters and risk of fatal stroke, NHANES II mortality study
    • Mar;
    • Brown DW, Giles WH, Greenlund KJ. Blood pressure parameters and risk of fatal stroke, NHANES II mortality study. Am J Hypertens 2007 Mar; 20 (3): 338-41
    • (2007) Am J Hypertens , vol.20 , Issue.3 , pp. 338-341
    • Brown, D.W.1    Giles, W.H.2    Greenlund, K.J.3
  • 7
    • 40949133247 scopus 로고    scopus 로고
    • Treatment potential for cholesterol management in patients with coronary heart disease in 15 European countries: Findings from the EUROASPIRE II survey
    • Apr;
    • Kotseva K, Stagmo M, De Bacquer D, et al. Treatment potential for cholesterol management in patients with coronary heart disease in 15 European countries: findings from the EUROASPIRE II survey. Atherosclerosis 2008 Apr; 197 (2): 710-7
    • (2008) Atherosclerosis , vol.197 , Issue.2 , pp. 710-717
    • Kotseva, K.1    Stagmo, M.2    De Bacquer, D.3
  • 8
    • 4143134423 scopus 로고    scopus 로고
    • Risk factor management in diabetic and non-diabetic patients with coronary heart disease: Findings from the EUROAS-PIRE I AND II surveys
    • Jul;
    • Pyorala K, Lehto S, De Bacquer D, et al. Risk factor management in diabetic and non-diabetic patients with coronary heart disease: findings from the EUROAS-PIRE I AND II surveys. Diabetologia 2004 Jul; 47 (7): 1257-65
    • (2004) Diabetologia , vol.47 , Issue.7 , pp. 1257-1265
    • Pyorala, K.1    Lehto, S.2    De Bacquer, D.3
  • 9
    • 12444263222 scopus 로고    scopus 로고
    • Blood pressure is insufficiently controlled in European patients with established coronary heart disease
    • Oct;
    • Boersma E, Keil U, De Bacquer D, et al. Blood pressure is insufficiently controlled in European patients with established coronary heart disease. J Hypertens 2003 Oct; 21 (10): 1831-40
    • (2003) J Hypertens , vol.21 , Issue.10 , pp. 1831-1840
    • Boersma, E.1    Keil, U.2    De Bacquer, D.3
  • 10
    • 34447314994 scopus 로고    scopus 로고
    • World Health Organization (WHO) and International Society of Hypertension (ISH) risk prediction charts: Assessment of cardiovascular risk for prevention and control of cardiovascular disease in low and middle-income countries
    • Aug;
    • Mendis S, Lindholm LH, Mancia G, et al. World Health Organization (WHO) and International Society of Hypertension (ISH) risk prediction charts: assessment of cardiovascular risk for prevention and control of cardiovascular disease in low and middle-income countries. J Hypertens 2007 Aug; 25 (8): 1578-82
    • (2007) J Hypertens , vol.25 , Issue.8 , pp. 1578-1582
    • Mendis, S.1    Lindholm, L.H.2    Mancia, G.3
  • 11
    • 53749091595 scopus 로고    scopus 로고
    • Long-term follow-up after tight control of blood pressure in type 2 diabetes
    • Oct 9;
    • Holman RR, Paul SK, Bethel MA, et al. Long-term follow-up after tight control of blood pressure in type 2 diabetes. N Engl J Med 2008 Oct 9; 359 (15): 1565-76
    • (2008) N Engl J Med , vol.359 , Issue.15 , pp. 1565-1576
    • Holman, R.R.1    Paul, S.K.2    Bethel, M.A.3
  • 12
    • 24644510705 scopus 로고    scopus 로고
    • Long-term effects of ramipril on cardiovascular events and on diabetes: Results of the HOPE study extension
    • Aug 30;
    • Bosch J, Lonn E, Pogue J, et al. Long-term effects of ramipril on cardiovascular events and on diabetes: results of the HOPE study extension. Circulation 2005 Aug 30; 112 (9): 1339-46
    • (2005) Circulation , vol.112 , Issue.9 , pp. 1339-1346
    • Bosch, J.1    Lonn, E.2    Pogue, J.3
  • 13
    • 33646181189 scopus 로고    scopus 로고
    • Ahn SA, Jong P, Yusuf S, et al. Early versus delayed enalapril in patients with left ventricular systolic dysfunction: impact on morbidity and mortality 15 years after the SOLVD trial. J Am Coll Cardiol 2006 May 2; 47 (9): 1904-5
    • Ahn SA, Jong P, Yusuf S, et al. Early versus delayed enalapril in patients with left ventricular systolic dysfunction: impact on morbidity and mortality 15 years after the SOLVD trial. J Am Coll Cardiol 2006 May 2; 47 (9): 1904-5
  • 14
    • 0032912752 scopus 로고    scopus 로고
    • Long-term survival in severe heart failure in patients treated with enalapril: Ten year follow-up of CONSENSUS I
    • Jan;
    • Swedberg K, Kjekshus J, Snapinn S. Long-term survival in severe heart failure in patients treated with enalapril: ten year follow-up of CONSENSUS I. Eur Heart J 1999 Jan; 20 (2): 136-9
    • (1999) Eur Heart J , vol.20 , Issue.2 , pp. 136-139
    • Swedberg, K.1    Kjekshus, J.2    Snapinn, S.3
  • 15
    • 49349109830 scopus 로고    scopus 로고
    • Development of heart failure in recent hypertension trials
    • Jul;
    • Tocci G, Sciarretta S, Volpe M. Development of heart failure in recent hypertension trials. J Hypertens 2008 Jul; 26 (7): 1477-86
    • (2008) J Hypertens , vol.26 , Issue.7 , pp. 1477-1486
    • Tocci, G.1    Sciarretta, S.2    Volpe, M.3
  • 16
    • 0345492460 scopus 로고    scopus 로고
