-
1
-
-
77049151988
-
A review of the influence of bacterial infection and of bacterial products (Coleys toxins) on malignant tumors in man; A critical analysis of 30 inoperable cases treated by Coleys mixed toxins, in which diagnosis was confirmed by microscopic examination selected for special study
-
Nauts HC, Fowler GA, Bogatko FH. A review of the influence of bacterial infection and of bacterial products (Coleys toxins) on malignant tumors in man; a critical analysis of 30 inoperable cases treated by Coleys mixed toxins, in which diagnosis was confirmed by microscopic examination selected for special study. Acta Med Scand Suppl. 1953;276:1-103.
-
(1953)
Acta Med Scand Suppl
, vol.276
, pp. 1-103
-
-
Nauts, H.C.1
Fowler, G.A.2
Bogatko, F.H.3
-
2
-
-
0003135066
-
The treatment of inoperable sarcoma by bacterial toxins (the mixed toxins of the Streptococcus erysipelas and the Bacillus prodigiosus)
-
Coley WB. The treatment of inoperable sarcoma by bacterial toxins (the mixed toxins of the Streptococcus erysipelas and the Bacillus prodigiosus). Proc R Soc Med. 1910;3:1-48.
-
(1910)
Proc R Soc Med
, vol.3
, pp. 1-48
-
-
Coley, W.B.1
-
3
-
-
77954801079
-
Improved survival with ipilimumab in patients with metastatic melanoma
-
Hodi FS, ODay SJ, McDermott DF, et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med. 2010; 363:711-723.
-
(2010)
N Engl J Med
, vol.363
, pp. 711-723
-
-
Hodi, F.S.1
Oday, S.J.2
McDermott, D.F.3
-
4
-
-
34247891741
-
More than one reason to rethink the use of peptides in vaccine design
-
DOI 10.1038/nrd2224, PII NRD2224
-
Purcell AW, McCluskey J, Rossjohn J.More than one reason to rethink the use of peptides in vaccine design. Nat Rev Drug Discov. 2007;6:404-414. (Pubitemid 46696551)
-
(2007)
Nature Reviews Drug Discovery
, vol.6
, Issue.5
, pp. 404-414
-
-
Purcell, A.W.1
McCluskey, J.2
Rossjohn, J.3
-
5
-
-
0028064628
-
Cloning and analysis of MAGE-1-related genes
-
DOI 10.1006/bbrc.1994.1963
-
Ding M, Beck RJ, Keller CJ, et al. Cloning and analysis of MAGE-1-related genes. Biochem Biophys Res Commun. 1994;202:549-555. (Pubitemid 24252635)
-
(1994)
Biochemical and Biophysical Research Communications
, vol.202
, Issue.1
, pp. 549-555
-
-
Ding, M.1
Beck, R.J.2
Keller, C.J.3
Fenton, R.G.4
-
6
-
-
0034791644
-
Immunotherapy of melanoma
-
Smith C, Cerundolo V. Immunotherapy of melanoma. Immunology. 2001;104:1-7.
-
(2001)
Immunology
, vol.104
, pp. 1-7
-
-
Smith, C.1
Cerundolo, V.2
-
7
-
-
0035339880
-
High-dose interferon alfa-2b significantly prolongs relapse-free and overall survival compared with the GM2-KLH/QS-21 vaccine in patients with resected stage IIB-III melanoma: Results of intergroup trial E1694/S9512/C509801
-
Kirkwood JM, Ibrahim JG, Sosman JA, et al. High-dose interferon alfa-2b significantly prolongs relapse-free and overall survival compared with the GM2-KLH/QS-21 vaccine in patients with resected stage IIB-III melanoma: results of intergroup trial E1694/S9512/C509801. J Clin Oncol. 2001;19:2370-2380. (Pubitemid 32391207)
-
(2001)
Journal of Clinical Oncology
, vol.19
, Issue.9
, pp. 2370-2380
-
-
Kirkwood, J.M.1
Ibrahim, J.G.2
Sosman, J.A.3
Sondak, V.K.4
Agarwala, S.S.5
Ernstoff, M.S.6
Rao, U.7
-
8
-
-
0031890206
-
Immunologic and therapeutic evaluation of a synthetic peptide vaccine for the treatment of patients with metastatic melanoma
-
DOI 10.1038/nm0398-321
-
Rosenberg SA, Yang JC, Schwartzentruber DJ, et al. Immunologic and therapeutic evaluation of a synthetic peptide vaccine for the treatment of patients with metastatic melanoma. Nat Med. 1998;4:321-327. (Pubitemid 28144091)
-
(1998)
Nature Medicine
, vol.4
, Issue.3
, pp. 321-327
-
-
Rosenberg, S.A.1
Yang, J.C.2
Schwartzentruber, D.J.3
Hwu, P.4
Marincola, F.M.5
Topalian, S.L.6
Restifo, N.P.7
Dudley, M.E.8
Schwarz, S.L.9
Spiess, P.J.10
Wunderlich, J.R.11
Parkhurst, M.R.12
Kawakami, Y.13
Seipp, C.A.14
Einhorn, J.H.15
White, D.E.16
-
9
-
-
44249085912
-
Three phase II cytokine working group trials of gp100 (210M) peptide plus high-dose interleukin-2 in patients with HLA-A2-positive advanced melanoma
-
Sosman JA, Carrillo C, Urba WJ, et al. Three phase II cytokine working group trials of gp100 (210M) peptide plus high-dose interleukin-2 in patients with HLA-A2-positive advanced melanoma. J Clin Oncol. 2008;26:2292-2298.
-
(2008)
J Clin Oncol
, vol.26
, pp. 2292-2298
-
-
Sosman, J.A.1
Carrillo, C.2
Urba, W.J.3
-
10
-
-
79957831345
-
Gp100 peptide vaccine and interleukin-2 in patients with advanced melanoma
-
Schwartzentruber DJ, Lawson DH, Richards JM, et al. gp100 peptide vaccine and interleukin-2 in patients with advanced melanoma. N Engl J Med. 2011;364:2119-2127.
