Anorexigenic cocaine- and amphetamine-regulated transcript peptide intensifies fear reactions in rats

Brain Research

Volumn 857, Issue 1-2, 2000, Pages 283-285

  Kask, Ants ^a,b   Schiöth, Helgi B ^b,c   Mutulis, Felikss ^b   Wikberg, Jarl E S ^b,c   Rägo, Lembit ^a  

^a UNIVERSITY OF TARTU   (Estonia)

^b UPPSALA UNIVERSITY   (Sweden)

^c Melacure Therapeutics   (Sweden)

Author keywords

Anxiety; Cocaine and amphetamine regulated transcript; Fear; Ingestive behavior; Stress

Indexed keywords

AMPHETAMINE; COCAINE; COCAINE AND AMPHETAMINE REGULATED TRANSCRIPT; COMPLEMENTARY DNA; LEPTIN; MESSENGER RNA; PEPTIDE FRAGMENT; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ANXIETY; CONTROLLED STUDY; DOSE RESPONSE; FLUID INTAKE; FOOD INTAKE; LOCOMOTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SHORT SURVEY;

EID: 0343484997     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(99)02383-5     Document Type: Article

References (12)

1. Couceyro P.R., Lambert P.D. CART peptides: therapeutic potential in obesity and feeding disorders. Drug News Perspect. 12:1999;133-136.
2. Douglass A., McKinzie P., Couceyro P. PCR differential display identifies a rat brain mRNA that is transcriptionally regulated by cocaine and amphetamine. J. Neurosci. 15:1995;2471-2481.
3. Dunn A.J., Berridge C.W. Physiological and behavioural responses to corticotropin-releasing factor administration: is CRF a mediator of anxiety or stress responses? Brain Res. Rev. 15:1990;71-100.
4. Handley S.L., Mithani S. Effects of alpha-adrenoceptor agonists and antagonists in a maze-exploration model of 'fear'-motivated behaviour. Naunyn-Schmiedeberg's Arch. Pharmacol. 327:1984;1-5.
5. Kask A., Mutulis F., Muceniece R., Pähkla R., Mutule I., Wikberg J.E.S., Rägo L., Schiöth H.B. Discovery of a novel superpotent and selective melanocortin-4 receptor antagonist (HS024): evaluation in vitro and in vivo. Endocrinology. 139:1998;5006-5014.
6. Koylu E.O., Couceyro P.R., Lambert P.D., Kuhar M.J. Cocaine- and amphetamine-regulated transcript peptide immunohistochemical localization in the rat brain. J. Comp. Neurol. 391:1998;115-132.
7. Koylu E.O., Smith Y., Coyceuro P.R., Kuhar M.J. CART peptides colocalize with tyrosine hyroxylase neurons in rat locus coeruleus. Synapse. 31:1999;309-311.
8. Kristensen P., Judge M.E., Thim L., Ribel U., Christjansen K.N., Wulff B.S., Clausen J.T., Jensen P.B., Madsen O.D., Vrang N., Larsen P.J., Hastrup S. Hypothalamic CART is a new anorectic peptide regulated by leptin. Nature. 393:1998;72-76.
9. Kuhar M.J., Dall Vechia S.E. CART peptides: novel addiction- and feeding-related neuropeptides. Trends Neurosci. 22:1999;316-320.
10. Lambert P.D., Couceyro P.R., McGirr K.M., Dall Vechia S.E., Smith Y., Kuhar M.J. CART peptides in the central control of feeding and interactions with neuropeptide Y. Synapse. 29:1998;293-298.
11. Thim L., Kristensen P., Larsen P.J., Wulff B.S. CART, a new anorectic peptide. Int. J. Biochem. Cell Biol. 30:1998;1281-1284.
12. Vrang N., Larsen P.J., Clausen J.T., Kristensen P. Neurochemical characterization of hypothalamic cocaine-amphetamine-regulated transcript neurons. J. Neurosci. 19(RC5):1999;1-8.