Oridonin induced the apoptosis of PC-3 cells and its mechanism

Journal of Central South University (Medical Sciences)

Volumn 36, Issue 8, 2011, Pages 754-759

  Li, Jin ^a   Yang, Luoyan ^b   Wu, Hongtao ^b  

^a Central Hospital of Xiangtan   (China)

^b CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Apoptosist; Inhibition; Oridonin; Pc 3 cell; Proliferation

Indexed keywords

BAX PROTEIN, HUMAN; CASP3 PROTEIN, HUMAN; CASPASE 3; KAURANE DERIVATIVE; ORIDONIN; PROTEIN BAX; PROTEIN BCL 2;

APOPTOSIS; ARTICLE; CELL PROLIFERATION; DOSE RESPONSE; DRUG EFFECT; HUMAN; MALE; METABOLISM; PATHOLOGY; PROSTATE; TUMOR CELL LINE;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CELL LINE, TUMOR; CELL PROLIFERATION; DITERPENES, KAURANE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MALE; PROSTATE; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 80053358027     PISSN: 16727347     EISSN: None     Source Type: Journal    
DOI: 10.3969/j.issn.1672-7347.2011.08.010     Document Type: Article

References (16)

1. Zhu Y, Xie L, Chen G, et al. Effects of oridonin on proliferation of HT29 human colon carcinoma cell lines both in vitro and in vivo in mice[J]. Pharmazie, 2007,62(6) :439-444.
2. Li D, Wu L J, Tashiro S, et al. Oridonin induces human epidermoid carcinoma A431 cell apoptosis through tyrosine kinase and mitochondrial pathway[J]. J Asian Nat Prod Res, 2008,10 (l/2):77-87.
3. Cui Q, Tashiro S, Onodera S, et al. Oridonin induced autophagy in human cervical carcinoma HeLa cells through Ras, JNK, and P38 regulation[J]. J Pharmacol Sci, 2007,105(4); 317-325.
4. Wang HJ, Li D, Yang FY, el al. Oridonin induces human melanoma A375-S2 cell death partially through inhibiting insulin-like growth factor 1 receptor signaling[J]. J Asian Nat Prod Res, 2008,10(7/8) : 787-798.
5. HE Xujun, WANG Huiju, XIA Yingjie, et al. Empirical study of oridonin-induced gastric cancer cells MKN45 apoptosis[J]. Zhonghua Wei Chang Wai Ke Za Zhi, 2009,12(6) : 607-610.
6. Singh M, Sharma H, Singh N. Hydrogen peroxide induces apoptosis in Hela cells through mitochondrial pathway[J]. Mitochondrion, 2007,7(6) : 367-373. (Pubitemid 350082358)
7. Yao J, Jiang Z, Duan W, et al. Involvement of mitochondrial pathway in triptolide-induced cytotoxicity in human normal liver L-02 cellsf[J]. Biol Pharm Bull, 2008, 31(4) : 592-597. (Pubitemid 351500486)
8. Hu Q, Pan R, Wang L, et al. Platycodon grandiflorum induces apoptosis in SK0V3 human ovarian cancer cells through mitochondrial-dependent pathway[J]. Am J Chin Med, 2010, 38(2) : 373-386.
9. Wang Z F, Yin J, Zhang Y, et al. Overexpression of tau proteins antagonizes amyioid-beta-potentiated apoptosis through mitochondria-caspase-3 pathway in N2a cells [J] . J Alzheimers Dis, 2010,20(1):145-157.
10. Choi E J, Kim G H. Apigenin induces apoptosis through a mitochondria/caspase-pathway in human breast cancer MDA-MB453 CeIIs[J]. J Clin Biochem Nutr, 2009, 44(3) : 260-265.
11. Tretiakova I, Blaesius D, Maxia L, et al. Myrtucommulone from Myrtus communis induces apoptosis in cancer cells via the mitochondrial pathway involving caspase-9 [J]. Apoptosis, 2008, 13(0:119-131.
12. Hoist C M, Johansson V M, Aim K, et al. Novel anti-apoptotic effect of Bcl-2 : prevention of polyamine depletion-induced cell death[J]. Cell Biol Int, 2008, 32(1) : 66-74. (Pubitemid 351249140)
13. Shaltouki A, Freer M, Mei Y, et al. Increased expression of the pro-apoptotic Bcl2 family member PUMA is required for mitochondrial release of cytochrome C and the apoptosis associated with skeletal myoblast differentiation [J]. Apoptosis, 2007, 12 (12) : 2143-2154. (Pubitemid 350077249)
14. Ji L, Chen Y, Liu T, et al. Involvement of Bcl-xL degradation and mitochondriai-mediated apoptotic pathway in pyrrolizidine alkaloids-induced apoptosis in hepatocytes [J]. Toxicol Appl Pharmacol, 2008, 231(3) : 393-400.
15. Brazeau E, Mahalingam R, Gilden D, et al. Varicella-zoster virus-induced apoptosis in MeWo cells is accompanied by down-regulation of Bcl-2 expression [J] . J Neurovirol, 2010, 16(2) : 133-140.
16. Nagaraj N S, Anilakumar K R, Singh O V. Diallyl disulfide causes caspase-dependent apoptosis in human cancer cells through a Bax-triggered mitochondrial pathway[J]. J Nutr Biochem, 2010, 21(5) : 405-412.