-
(2011)
N Engl J Med
, vol.364
, pp. 2119-2127
-
-
Schwartzentruber, D.J.1
Lawson, D.H.2
Richards, J.M.3
-
11
-
-
34247255391
-
Chemical adjuvants for plasmid DNA vaccines
-
DOI 10.1016/j.vaccine.2007.01.120, PII S0264410X07001545
-
Greenland JR, Letvin NL. Chemical adjuvants for plasmid DNA vaccines. Vaccine. 2007;25:3731-3741. (Pubitemid 46613830)
-
(2007)
Vaccine
, vol.25
, Issue.19
, pp. 3731-3741
-
-
Greenland, J.R.1
Letvin, N.L.2
-
12
-
-
35548944929
-
Safety and immunogenicity of tyrosinase DNA vaccines in patients with melanoma
-
DOI 10.1038/sj.mt.6300290, PII 6300290
-
Wolchok JD, Yuan J, Houghton AN, et al. Safety and immunogenicity of tyrosinase DNA vaccines in patients with melanoma. Mol Ther. 2007;15:2044-2050. (Pubitemid 350011745)
-
(2007)
Molecular Therapy
, vol.15
, Issue.11
, pp. 2044-2050
-
-
Wolchok, J.D.1
Yuan, J.2
Houghton, A.N.3
Gallardo, H.F.4
Rasalan, T.S.5
Wang, J.6
Zhang, Y.7
Ranganathan, R.8
Chapman, P.B.9
Krown, S.E.10
Livingston, P.O.11
Heywood, M.12
Riviere, I.13
Panageas, K.S.14
Terzulli, S.L.15
Perales, M.A.16
-
13
-
-
0032531161
-
Tumor immunity and autoimmunity induced by immunization with homologous DNA
-
Weber LW, Bowne WB, Wolchok JD, et al. Tumor immunity and autoimmunity induced by immunization with homologous DNA. J Clin Invest. 1998;102:1258-1264. (Pubitemid 28436286)
-
(1998)
Journal of Clinical Investigation
, vol.102
, Issue.6
, pp. 1258-1264
-
-
Weber, L.W.1
Bowne, W.B.2
Wolchok, J.D.3
Srinivasan, R.4
Qin, J.5
Moroi, Y.6
Clynes, R.7
Song, P.8
Lewis, J.J.9
Houghton, A.N.10
-
14
-
-
0037389779
-
Long-term survival of dogs with advanced malignant melanoma after DNA vaccination with xenogeneic human tyrosinase: A phase I trial
-
Bergman PJ, McKnight J, Novosad A, et al. Long-term survival of dogs with advanced malignant melanoma after DNA vaccination with xenogeneic human tyrosinase: a phase I trial. Clin Cancer Res. 2003;9: 1284-1290. (Pubitemid 36418378)
-
(2003)
Clinical Cancer Research
, vol.9
, Issue.4
, pp. 1284-1290
-
-
Bergman, P.J.1
McKnight, J.2
Novosad, A.3
Charney, S.4
Farrelly, J.5
Craft, D.6
Wulderk, M.7
Jeffers, Y.8
Sadelain, M.9
Hohenhaus, A.E.10
Segal, N.11
Gregor, P.12
Engelhorn, M.13
Riviere, I.14
Houghton, A.N.15
Wolchok, J.D.16
-
15
-
-
0032539190
-
Immunizing patients with metastatic melanoma using recombinant adenoviruses encoding MART-1 or gp100 melanoma antigens
-
Rosenberg SA, Zhai Y, Yang JC, et al. Immunizing patients with metastatic melanoma using recombinant adenoviruses encoding MART-1 or gp100 melanoma antigens. J Natl Cancer Inst. 1998;90:1894-1900. (Pubitemid 29014223)
-
(1998)
Journal of the National Cancer Institute
, vol.90
, Issue.24
, pp. 1894-1900
-
-
Rosenberg, S.A.1
Zhai, Y.2
Yang, J.C.3
Schwartzentruber, D.J.4
Hwu, P.5
Marincola, F.M.6
Topalian, S.L.7
Restifo, N.P.8
Seipp, C.A.9
Einhorn, J.H.10
Roberts, B.11
White, D.E.12
-
16
-
-
78349284842
-
Vaccination of metastatic renal cancer patients with MVA-5T4: A randomized, double-blind, placebo-controlled phase III study
-
Amato RJ, Hawkins RE, Kaufman HL, et al. Vaccination of metastatic renal cancer patients with MVA-5T4: a randomized, double-blind, placebo-controlled phase III study. Clin Cancer Res. 2010;16:5539-5547.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 5539-5547
-
-
Amato, R.J.1
Hawkins, R.E.2
Kaufman, H.L.3
-
17
-
-
0034919938
-
Dendritic cell lineage, plasticity and cross-regulation
-
DOI 10.1038/89726
-
Liu YJ, Kanzler H, Soumelis V, et al. Dendritic cell lineage, plasticity and cross-regulation. Nat Immunol. 2001;2:585-589. (Pubitemid 32677624)
-
(2001)
Nature Immunology
, vol.2
, Issue.7
, pp. 585-589
-
-
Liu Yong-Jun1
Kanzler, H.2
Soumelis, V.3
Gilliet, M.4
-
18
-
-
0035892109
-
Dendritic cells from patients with myeloma are numerically normal but functionally defective as they fail to up-regulate CD80 (B7-1) expression after huCD40LT stimulation because of inhibition by transforming growth factor-beta1 and interleukin-10
-
Brown RD, Pope B, Murray A, et al. Dendritic cells from patients with myeloma are numerically normal but functionally defective as they fail to up-regulate CD80 (B7-1) expression after huCD40LT stimulation because of inhibition by transforming growth factor-beta1 and interleukin-10. Blood. 2001;98:2992-2998.
-
(2001)
Blood
, vol.98
, pp. 2992-2998
-
-
Brown, R.D.1
Pope, B.2
Murray, A.3
-
19
-
-
2542421141
-
Dendritic cells are dysfunctional in patients with operable breast cancer
-
DOI 10.1007/s00262-003-0485-5
-
Satthaporn S, Robins A, Vassanasiri W, et al. Dendritic cells are dysfunctional in patients with operable breast cancer. Cancer Immunol Immunother. 2004;53:510-518. (Pubitemid 38680257)
-
(2004)
Cancer Immunology, Immunotherapy
, vol.53
, Issue.6
, pp. 510-518
-
-
Satthaporn, S.1
Robins, A.2
Vassanasiri, W.3
El-Sheemy, M.4
Jibril, J.A.5
Clark, D.6
Valerio, D.7
Eremin, O.8
-
20
-
-
0031941423
-
Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells
-
DOI 10.1038/nm0398-328
-
Nestle FO, Alijagic S, Gilliet M, et al. Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells. Nat Med. 1998;4: 328-332. (Pubitemid 28144092)
-
(1998)
Nature Medicine
, vol.4
, Issue.3
, pp. 328-332
-
-
Nestle, F.O.1
Alijagic, S.2
Gilliet, M.3
Sun, Y.4
Grabbe, S.5
Dummer, R.6
Burg, G.7
Schadendorf, D.8
-
21
-
-
33645325115
-
Dacarbazine (DTIC) versus vaccination with autologous peptide-pulsed dendritic cells (DC) in first-line treatment of patients with metastatic melanoma: A randomized phase III trial of the DC study group of the DeCOG
-
Schadendorf D, Ugurel S, Schuler-Thurner B, et al. Dacarbazine (DTIC) versus vaccination with autologous peptide-pulsed dendritic cells (DC) in first-line treatment of patients with metastatic melanoma: a randomized phase III trial of the DC study group of the DeCOG. Ann Oncol. 2006;17:563-570.
