Transforming growth factor-β signaling in hypertensive remodeling of porcine aorta

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 297, Issue 6, 2009, Pages

  Popovic, Natasa ^a   Bridenbaugh, Eric A ^a   Neiger, Jessemy D ^a   Hu, Jin Jia ^b   Vannucci, Marina ^a,c   Mo, Qianxing ^a   Trzeciakowski, Jerome ^a   Miller, Matthew W ^a   Fossum, Theresa W ^a   Humphrey, Jay D ^a,b   Wilson, Emily ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

^b Texas A and M University   (United States)

^c Rice University   (United States)

Author keywords

Control element; Hypertensive vascular remodeling; Mechanosensation; Transforming growth factor ; Transforming growth factor 1 activation; Wall stress

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 4; LATENCY ASSOCIATED PEPTIDE; SMAD1 PROTEIN; SMAD2 PROTEIN; SMAD5 PROTEIN; SMAD8 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; TRANSFORMING GROWTH FACTOR BETA3;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; AORTA COARCTATION; ARTICLE; CONTROLLED STUDY; CYTOSKELETON; DATA BASE; DOWN REGULATION; GENE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENOME; HYPERTENSION; IMMUNOHISTOCHEMISTRY; MEAN ARTERIAL PRESSURE; MICROARRAY ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SHAM PROCEDURE; STAINING; SWINE; UPREGULATION; WESTERN BLOTTING;

ANIMALS; AORTA; AORTIC COARCTATION; BLOTTING, WESTERN; BONE MORPHOGENETIC PROTEINS; CELL DIFFERENTIATION; DATABASES, GENETIC; DISEASE MODELS, ANIMAL; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HYPERTENSION; IMMUNOHISTOCHEMISTRY; MUSCLE, SMOOTH, VASCULAR; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHOSPHORYLATION; POLYMERASE CHAIN REACTION; REGIONAL BLOOD FLOW; SIGNAL TRANSDUCTION; SMAD PROTEINS; SWINE; SWINE, MINIATURE; TRANSFORMING GROWTH FACTOR BETA; ULTRASONOGRAPHY, DOPPLER, COLOR;

EID: 72249108953     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.01015.2008     Document Type: Article

References (38)