    • A calcium antagonist vs a non-calcium antagonist hypertension treatment strategy for patients with coronary artery disease. The International Verapamil-Trandolapril Study (INVEST): A randomized controlled trial
    • Dec 3;
    • Pepine CJ, Handberg EM, Cooper-DeHoff RM, et al. A calcium antagonist vs a non-calcium antagonist hypertension treatment strategy for patients with coronary artery disease. The International Verapamil-Trandolapril Study (INVEST): a randomized controlled trial. JAMA 2003 Dec 3; 290 (21): 2805-16
    • (2003) JAMA , vol.290 , Issue.21 , pp. 2805-2816
    • Pepine, C.J.1    Handberg, E.M.2    Cooper-DeHoff, R.M.3
  • 17
    • 0344373794 scopus 로고    scopus 로고
    • Major outcomes in high-risk hypertensive patients ran-domized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)
    • ALLHAT Investigators, Dec 18;
    • ALLHAT Investigators. Major outcomes in high-risk hypertensive patients ran-domized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic: the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). JAMA 2002 Dec 18; 288 (23): 2981-97
    • (2002) JAMA , vol.288 , Issue.23 , pp. 2981-2997
  • 18
    • 0029584472 scopus 로고
    • Evaluating the benefits of an antihypertensive agent using trials based on event and organ damage: The Systolic Hypertension in the Elderly Long-term Lacidipine (SHELL) trial and the European Lacidipine Study on Atherosclerosis (ELSA)
    • Dec;
    • Zanchetti A. Evaluating the benefits of an antihypertensive agent using trials based on event and organ damage: the Systolic Hypertension in the Elderly Long-term Lacidipine (SHELL) trial and the European Lacidipine Study on Atherosclerosis (ELSA). J Hypertens Suppl 1995 Dec; 13 (4): S35-9
    • (1995) J Hypertens Suppl , vol.13 , Issue.4
    • Zanchetti, A.1
  • 19
    • 0034688194 scopus 로고    scopus 로고
    • Effects of an angiotensin-converting- enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators
    • Jan 20;
    • Yusuf S, Sleight P, Pogue J, et al. Effects of an angiotensin-converting- enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators. N Engl J Med 2000 Jan 20; 342 (3): 145-53
    • (2000) N Engl J Med , vol.342 , Issue.3 , pp. 145-153
    • Yusuf, S.1    Sleight, P.2    Pogue, J.3
  • 20
    • 0035968623 scopus 로고    scopus 로고
    • Randomised trial of a perindopril-based blood-pressure-lowering regimen among 6,105 individuals with previous stroke or transient ischaemic attack
    • Group TPpaRSSPC, Sep 29;
    • Group TPpaRSSPC. Randomised trial of a perindopril-based blood-pressure-lowering regimen among 6,105 individuals with previous stroke or transient ischaemic attack. Lancet 2001 Sep 29; 358 (9287): 1033-41
    • (2001) Lancet , vol.358 , Issue.9287 , pp. 1033-1041
  • 21
    • 0042330455 scopus 로고    scopus 로고
    • Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: Randomised, double-blind, placebo-controlled, multicentre trial (the EUROPA study)
    • Sep 6;
    • Fox KM. Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: randomised, double-blind, placebo-controlled, multicentre trial (the EUROPA study). Lancet 2003 Sep 6; 362 (9386): 782-8
    • (2003) Lancet , vol.362 , Issue.9386 , pp. 782-788
    • Fox, K.M.1
  • 22
    • 19644400972 scopus 로고    scopus 로고
    • Braunwald E, Domanski MJ, Fowler SE, et al. Angiotensin-converting-enzyme inhibition in stable coronary artery disease. N Engl J Med 2004 Nov 11; 351 (20): 2058-68
    • Braunwald E, Domanski MJ, Fowler SE, et al. Angiotensin-converting-enzyme inhibition in stable coronary artery disease. N Engl J Med 2004 Nov 11; 351 (20): 2058-68
  • 23
    • 0037420492 scopus 로고    scopus 로고
    • Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial-Lipid Lowering Arm (ASCOT-LLA): A multicentre randomised controlled trial
    • Apr 5;
    • Sever PS, Dahlof B, Poulter NR, et al. Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial-Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial. Lancet 2003 Apr 5; 361 (9364): 1149-58
    • (2003) Lancet , vol.361 , Issue.9364 , pp. 1149-1158
    • Sever, P.S.1    Dahlof, B.2    Poulter, N.R.3
  • 24
    • 0026785561 scopus 로고
    • Effect of enalapril on mortality and the development of heart failure in asymptomatic patients with reduced left ventricular ejection fractions
    • The SOLVD Investigators, Sep 3;
    • The SOLVD Investigators. Effect of enalapril on mortality and the development of heart failure in asymptomatic patients with reduced left ventricular ejection fractions. N Engl J Med 1992 Sep 3; 327 (10): 685-91
    • (1992) N Engl J Med , vol.327 , Issue.10 , pp. 685-691
  • 25
    • 0025913812 scopus 로고
    • Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure
    • The SOLVD Investigators, Aug 1;
    • The SOLVD Investigators. Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. N Engl J Med 1991 Aug 1; 325 (5): 293-302
    • (1991) N Engl J Med , vol.325 , Issue.5 , pp. 293-302
  • 26
    • 34548420712 scopus 로고    scopus 로고