-
(2006)
Ann Oncol
, vol.17
, pp. 563-570
-
-
Schadendorf, D.1
Ugurel, S.2
Schuler-Thurner, B.3
-
22
-
-
18844445590
-
Immunotherapy of murine prostate cancer using whole tumor cells killed ex vivo by herpes simplex viral thymidine kinase/ ganciclovir suicide gene therapy
-
DOI 10.1038/sj.cgt.7700836
-
Pandha H, Eaton J, Greenhalgh R, et al. Immunotherapy of murine prostate cancer using whole tumor cells killed ex vivo by herpes simplex viral thymidine kinase/ganciclovir suicide gene therapy. Cancer Gene Ther. 2005;12:572-578. (Pubitemid 40686597)
-
(2005)
Cancer Gene Therapy
, vol.12
, Issue.6
, pp. 572-578
-
-
Pandha, H.1
Eaton, J.2
Greenhalgh, R.3
Soars, D.4
Dalgleish, A.5
-
23
-
-
0027538181
-
Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity
-
Dranoff G, Jaffee E, Lazenby A, et al. Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colonystimulating factor stimulates potent, specific, and long-lasting antitumor immunity. Proc Natl Acad Sci U S A. 1993;90:3539-3543. (Pubitemid 23111402)
-
(1993)
Proceedings of the National Academy of Sciences of the United States of America
, vol.90
, Issue.8
, pp. 3539-3543
-
-
Dranoff, G.1
Jaffee, E.2
Lazenby, A.3
Golumbek, P.4
Levitsky, H.5
Brose, K.6
Jackson, V.7
Hamada, H.8
Pardoll, D.9
Mulligan, R.C.10
-
24
-
-
0036896972
-
Prolonged survival after complete resection of disseminated melanoma and active immunotherapy with a therapeutic cancer vaccine
-
DOI 10.1200/JCO.2002.01.151
-
Hsueh EC, Essner R, Foshag LJ, et al. Prolonged survival after complete resection of disseminated melanoma and active immunotherapy with a therapeutic cancer vaccine. J Clin Oncol. 2002;20:4549-4554. (Pubitemid 35402957)
-
(2002)
Journal of Clinical Oncology
, vol.20
, Issue.23
, pp. 4549-4554
-
-
Hsueh, E.C.1
Essner, R.2
Foshag, L.J.3
Ollila, D.W.4
Gammon, G.5
O'Day, S.J.6
Boasberg, P.D.7
Stern, S.L.8
Ye, X.9
Morton, D.L.10
-
25
-
-
0033616482
-
Active specific immunotherapy for stage II and stage III human colon cancer: A randomised trial
-
DOI 10.1016/S0140-6736(98)07186-4
-
Vermorken JB, Claessen AM, van Tinteren H, et al. Active specific immunotherapy for stage II and stage III human colon cancer: a randomised trial. Lancet. 1999;353:345-350. (Pubitemid 29088160)
-
(1999)
Lancet
, vol.353
, Issue.9150
, pp. 345-350
-
-
Vermorken, J.B.1
Claessen, A.M.E.2
Van Tinteren, H.3
Gall, H.E.4
Ezinga, R.5
Meijer, S.6
Scheper, R.J.7
Meijer, C.J.L.M.8
Bloemena, E.9
Ransom, J.H.10
Hanna Jr., M.G.11
Pinedo, H.M.12
-
27
-
-
10744230275
-
Adjuvant autologous renal tumour cell vaccine and risk of tumour progression in patients with renal-cell carcinoma after radical nephrectomy: Phase III, randomised controlled trial
-
DOI 10.1016/S0140-6736(04)15590-6
-
Jocham D, Richter A, Hoffman L, et al. Adjuvant autologous renal tumour cell vaccine and risk of tumour progression in patients with renal-cell carcinoma after radical nephrectomy: phase III, randomised controlled trial. Lancet. 2004;363:594-599. (Pubitemid 38264176)
-
(2004)
Lancet
, vol.363
, Issue.9409
, pp. 594-599
-
-
Jocham, D.1
Richter, A.2
Hoffmann, L.3
Iwig, K.4
Fahlenkamp, D.5
Zakrzewski, G.6
Schmitt, E.7
Dannenberg, T.8
Lehmacher, W.9
Von Wietersheim, J.10
Doehn, C.11
-
28
-
-
39749186213
-
Phase III comparison of vitespen, an autologous tumor-derived heat shock protein gp96 peptide complex vaccine, with physician's choice of treatment for stage IV melanoma: The C-100-21 study group
-
DOI 10.1200/JCO.2007.11.9941
-
Testori A, Richards J, Whitman E, et al. Phase III comparison of vitespen, an autologous tumor-derived heat shock protein gp96 peptide complex vaccine, with physicians choice of treatment for stage IV melanoma: the C-100-21 Study Group. J Clin Oncol. 2008;26:955-962. (Pubitemid 351398090)
-
(2008)
Journal of Clinical Oncology
, vol.26
, Issue.6
, pp. 955-962
-
-
Testori, A.1
Richards, J.2
Whitman, E.3
Mann, G.B.4
Lutzky, J.5
Camacho, L.6
Parmiani, G.7
Tosti, G.8
Kirkwood, J.M.9
Hoos, A.10
Yuh, L.11
Gupta, R.12
Srivastava, P.K.13
-
29
-
-
54149097564
-
A vaccine for renal cancer
-
Wood C. A vaccine for renal cancer. Lancet. 2008;372:1460-1461.
-
(2008)
Lancet
, vol.372
, pp. 1460-1461
-
-
Wood, C.1
-
30
-
-
4644324025
-
Cancer immunotherapy: Moving beyond current vaccines
-
DOI 10.1038/nm1100
-
Rosenberg SA, Yang JC, Restifo NP. Cancer immunotherapy: moving beyond current vaccines. Nat Med. 2004;10:909-915. (Pubitemid 39273730)
-
(2004)
Nature Medicine
, vol.10
, Issue.9
, pp. 909-915
-
-
Rosenberg, S.A.1
Yang, J.C.2
Restifo, N.P.3
-
31
-
-
78650574270
-
Therapeutic cancer vaccines: Are we there yet?
-
Klebanoff CA, Acquavella N, Yu Z, et al. Therapeutic cancer vaccines: are we there yet? Immunol Rev. 2011;239:27-44.
-
(2011)
Immunol Rev
, vol.239
, pp. 27-44
-
-
Klebanoff, C.A.1
Acquavella, N.2
Yu, Z.3
-
32
-
-
14544284502
-
Risks and benefits of phase 1 oncology trials, 1991 through 2002
-
DOI 10.1056/NEJMsa042220
-
Horstmann E, McCabe MS, Grochow L, et al. Risks and benefits of phase 1 oncology trials, 1991 through 2002. N Engl J Med. 2005;352: 895-904. (Pubitemid 40300298)
-
(2005)
New England Journal of Medicine
, vol.352
, Issue.9
, pp. 895-904
-
-
Horstmann, E.1
McCabe, M.S.2
Grochow, L.3
Yamamoto, S.4
Rubinstein, L.5
Budd, T.6
Shoemaker, D.7
Emanuel, E.J.8
Grady, C.9
-
33
-
-
7244243743
-
Trends in the risk and benefits to patients with cancer participating in phase 1 clinical trials
-
DOI 10.1001/jama.292.17.2130
-
Roberts TG Jr, Goulart BH, Squitieri L, et al. Trends in the risks and benefits to patients with cancer participating in phase 1 clinical trials. JAMA. 2004;292:2130-2140. (Pubitemid 39435104)
-
(2004)
Journal of the American Medical Association
, vol.292
, Issue.17
, pp. 2130-2140
-
-
Roberts Jr., T.G.1
Goulart, B.H.2
Squitieri, L.3
Stallings, S.C.4
Halpern, E.F.5
Chabner, B.A.6
Gazelle, G.S.7
Finkelstein, S.N.8
Clark, J.W.9
-
34
-
-
77955066199
-
Sipuleucel-T immunotherapy for castration-resistant prostate cancer
-
Kantoff PW, Higano CS, Shore ND, et al. Sipuleucel-T immunotherapy for castration-resistant prostate cancer. N Engl J Med. 2010;363: 411-422.
-
(2010)
N Engl J Med
, vol.363
, pp. 411-422
-
-
Kantoff, P.W.1
Higano, C.S.2
Shore, N.D.3
-
35
-
-
33746012881
-
Placebo-controlled phase III trial of immunologic therapy with Sipuleucel-T (APC8015) in patients with metastatic, asymptomatic hormone refractory prostate cancer
-
DOI 10.1200/JCO.2005.04.5252
-
Small EJ, Schellhammer PF, Higano CS, et al. Placebo-controlled phase III trial of immunologic therapy with sipuleucel-T (APC8015) in patients with metastatic, asymptomatic hormone refractory prostate cancer. J Clin Oncol. 2006;24:3089-3094. (Pubitemid 46638945)
-
(2006)
Journal of Clinical Oncology
, vol.24
, Issue.19
, pp. 3089-3094
-
-
Small, E.J.1
Schellhammer, P.F.2
Higano, C.S.3
Redfern, C.H.4
Nemunaitis, J.J.5
Valone, F.H.6
Verjee, S.S.7
Jones, L.A.8
Hershberg, R.M.9
-
36
-
-
77949895922
-
Overall survival analysis of a phase II randomized controlled trial of a poxviral-based PSA-targeted immunotherapy in metastatic castration-resistant prostate cancer
-
Kantoff PW, Schuetz TJ, Blumenstein BA, et al. Overall survival analysis of a phase II randomized controlled trial of a poxviral-based PSA-targeted immunotherapy in metastatic castration-resistant prostate cancer. J Clin Oncol. 2010;28:1099-1105.
