Pharmacological, pharmacognostic and phytochemical review of saffron

International Journal of Pharmacy and Technology

Volumn 3, Issue 3, 2011, Pages 1214-1234

  Padmavathy, J ^a   Praveen Kumar, Ch ^a   Sai Saraswathi, V ^a   Saravanan, D ^a   Aparna Lakshmi, I ^a   Hima Sai Bindu, N ^a   Hemafaith, V ^a  

^a Ratnam Institute of Pharmacy   (India)

Author keywords

Anticancer; Depression; Saffron

Indexed keywords

CROCIN; HERBACEOUS AGENT; PICROCROCIN; PLANT MEDICINAL PRODUCT; SAFRANAL; SEROTONIN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANTIBACTERIAL ACTIVITY; ANTICONVULSANT ACTIVITY; ANTIDEPRESSANT ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; CLINICAL PHARMACOLOGY; CORONARY ARTERY DISEASE; CROCUS SATIVUS; DEPRESSION; DIARRHEA; DRUG ACTIVITY; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG POTENTIATION; DRUG SAFETY; DRUG STRUCTURE; DYSURIA; ERECTILE DYSFUNCTION; FEVER; HUMAN; IMPOTENCE; INDIGESTION; MENSTRUATION DISORDER; NAUSEA; NEOPLASM; NONHUMAN; PAIN; PHYTOCHEMISTRY; PSORIASIS; REVIEW; SKIN DISEASE; SWELLING; TAXONOMIC RANK; TOXICITY TESTING; VOMITING; WEAKNESS;

EID: 80053330704     PISSN: None     EISSN: 0975766X     Source Type: Journal    
DOI: None     Document Type: Review

References (53)

