Discovery of a novel neuroprotective compound, AS1219164, by high-throughput chemical screening of a newly identified apoptotic gene marker

European Journal of Pharmacology

Volumn 669, Issue 1-3, 2011, Pages 7-14

  Yamazaki, Takao ^a   Muramoto, Masakazu ^a   Okitsu, Osamu ^a   Morikawa, Noriyuki ^a   Kita, Yasuhiro ^b  

^a ASTELLAS PHARMA INC   (Japan)

^b DAIICHI SANKYO CO   (Japan)

Author keywords

AS1219164; Diclofenac; FK506; LBH gene; Neuroprotection; TMEM100 gene

Indexed keywords

[3 [2 [5 (2 PYRIDIN 4 YLVINYL)PYRIDIN 3 YL]VINYL]ANILINE]; AS 1219164; COMPLEMENTARY DNA; DICLOFENAC; MEMBRANE PROTEIN; MEMBRANE PROTEIN 100; NEUROPROTECTIVE AGENT; STAUROSPORINE; TACROLIMUS; THAPSIGARGIN; TUNICAMYCIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL DEATH; CELL PROTECTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISEASE MARKER; DRUG IDENTIFICATION; DRUG SCREENING; DRUG TARGETING; GENE; GENE EXPRESSION PROFILING; GENE IDENTIFICATION; GENETIC TRANSCRIPTION; HEART; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IN VITRO STUDY; INTRACELLULAR SIGNALING; LBH GENE; LIMB BUD; MARKER GENE; MOLECULAR INTERACTION; NEUROPROTECTION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; TMEM100 GENE; TRANSACTIVATION; TRANSCRIPTION REGULATION;

ANILINE COMPOUNDS; APOPTOSIS; BIOLOGICAL MARKERS; CASPASE 3; CELL LINE, TUMOR; CELL SURVIVAL; DICLOFENAC; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENES, REPORTER; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; LUCIFERASES; NEUROPROTECTIVE AGENTS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROMOTER REGIONS, GENETIC; PYRIDINES; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; TACROLIMUS; THAPSIGARGIN; TRANS-ACTIVATORS;

EID: 80053324355     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2011.07.027     Document Type: Article

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