-
(2010)
J Clin Oncol
, vol.28
, pp. 1099-1105
-
-
Kantoff, P.W.1
Schuetz, T.J.2
Blumenstein, B.A.3
-
37
-
-
73149092567
-
Guidelines for the evaluation of immune therapy activity in solid tumors: Immune-related response criteria
-
Wolchok JD, Hoos A, ODays S, et al. Guidelines for the evaluation of immune therapy activity in solid tumors: immune-related response criteria. Clin Cancer Res. 2009;15:7412-7420.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 7412-7420
-
-
Wolchok, J.D.1
Hoos, A.2
Odays, S.3
-
38
-
-
0030443168
-
Regulation of Surface and Intracellular Expression of CTLA4 on Mouse T Cells
-
Alegre ML, Noel PJ, Eisfelder BJ, et al. Regulation of surface and intracellular expression of CTLA4 on mouse T cells. J Immunol. 1996; 157:4762-4770. (Pubitemid 126449549)
-
(1996)
Journal of Immunology
, vol.157
, Issue.11
, pp. 4762-4770
-
-
Alegre, M.-L.1
Noel, P.J.2
Eisfelder, B.J.3
Chuang, E.4
Clark, M.R.5
Reiner, S.L.6
Thompson, C.B.7
-
39
-
-
0031054242
-
CD80 (B7-1) binds both CD28 and CTLA-4 with a low affinity and very fast kinetics
-
DOI 10.1084/jem.185.3.393
-
van der Merwe PA, Bodian DL, Daenke S, et al. CD80 (B7-1) binds both CD28 and CTLA-4 with a low affinity and very fast kinetics. J Exp Med. 1997;185:393-403. (Pubitemid 27078358)
-
(1997)
Journal of Experimental Medicine
, vol.185
, Issue.3
, pp. 393-403
-
-
Van Der Merwe, P.A.1
Bodian, D.L.2
Daenke, S.3
Linsley, P.4
Davis, S.J.5
-
40
-
-
0030176371
-
Intracellular trafficking of CTLA-4 and focal localization towards sites of TCR engagement
-
DOI 10.1016/S1074-7613(00)80480-X
-
Linsley PS, Bradshaw J, Greene J, et al. Intracellular trafficking of CTLA-4 and focal localization towards sites of TCR engagement. Immunity. 1996;4:535-543. (Pubitemid 26233307)
-
(1996)
Immunity
, vol.4
, Issue.6
, pp. 535-543
-
-
Linsley, P.S.1
Bradshaw, J.2
Greene, J.3
Peach, R.4
Bennett, K.L.5
Mittler, R.S.6
-
41
-
-
0028867420
-
Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
-
Tivol EA, Borriello F, Schweitzer AN, et al. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity. 1995;3:541-547.
-
(1995)
Immunity
, vol.3
, pp. 541-547
-
-
Tivol, E.A.1
Borriello, F.2
Schweitzer, A.N.3
-
42
-
-
53749094183
-
CTLA-4 control over Foxp3+ regulatory T cell function
-
Wing K, Onishi Y, Prieto-Martin P, et al. CTLA-4 control over Foxp3+ regulatory T cell function. Science. 2008;322:271-275.
-
(2008)
Science
, vol.322
, pp. 271-275
-
-
Wing, K.1
Onishi, Y.2
Prieto-Martin, P.3
-
43
-
-
0032544067
-
CTLA-4 blockade synergizes with tumor-derived granulocyte-macrophage colony-stimulating factor for treatment of an experimental mammary carcinoma
-
DOI 10.1073/pnas.95.17.10067
-
Hurwitz AA, Yu TF, Leach DR, et al. CTLA-4 blockade synergizes with tumor-derived granulocyte-macrophage colony-stimulating factor for treatment of an experimental mammary carcinoma. Proc Natl Acad Sci U S A. 1998;95:10067-10071. (Pubitemid 28415295)
-
(1998)
Proceedings of the National Academy of Sciences of the United States of America
, vol.95
, Issue.17
, pp. 10067-10071
-
-
Hurwitz, A.A.1
Yu, T.F.-Y.2
Leach, D.R.3
Allison, J.P.4
-
44
-
-
0033517152
-
Combination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and granulocyte/macrophage colony- stimulating factor (GM-CSF)-producing vaccines induces rejection of subcutaneous and metastatic tumors accompanied by autoimmune depigmentation
-
DOI 10.1084/jem.190.3.355
-
van Elsas A, Hurwitz AA, Allison JP. Combination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and granulocyte/macrophage colony-stimulating factor (GM-CSF)-producing vaccines induces rejection of subcutaneous and metastatic tumors accompanied by autoimmune depigmentation. J Exp Med. 1999;190:355-366. (Pubitemid 29374833)
-
(1999)
Journal of Experimental Medicine
, vol.190
, Issue.3
, pp. 355-366
-
-
Van Elsas, A.1
Hurwitz, A.A.2
Allison, J.P.3
-
45
-
-
0034194329
-
Combination immunotherapy of primary prostate cancer in a transgenic mouse model using CTLA-4 blockade
-
Hurwitz AA, Foster BA, Kwon ED, et al. Combination immunotherapy of primary prostate cancer in a transgenic mouse model using CTLA-4 blockade. Cancer Res. 2000;60:2444-2448. (Pubitemid 30262435)
-
(2000)
Cancer Research
, vol.60
, Issue.9
, pp. 2444-2448
-
-
Hurwitz, A.A.1
Foster, B.A.2
Kwon, E.D.3
Truong, T.4
Choi, E.M.5
Greenberg, N.M.6
Burg, M.B.7
Allison, J.P.8
-
46
-
-
0037443573
-
CTLA-4 blockade enhances the therapeutic effect of an attenuated poxvirus vaccine targeting p53 in an established murine tumor model
-
Espenschied J, Lamont J, Longmate J, et al. CTLA-4 blockade enhances the therapeutic effect of an attenuated poxvirus vaccine targeting p53 in an established murine tumor model. J Immunol. 2003;170:3401-3407. (Pubitemid 36302220)
-
(2003)
Journal of Immunology
, vol.170
, Issue.6
, pp. 3401-3407
-
-
Espenschied, J.1
Lamont, J.2
Longmate, J.3
Pendas, S.4
Wang, Z.5
Diamond, D.J.6
Ellenhorn, J.D.I.7
-
47
-
-
11144353596
-
CTLA-4 blockade in combination with xenogeneic DNA vaccines enhances T-cell responses, tumor immunity and autoimmunity to self antigens in animal and cellular model systems
-
DOI 10.1016/j.vaccine.2003.10.048, PII S0264410X04000933
-
Gregor PD, Wolchok JD, Ferrone CR, et al. CTLA-4 blockade in combination with xenogeneic DNA vaccines enhances T-cell responses, tumor immunity and autoimmunity to self antigens in animal and cellular model systems. Vaccine. 2004;22:1700-1708. (Pubitemid 38447218)
-
(2004)
Vaccine
, vol.22
, Issue.13-14
, pp. 1700-1708
-
-
Gregor, P.D.1
Wolchok, J.D.2
Ferrone, C.R.3
Buchinshky, H.4
Guevara-Patino, J.A.5
Perales, M.-A.6
Mortazavi, F.7
Bacich, D.8
Heston, W.9
Latouche, J.-B.10
Sadelain, M.11
Allison, J.P.12
Scher, H.I.13
Houghton, A.N.14
-
48
-
-
69949085196
-
Fractionated but not single-dose radiotherapy induces an immune-mediated abscopal effect when combined with anti-CTLA-4 antibody
-
Dewan MZ, Galloway AE, Kawashima N, et al. Fractionated but not single-dose radiotherapy induces an immune-mediated abscopal effect when combined with anti-CTLA-4 antibody. Clin Cancer Res. 2009; 15:5379-5388.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 5379-5388
-
-
Dewan, M.Z.1
Galloway, A.E.2
Kawashima, N.3
-
49
-
-
76049092889
-
Phase II Trial of Tremelimumab (CP-675, 206) in Patients with Advanced Refractory or Relapsed Melanoma
-
Kirkwood JM, Lorigan P, Hersey P, et al. Phase II trial of tremelimumab (CP-675,206) in patients with advanced refractory or relapsed melanoma. Clin Cancer Res. 2010;16:1042-1048.