1. Abdullaev, F.I. 1993. Biological effects of saffron. Bio Factors. 4: 83-86.
2. Abdullaev, F.I. 2004. Biomedical properties of saffron and its potential use in cancer therapy and chemoprevention trials. Cancer Det. Preven. 28 (6):426-432.
3. Shultes RE. The kingdom of plants. In: Thomson WAR, editor. Medicines from the earth. New York, NY: McGraw-Hill Book Co.; 1978. p. 208.
4. Rios JL, Recio MC, Giner RM, Manez S. An update review of saffron and its constituents, 1996;10:189-93.
5. Duke, JA. Handbook of Medicinal Herbs. Boca Raton, Florida: CRC Press, 1985.
6. Deo, B. (2003). Growing saffron The world's most expensive spice. Crop & Food Research, 20, 1-4.
7. Akhondzadeh S, et al., Comparison of Crocus sativus and imipramine in the treatment of mild to moderate depression: a pilot double-blind randomized trial, Biomed Central Complementary and Alternative Medicine 2004; 4(1): 12.
8. Hill, T. (2004). The contemporary encyclopedia of herbs and spices: Seasonings for the global kitchen. Hoboken: John Wiley & Sons, Inc.
9. ISO Technical Specifications 3632-1/2. (2003). Saffron (Crocus sativus L.). Part 1: Specifications and Part 2: Test methods.
10. Noorbala AA, Hydro-alcoholic extract of Crocus sativus versus fluoxetine in the treatment of mild to moderate depression: a double-blind, randomized pilot trial, Journal of Ethnopharmacology 2005; 97(2): 281-284
11. Bucheker, R.; Eugster, C. H. Absolute configuration of picrocrocin. Helv. Chim. Acta 1973, 56, (3), 1121-1125.
12. Cadwallader, K.R.; Back, H.H.; Cai, M.; ACS Symposium Series, No. 166 (Spices), American Chemical Society, Pub., Washington DC, 1997, pp.66-79.
13. Teale; Stephen A.; Webster; Francis X.; Zhang; Aijun, New aggregation pheromone for the bark beetle Ips pini and uses thereof, United States Patent 5,167,955, December 1, 1992
14. st National Conference on Saffron, Heart, Afghanistan.
15. Rios, J. L., Recio, M. C., Giner, R. M., & Manez, S. (1996). A update review of saffron and its active constituents. Phytotherapy Research, 10, 189-193.
16. Alonso, G. L., Salinas, M. R., Garijo, J., & Sanchez-Fernadez, M. A. (2001). Composition of crocins and picrocrocin from Spanish saffron (Crocus sativus L.). Journal of Food Quality, 24(3), 219-233.
17. Carmona, M., Zalacain, A., Salinas, M. R., & Alonso, G. L. (2007). A new approach to saffron aroma. Critical Reviews in Food Science and Nutrition, 47, 145-159.
18. Maggi, L., Carmona, M., del Campo, C. P., Kanakis, C. D., Anastasaki, E., Tarantilis, P. A., et al. (2009). Worldwide market screening of saffron volatile composition. Journal of the Science of Food and Agriculture, 89(11), 1950-1954
19. Martin, G. 2002. Evaluation of the developmental toxicity of crocetin on Xenopus Food Chem. Toxicol. 40(7):959-964.
20. Becker RE, Greig NH (2008) Alzheimer's disease drug development in beyond: problems and opportunities. Curr Alzheimer Res 5:346-357.
21. Tsuno N (2009) Donepezil in the treatment of patients with Alzheimer's disease. Expert Rev Neurother 9:591- 598.
22. Akhondzadeh Basti, A., Moshiri, E., Noorbala, A., Jamshidi, A., Abbasi, S. H., & Akhondzadeh, S. (2007). Comparison of petal of Crocus sativus L. and fluoxetine in the treatment of depressed outpatients: A pilot double-blind randomized trial. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 31(2), 439-442.
23. Akhondzadeh, S., Fallah-Pour, H., Afkham, K., Jamshidi, A., & Khalighi-Cigaroudi, F. (2004). Comparison of Crocus sativus L. and imipramine in the treatment of mild to moderate depression: A pilot double-blind randomized trial. BMC Complementary Alternative Medicine, 4, 12.
24. Kim, Y.K., Jung, J.S., Lee, S.H., Kim, Y.W., 1997. Effects of antioxidants and Ca2+ in cisplatin-induced cell injury in rabbit renal cortical slices. Toxicol. Appl.Pharmacol. 146, 261-269.
25. Limaye, P.V., Raghuram, N., Sivakami, S., 2003. Oxidative stress and gene expression of antioxidant enzymes in the renal cortex of streptozotocin induced diabetic rats. Mol. Cell. Biochem. 243, 147-152.
26. Kaur, G., Han, S.J., Yang, I., Crane, C., 2010. Microglia and central nervous system immunity. Neurosurg. Clin. N. Am. 21, 43-51.
27. Graeber, M.B., Streit, W.J., 2010. Microglia: biology and pathology. Acta Neuropathol. 119, 89-105.
28. Sagoo, S. K., Little, C. L., Greenwood, M., Mithani, V., Grant, K. A., McLauchlin, J., et al. (2009). Assessment of the microbiological safety of dried spices and herbs from production and retail premises in the United Kingdom. Food Microbiology, 26, 39-43.