    • Effects of a fixed combination of perindopril and indapamide on macrovascular and microvascular outcomes in patients with type 2 diabetes mellitus (the ADVANCE trial): A randomised controlled trial
    • Sep 8;
    • Patel A, MacMahon S, Chalmers J, et al. Effects of a fixed combination of perindopril and indapamide on macrovascular and microvascular outcomes in patients with type 2 diabetes mellitus (the ADVANCE trial): a randomised controlled trial. Lancet 2007 Sep 8; 370 (9590): 829-40
    • (2007) Lancet , vol.370 , Issue.9590 , pp. 829-840
    • Patel, A.1    MacMahon, S.2    Chalmers, J.3
  • 27
    • 0023266532 scopus 로고
    • Effects of enalapril on mortality in severe congestive heart failure: Results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS)
    • The CONSENSUS Trial Study Group, Jun 4;
    • The CONSENSUS Trial Study Group. Effects of enalapril on mortality in severe congestive heart failure: results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS). N Engl J Med 1987 Jun 4; 316 (23): 1429-35
    • (1987) N Engl J Med , vol.316 , Issue.23 , pp. 1429-1435
  • 28
    • 42049107348 scopus 로고    scopus 로고
    • Telmisartan, ramipril, or both in patients at high risk for vascular events
    • Apr 10;
    • Yusuf S, Teo KK, Pogue J, et al. Telmisartan, ramipril, or both in patients at high risk for vascular events. N Engl J Med 2008 Apr 10; 358 (15): 1547-59
    • (2008) N Engl J Med , vol.358 , Issue.15 , pp. 1547-1559
    • Yusuf, S.1    Teo, K.K.2    Pogue, J.3
  • 29
    • 0037160969 scopus 로고    scopus 로고
    • Cardiovascular morbidity and mortality in patients with diabetes in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): A randomised trial against atenolol
    • Mar 23;
    • Lindholm LH, Ibsen H, Dahlof B, et al. Cardiovascular morbidity and mortality in patients with diabetes in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol. Lancet 2002 Mar 23; 359 (9311): 1004-10
    • (2002) Lancet , vol.359 , Issue.9311 , pp. 1004-1010
    • Lindholm, L.H.1    Ibsen, H.2    Dahlof, B.3
  • 30
    • 34247379373 scopus 로고    scopus 로고
    • Valsartan in a Japanese population with hypertension and other cardiovascular disease (Jikei Heart Study): A randomised, open-label, blinded endpoint morbidity-mortality study
    • Apr 28;
    • Mochizuki S, Dahlof B, Shimizu M, et al. Valsartan in a Japanese population with hypertension and other cardiovascular disease (Jikei Heart Study): a randomised, open-label, blinded endpoint morbidity-mortality study. Lancet 2007 Apr 28; 369 (9571): 1431-9
    • (2007) Lancet , vol.369 , Issue.9571 , pp. 1431-1439
    • Mochizuki, S.1    Dahlof, B.2    Shimizu, M.3
  • 31
    • 2942635317 scopus 로고    scopus 로고
    • Julius S, Kjeldsen SE, Weber M, et al. Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine: the VALUE randomised trial. Lancet 2004 Jun 19; 363 (9426): 2022-31
    • Julius S, Kjeldsen SE, Weber M, et al. Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine: the VALUE randomised trial. Lancet 2004 Jun 19; 363 (9426): 2022-31
  • 32
    • 0242490542 scopus 로고    scopus 로고
    • Pfeffer MA, McMurray JJ, Velazquez EJ, et al. Valsartan, captopril, or both in myocardial infarction complicated by heart failure, left ventricular dysfunction, or both. N Engl J Med 2003 Nov 13; 349 (20): 1893-906
    • Pfeffer MA, McMurray JJ, Velazquez EJ, et al. Valsartan, captopril, or both in myocardial infarction complicated by heart failure, left ventricular dysfunction, or both. N Engl J Med 2003 Nov 13; 349 (20): 1893-906
  • 33
    • 0035818884 scopus 로고    scopus 로고
    • A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure
    • Dec 6;
    • Cohn JN, Tognoni G. A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure. N Engl J Med 2001 Dec 6; 345 (23): 1667-75
    • (2001) N Engl J Med , vol.345 , Issue.23 , pp. 1667-1675
    • Cohn, J.N.1    Tognoni, G.2
  • 34
    • 0035922444 scopus 로고    scopus 로고
    • The effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes
    • Sep 20;
    • Parving HH, Lehnert H, Brochner-Mortensen J, et al. The effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes. N Engl J Med 2001 Sep 20; 345 (12): 870-8
    • (2001) N Engl J Med , vol.345 , Issue.12 , pp. 870-878
    • Parving, H.H.1    Lehnert, H.2    Brochner-Mortensen, J.3
  • 35
    • 52249116778 scopus 로고    scopus 로고
    • Telmisartan to prevent recurrent stroke and cardiovascular events
    • Sep 18;
    • Yusuf S, Diener HC, Sacco RL, et al. Telmisartan to prevent recurrent stroke and cardiovascular events. N Engl J Med 2008 Sep 18; 359 (12): 1225-37
    • (2008) N Engl J Med , vol.359 , Issue.12 , pp. 1225-1237
    • Yusuf, S.1    Diener, H.C.2    Sacco, R.L.3
  • 36
    • 53049109468 scopus 로고    scopus 로고
    • Telmisartan Randomised AssessmeNt Study in ACE iNtolerant subjects with cardiovascular Disease (TRANSCEND) Investigators. Effects of the angiotensin-receptor blocker telmisartan on cardiovascular events in high-risk patients intolerant to angiotensin-converting enzyme inhibitors: A randomised controlled trial