-
(2010)
Clin Cancer Res.
, vol.16
, pp. 1042-1048
-
-
Kirkwood, J.M.1
Lorigan, P.2
Hersey, P.3
-
50
-
-
77649136167
-
Modulation of lymphocyte regulation for cancer therapy: A phase II trial of tremelimumab in advanced gastric and esophageal adenocarcinoma
-
Ralph C, Elkord E, Burt DJ, et al. Modulation of lymphocyte regulation for cancer therapy: a phase II trial of tremelimumab in advanced gastric and esophageal adenocarcinoma. Clin Cancer Res. 2010;16:1662-1672.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 1662-1672
-
-
Ralph, C.1
Elkord, E.2
Burt, D.J.3
-
51
-
-
79959772576
-
Ipilimumab plus dacarbazine for previously untreated metastatic melanoma
-
Robert C, Thomas C, Bondarenko I, et al. Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N Engl J Med. 2011; 364:2517-2526.
-
(2011)
N Engl J Med
, vol.364
, pp. 2517-2526
-
-
Robert, C.1
Thomas, C.2
Bondarenko, I.3
-
52
-
-
37349072460
-
Ipilimumab (anti-CTLA4 antibody) causes regression of metastatic renal cell cancer associated with enteritis and hypophysitis
-
DOI 10.1097/CJI.0b013e318156e47e, PII 0000237120071100000005
-
Yang C, Hughes M, Kammula U, et al. Ipilimumab (anti-CTLA4 antibody) causes regression of metastatic renal cell cancer associated with enteritis and hypophysitis. J Immunother. 2007;30:825-830. (Pubitemid 350295361)
-
(2007)
Journal of Immunotherapy
, vol.30
, Issue.8
, pp. 825-830
-
-
Yang, J.C.1
Hughes, M.2
Kammula, U.3
Royal, R.4
Sherry, R.M.5
Topalian, S.L.6
Suri, K.B.7
Levy, C.8
Allen, T.9
Mavroukakis, S.10
Lowy, I.11
White, D.E.12
Rosenberg, S.A.13
-
53
-
-
58349090027
-
Potentiating endogenous antitumor immunity to prostate cancer through combination immunotherapy with CTLA4 blockade and GM-CSF
-
Fong L, Kwek SS, OBrien S, et al. Potentiating endogenous antitumor immunity to prostate cancer through combination immunotherapy with CTLA4 blockade and GM-CSF. Cancer Res. 2009;69:609-615.
-
(2009)
Cancer Res
, vol.69
, pp. 609-615
-
-
Fong, L.1
Kwek, S.S.2
Obrien, S.3
-
54
-
-
0034596948
-
Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation
-
Freeman GJ, Long AJ, Iwai Y, et al. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J Exp Med. 2000;192:1027-1034.
-
(2000)
J Exp Med
, vol.192
, pp. 1027-1034
-
-
Freeman, G.J.1
Long, A.J.2
Iwai, Y.3
-
55
-
-
13444270323
-
Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity
-
Hirano F, Kaneko K, Tamura H, et al. Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity. Cancer Res. 2005;65:1089-1096. (Pubitemid 40216472)
-
(2005)
Cancer Research
, vol.65
, Issue.3
, pp. 1089-1096
-
-
Hirano, F.1
Kaneko, K.2
Tamura, H.3
Dong, H.4
Wang, S.5
Ichikawa, M.6
Rietz, C.7
Flies, D.B.8
Lau, J.S.9
Zhu, G.10
Tamada, K.11
Chen, L.12
-
56
-
-
18544380239
-
Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion
-
Dong H, Strome SE, Salomao DR, et al. Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nat Med. 2002;8:793-800.
-
(2002)
Nat Med
, vol.8
, pp. 793-800
-
-
Dong, H.1
Strome, S.E.2
Salomao, D.R.3
-
57
-
-
43549115533
-
B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells
-
Azuma T, Yao S, Zhu G, et al. B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells. Blood. 2008;111:3635-3643.
-
(2008)
Blood
, vol.111
, pp. 3635-3643
-
-
Azuma, T.1
Yao, S.2
Zhu, G.3
-
58
-
-
77950283280
-
Tumor cell expression of programmed cell death-1 ligand 1 is a prognostic factor for malignant melanoma
-
Hino R, Kabashima K, Kato Y, et al. Tumor cell expression of programmed cell death-1 ligand 1 is a prognostic factor for malignant melanoma. Cancer. 2010;116:1757-1766.
-
(2010)
Cancer
, vol.116
, pp. 1757-1766
-
-
Hino, R.1
Kabashima, K.2
Kato, Y.3
-
59
-
-
34247532726
-
Clinical significance and therapeutic potential of the programmed death-1 ligand/programmed death-1 pathway in human pancreatic cancer
-
DOI 10.1158/1078-0432.CCR-06-2746
-
Nomi T, Sho M, Akahori T, et al. Clinical significance and therapeutic potential of the programmed death-1 ligand/programmed death-1 pathway in human pancreatic cancer. Clin Cancer Res. 2007;13:2151-2157. (Pubitemid 46649885)
-
(2007)
Clinical Cancer Research
, vol.13
, Issue.7
, pp. 2151-2157
-
-
Nomi, T.1
Sho, M.2
Akahori, T.3
Hamada, K.4
Kubo, A.5
Kanehiro, H.6
Nakamura, S.7
Enomoto, K.8
Yagita, H.9
Azuma, M.10
Nakajima, Y.11
-
60
-
-
33847611968
-
+ T lymphocytes are prognostic factors of human ovarian cancer
-
DOI 10.1073/pnas.0611533104
-
Hamanishi J, Mandai M, Iwasaki M, et al. Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer. Proc Natl Acad Sci U S A. 2007;104:3360-3365. (Pubitemid 46364164)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.9
, pp. 3360-3365
-
-
Hamanishi, J.1
Mandai, M.2
Iwasaki, M.3
Okazaki, T.4
Tanaka, Y.5
Yamaguchi, K.6
Higuchi, T.7
Yagi, H.8
Takakura, K.9
Minato, N.10
Honjo, T.11
Fujii, S.12
-
61
-
-
33645736792
-
Tumor B7-H1 is associated with poor prognosis in renal cell carcinoma patients with longterm follow-up
-
Thompson RH, Kuntz SM, Leibovich BC, et al. Tumor B7-H1 is associated with poor prognosis in renal cell carcinoma patients with longterm follow-up. Cancer Res. 2006;66:3381-3385.