29. Gustavsen, S., & Breen, O. (1984). Investigation of an outbreak of Salmonella oranienburg infections in Norway, caused by contaminated black pepper. American Journal of Epidemiology, 119, 806-812.
30. Cosano, I., Pintado, C., Acevedo, A., Novella, J., Carmona, M., de la Rosa, C., et al. (2009). Microbiological quality of saffron from the main producer countries. Journal of Food Protection, 72, 2217-2220.
31. Verma SK, Bordia A. Antioxidant property of saffron in man. Indian J Med Sci 1998; 52(5):205-7.
32. Abe K, Saito H. Effects of saffron extract and its constituent crocin on learning behaviour and long-term potentiation. Phytother Res 2000; 14(3):49-52.
33. Abe K, Suguira M, Yamaguchi S, Shoyama Y, Saito H. Saffron extract prevents acetaldehyde-induced inhibition of long-term potentiation in the rat dentate gyrus in vivo. Brain Res 1999;851(1-2):287-9.
34. Zhang Y, Shoyama Y, Sugiura M, Satto H. Effects of Crocus sativus L. on the ethanol-induced impairments of passive avoidance performances in mice. Biol Pharm Bull 1994;17(2):217-21.
35. Sugiura M, Shoyama Y, Saito H, Abe K, Crocin. (crocetin di-gentiobiose ester) prevents the inhibitory effect of ethanol on long-term potentiation in the dentate gyrus in vivo. JPET 1994;271(2):703-7.
36. Sugiura M, Shoyama Y, Saito H, Nishiyama N. Crocin improves the ethanol-induced impairment of learning behaviors of mice in passive avoidance tasks. Proc Jpn Acad 1995;71(ser B):319-24.
37. Sugiura M, Saito H, Abe K. Ethanol extract of Crocus sativus L. antagonizes the inhibitory action of ethanol on hippocampal long-term potentiation in vivo. Phytother Res 1995;9:100-4.
38. Hans peter W, Deuter M, Imilda E: Chemoprevention of tobacco smoke induced lung carcinogenesis in mice. Carcinogenesis 21: 977-82, 2000.
39. Anto RJ, Mukhopadyah A, Denning K, Aggarwal BB: Curcumin induces apoptosis through activation of caspase-8, BID cleavage and cytochrome c release: its suppression by ectopic expression of Bcl-2 and Bcl-xl. Carcinogenesis 23: 143-50, 2002.
40. Stephen S, Pramod Upadhaya, Mingyao Wang, Robin L. Bliss, Edward J. Mcintee, Patrick MJ Kenney: Inhibition of lung tumorigenesis in A/J mice by N-acetyl-S-(N-2-phenethylthiocarbamoyl)-L- cysteine and myo-inositol, individually and in combination. Carcinogenesis 29: 1455-1461, 2002.
41. Demming-Adams B, Gilmore AM, Adams WW: In Vivo Functions Of Carotenoids In Higher Plants, FASEB Journal 10: 403-412, 1996.
42. Jagadeswaran R, Thirunavukkarasu C, Gunasekaran P, Nalini Ramamurthy, Sakthisekaran D: In vitro studies on the selective cytotoxic effect of crocetin and quercetin. Fitoterapia 71: 395-399, 2000.
43. Abdullaev FI: Cancer chemopreventive and tumoricidal properties of saffron (Crocus sativus,L). Exptl Biol Med 227: 20-5, 2002.
44. Chang VC, Lin YL, Lee MJ, Show SJ, Wang CJ: Inhibitory effect of crocetin on benzo(a)pyrece genotoxicity and neoplastic transformation in C3H1OT1/2 cells. Anticancer Res 765: 3603-3608, 1996.
45. Nair SC, Pannikar B, Pannikar KR: Antitumour activity of saffron (Crocus sativus). Cancer Lett 57: 109-14, 1991.
46. Salomi MJ, Nair SC, Panikkar PR: Cytotoxicity and nonmutagenicity of Nigela sativa and saffron (Crocus sativus) in vitro. Proc Ker Congr 5: 244, 1991.
47. Tarantilis PA, Tsoupras G, Polissiou M: Determination of saffron (Crocus sativus. L) components in crude plant extract using HPLC-UV Visible photodiode-array detection-mass spectrometry. J Chromatography 699: 107-18, 1995.
48. Daly ES: Protective effect of cystein and vitamin A, Crocus sativus and Nigela sativa extracts on cysplatin induced toxicity in rats. J Pharm Belg 53: 93-5, 1998.
49. Hosseinzadeh H and Khosravan V, Anticonvulsant effects aqueous and ethanolic extracts of Crocus sativus stigmas in mice, Archives of Iranian Medicine 2002; 5: 44-47.
50. Xuan B, Zhou YH, Li N, Min ZD, Chiou GC. Effects of crocin analogs on ocular blood flow and retinal function. J Ocul Pharmacol Ther. 1999;15(2):143-152.
51. Laabich A, Vissvesvaran GP, Lieu KL, et al. Protective effect of crocin against blue light- and white light- mediated photoreceptor cell death in bovine and primate retinal primary cell culture. Invest Ophthalmol Vis Sci. 2006;47(7):3156-3163.
52. Maccarone R, Di Marco S, Bisti S. Saffron supplement maintains morphology and function after exposure to damaging light in mammalian retina. Invest Ophthalmol Vis Sci 2008;49(3):1254-1261.
53. Brown AC, Hairfield M, Richards DG, McMillin DL, Mein EA, Nelson CD. Medical nutrition therapy as a potential complementary treatment for psoriasis-five case reports. AlternMedRev 2004;9(3):297-307.