    • Sep 27;
    • Yusuf S, Teo K, Anderson C, et al., Telmisartan Randomised AssessmeNt Study in ACE iNtolerant subjects with cardiovascular Disease (TRANSCEND) Investigators. Effects of the angiotensin-receptor blocker telmisartan on cardiovascular events in high-risk patients intolerant to angiotensin-converting enzyme inhibitors: a randomised controlled trial. Lancet. 2008 Sep 27; 372 (9644): 1174-83
    • (2008) Lancet , vol.372 , Issue.9644 , pp. 1174-1183
    • Yusuf, S.1    Teo, K.2    Anderson, C.3
  • 37
    • 20444427156 scopus 로고    scopus 로고
    • Morbidity and Mortality After Stroke, Eprosartan Compared with Nitrendipine for Secondary Prevention: Principal results of a prospective randomized controlled study (MOSES)
    • Jun;
    • Schrader J, Luders S, Kulschewski A, et al. Morbidity and Mortality After Stroke, Eprosartan Compared with Nitrendipine for Secondary Prevention: principal results of a prospective randomized controlled study (MOSES). Stroke 2005 Jun; 36 (6): 1218-26
    • (2005) Stroke , vol.36 , Issue.6 , pp. 1218-1226
    • Schrader, J.1    Luders, S.2    Kulschewski, A.3
  • 38
    • 34548383480 scopus 로고    scopus 로고
    • ESH-ESC Practice Guidelines for the Management of Arterial Hypertension: ESH-ESC Task Force on the Management of Arterial Hypertension
    • Sep;
    • Mancia G, De Backer G, Dominiczak A, et al. 2007 ESH-ESC Practice Guidelines for the Management of Arterial Hypertension: ESH-ESC Task Force on the Management of Arterial Hypertension. J Hypertens 2007 Sep; 25 (9): 1751-62
    • (2007) J Hypertens , vol.25 , Issue.9 , pp. 1751-1762
    • Mancia, G.1    De Backer, G.2    Dominiczak, A.3
  • 39
    • 39449086771 scopus 로고    scopus 로고
    • Therapeutic implications of recent megatrials in hypertension: In favor of new drugs
    • Nov-Dec;
    • Volpe M, Tocci G. Therapeutic implications of recent megatrials in hypertension: in favor of new drugs. J Nephrol 2007 Nov-Dec; 20 Suppl. 12: S12-8
    • (2007) J Nephrol , vol.20 , Issue.SUPPL. 12
    • Volpe, M.1    Tocci, G.2
  • 40
    • 33645470860 scopus 로고    scopus 로고
    • Fewer mega-trials and more clinically oriented studies in hypertension research? The case of blocking the renin-angiotensin-aldosterone system
    • Apr;
    • Volpe M, Tocci G, Pagannone E. Fewer mega-trials and more clinically oriented studies in hypertension research? The case of blocking the renin-angiotensin-aldosterone system. J Am Soc Nephrol 2006 Apr; 17 (4 Suppl. 2): S36-43
    • (2006) J Am Soc Nephrol , vol.17 , Issue.4 SUPPL. 2
    • Volpe, M.1    Tocci, G.2    Pagannone, E.3
  • 41
    • 34250322546 scopus 로고    scopus 로고
    • Blood pressure control in Italy: Results of recent surveys on hypertension
    • Jul;
    • Volpe M, Tocci G, Trimarco B, et al. Blood pressure control in Italy: results of recent surveys on hypertension. J Hypertens 2007 Jul; 25 (7): 1491-8
    • (2007) J Hypertens , vol.25 , Issue.7 , pp. 1491-1498
    • Volpe, M.1    Tocci, G.2    Trimarco, B.3
  • 42
    • 0036668188 scopus 로고    scopus 로고
    • Systolic and diastolic blood pressure control in antihypertensive drug trials
    • Aug;
    • Mancia G, Grassi G. Systolic and diastolic blood pressure control in antihypertensive drug trials. J Hypertens 2002 Aug; 20 (8): 1461-4
    • (2002) J Hypertens , vol.20 , Issue.8 , pp. 1461-1464
    • Mancia, G.1    Grassi, G.2
  • 43
    • 34047231332 scopus 로고    scopus 로고
    • Angiotensin II reactivation and aldosterone escape phenomena in renin-angiotensin-aldosterone system blockade: Is oral renin inhibition the solution?
    • Apr;
    • Athyros VG, Mikhailidis DP, Kakafika AI, et al. Angiotensin II reactivation and aldosterone escape phenomena in renin-angiotensin-aldosterone system blockade: is oral renin inhibition the solution? Expert Opin Pharmacother 2007 Apr; 8 (5): 529-35
    • (2007) Expert Opin Pharmacother , vol.8 , Issue.5 , pp. 529-535
    • Athyros, V.G.1    Mikhailidis, D.P.2    Kakafika, A.I.3
  • 44
    • 58149391855 scopus 로고    scopus 로고
    • Renin receptor blockade: A better strategy for renal protection than renin-angiotensin system inhibition?
    • Oct;
    • Muller DN, Luft FC. Renin receptor blockade: a better strategy for renal protection than renin-angiotensin system inhibition? Curr Hypertens Rep 2008 Oct; 10 (5): 405-9
    • (2008) Curr Hypertens Rep , vol.10 , Issue.5 , pp. 405-409
    • Muller, D.N.1    Luft, F.C.2
  • 45
    • 33749985149 scopus 로고    scopus 로고
    • Oral renin inhibitors
    • Oct 21;
    • Staessen JA, Li Y, Richart T. Oral renin inhibitors. Lancet 2006 Oct 21; 368 (9545): 1449-56
    • (2006) Lancet , vol.368 , Issue.9545 , pp. 1449-1456
    • Staessen, J.A.1    Li, Y.2    Richart, T.3
  • 46
    • 0042738775 scopus 로고    scopus 로고
    • Angiotensin II AT2 receptor subtype: An uprising frontier in cardiovascular disease?