-
(2006)
Cancer Res
, vol.66
, pp. 3381-3385
-
-
Thompson, R.H.1
Kuntz, S.M.2
Leibovich, B.C.3
-
62
-
-
34248586083
-
Overexpression of B7-H1 (PD-L1) significantly associates with tumor grade and postoperative prognosis in human urothelial cancers
-
DOI 10.1007/s00262-006-0266-z
-
Nakanishi J, Wada Y, Matsumoto K, et al. Overexpression of B7-H1 (PD-L1) significantly associates with tumor grade and postoperative prognosis in human urothelial cancers. Cancer Immunol Immunother. 2007;56:1173-1182. (Pubitemid 46763932)
-
(2007)
Cancer Immunology, Immunotherapy
, vol.56
, Issue.8
, pp. 1173-1182
-
-
Nakanishi, J.1
Wada, Y.2
Matsumoto, K.3
Azuma, M.4
Kikuchi, K.5
Ueda, S.6
-
63
-
-
33745491116
-
Immunohistochemical localization of programmed death-1 ligand-1 (PD-L1) in gastric carcinoma and its clinical significance
-
DOI 10.1016/j.acthis.2006.01.003, PII S0065128106000146
-
Wu C, Zhu Y, Jiang J, et al. Immunohistochemical localization of programmed death-1 ligand-1 (PD-L1) in gastric carcinoma and its clinical significance. Acta Histochem. 2006;108:19-24. (Pubitemid 44316588)
-
(2006)
Acta Histochemica
, vol.108
, Issue.1
, pp. 19-24
-
-
Wu, C.1
Zhu, Y.2
Jiang, J.3
Zhao, J.4
Zhang, X.-G.5
Xu, N.6
-
64
-
-
77957551174
-
Increase of programmed death-1Yexpressing intratumoral CD8 T cells predicts a poor prognosis for nasopharyngeal carcinoma
-
Hsu MC, Hsiao JR, Chang KC WB, et al. Increase of programmed death-1Yexpressing intratumoral CD8 T cells predicts a poor prognosis for nasopharyngeal carcinoma. Mod Pathol. 2010;23:1393-1403.
-
(2010)
Mod Pathol
, vol.23
, pp. 1393-1403
-
-
Hsu, M.C.1
Hsiao, J.R.2
Chang, K.C.W.B.3
-
65
-
-
49649114804
-
Phase i safety and pharmacokinetic study of CT-011, a humanized antibody interacting with PD-1, in patients with advanced hematologic malignancies
-
Berger R, Rotem-Yehudar R, Slama G, et al. Phase I safety and pharmacokinetic study of CT-011, a humanized antibody interacting with PD-1, in patients with advanced hematologic malignancies. Clin Cancer Res. 2008;14:3044-3051.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 3044-3051
-
-
Berger, R.1
Rotem-Yehudar, R.2
Slama, G.3
-
66
-
-
74349098352
-
Phase II experience with MDX-1106 (ONO-4538), an anti-PD-1 monoclonal antibody, in patients with selected refractory or relapsed malignancies
-
abstract 3015
-
Brahmer JR, Topalian SL, Powderly J, et al. Phase II experience with MDX-1106 (ONO-4538), an anti-PD-1 monoclonal antibody, in patients with selected refractory or relapsed malignancies. J Clin Oncol. 2008;27(suppl):abstract 3015.
-
(2008)
J Clin Oncol
, vol.27
, Issue.SUPPL.
-
-
Brahmer, J.R.1
Topalian, S.L.2
Powderly, J.3
-
67
-
-
77954899030
-
Phase i study of single-agent antiprogrammed death-1 (MDX-1106) in refractory solid tumors: Safety, clinical activity, pharmacodynamics, and immunologic correlates
-
Brahmer JR, Drake CJ, Wollner I. Phase I study of single-agent antiprogrammed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates. J Clin Oncol. 2010;28(suppl):3167-3175.
-
(2010)
J Clin Oncol
, vol.28
, Issue.SUPPL.
, pp. 3167-3175
-
-
Brahmer, J.R.1
Drake, C.J.2
Wollner, I.3
-
68
-
-
70349561448
-
PD-1/PD-L1 interactions inhibit antitumor immune responses in a murine acute myeloid leukemia model
-
Zhang L, Gajewski TF, Kline J. PD-1/PD-L1 interactions inhibit antitumor immune responses in a murine acute myeloid leukemia model. Blood. 2009;114:1545-1552.
-
(2009)
Blood
, vol.114
, pp. 1545-1552
-
-
Zhang, L.1
Gajewski, T.F.2
Kline, J.3
-
69
-
-
61349114199
-
Ipilimumab: Controversies in its development, utility and autoimmune adverse events
-
Weber J. Ipilimumab: controversies in its development, utility and autoimmune adverse events. Cancer Immunol Immunother. 2009;58: 823-830.
-
(2009)
Cancer Immunol Immunother
, vol.58
, pp. 823-830
-
-
Weber, J.1
-
70
-
-
75249100054
-
Ipilimumab monotherapy in patients with pretreated advanced melanoma: A randomised, doubleblind, multicentre, phase 2, dose-ranging study
-
Wolchok JD, Neyns B, Linette G, et al. Ipilimumab monotherapy in patients with pretreated advanced melanoma: a randomised, doubleblind, multicentre, phase 2, dose-ranging study. Lancet Oncol. 2010; 11:155-164.
-
(2010)
Lancet Oncol
, vol.11
, pp. 155-164
-
-
Wolchok, J.D.1
Neyns, B.2
Linette, G.3
-
71
-
-
36748999428
-
Prognostic factors related to clinical response in patients with metastatic melanoma treated by CTL-associated antigen-4 blockade
-
DOI 10.1158/1078-0432.CCR-07-0187
-
Downey SG, Klapper JA, Smith FO, et al. Prognostic factors related to clinical response in patients with metastatic melanoma treated by CTLassociated antigen-4 blockade. Clin Cancer Res. 2007;13:6681-6688. (Pubitemid 350206804)
-
(2007)
Clinical Cancer Research
, vol.13
, Issue.22
, pp. 6681-6688
-
-
Downey, S.G.1
Klapper, J.A.2
Smith, F.O.3
Yang, J.C.4
Sherry, R.M.5
Royal, R.E.6
Kammula, U.S.7
Hughes, M.S.8
Allen, T.E.9
Levy, C.L.10
Yellin, M.11
Nichol, G.12
White, D.E.13
Steinberg, S.M.14
Rosenberg, S.A.15
-
72
-
-
33744792341
-
Enterocolitis in patients with cancer after antibody blockade of cytotoxic T-lymphocyte-associated antigen 4
-
DOI 10.1200/JCO.2005.04.5716
-
Beck KE, Blansfield JA, Tran KQ, et al. Enterocolitis in patients with cancer after antibody blockade of cytotoxic T-lymphocyte-associated antigen 4. J Clin Oncol. 2006;24:2283-2289. (Pubitemid 46630658)
-
(2006)
Journal of Clinical Oncology
, vol.24
, Issue.15
, pp. 2283-2289
-
-
Beck, K.E.1
Blansfield, J.A.2
Tran, K.Q.3
Feldman, A.L.4
Hughes, M.S.5
Royal, R.E.6
Kammula, U.S.7
Topalian, S.L.8
Sherry, R.M.9
Kleiner, D.10
Quezado, M.11
Lowy, I.12
Yellin, M.13
Rosenberg, S.A.14
Yang, J.C.15
-
73
-
-
27444440093
-
Cytotoxic T-lymphocyte-associated antigen-4 blockage can induce autoimmune hypophysitis in patients with metastatic melanoma and renal cancer
-
Blansfield JA, BeckKE, Tran K, et al. Cytotoxic T-lymphocyte-associated antigen-4 blockage can induce autoimmune hypophysitis in patients with metastatic melanoma and renal cancer. J Immunother. 2005;28: 593-598. (Pubitemid 41533093)
-
(2005)
Journal of Immunotherapy
, vol.28
, Issue.6
, pp. 593-598
-
-
Blansfield, J.A.1
Beck, K.E.2
Tran, K.3
Yang, J.C.4
Hughes, M.S.5
Kammula, U.S.6
Royal, R.E.7
Topalian, S.L.8
Haworth, L.R.9
Levy, C.10
Rosenberg, S.A.11
Sherry, R.M.12
-
74
-
-
0038153907
-
Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma
-
DOI 10.1073/pnas.1533209100
-
Phan GQ, Yang JC, Sherry RM, et al. Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma. Proc Natl Acad Sci USA. 2003;100:8372-8377. (Pubitemid 36842552)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.14
, pp. 8372-8377
-
-
Phan, G.Q.1
Yang, J.C.2
Sherry, R.M.3
Hwu, P.4
Topalian, S.L.5
Schwartzentruber, D.J.6
Restifo, N.P.7
Haworth, L.R.8
Seipp, C.A.9
Freezer, L.J.10
Morton, K.E.11
Mavroukakis, S.A.12
Duray, P.H.13
Steinberg, S.M.14
Allison, J.P.15
Davis, T.A.16
Rosenberg, S.A.17
-
75
-
-
58049202334
-
Phase I/II study of ipilimumab for patients with metastatic melanoma
-
Weber JS, ODay S, Urba W, et al. Phase I/II study of ipilimumab for patients with metastatic melanoma. J Clin Oncol. 2008;26:5950-5956.