1. Abreu JG, Ketpura NI, Reversade B, De Robertis EM. Connectivetissue growth factor (CTGF) modulates cell signalling by BMP and TGF-beta. Nat Cell Biol 4: 599-604, 2002. (Pubitemid 34905599)
2. American Heart Association. Heart Disease and Stroke Statistics-2006 Update. Dallas, TX: American Heart Association, 2006, p. 18.
3. Annes JP, Munger JS, Rifkin DB. Making sense of latent TGFbeta activation. J Cell Sci 116: 217-224, 2003.
4. Assoian RK, Fleurdelys BE, Stevenson HC, Miller PJ, Madtes DK, Raines EW, Ross R, Sporn MB. Expression and secretion of type beta transforming growth factor by activated human macrophages. Proc Natl Acad Sci USA 84: 6020-6024, 1987. (Pubitemid 17140174)
5. Assoian RK, Sporn MB. Type beta transforming growth factor in human platelets: release during platelet degranulation and action on vascular smooth muscle cells. J Cell Biol 102: 1217-1223, 1986.
6. Chaudhry SS, Cain SA, Morgan A, Dallas SL, Shuttleworth CA, Kielty CM. Fibrillin-1 regulates the bioavailability of TGFbeta1. J Cell Biol 176: 355-367, 2007.
7. Churchill GA. Fundamentals of experimental design for cDNA microarrays. Nat Genet 32, Suppl: 490-495, 2002.
8. Dobbin K, Shih JH, Simon R. Questions and answers on design of dual-label microarrays for identifying differentially expressed genes. J Natl Cancer Inst 95: 1362-1369, 2003. (Pubitemid 37220455)
9. Ehrhart EJ, Segarini P, Tsang ML, Carroll AG, Barcellos-Hoff MH. Latent transforming growth factor beta1 activation in situ: quantitative and functional evidence after low-dose gamma-irradiation. FASEB J 11: 991-1002, 1997. (Pubitemid 27425901)
10. Fossum TW, Baltzer WI, Miller MW, Aguirre M, Whitlock D, Solter P, Makarski LA, McDonald MM, An MY, Humphrey JD. A novel aortic coarctation model for studying hypertension in the pig. J Invest Surg 16: 35-44, 2003. (Pubitemid 36372583)
11. Ge G, Greenspan DS. BMP1 controls TGFbeta1 activation via cleavage of latent TGFbeta-binding protein. J Cell Biol 175: 111-120, 2006. (Pubitemid 44537203)
12. Hautmann MB, Madsen CS, Owens GK. A transforming growth factor beta (TGFbeta) control element drives TGFbeta-induced stimulation of smooth muscle alpha-actin gene expression in concert with two CArG elements. J Biol Chem 272: 10948-10956, 1997. (Pubitemid 27181115)
13. Hu JJ, Ambrus A, Fossum TW, Miller MW, Humphrey JD, Wilson E. Time courses of growth and remodeling of porcine aortic media during hypertension: a quantitative immunohistochemical examination. J Histochem Cytochem 56: 359-370, 2008.
14. Izzo JL Jr, Sica DA, Black HR. Hypertension Primer (4th Ed.). Philadelphia, PA: Lippincot, Williams and Wilkins, 2008, p. 8-12.
15. Izzo JL Jr, Sica DA, Black HR. Hypertension Primer (4th Ed.). Philadelphia, PA: Lippincot, Williams and Wilkins, 2008, p. 14-23.
16. King KE, Iyemere VP, Weissberg PL, Shanahan CM. Kruppel-like factor 4 (KLF4/GKLF) is a target of bone morphogenetic proteins and transforming growth factor beta 1 in the regulation of vascular smooth muscle cell phenotype. J Biol Chem 278: 11661-11669, 2003.
17. Li Q, Muragaki Y, Hatamura I, Ueno H, Ooshima A. Stretch-induced collagen synthesis in cultured smooth muscle cells from rabbit aortic media and a possible involvement of angiotensin II and transforming growth factor-beta. J Vasc Res 35: 93-103, 1998. (Pubitemid 28191775)
18. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2[-delta delta C(T)] method. Methods 25: 402-408, 2001. (Pubitemid 34164012)
19. Lyons KM, Pelton RW, Hogan BL. Organogenesis and pattern formation in the mouse: RNA distribution patterns suggest a role for bone morphogenetic protein-2A (BMP-2A). Development 109: 833-844, 1990. (Pubitemid 20267195)
20. Matsumoto T, Hayashi K. Stress and strain distribution in hypertensive and normotensive rat aorta considering residual strain. J Biomech Eng 118: 62-73, 1996. (Pubitemid 26087284)
21. Neptune ER, Frischmeyer PA, Arking DE, Myers L, Bunton TE, Gayraud B, Ramirez F, Sakai LY, Dietz HC. Dysregulation of TGFbeta activation contributes to pathogenesis in Marfan syndrome. Nat Genet 33: 407-411, 2003. (Pubitemid 36278859)
22. Nikol S, Isner JM, Pickering JG, Kearney M, Leclerc G, Weir L. Expression of transforming growth factor-beta 1 is increased in human vascular restenosis lesions. J Clin Invest 90: 1582-1592, 1992.
23. Owens GK, Kumar MS, Wamhoff BR. Molecular regulation of vascular smooth muscle cell differentiation in development and disease. Physiol Rev 84: 767-801, 2004. (Pubitemid 38823766)
24. Prewitt RL, Rice DC, Dobrian AD. Adaptation of resistance arteries to increases in pressure. Microcirculation 9: 295-304, 2002.
25. Rice P, Longden I, Bleasby A. EMBOSS: the European Molecular Biology Open Software Suite. Trends Genet 16: 276-277, 2000.
26. Rodriguez-Vita J, Ruiz-Ortega M, Ruperez M, Esteban V, Sanchez- Lopez E, Plaza JJ, Egido J. Endothelin-1, via ETA receptor and independently of transforming growth factor-beta, increases the connective tissue growth factor in vascular smooth muscle cells. Circ Res 97: 125-134, 2005. (Pubitemid 41033468)
27. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 362: 801-809, 1993.
28. Ruiz-Ortega M, Rodríguez-Vita J, Sanchez-Lopez E, Carvajal G, Egido J. TGF-β signaling in vascular fibrosis. Cardiovasc Res 74: 196-206, 2007.
29. Saltis J, Agrotis A, Bobik A. TGF-beta 1 potentiates growth factorstimulated proliferation of vascular smooth muscle cells in genetic hypertension. Am J Physiol Cell Physiol 263: C420-C428, 1992.
30. Sanford LP, Ormsby I, Gittenberger-de Groot AC, Sariola H, Friedman R, Boivin GP, Cardell EL, Doetschman T. TGFbeta2 knockout mice have multiple developmental defects that are non-overlapping with other TGFbeta knockout phenotypes. Development 124: 2659-2670, 1997. (Pubitemid 27341765)
31. Sato Y, Rifkin DB. Inhibition of endothelial cell movement by pericytes and smooth muscle cells: activation of a latent transforming growth factor-beta 1-like molecule by plasmin during co-culture. J Cell Biol 109: 309-315, 1989. (Pubitemid 19180138)
32. Schmierer B, Hill CS. TGFbeta-SMAD signal transduction: molecular specificity and functional flexibility. Nat Rev Mol Cell Biol 8: 970-982, 2007. (Pubitemid 350174642)
33. Sheppard D. Integrin-mediated activation of latent transforming growth factor beta. Cancer Metastasis Rev 24: 395-402, 2005. (Pubitemid 41569979)
34. Shi Y, Massague J. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 113: 685-700, 2003. (Pubitemid 36724933)
35. Sun Q, Chen G, Streb JW, Long X, Yang Y, Stoeckert CJ Jr, Miano JM. Defining the mammalian CArGome. Genome Res 16: 197-207, 2006.
36. Topouzis S, Majesky MW. Smooth muscle lineage diversity in the chick embryo. Dev Biol 178: 430-445, 1996.
37. Wang W, Huang XR, Canlas E, Oka K, Truong LD, Deng C, Bhowmick NA, Ju W, Bottinger EP, Lan HY. Essential role of Smad3 in angiotensin II-induced vascular fibrosis. Circ Res 98: 1032-1039, 2006. (Pubitemid 43755224)
38. Young GD, Murphy-Ullrich JE. Molecular interactions that confer latency to transforming growth factor-beta. J Biol Chem 279: 38032-38039, 2004.