    • Aug;
    • Volpe M, Musumeci B, De Paolis P, et al. Angiotensin II AT2 receptor subtype: an uprising frontier in cardiovascular disease? J Hypertens 2003 Aug; 21 (8): 1429-43
    • (2003) J Hypertens , vol.21 , Issue.8 , pp. 1429-1443
    • Volpe, M.1    Musumeci, B.2    De Paolis, P.3
  • 47
    • 33845882230 scopus 로고    scopus 로고
    • The cardiovascular disease continuum validated: Clinical evidence of improved patient outcomes, part II: clinical trial evidence (acute coronary syndromes through renal disease) and future directions
    • Dec 19;
    • Dzau VJ, Antman EM, Black HR, et al. The cardiovascular disease continuum validated: clinical evidence of improved patient outcomes, part II: clinical trial evidence (acute coronary syndromes through renal disease) and future directions. Circulation 2006 Dec 19; 114 (25): 2871-91
    • (2006) Circulation , vol.114 , Issue.25 , pp. 2871-2891
    • Dzau, V.J.1    Antman, E.M.2    Black, H.R.3
  • 48
    • 33845902544 scopus 로고    scopus 로고
    • The cardiovascular disease continuum validated: Clinical evidence of improved patient outcomes, part I: pathophysiology and clinical trial evidence (risk factors through stable coronary artery disease)
    • Dec 19;
    • Dzau VJ, Antman EM, Black HR, et al. The cardiovascular disease continuum validated: clinical evidence of improved patient outcomes, part I: pathophysiology and clinical trial evidence (risk factors through stable coronary artery disease). Circulation 2006 Dec 19; 114 (25): 2850-70
    • (2006) Circulation , vol.114 , Issue.25 , pp. 2850-2870
    • Dzau, V.J.1    Antman, E.M.2    Black, H.R.3
  • 49
    • 18544369738 scopus 로고    scopus 로고
    • The cardiovascular continuum and renin-angiotensin-aldosterone system blockade
    • Apr;
    • Dzau V. The cardiovascular continuum and renin-angiotensin-aldosterone system blockade. J Hypertens Suppl 2005 Apr; 23 (1): S9-17
    • (2005) J Hypertens Suppl , vol.23 , Issue.1
    • Dzau, V.1
  • 50
    • 0029065156 scopus 로고
    • Renin-angiotensin-aldosterone system for blood pressure and electrolyte homeostasis and its involvement in hypertension, in congestive heart failure and in associated cardiovascular damage (myocardial infarction and stroke)
    • Jun;
    • Laragh JH. Renin-angiotensin-aldosterone system for blood pressure and electrolyte homeostasis and its involvement in hypertension, in congestive heart failure and in associated cardiovascular damage (myocardial infarction and stroke). J Hum Hypertens 1995 Jun; 9 (6): 385-90
    • (1995) J Hum Hypertens , vol.9 , Issue.6 , pp. 385-390
    • Laragh, J.H.1
  • 51
    • 0015333482 scopus 로고
    • Renin, angiotensin and aldosterone system in pathogenesis and management of hypertensive vascular disease
    • May;
    • Laragh JH, Baer L, Brunner HR, et al. Renin, angiotensin and aldosterone system in pathogenesis and management of hypertensive vascular disease. Am J Med 1972 May; 52 (5): 633-52
    • (1972) Am J Med , vol.52 , Issue.5 , pp. 633-652
    • Laragh, J.H.1    Baer, L.2    Brunner, H.R.3
  • 52
    • 45149113838 scopus 로고    scopus 로고
    • Aliskiren: Renin inhibitor for hypertension management
    • Jan;
    • Cheng JW. Aliskiren: Renin inhibitor for hypertension management. Clin Ther 2008 Jan; 30 (1): 31-47
    • (2008) Clin Ther , vol.30 , Issue.1 , pp. 31-47
    • Cheng, J.W.1
  • 53
    • 50349094508 scopus 로고    scopus 로고
    • Aug 12;
    • Brown MJ. Aliskiren. Circulation 2008 Aug 12; 118 (7): 773-84
    • (2008) Circulation , vol.118 , Issue.7 , pp. 773-784
    • Aliskiren, B.M.J.1
  • 54
    • 33846996406 scopus 로고    scopus 로고
    • The (pro)renin receptor: Pathophysiological roles in cardiovascular and renal pathology
    • Mar;
    • Nguyen G. The (pro)renin receptor: pathophysiological roles in cardiovascular and renal pathology. Curr Opin Nephrol Hypertens 2007 Mar; 16 (2): 129-33
    • (2007) Curr Opin Nephrol Hypertens , vol.16 , Issue.2 , pp. 129-133
    • Nguyen, G.1
  • 55
    • 27444447364 scopus 로고    scopus 로고
    • Renin, prorenin and the putative (pro)renin receptor
    • Nov;
    • Danser AH, Deinum J. Renin, prorenin and the putative (pro)renin receptor. Hypertension 2005 Nov; 46 (5): 1069-76
    • (2005) Hypertension , vol.46 , Issue.5 , pp. 1069-1076
    • Danser, A.H.1    Deinum, J.2
  • 56
    • 47049089844 scopus 로고    scopus 로고
    • Clinical pharmacokinetics and pharmacodynamics of aliskiren
    • Vaidyanathan S, Jarugula V, Dieterich HA, et al. Clinical pharmacokinetics and pharmacodynamics of aliskiren. Clin Pharmacokinet 2008; 47 (8): 515-31
    • (2008) Clin Pharmacokinet , vol.47 , Issue.8 , pp. 515-531
    • Vaidyanathan, S.1    Jarugula, V.2    Dieterich, H.A.3