-
(2008)
J Clin Oncol
, vol.26
, pp. 5950-5956
-
-
Weber, J.S.1
Oday, S.2
Urba, W.3
-
76
-
-
0033180181
-
Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor
-
DOI 10.1016/S1074-7613(00)80089-8
-
Nishimura H, Nose M, Hiai H, et al. Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. Immunity. 1999;11:141-151. (Pubitemid 29428807)
-
(1999)
Immunity
, vol.11
, Issue.2
, pp. 141-151
-
-
Nishimura, H.1
Nose, M.2
Hiai, H.3
Minato, N.4
Honjo, T.5
-
77
-
-
0035846991
-
Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice
-
DOI 10.1126/science.291.5502.319
-
Nishimura H, Okazaki T, Tanaka Y, et al. Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice. Science. 2001;291: 319-322. (Pubitemid 32096320)
-
(2001)
Science
, vol.291
, Issue.5502
, pp. 319-322
-
-
Nishimura, H.1
Okazaki, T.2
Tanaka, Y.3
Nakatani, K.4
Hara, M.5
Matsumori, A.6
Sasayama, S.7
Mizoguchi, A.8
Hiai, H.9
Minato, N.10
Honjo, T.11
-
78
-
-
0032984496
-
CD40 activation in vivo overcomes peptide-induced peripheral cytotoxic T-lymphocyte tolerance and augments anti-tumor vaccine efficacy
-
DOI 10.1038/10495
-
Diehl L, den Boer AT, Schoenberger SP, et al. CD40 activation in vivo overcomes peptide-induced peripheral cytotoxic T-lymphocyte tolerance and augments anti-tumor vaccine efficacy. Nat Med. 1999;5:774-779. (Pubitemid 29318611)
-
(1999)
Nature Medicine
, vol.5
, Issue.7
, pp. 774-779
-
-
Diehl, L.1
Den Boer, A.Th.2
Schoenberger, S.P.3
Van Der Voort, E.I.H.4
Schumacher, T.N.M.5
Melief, C.J.M.6
Offringa, R.7
Toes, R.E.M.8
-
79
-
-
34447629669
-
Dendritic cell defects in patients with cancer: Mechanisms and significance
-
Lenahan C, Avigan D. Dendritic cell defects in patients with cancer: mechanisms and significance. Breast Cancer Res. 2006;8:101.
-
(2006)
Breast Cancer Res
, vol.8
, pp. 101
-
-
Lenahan, C.1
Avigan, D.2
-
80
-
-
78549256115
-
Immune modulation with weekly dosing of an agonist CD40 antibody in a phase i study of patients with advanced solid tumors
-
Ruter J, Antonia SJ, Burris HA, et al. Immune modulation with weekly dosing of an agonist CD40 antibody in a phase I study of patients with advanced solid tumors. Cancer Biol Ther. 2010;10:983-993.
-
(2010)
Cancer Biol Ther
, vol.10
, pp. 983-993
-
-
Ruter, J.1
Antonia, S.J.2
Burris, H.A.3
-
81
-
-
33947506186
-
Clinical activity and immune modulation in cancer patients treated with CP-870,893, a novel CD40 agonist monoclonal antibody
-
DOI 10.1200/JCO.2006.08.3311
-
Vonderheide RH, Flaherty KT, Khalil M, et al. Clinical activity and immune modulation in cancer patients treated with CP-870,893, a novel CD40 agonist monoclonal antibody. J Clin Oncol. 2007;25:876-883. (Pubitemid 350002889)
-
(2007)
Journal of Clinical Oncology
, vol.25
, Issue.7
, pp. 876-883
-
-
Vonderheide, R.H.1
Flaherty, K.T.2
Khalil, M.3
Stumacher, M.S.4
Bajor, D.L.5
Hutnick, N.A.6
Sullivan, P.7
Mahany, J.J.8
Gallagher, M.9
Kramer, A.10
Green, S.J.11
O'Dwyer, P.J.12
Running, K.L.13
Huhn, R.D.14
Antonia, S.J.15
-
82
-
-
79953154967
-
CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans
-
Beatty GL, Chiorean EG, Fishman MP, et al. CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans. Science. 2011;331:1612-1616.
-
(2011)
Science
, vol.331
, pp. 1612-1616
-
-
Beatty, G.L.1
Chiorean, E.G.2
Fishman, M.P.3
-
83
-
-
70349334508
-
Phase i study of the humanized anti-CD40 monoclonal antibody dacetuzumab in refractory or recurrent non-Hodgkins lymphoma
-
Advani R, Forero-Torres A, Furman RR, et al. Phase I study of the humanized anti-CD40 monoclonal antibody dacetuzumab in refractory or recurrent non-Hodgkins lymphoma. J Clin Oncol. 2009;27: 4371-4377.
-
(2009)
J Clin Oncol
, vol.27
, pp. 4371-4377
-
-
Advani, R.1
Forero-Torres, A.2
Furman, R.R.3
-
84
-
-
0037096878
-
+ T cells
-
May KF Jr, Chen L, Zheng P, et al. AntiY4-1BB monoclonal antibody enhances rejection of large tumor burden by promoting survival but not clonal expansion of tumor-specific CD8+ T cells. Cancer Res. 2002; 62:3459-3465. (Pubitemid 34651393)
-
(2002)
Cancer Research
, vol.62
, Issue.12
, pp. 3459-3465
-
-
May Jr., K.F.1
Chen, L.2
Zheng, P.3
Liu, Y.4
-
85
-
-
55949113750
-
Phase i study of BMS-663513, a fully human anti-CD137 agonist monoclonal antibody, in patients (pts) with advanced cancer (CA)
-
Abstract 3007
-
Sznol M, Hodi FS, Margolin K, et al. Phase I study of BMS-663513, a fully human anti-CD137 agonist monoclonal antibody, in patients (pts) with advanced cancer (CA). J Clin Oncol. 2008;26(20 suppl). Abstract 3007.
