Transforming growth factor-β signaling pathway in Marfan's syndrome: A preliminary histopathological study;Transforming growth factor-β signalpfad beim Marfan-syndrom: Eine präliminäre histopathologische Studie

Vasa - Journal of Vascular Diseases

Volumn 40, Issue 5, 2011, Pages 369-374

  Yuan, S M ^a   Ma, H H ^a   Zhang, R S ^a   Jing, H ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

Marfan syndrome; Signal transduction; Smad proteins; Transforming growth factor beta; Transforming growth factor beta receptors

Indexed keywords

ACID GLYCOSAMINOGLYCAN; ALCIAN BLUE; COLLAGEN; EOSIN; HEMATOXYLIN; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA1;

ADULT; ADVENTITIA; AORTA; AORTA MEDIA; AORTA WALL; ARTERY MEDIA; ARTICLE; AUTOPSY; BIOACCUMULATION; CELL NUCLEUS; CONTROLLED STUDY; CYTOPLASM; ELASTIC FIBER; ELASTIC TISSUE; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTIMA; MARFAN SYNDROME; PERIODIC ACID SCHIFF STAIN; SIGNAL TRANSDUCTION; TISSUE SECTION; TISSUE STRUCTURE; VASCULAR SMOOTH MUSCLE;

EID: 80053372171     PISSN: 03011526     EISSN: None     Source Type: Journal    
DOI: 10.1024/0301-1526/a000133     Document Type: Article

References (25)