  • 57
    • 34547628374 scopus 로고    scopus 로고
    • Pharmacokinetics of the oral direct renin inhibitor aliskiren alone and in combination with irbesartan in renal impairment
    • Vaidyanathan S, Bigler H, Yeh C, et al. Pharmacokinetics of the oral direct renin inhibitor aliskiren alone and in combination with irbesartan in renal impairment. Clin Pharmacokinet 2007; 46 (8): 661-75
    • (2007) Clin Pharmacokinet , vol.46 , Issue.8 , pp. 661-675
    • Vaidyanathan, S.1    Bigler, H.2    Yeh, C.3
  • 58
    • 33846456943 scopus 로고    scopus 로고
    • Pharmacokinetics, safety, and tolerability of the oral renin inhibitor aliskiren in patients with hepatic impairment
    • Feb;
    • Vaidyanathan S, Warren V, Yeh C, et al. Pharmacokinetics, safety, and tolerability of the oral renin inhibitor aliskiren in patients with hepatic impairment. J Clin Pharmacol 2007 Feb; 47 (2): 192-200
    • (2007) J Clin Pharmacol , vol.47 , Issue.2 , pp. 192-200
    • Vaidyanathan, S.1    Warren, V.2    Yeh, C.3
  • 59
    • 33749853955 scopus 로고    scopus 로고
    • Lack of pharmacokinetic interactions of aliskiren, a novel direct renin inhibitor for the treatment of hypertension, with the antihypertensives amlodipine, valsartan, hydrochlorothiazide (HCTZ) and ramipril in healthy volunteers
    • Nov;
    • Vaidyanathan S, Valencia J, Kemp C, et al. Lack of pharmacokinetic interactions of aliskiren, a novel direct renin inhibitor for the treatment of hypertension, with the antihypertensives amlodipine, valsartan, hydrochlorothiazide (HCTZ) and ramipril in healthy volunteers. Int J Clin Pract 2006 Nov; 60 (11): 1343-56
    • (2006) Int J Clin Pract , vol.60 , Issue.11 , pp. 1343-1356
    • Vaidyanathan, S.1    Valencia, J.2    Kemp, C.3
  • 60
    • 54049086657 scopus 로고    scopus 로고
    • Pharmacokinetics of the oral direct renin inhibitor aliskiren in combination with digoxin, atorvastatin, and ketoconazole in healthy subjects: The role of p-glycoprotein in the disposition of aliskiren
    • Nov;
    • Vaidyanathan S, Camenisch G, Schuetz H, et al. Pharmacokinetics of the oral direct renin inhibitor aliskiren in combination with digoxin, atorvastatin, and ketoconazole in healthy subjects: the role of p-glycoprotein in the disposition of aliskiren. J Clin Pharmacol 2008 Nov; 48 (11): 1323-38
    • (2008) J Clin Pharmacol , vol.48 , Issue.11 , pp. 1323-1338
    • Vaidyanathan, S.1    Camenisch, G.2    Schuetz, H.3
  • 61
    • 53549097913 scopus 로고    scopus 로고
    • The development of the direct renin inhibitor aliskiren: Treating hypertension and beyond
    • Sep;
    • Siragy H, Huang J, Lieb DC. The development of the direct renin inhibitor aliskiren: treating hypertension and beyond. Expert Opin Emerg Drugs 2008 Sep; 13 (3): 417-30
    • (2008) Expert Opin Emerg Drugs , vol.13 , Issue.3 , pp. 417-430
    • Siragy, H.1    Huang, J.2    Lieb, D.C.3
  • 62
    • 34547925543 scopus 로고    scopus 로고
    • Aliskiren: A review of its use in the management of hypertension
    • Frampton JE, Curran MP. Aliskiren: a review of its use in the management of hypertension. Drugs 2007; 67 (12): 1767-92
    • (2007) Drugs , vol.67 , Issue.12 , pp. 1767-1792
    • Frampton, J.E.1    Curran, M.P.2
  • 63
    • 33947182655 scopus 로고    scopus 로고
    • Aliskiren, an oral renin inhibitor, provides dose-dependent efficacy and sustained 24-hour blood pressure control in patients with hypertension
    • Mar 20;
    • Oh BH, Mitchell J, Herron JR, et al. Aliskiren, an oral renin inhibitor, provides dose-dependent efficacy and sustained 24-hour blood pressure control in patients with hypertension. J Am Coll Cardiol 2007 Mar 20; 49 (11): 1157-63
    • (2007) J Am Coll Cardiol , vol.49 , Issue.11 , pp. 1157-1163
    • Oh, B.H.1    Mitchell, J.2    Herron, J.R.3
  • 64
    • 36949012071 scopus 로고    scopus 로고
    • Safety and efficacy of the oral direct renin inhibitor aliskiren in elderly patients with hypertension
    • Verdecchia P, Calvo C, Mockel V, et al. Safety and efficacy of the oral direct renin inhibitor aliskiren in elderly patients with hypertension. Blood Press 2007; 16 (6): 381-91
    • (2007) Blood Press , vol.16 , Issue.6 , pp. 381-391
    • Verdecchia, P.1    Calvo, C.2    Mockel, V.3
  • 65
    • 53349092083 scopus 로고    scopus 로고
    • Direct renin inhibition: An evaluation of the safety and tolerability of aliskiren
    • Sep;
    • Rashid H. Direct renin inhibition: an evaluation of the safety and tolerability of aliskiren. Curr Med Res Opin 2008 Sep; 24 (9): 2627-37
    • (2008) Curr Med Res Opin , vol.24 , Issue.9 , pp. 2627-2637
    • Rashid, H.1
  • 66
    • 33750357566 scopus 로고    scopus 로고
