Extracellular signal-regulated kinase1/2 activated by fluid shear stress promotes osteogenic differentiation of human bone marrow-derived mesenchymal stem cells through novel signaling pathways

International Journal of Biochemistry and Cell Biology

Volumn 43, Issue 11, 2011, Pages 1591-1601

  Liu, Liyue ^a   Shao, Lan ^a   Li, Bo ^b   Zong, Chen ^a   Li, Jianhu ^b   Zheng, Qiang ^b   Tong, Xiangming ^b   Gao, Changyou ^b   Wang, Jinfu ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY   (China)

Author keywords

Extracellular signal regulated kinase1 2; Fluid shear stress; Human mesenchymal stem cells; Molecular signaling network; Osteogenic differentiation

Indexed keywords

ALKALINE PHOSPHATASE; BETA1 INTEGRIN; BONE MORPHOGENETIC PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; SMAD PROTEIN; TRANSCRIPTION FACTOR RUNX2;

ARTICLE; BONE MARROW DERIVED MESENCHYMAL STEM CELL; BONE TISSUE; CELL DIFFERENTIATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ASSAY; GENE EXPRESSION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; MESENCHYMAL STEM CELL; NUCLEOTIDE SEQUENCE; OSTEOGENIC DIFFERENTIATION; PROTEIN EXPRESSION; SHEAR STRESS; SIGNAL TRANSDUCTION; TISSUE ENGINEERING;

ADULT; ANTIGENS, CD29; BONE MARROW CELLS; BONE MORPHOGENETIC PROTEINS; CELL DIFFERENTIATION; CORE BINDING FACTOR ALPHA 1 SUBUNIT; HUMANS; MALE; MAP KINASE SIGNALING SYSTEM; MESENCHYMAL STEM CELLS; MIDDLE AGED; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NF-KAPPA B; OSTEOGENESIS; PHOSPHORYLATION; REAL-TIME POLYMERASE CHAIN REACTION; STRESS, MECHANICAL; TISSUE ENGINEERING; UP-REGULATION;

EID: 80053356610     PISSN: 13572725     EISSN: 18785875     Source Type: Journal    
DOI: 10.1016/j.biocel.2011.07.008     Document Type: Article

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