1. Agrotis A, Kalinina N, Bobik A. Transforming growth factor-β, cell signaling and cardiovascular disorders. Curr Vasc Pharmacol 2005; 3: 55-61
2. Dean JC. Management of Marfan syndrome. Heart 2002; 88: 97-103
3. Gomez D, Coyet A, Ollivier V, Jeunemaitre X, Jondeau G, Michel JB, Vranckx R. Epigenetic control of vascular smooth muscle cellsin Marfan and non-Marfan thoracic aorticaneurysms. Cardiovasc Res 2011; 89: 446-56
4. Hilhorst-Hofstee Y, Hamel BC, Verheij JB, Rijlaarsdam ME, Mancini GM, Cobben JM, Giroth C, Ruivenkamp CA, Hansson KB, Timmermans J, Moll HA, Breuning MH, Pals G. Th e clinical spectrum of complete FBN1 allele deletions. Eur J Hum Genet 2010; 19: 247-52
5. Horbelt D, Guo G, Robinson PN, Knaus P. Quantitative analysis of TβRII mutations in Marfan-syndrome-related disorders suggests a correlation between phenotypic severity and Smad signaling activity. J Cell Sci 2010; 123 (Pt 24): 4340-50
6. Ishida W, Mori Y, Lakos G, Sun L, Shan F, Bowes S, Josiah S, Lee WC, Singh J, Ling LE, Varga J. Intracel-lular TGF-β receptor blockade abrogates Smad-dependent fi broblast activation in vitro and in vivo. J Invest Dermatol 2006; 126: 1733-44
7. Johnson PT, Chen JK, Loeys BL, Dietz HC, Fishman EK. Loeys-Dietz syndrome: MDCT angiography fi ndings. AJR Am J Roentgenol 2007; 189:W29-35
8. Jones JA, Barbour JR, Stroud RE, Bouges S, Stephens SL, Spinale FG, Ikonomidis JS. Altered transforming growth factor-β signaling in a murine model of thoracic aortic aneurysm. J Vasc Res 2008; 45: 457-68
9. Jones JA, Spinale FG, Ikonomidis JS. Transforming growth factor-beta signaling in thoracic aortic aneurysm development: a paradox in pathogenesis. J Vasc Res 2009; 46: 119-37
10. Kaartinen V, Warburton D. Fibrillin controls TGF-β activation. Nat Genet 2003; 33: 331-2
11. Karthikeyan M, Blobe GC. TGFbeta type I receptor. UCSD-Nature Molecule Pages 2007. Doi: 10.1038/ mp.a002272.01
12. Maleszewski JJ, Miller DV, Lu J, Dietz HC, Halushka MK. Histopathologic fi ndings in ascending aortas from individuals with Loeys-Dietz syndrome (LDS). Am J Surg Pathol 2009; 33: 194-201
13. Matsumura G, Miyagawa-Tomita S, Shin'oka T, Ikada Y, Kurosawa H. First evidence that bone marrow cells contribute to the construction of tissue-engineered vascular autograft s in vivo. Circulation 2003; 108: 1729-34
14. Milewicz DM, Dietz HC, Miller DC. Treatment of aortic disease in patients with Marfan syndrome. Circulation 2005; 111:e150-7
15. Mizuguchi T, Collod-Beroud G, Akiyama T, Abifadel M, Harada N, Morisaki T, Allard D, Varret M, Claustres M, Morisaki H, Ihara M, Kinoshita A, Yoshiura K, Junien C, Kajii T, Jondeau G, Ohta T, Kishino T, Furukawa Y, Nakamura Y, Niikawa N, Boileau C, Matsumoto N. Heterozygous TGFBR2 mutations in Marfan syndrome. Nat Genet 2004; 36: 855-60
16. Mori Y, Ishida W, Bhattacharyya S, Li Y, Platanias LC, Varga J. Selective inhibition of activin receptor-like kinase 5 signaling blocks profi brotic transforming growth factor β responses in skin fi broblasts. Arthritis Rheum 2004; 50: 4008-21
17. Nataatmadja M, West M, West J, Summers K, Walker P, Nagata M, Watanabe T. Abnormal extracellular matrix protein transport associated with increased apoptosis of vascular smooth muscle cells in marfan syndrome and bicuspid aortic valve thoracic aortic aneurysm. Circulation 2003; 108 Suppl 1:II329-II34.
18. Popovic N, Bridenbaugh EA, Neiger JD, Hu JJ, Vannucci M, Mo Q, Trzeciakowski J, Miller MW, Fossum TW, Humphrey JD, Wilson E. Transforming growth factor-β signaling in hypertensive remodeling of porcine aorta. Am J Physiol Heart Circ Physiol 2009; 297:H2044-53
19. Recchia D, Sharkey AM, Bosner MS, Kouchoukos NT, Wickline SA. Sensitive detection of abnormal aortic architecture in Marfan syndrome with high-frequency ultrasonic tissue characterization. Circulation 1995; 91: 1036-43
20. Rodriguez-Vita J, Sanchez-Lopez E, Esteban V, Ruperez M, Egido J, Ruiz-Ortega M. Angiotensin II activates the Smad pathway in vascular smooth muscle cells by a transforming growth factor-β-independent mechanism. Circulation 2005; 111: 2509-17
21. Sun F, Hayama E, Nakanishi T. Abstract 2606: Expression of transforming growth factor-β in the aorta of congenital heart disease. Circulation 2008; 118:S752.
22. Taipale J, Saharinen J, Hedman K, Keski-Oja J. Latent transforming growth factor-β1 and its binding protein are components of extracellular matrix microfi brils. J Histochem Cytochem 1996; 44: 875-89
23. von Kodolitsch Y, Rybczynski M, Bernhardt A, Mir TS, Treede H, Dodge-Khatami A, Robinson PN, Sheikhzadeh S, Reichenspurner H, Meinertz T. Marfan syndrome and the evolving spectrum of heritable thoracic aortic disease: do we need genetics for clinical decisions? Vasa 2010; 39: 17-32
24. Wang X, LeMaire SA, Chen L, Shen YH, Gan Y, Bartsch H, Carter SA, Utama B, Ou H, Coselli JS, Wang XL. Increased collagen deposition and elevated expression of connective tissue growth factor in human thoracic aortic dissection. Circulation 2006; 114 (1 Suppl):I200-5
25. Yamashita T, Ohneda O, Nagano M, Iemitsu M, Makino Y, Tanaka H, Miyauchi T, Goto K, Ohneda K, Fujii-Kuriyama Y, Poellinger L, Yamamoto M. Abnormal heart development and lung remodeling in mice lacking the hypoxia-inducible factor-related basic helix-loop-helix PAS protein NEPAS. Mol Cell Biol 2008; 28: 1285-97.