    • Aliskiren, a novel orally effective renin inhibitor, exhibits similar pharmacokinetics and pharmacodynamics in Japanese and Caucasian subjects
    • Dec;
    • Vaidyanathan S, Jermany J, Yeh C, et al. Aliskiren, a novel orally effective renin inhibitor, exhibits similar pharmacokinetics and pharmacodynamics in Japanese and Caucasian subjects. Br J Clin Pharmacol 2006 Dec; 62 (6): 690-8
    • (2006) Br J Clin Pharmacol , vol.62 , Issue.6 , pp. 690-698
    • Vaidyanathan, S.1    Jermany, J.2    Yeh, C.3
  • 67
    • 33846781398 scopus 로고    scopus 로고
    • Aliskiren, a novel oral renin inhibitor, provides dose-dependent efficacy and placebo-like tolerability in Japanese patients with hypertension
    • Dec;
    • Kushiro T, Itakura H, Abo Y, et al. Aliskiren, a novel oral renin inhibitor, provides dose-dependent efficacy and placebo-like tolerability in Japanese patients with hypertension. Hypertens Res 2006 Dec; 29 (12): 997-1005
    • (2006) Hypertens Res , vol.29 , Issue.12 , pp. 997-1005
    • Kushiro, T.1    Itakura, H.2    Abo, Y.3
  • 68
    • 34247867955 scopus 로고    scopus 로고
    • Direct renin inhibition with aliskiren in obese patients with arterial hypertension
    • May;
    • Jordan J, Engeli S, Boye SW, et al. Direct renin inhibition with aliskiren in obese patients with arterial hypertension. Hypertension 2007 May; 49 (5): 1047-55
    • (2007) Hypertension , vol.49 , Issue.5 , pp. 1047-1055
    • Jordan, J.1    Engeli, S.2    Boye, S.W.3
  • 69
    • 33750289480 scopus 로고    scopus 로고
    • Aliskiren exhibits similar pharmacokinetics in healthy volunteers and patients with type 2 diabetes mellitus
    • Zhao C, Vaidyanathan S, Yeh CM, et al. Aliskiren exhibits similar pharmacokinetics in healthy volunteers and patients with type 2 diabetes mellitus. Clin Pharmacokinet 2006; 45 (11): 1125-34
    • (2006) Clin Pharmacokinet , vol.45 , Issue.11 , pp. 1125-1134
    • Zhao, C.1    Vaidyanathan, S.2    Yeh, C.M.3
  • 70
    • 33846421005 scopus 로고    scopus 로고
    • Aliskiren reduces blood pressure and suppresses plasma renin activity in combination with a thiazide diuretic, an angiotensin-converting enzyme inhibitor, or an angiotensin receptor blocker
    • Feb;
    • O'Brien E, Barton J, Nussberger J, et al. Aliskiren reduces blood pressure and suppresses plasma renin activity in combination with a thiazide diuretic, an angiotensin-converting enzyme inhibitor, or an angiotensin receptor blocker. Hypertension 2007 Feb; 49 (2): 276-84
    • (2007) Hypertension , vol.49 , Issue.2 , pp. 276-284
    • O'Brien, E.1    Barton, J.2    Nussberger, J.3
  • 71
    • 9644287897 scopus 로고    scopus 로고
    • Pharmacologic demonstration of the synergistic effects of a combination of the renin inhibitor aliskiren and the AT1 receptor antagonist valsartan on the angiotensin II-renin feedback interruption
    • Dec;
    • Azizi M, Menard J, Bissery A, et al. Pharmacologic demonstration of the synergistic effects of a combination of the renin inhibitor aliskiren and the AT1 receptor antagonist valsartan on the angiotensin II-renin feedback interruption. J Am Soc Nephrol 2004 Dec; 15 (12): 3126-33
    • (2004) J Am Soc Nephrol , vol.15 , Issue.12 , pp. 3126-3133
    • Azizi, M.1    Menard, J.2    Bissery, A.3
  • 72
    • 0346447922 scopus 로고    scopus 로고
    • BP lowering with SPP 100: A novel orally active renin inhibitor - a pilot study [abstract]
    • Sept 1;
    • Stanton AV, Jensen C, Mann J, et al. BP lowering with SPP 100: a novel orally active renin inhibitor - a pilot study [abstract]. Hypertension 2001 Sept 1; 38 (3): 526
    • (2001) Hypertension , vol.38 , Issue.3 , pp. 526
    • Stanton, A.V.1    Jensen, C.2    Mann, J.3
  • 73
    • 0036372173 scopus 로고    scopus 로고
    • Angiotensin II suppression in humans by the orally active renin inhibitor aliskiren (SPP100): Comparison with enalapril
    • Jan;
    • Nussberger J, Wuerzner G, Jensen C, et al. Angiotensin II suppression in humans by the orally active renin inhibitor aliskiren (SPP100): comparison with enalapril. Hypertension 2002 Jan; 39 (1): E1-8
    • (2002) Hypertension , vol.39 , Issue.1
    • Nussberger, J.1    Wuerzner, G.2    Jensen, C.3
  • 74
    • 0347479295 scopus 로고    scopus 로고
    • Blood pressure lowering in essential hypertension with an oral renin inhibitor, aliskiren
    • Dec;
    • Stanton A, Jensen C, Nussberger J, et al. Blood pressure lowering in essential hypertension with an oral renin inhibitor, aliskiren. Hypertension 2003 Dec; 42 (6): 1137-43
    • (2003) Hypertension , vol.42 , Issue.6 , pp. 1137-1143
    • Stanton, A.1    Jensen, C.2    Nussberger, J.3
  • 75
    • 14844363404 scopus 로고    scopus 로고
