Combination of BAY 60-4552 and vardenafil exerts proerectile facilitator effects in rats with cavernous nerve injury: A proof of concept study for the treatment of phosphodiesterase type 5 inhibitor failure

European Urology

Volumn 60, Issue 5, 2011, Pages 1020-1026

  Oudot, Alexandra ^a,d   Behr Roussel, Delphine ^a,d   Poirier, Sarah ^a   Sandner, Peter ^b   Bernabé, Jacques ^a,d   Alexandre, Laurent ^a   Giuliano, Franois ^c,d  

^a Pelvipharm   (France)

^b BAYER PHARMA AG   (Germany)

^c RAYMOND POINCARÉ HOSPITAL   (France)

^d LABORATOIRE DES SCIENCES DU CLIMAT ET DE L ENVIRONNEMENT   (France)

Author keywords

Erectile dysfunction; Experimental; Nonresponders; Pharmacology; Radical prostatectomy

Indexed keywords

BAY 60 4552; GUANYLATE CYCLASE ACTIVATOR; PHOSPHODIESTERASE V INHIBITOR; UNCLASSIFIED DRUG; URETHAN; VARDENAFIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CORPUS CAVERNOSUM; CRUSH TRAUMA; DRUG TREATMENT FAILURE; ELECTROSTIMULATION; ERECTILE DYSFUNCTION; LAPAROTOMY; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PENIS ERECTION; PENIS INJURY; PRIORITY JOURNAL; RAT;

ANIMALS; BLOOD PRESSURE; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 5; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; ELECTRIC STIMULATION; ENZYME ACTIVATION; ENZYME ACTIVATORS; ERECTILE DYSFUNCTION; GUANYLATE CYCLASE; IMIDAZOLES; MALE; NERVE CRUSH; PENIS; PHOSPHODIESTERASE 5 INHIBITORS; PIPERAZINES; PYRAZOLES; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SULFONES; TIME FACTORS; TREATMENT FAILURE; TRIAZINES;

EID: 80053330658     PISSN: 03022838     EISSN: 18737560     Source Type: Journal    
DOI: 10.1016/j.eururo.2011.07.052     Document Type: Article

References (35)

