Effect of sphingosine kinase 1 on the apoptosis, migration and invasion of colon cancer TH-29 cells and its molecular mechanisms

Chinese Journal of Oncology

Volumn 33, Issue 3, 2011, Pages 178-182

  Liu, Shi Quan ^a   Qin, Meng Bin ^a   Huang, Jie An ^a   Zhong, Yue Yuan ^a   Tang, Guo Du ^a   Jiang, Hai Xing ^a  

^a GUANGXI MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Cell line; Colonic neoplasms; Invasion; Migration; Sphingosine kinase 1

Indexed keywords

JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; N,N DIMETHYLSPHINGOSINE; PHORBOL 13 ACETATE 12 MYRISTATE; SPHINGOSINE KINASE 1;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INVASION; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CELL VIABILITY; COLON CANCER; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME INHIBITION; FLOW CYTOMETRY; PROTEIN EXPRESSION; WESTERN BLOTTING;

APOPTOSIS; CARCINOGENS; CELL MOVEMENT; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HT29 CELLS; HUMANS; MAP KINASE KINASE 4; NEOPLASM INVASIVENESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); SPHINGOSINE; TETRADECANOYLPHORBOL ACETATE; TIME FACTORS;

EID: 80053386946     PISSN: 02533766     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0253-3766.2011.03.006     Document Type: Article

References (11)

1. Shida D, Takabe K, Kapitonov D, et al. Targeting SphK1 as a new strategy against cancer. Curr Drug Targets, 2008, 9:662-673.
2. Sarkar S, Maceyka M, Hait NC, et al. Sphingosine kinase 1 is required for migration, proliferation and survival of MCF-7 human breast cancer cells. FEBS Lett, 2005, 579:5313-5317. (Pubitemid 41395149)
3. Guillermet-Guibert J, Davenne L, Pchejetski D, et al. Targeting the sphingolipid metabolism to defeat pancreatic cancer cell resistance to the chemotherapeutic gemcitabine drug. Mol Cancer Ther, 2009, 8:809-820.
4. Kapitonov D, Allegood JC, Mitchell C, et al. Targeting sphingosine kinase 1 inhibits Akt signaling, induces apoptosis, and suppresses growth of human glioblastoma cells and xenografts. Cancer Res, 2009, 69:6915-6923.
5. Pchejetski D, Golzio M, Bonhoure E, et al. Sphingosine kinase-1 as a chemotherapy sensor in prostate adenocarcinoma cell and mouse models. Cancer Res, 2005, 65:11667-11675. (Pubitemid 41821727)
6. Kawamori T, Osta W, Johnson KR, et al. Sphingosine kinase 1 is up-regulated in colon carcinogenesis. FASEB J, 2006, 20:386-388. (Pubitemid 46671180)
7. Kawamori T, Kaneshiro T, Okumura M, et al. Role for sphingosine kinase 1 in colon carcinogenesis. FASEB J, 2009, 23:405414.
8. Shida D, Fang X, Kordula T, et al. Cross-talk between LPA1 and epidermal growth factor receptors mediates up-regulation of sphingosine kinase 1 to promote gastric cancer cell motility and invasion. Cancer Res, 2008, 68:6569-6577.
9. Gulmann C, Sheehan KM, Conroy RM, et al. Quantitative cell signalling analysis reveals down-regulation of MAPK pathway activation in colorectal cancer. J Pathol, 2009, 218:514-519.
10. Palozza P, Torelli C, Boninsegna A, et al. Growth-inhibitory effects of the astaxanthin-rich alga Haematococcus pluvialis in human colon cancer cells. Cancer Lett, 2009, 283:108-117.
11. Nemoto S, Nakamura M, Osawa Y, et al. Sphingosine kinase isoforms regulate oxaliplatin sensitivity of human colon cancer cells through ceramide accumulation and Akt activation. J Biol Chem, 2009, 284:10422-10432.