-
(2008)
J Clin Oncol
, vol.26
, Issue.20 SUPPL.
-
-
Sznol, M.1
Hodi, F.S.2
Margolin, K.3
-
86
-
-
0033602151
-
Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR
-
DOI 10.1016/S0960-9822(99)80093-1
-
Gurney AL, Marsters SA, Huang RM, et al. Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR. Curr Biol. 1999;9:215-218. (Pubitemid 29120387)
-
(1999)
Current Biology
, vol.9
, Issue.4
, pp. 215-218
-
-
Gurney, A.L.1
Marsters, S.A.2
Huang, A.3
Pitti, R.M.4
Mark, M.5
Baldwin, D.T.6
Gray, A.M.7
Dowd, P.8
Brush, J.9
Heldens, S.10
Schow, P.11
Goddard, A.D.12
Wood, W.I.13
Baker, K.P.14
Godowski, P.J.15
Ashkenazi, A.16
-
87
-
-
0345598872
-
Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cells
-
DOI 10.1073/pnas.2334901100
-
Tone M, Tone Y, Adams E, et al. Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cells. Proc Natl Acad Sci U S A. 2003;100:15059-15064. (Pubitemid 37518016)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.25
, pp. 15059-15064
-
-
Tone, M.1
Tone, Y.2
Adams, E.3
Yates, S.F.4
Frewin, M.R.5
Cobbold, S.P.6
Waldmann, H.7
-
88
-
-
4644342928
-
Concomitant tumor immunity to a poorly immunogenic melanoma is prevented by regulatory T cells
-
DOI 10.1084/jem.20041130
-
Turk MJ, Guevara-Patiño JA, Rizzuto GA, et al. Concomitant tumor immunity to a poorly immunogenic melanoma is prevented by regulatory T cells. J Exp Med. 2004;200:771-782. (Pubitemid 39299463)
-
(2004)
Journal of Experimental Medicine
, vol.200
, Issue.6
, pp. 771-782
-
-
Turk, M.J.1
Guevara-Patino, J.A.2
Rizzuto, G.A.3
Engelhorn, M.E.4
Houghton, A.N.5
-
89
-
-
33646419260
-
Agonist anti-GITR antibody enhances vaccine-induced CD8(+) T-cell responses and tumor immunity
-
Cohen AD, Diab A, Perales MA, et al. Agonist anti-GITR antibody enhances vaccine-induced CD8(+) T-cell responses and tumor immunity. Cancer Res. 2006;66:4904-4912.
-
(2006)
Cancer Res
, vol.66
, pp. 4904-4912
-
-
Cohen, A.D.1
Diab, A.2
Perales, M.A.3
-
90
-
-
77955279163
-
Agonist anti-GITR monoclonal antibody induces melanoma tumor immunity in mice by altering regulatory T cell stability and intra-tumor accumulation
-
Cohen AD, Schaer DA, Liu C, et al. Agonist anti-GITR monoclonal antibody induces melanoma tumor immunity in mice by altering regulatory T cell stability and intra-tumor accumulation. PLoS One. 2010; 5:e10436.
-
(2010)
PLoS One
, vol.5
-
-
Cohen, A.D.1
Schaer, D.A.2
Liu, C.3
-
91
-
-
0035892897
-
+ T cell mobilization/memory development and humoral immunity: Comparison of OX-40 with CTLA-4
-
Evans DE, Prell RA, Thalhofer CJ, et al. Engagement of OX40 enhances antigen-specific CD4(+) T cell mobilization/memory development and humoral immunity: comparison of alphaOX-40 with alphaCTLA-4. J Immunol. 2001;167:6804-6811. (Pubitemid 33144171)
-
(2001)
Journal of Immunology
, vol.167
, Issue.12
, pp. 6804-6811
-
-
Evans, D.E.1
Prell, R.A.2
Thalhofer, C.J.3
Hurwitz, A.A.4
Weinberg, A.D.5
-
92
-
-
0034651736
-
Engagement of the OX-40 receptor in vivo enhances antitumor immunity
-
Weinberg AD, Rivera MM, Prell R, et al. Engagement of the OX-40 receptor in vivo enhances antitumor immunity. J Immunol. 2000;164: 2160-2169. (Pubitemid 30108775)
-
(2000)
Journal of Immunology
, vol.164
, Issue.4
, pp. 2160-2169
-
-
Weinberg, A.D.1
Rivera, M.-M.2
Prell, R.3
Morris, A.4
Ramstad, T.5
Vetto, J.T.6
Urba, W.J.7
Alvord, G.8
Bunce, C.9
Shields, J.10
-
93
-
-
38849164304
-
Defects in the acquisition of CD8 T cell effector function after priming with tumor or soluble antigen can be overcome by the addition of an OX40 agonist
-
Redmond WL, Gough MJ, Charbonneau B, et al. Defects in the acquisition of CD8 T cell effector function after priming with tumor or soluble antigen can be overcome by the addition of an OX40 agonist. J Immunol. 2007;179:7244-7253.
-
(2007)
J Immunol
, vol.179
, pp. 7244-7253
-
-
Redmond, W.L.1
Gough, M.J.2
Charbonneau, B.3
-
94
-
-
78449237498
-
Signaling through OX40 enhances antitumor immunity
-
Jensen SM, Maston LD, Gough MJ, et al. Signaling through OX40 enhances antitumor immunity. Semin Oncol. 2010;37:524-532.
-
(2010)
Semin Oncol
, vol.37
, pp. 524-532
-
-
Jensen, S.M.1
Maston, L.D.2
Gough, M.J.3
-
95
-
-
77958047687
-
Adjuvant therapy with agonistic antibodies to CD134 (OX40) increases local control after surgical or radiation therapy of cancer in mice
-
Gough MJ, Crittenden MR, Sarff M, et al. Adjuvant therapy with agonistic antibodies to CD134 (OX40) increases local control after surgical or radiation therapy of cancer in mice. J Immunother. 2010;33:798-809.
-
(2010)
J Immunother
, vol.33
, pp. 798-809
-
-
Gough, M.J.1
Crittenden, M.R.2
Sarff, M.3
-
96
-
-
0036273628
-
Survival in human colorectal cancer correlates with expression of the T-cell costimulatory molecule OX-40 (CD134)
-
DOI 10.1016/S0002-9610(02)00831-0, PII S0002961002008310
-
Petty JK, He K, Corless CL, et al. Survival in human colorectal cancer correlates with expression of the T-cell costimulatory molecule OX-40 (CD134). Am J Surg. 2002;183:512-518. (Pubitemid 34603419)
-
(2002)
American Journal of Surgery
, vol.183
, Issue.5
, pp. 512-518
-
-
Petty, J.K.1
He, K.2
Corless, C.L.3
Vetto, J.T.4
Weinberg, A.D.5
-
97
-
-
78449265422
-
Increased CD4 and CD8 memory T cell proliferation following anti-OX40 administration to cancer patients: Immunologic assessment of a phase i clinical trial [abstract]
-
Kovacsovics-Bankowski M, Walker E, Floyd K, et al. Increased CD4 and CD8 memory T cell proliferation following anti-OX40 administration to cancer patients: immunologic assessment of a phase I clinical trial [abstract]. J Immunother 2009;32:952.
-
(2009)
J Immunother
, vol.32
, pp. 952
-
-
Kovacsovics-Bankowski, M.1
Walker, E.2
Floyd, K.3
|