1. K.J. Hurt, B. Musicki, and M.A. Palese Akt-dependent phosphorylation of endothelial nitric-oxide synthase mediates penile erection Proc Natl Acad Sci U S A 99 2002 4061 4066 (Pubitemid 34252229)
2. T.F. Lue Erectile dysfunction N Engl J Med 342 2000 1802 1813 (Pubitemid 30390241)
3. E. Waldkirch, S. Uckert, and K. Sigl Expression and distribution of cyclic GMP-dependent protein kinase-1 isoforms in human penile erectile tissue J Sex Med 5 2008 536 543 (Pubitemid 351337879)
4. F. Montorsi, G. Adaikan, and E. Becher Summary of the recommendations on sexual dysfunctions in men J Sex Med 7 2010 3572 3588
5. K. Hatzimouratidis, E. Amar, and I. Eardley Guidelines on male sexual dysfunction: erectile dysfunction and premature ejaculation Eur Urol 57 2010 804 814
6. C.L. Miles, B. Candy, and L. Jones Interventions for sexual dysfunction following treatments for cancer Cochrane Database Syst Rev 2007 CD005540
7. H. Garban, D. Vernet, A. Freedman, J. Rajfer, and N. Gonzalez-Cadavid Effect of aging on nitric oxide-mediated penile erection in rats Am J Physiol 268 1995 H467 H475
8. J.A. Kim, M. Montagnani, K.K. Koh, and M.J. Quon Reciprocal relationships between insulin resistance and endothelial dysfunction: molecular and pathophysiological mechanisms Circulation 113 2006 1888 1904 (Pubitemid 43739401)
9. G. Brock, A. Nehra, and L.I. Lipshultz Safety and efficacy of vardenafil for the treatment of men with erectile dysfunction after radical retropubic prostatectomy J Urol 170 2003 1278 1283 (Pubitemid 37108132)
10. K. Hatzimouratidis, A.L. Burnett, and D. Hatzichristou Phosphodiesterase type 5 inhibitors in postprostatectomy erectile dysfunction: a critical analysis of the basic science rationale and clinical application Eur Urol 55 2009 334 347
11. F. Montorsi, H.P. Nathan, and A. McCullough Tadalafil in the treatment of erectile dysfunction following bilateral nerve sparing radical retropubic prostatectomy: a randomized, double-blind, placebo controlled trial J Urol 172 2004 1036 1041 (Pubitemid 39096457)
12. T.J. Bivalacqua, T. Liu, B. Musicki, H.C. Champion, and A.L. Burnett Endothelial nitric oxide synthase keeps erection regulatory function balance in the penis Eur Urol 51 2007 1732 1740 (Pubitemid 46634738)
13. M. Kendirci, O. Tanriverdi, L. Trost, and W.J. Hellstrom Management of sildenafil treatment failures Curr Opin Urol 16 2006 449 459 (Pubitemid 44624580)
14. J.D. Brioni, M. Nakane, and G.C. Hsieh Activators of soluble guanylate cyclase for the treatment of male erectile dysfunction Int J Impot Res 14 2002 8 14 (Pubitemid 34188625)
15. G.C. Hsieh, A.B. O'Neill, R.B. Moreland, J.P. Sullivan, and J.D. Brioni YC-1 potentiates the nitric oxide/cyclic GMP pathway in corpus cavernosum and facilitates penile erection in rats Eur J Pharmacol 458 2003 183 189 (Pubitemid 36050718)
16. J.S. Kalsi, R.W. Rees, and A.J. Hobbs BAY41-2272, a novel nitric oxide independent soluble guanylate cyclase activator, relaxes human and rabbit corpus cavernosum in vitro J Urol 169 2003 761 766 (Pubitemid 36133038)
17. H. Mizusawa, P. Hedlund, J.D. Brioni, J.P. Sullivan, and K.E. Andersson Nitric oxide independent activation of guanylate cyclase by YC-1 causes erectile responses in the rat J Urol 167 2002 2276 2281 (Pubitemid 34309719)
18. L.N. Miller, M. Nakane, and G.C. Hsieh A-350619: a novel activator of soluble guanylyl cyclase Life Sci 72 2003 1015 1025 (Pubitemid 36001981)
19. E. Bischoff, M. Schramm, A. Straub, A. Feurer, and J.P. Stasch BAY 41-2272: a stimulator of soluble guanylyl cyclase induces nitric oxide-dependent penile erection in vivo Urology 61 2003 464 467 (Pubitemid 36206566)
20. T. Nagayama, M. Zhang, S. Hsu, E. Takimoto, and D.A. Kass Sustained soluble guanylate cyclase stimulation offsets nitric-oxide synthase inhibition to restore acute cardiac modulation by sildenafil J Pharmacol Exp Ther 326 2008 380 387
21. O. Canguven, and A. Burnett Cavernous nerve injury using rodent animal models J Sex Med 5 2008 1776 1785
22. M. Mullerad, J.F. Donohue, P.S. Li, P.T. Scardino, and J.P. Mulhall Functional sequelae of cavernous nerve injury in the rat: is there model dependency J Sex Med 3 2006 77 83
23. F. Giuliano, O. Rampin, J. Bernabé, and J. Rousseau Neural control of penile erection in the rat J Auton Nerv Syst 55 1995 36 44
24. F. Giuliano, J. Bernabe, A. Jardin, and J.P. Rousseau Antierectile role of the sympathetic nervous system in rats J Urol 150 1993 519 524 (Pubitemid 23215916)
25. D.M. Quinlan, R.J. Nelson, A.W. Partin, J.L. Mostwin, and P.C. Walsh The rat as a model for the study of penile erection J Urol 141 1989 656 661 (Pubitemid 19089182)
26. J.P. Mulhall, A. Muller, and J.F. Donohue The functional and structural consequences of cavernous nerve injury are ameliorated by sildenafil citrate J Sex Med 5 2008 1126 1136 (Pubitemid 351606701)
27. C. Gratzke, T.D. Strong, and M.A. Gebska Activated RhoA/Rho kinase impairs erectile function after cavernous nerve injury in rats J Urol 184 2010 2197 2204
28. A.R. McCullough, J.H. Barada, A. Fawzy, A.T. Guay, and D. Hatzichristou Achieving treatment optimization with sildenafil citrate (Viagra) in patients with erectile dysfunction Urology 60 2002 28 38 (Pubitemid 35300144)
29. F. Montorsi, G. Brock, and J. Lee Effect of nightly versus on-demand vardenafil on recovery of erectile function in men following bilateral nerve-sparing radical prostatectomy Eur Urol 54 2008 924 931
30. J.P. Stasch, K. Dembowsky, E. Perzborn, E. Stahl, and M. Schramm Cardiovascular actions of a novel NO-independent guanylyl cyclase stimulator, BAY 41-8543: in vivo studies Br J Pharmacol 135 2002 344 355 (Pubitemid 34151166)
31. M.R. Nangle, and J.R. Keast Reduced efficacy of nitrergic neurotransmission exacerbates erectile dysfunction after penile nerve injury despite axonal regeneration Exp Neurol 207 2007 30 41 (Pubitemid 47332480)
32. C.H. Lee, H.S. Kim, and M.J. Goo Chronic administration of udenafil, a selective phosphodiesterase type 5 inhibitor, promotes erectile function recovery in an animal model of bilateral cavernous nerve crush injury J Sex Med 8 2011 1330 1340
33. L. Vignozzi, S. Filippi, and A. Morelli Effect of chronic tadalafil administration on penile hypoxia induced by cavernous neurotomy in the rat J Sex Med 3 2006 419 431
34. J.S. Kalsi, D.J. Ralph, D.J. Madge, P.D. Kell, and S. Cellek A comparative study of sildenafil, NCX-911 and BAY41-2272 on the anococcygeus muscle of diabetic rats Int J Impot Res 16 2004 479 485 (Pubitemid 39664854)
35. A. Zucchi, G. Arienti, and L. Mearini Recovery of sexual function after nerve-sparing radical retropubic prostatectomy: is cavernous nitric oxide level a prognostic index? Int J Impot Res 18 2006 198 200 (Pubitemid 43336488)