    • Aliskiren, a novel orally effective renin inhibitor, provides dose-dependent antihypertensive efficacy and placebo-like tolerability in hypertensive patients
    • Mar 1;
    • Gradman AH, Schmieder RE, Lins RL, et al. Aliskiren, a novel orally effective renin inhibitor, provides dose-dependent antihypertensive efficacy and placebo-like tolerability in hypertensive patients. Circulation 2005 Mar 1; 111 (8): 1012-8
    • (2005) Circulation , vol.111 , Issue.8 , pp. 1012-1018
    • Gradman, A.H.1    Schmieder, R.E.2    Lins, R.L.3
  • 76
    • 33845366982 scopus 로고    scopus 로고
    • Renin inhibition with aliskiren provides additive antihypertensive efficacy when used in combination with hydrochlorothiazide
    • Jan;
    • Villamil A, Chrysant SG, Calhoun D, et al. Renin inhibition with aliskiren provides additive antihypertensive efficacy when used in combination with hydrochlorothiazide. J Hypertens 2007 Jan; 25 (1): 217-26
    • (2007) J Hypertens , vol.25 , Issue.1 , pp. 217-226
    • Villamil, A.1    Chrysant, S.G.2    Calhoun, D.3
  • 77
    • 36248931230 scopus 로고    scopus 로고
    • Antihypertensive efficacy of the oral direct renin inhibitor aliskiren as add-on therapy in patients not responding to amlodipine monotherapy
    • Oct;
    • Drummond W, Munger MA, Rafique Essop M, et al. Antihypertensive efficacy of the oral direct renin inhibitor aliskiren as add-on therapy in patients not responding to amlodipine monotherapy. J Clin Hypertens (Greenwich) 2007 Oct; 9 (10): 742-50
    • (2007) J Clin Hypertens (Greenwich) , vol.9 , Issue.10 , pp. 742-750
    • Drummond, W.1    Munger, M.A.2    Rafique Essop, M.3
  • 78
    • 38649102508 scopus 로고    scopus 로고
    • Efficacy and safety of the direct renin inhibitor aliskiren and ramipril alone or in combination in patients with diabetes and hypertension
    • Dec;
    • Uresin Y, Taylor AA, Kilo C, et al. Efficacy and safety of the direct renin inhibitor aliskiren and ramipril alone or in combination in patients with diabetes and hypertension. J Renin Angiotensin Aldosterone Syst 2007 Dec; 8 (4): 190-8
    • (2007) J Renin Angiotensin Aldosterone Syst , vol.8 , Issue.4 , pp. 190-198
    • Uresin, Y.1    Taylor, A.A.2    Kilo, C.3
  • 79
    • 39849089447 scopus 로고    scopus 로고
    • Comparative efficacy and safety of aliskiren, an oral direct renin inhibitor, and ramipril in hypertension: A 6-month, randomized, double-blind trial
    • Mar;
    • Andersen K, Weinberger MH, Egan B, et al. Comparative efficacy and safety of aliskiren, an oral direct renin inhibitor, and ramipril in hypertension: a 6-month, randomized, double-blind trial. J Hypertens 2008 Mar; 26 (3): 589-99
    • (2008) J Hypertens , vol.26 , Issue.3 , pp. 589-599
    • Andersen, K.1    Weinberger, M.H.2    Egan, B.3
  • 80
    • 34447521458 scopus 로고    scopus 로고
    • Efficacy and safety of combined use of aliskiren and valsartan in patients with hypertension: A randomised, double-blind trial
    • Jul 21;
    • Oparil S, Yarows SA, Patel S, et al. Efficacy and safety of combined use of aliskiren and valsartan in patients with hypertension: a randomised, double-blind trial. Lancet 2007 Jul 21; 370 (9583): 221-9
    • (2007) Lancet , vol.370 , Issue.9583 , pp. 221-229
    • Oparil, S.1    Yarows, S.A.2    Patel, S.3
  • 81
    • 33747332458 scopus 로고    scopus 로고
    • The novel renin inhibitor aliskiren is not associated with rebound effects on blood pressure or plasma renin activity following treatment withdrawal [abstract]
    • Herron J, Mitchell J, Oh B. The novel renin inhibitor aliskiren is not associated with rebound effects on blood pressure or plasma renin activity following treatment withdrawal [abstract]. J Clin Hypertens 2006; 8 (5 Suppl. A): A86-7
    • (2006) J Clin Hypertens , vol.8 , Issue.5 SUPPL. A
    • Herron, J.1    Mitchell, J.2    Oh, B.3
  • 82
    • 44849114597 scopus 로고    scopus 로고
    • Aliskiren combined with losartan in type 2 diabetes and nephropathy
    • Jun 5;
    • Parving HH, Persson F, Lewis JB, et al. Aliskiren combined with losartan in type 2 diabetes and nephropathy. N Engl J Med 2008 Jun 5; 358 (23): 2433-46
    • (2008) N Engl J Med , vol.358 , Issue.23 , pp. 2433-2446
    • Parving, H.H.1    Persson, F.2    Lewis, J.B.3
  • 83
    • 0035922441 scopus 로고    scopus 로고
    • Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy
    • Sep 20;
    • Brenner BM, Cooper ME, de Zeeuw D, et al. Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy. N Engl J Med 2001 Sep 20; 345 (12): 861-9
    • (2001) N Engl J Med , vol.345 , Issue.12 , pp. 861-869
    • Brenner, B.M.1    Cooper, M.E.2    de Zeeuw, D.3


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